@article{MTMT:30654928,
	title = {Chemically Modified Derivatives of the Activator Compound Cloxyquin Exert Inhibitory Effect on TRESK (K2P18.1) Background Potassium Channel},
	url = {https://m2.mtmt.hu/api/publication/30654928},
	author = {Lengyel, Miklós and Erdélyi, Ferenc and Pergel, Enikő and Polonkáné Bálint, Ágnes and Dobolyi, Alice and Bozsaki, Peter and Dux, Mária and Király, Kornél P and Hegedűs, Tamás and Czirják, Gábor and Mátyus, Péter and Enyedi, Péter},
	doi = {10.1124/mol.118.115626},
	journal-iso = {MOL PHARMACOL},
	journal = {MOLECULAR PHARMACOLOGY},
	volume = {95},
	unique-id = {30654928},
	issn = {0026-895X},
	abstract = {Cloxyquin has been reported as a specific activator of TRESK (K2P18.1, TWIK-related spinal cord K+ channel) background potassium channel. In this study, we have synthetized chemically modified analogues of cloxyquin and tested their effects on TRESK and other K2P channels. The currents of murine K2P channels, expressed heterologously in Xenopus oocytes, were measured by two-electrode voltage clamp, whereas the native background K+ conductance of mouse dorsal root ganglion (DRG) neurons was examined by the whole-cell patch clamp method. Some of the analogues retained the activator character of the parent compound, but more interestingly, other derivatives inhibited mouse TRESK current. The inhibitor analogues (A2764 and A2793) exerted state-dependent effect. The degree of inhibition by 100 µM A2764 (77.8±1.5%, n=6) was larger in the activated state of TRESK (i.e. after calcineurin-dependent stimulation) than in the resting state of the channel (42.8±4.3% inhibition, n=7). The selectivity of the inhibitor compounds was tested on several K2P channels. A2793 inhibited TASK-1 (100 µM, 53.4±6%, n=5), while A2764 was more selective for TRESK, it only moderately influenced TREK-1 and TALK-1. The effect of A2764 was also examined on the background K+ currents of DRG neurons. A subpopulation of DRG neurons, prepared from wild-type animals, expressed background K+ currents sensitive to A2764, while the inhibitor did not affect the currents in the DRG neurons of TRESK-deficient mice. Accordingly, A2764 may prove to be useful for the identification of TRESK current in native cells, and for the investigation of the role of the channel in nociception and migraine.},
	keywords = {POTASSIUM CHANNELS; PAIN; ION CHANNELS; Electrophysiology},
	year = {2019},
	eissn = {1521-0111},
	pages = {652-660},
	orcid-numbers = {Lengyel, Miklós/0000-0001-6382-6369; Dux, Mária/0000-0002-9941-8188; Király, Kornél P/0000-0002-7252-0422; Hegedűs, Tamás/0000-0002-0331-9629; Czirják, Gábor/0000-0002-5485-2327; Mátyus, Péter/0000-0003-3963-9445; Enyedi, Péter/0000-0001-9541-0712}
}

@article{MTMT:2855891,
	title = {Aza-ring annelation via type 2 tert-amino effect: mechanism and scope},
	url = {https://m2.mtmt.hu/api/publication/2855891},
	author = {Mátyus, Péter and Polonkáné Bálint, Ágnes and Dunkel, Petra and Földi, Á and Ludányi, K and Bényei, Cs A},
	journal-iso = {B SOC QUIM MEX},
	journal = {BOLETÍN DE LA SOCIEDAD QUÍMICA DE MÉXICO},
	volume = {5},
	unique-id = {2855891},
	issn = {1870-1809},
	year = {2011},
	pages = {37-37},
	orcid-numbers = {Mátyus, Péter/0000-0003-3963-9445; Dunkel, Petra/0000-0001-5445-8357}
}

@misc{MTMT:1753121,
	title = {Semicarbazide-sensitive amine oxidase/vascular adhesion protein-1 inhibitors as novel anti-inflammatory agents},
	url = {https://m2.mtmt.hu/api/publication/1753121},
	author = {Mátyus, Péter and Dunkel, Petra and Polonkáné Bálint, Ágnes and Földi, Á and Deme, Ruth and Gyires, Klára and Magyar, K and Tábi, T and Szökő, É},
	unique-id = {1753121},
	year = {2011},
	orcid-numbers = {Mátyus, Péter/0000-0003-3963-9445; Dunkel, Petra/0000-0001-5445-8357; Deme, Ruth/0000-0002-0798-6912; Gyires, Klára/0000-0002-4718-2345}
}

@misc{MTMT:2029634,
	title = {Váratlan termékek képződése vinilcsoporttal szubsztituált tercier arilaminokból},
	url = {https://m2.mtmt.hu/api/publication/2029634},
	author = {Földi, ÁA and Polonkáné Bálint, Ágnes and Drahos, László and Mátyus, Péter},
	unique-id = {2029634},
	year = {2010},
	orcid-numbers = {Mátyus, Péter/0000-0003-3963-9445}
}

@misc{MTMT:2027325,
	title = {terc-amino effektus alkalmazása policiklusos vegyületek előállítására},
	url = {https://m2.mtmt.hu/api/publication/2027325},
	author = {Deme, Ruth and Polonkáné Bálint, Ágnes and Földi, ÁA and Dunkel, Petra and Mátyus, Péter},
	unique-id = {2027325},
	year = {2010},
	orcid-numbers = {Deme, Ruth/0000-0002-0798-6912; Dunkel, Petra/0000-0001-5445-8357; Mátyus, Péter/0000-0003-3963-9445}
}

@misc{MTMT:2027279,
	title = {Azocin és azecin gyűrűrendszerek előállítása a terc-amino effektus alkalmazásával},
	url = {https://m2.mtmt.hu/api/publication/2027279},
	author = {Deme, Ruth and Dunkel, Petra and Polonkáné Bálint, Ágnes and Mátyus, Péter},
	unique-id = {2027279},
	year = {2009},
	orcid-numbers = {Deme, Ruth/0000-0002-0798-6912; Dunkel, Petra/0000-0001-5445-8357; Mátyus, Péter/0000-0003-3963-9445}
}

@article{MTMT:1344109,
	title = {Pd-catalyzed intramolecular direct arylations at high temperature},
	url = {https://m2.mtmt.hu/api/publication/1344109},
	author = {Franck, P and Hostyn, S and Dajka-Halasz, B and Polonkáné Bálint, Ágnes and Monsieurs, K and Mátyus, Péter and Maes, BUW},
	doi = {10.1016/j.tet.2008.01.060},
	journal-iso = {TETRAHEDRON},
	journal = {TETRAHEDRON},
	volume = {64},
	unique-id = {1344109},
	issn = {0040-4020},
	year = {2008},
	eissn = {1464-5416},
	pages = {6030-6037},
	orcid-numbers = {Mátyus, Péter/0000-0003-3963-9445}
}

@article{MTMT:1189926,
	title = {Novel Extensions of the tert-Amino Effect: Formation of Phenanthridines and Diarene-Fused Azocines from ortho-ortho′-Functionalized Biaryls},
	url = {https://m2.mtmt.hu/api/publication/1189926},
	author = {Polonkáné Bálint, Ágnes and Saraceno, C and Ludányi, Krisztina and Bényei, Attila Csaba and Mátyus, Péter},
	doi = {10.1055/s-0028-1083537},
	journal-iso = {SYNLETT},
	journal = {SYNLETT},
	volume = {2008},
	unique-id = {1189926},
	issn = {0936-5214},
	abstract = {Phenanthridines and azocines fused to two benzene rings or one benzene
		and one pyridazinone ring, which are otherwise difficult to access,
		were prepared via two new extensions of the tert-amino effect. The
		synthetic pathway includes three steps: i) Suzuki reaction of an
		ortho-functionalized phenylboronic acid with ortho-disubstituted
		benzenes or pyridazinones; ii) the Knoevenagel condensation reaction of
		the biaryl aldehydes formed with active methylene compounds to obtain
		vinyl derivatives or, through their cyclization, phenanthridines via a
		tert-amino effect; and iii) thermal isomerization of vinyl or
		phenanthridinium compounds to fused azocines via another type of
		tert-amino effect.},
	year = {2008},
	eissn = {1437-2096},
	pages = {2846-2850},
	orcid-numbers = {Ludányi, Krisztina/0000-0002-2380-9529; Mátyus, Péter/0000-0003-3963-9445}
}

@misc{MTMT:1344145,
	title = {Új típusú azocin és azecin gyűrűrendszerek előállítása új úton: a terc-amino effektus kiterjesztése},
	url = {https://m2.mtmt.hu/api/publication/1344145},
	author = {Polonkáné Bálint, Ágnes and Dunkel, Petra and Mátyus, P},
	unique-id = {1344145},
	year = {2007},
	orcid-numbers = {Dunkel, Petra/0000-0001-5445-8357}
}

@misc{MTMT:1344144,
	title = {Syntheses of dibenzazocines and a pyridazino-fused benzazocine by application of a new type of tert-amino effect},
	url = {https://m2.mtmt.hu/api/publication/1344144},
	author = {Polonkáné Bálint, Ágnes and Saraceno, C and Czugler, Mátyás and Mátyus, Péter},
	unique-id = {1344144},
	year = {2006},
	orcid-numbers = {Mátyus, Péter/0000-0003-3963-9445}
}