@article{MTMT:34123133, title = {Lipase-Catalyzed Strategies for the Preparation of Enantiomeric THIQ and THβC Derivatives: Green Aspects}, url = {https://m2.mtmt.hu/api/publication/34123133}, author = {Orsy, György and Forró, Enikő}, doi = {10.3390/molecules28176362}, journal-iso = {MOLECULES}, journal = {MOLECULES}, volume = {28}, unique-id = {34123133}, issn = {1420-3049}, abstract = {This report reviews the most important lipase-catalyzed strategies for the preparation of pharmaceutically and chemically important tetrahydroisoquinoline and tetrahydro-β-carboline enantiomers through O-acylation of the primary hydroxy group, N-acylation of the secondary amino group, and COOEt hydrolysis of the corresponding racemic compounds with simple molecular structure, which have been reported during the last decade. A brief introduction describes the importance and synthesis of tetrahydroisoquinoline and tetrahydro-β-carboline derivatives, and it formulates the objectives of this compilation. The strategies are presented in chronological order, classified according to function of the reaction type, as kinetic and dynamic kinetic resolutions, in the main text. These reactions result in the desired products with excellent ee values. The pharmacological importance of the products together with their synthesis is given in the main text. The enzymatic hydrolysis of the hydrochloride salts as racemates of the starting amino carboxylic esters furnished the desired enantiomeric amino carboxylic acids quantitatively. The enzymatic reactions, performed in tBuOMe or H2O as usable solvents, and the transformations carried out in a continuous-flow system, indicate clear advantages, including atom economy, reproducibility, safer solvents, short reaction time, rapid heating and compression vs. shaker reactions. These features are highlighted in the main text.}, year = {2023}, eissn = {1420-3049}, orcid-numbers = {Forró, Enikő/0000-0001-6796-3889} } @article{MTMT:34082152, title = {A Sustainable Green Enzymatic Method for Amide Bond Formation}, url = {https://m2.mtmt.hu/api/publication/34082152}, author = {Orsy, György and Shahmohammadi, Sayeh and Forró, Enikő}, doi = {10.3390/molecules28155706}, journal-iso = {MOLECULES}, journal = {MOLECULES}, volume = {28}, unique-id = {34082152}, issn = {1420-3049}, abstract = {A sustainable enzymatic strategy for the preparation of amides by using Candida antarctica lipase B as the biocatalyst and cyclopentyl methyl ether as a green and safe solvent was devised. The method is simple and efficient and it produces amides with excellent conversions and yields without the need for intensive purification steps. The scope of the reaction was extended to the preparation of 28 diverse amides using four different free carboxylic acids and seven primary and secondary amines, including cyclic amines. This enzymatic methodology has the potential to become a green and industrially reliable process for direct amide synthesis.}, year = {2023}, eissn = {1420-3049}, orcid-numbers = {Shahmohammadi, Sayeh/0000-0001-7681-5458; Forró, Enikő/0000-0001-6796-3889} } @CONFERENCE{MTMT:33672957, title = {Green enzymatic strategies for the preparation of enantiomeric carbocyclic beta-amino acid derivatives}, url = {https://m2.mtmt.hu/api/publication/33672957}, author = {Shahmohammadi, Sayeh and Faragó, Tünde and Palkó, Márta and Forró, Enikő}, booktitle = {GreenCat 2022 Book of Abstracts}, unique-id = {33672957}, year = {2022}, orcid-numbers = {Shahmohammadi, Sayeh/0000-0001-7681-5458; Faragó, Tünde/0000-0002-3052-8258; Palkó, Márta/0000-0002-8265-7377; Forró, Enikő/0000-0001-6796-3889} } @{MTMT:33551486, title = {Liquid Chromatographic Enantioseparation of Fluorinated ß-Phenylalanine Analogs Utilizing Superficially Porous Particles}, url = {https://m2.mtmt.hu/api/publication/33551486}, author = {Tanács, Dániel and Berkecz, Róbert and Shahmohammadi, Sayeh and Forró, Enikő and Daniel, W. Armstrong and Péter, Antal and Ilisz, István}, booktitle = {33rd International Symposium on Chromatography – ISC 2022}, unique-id = {33551486}, year = {2022}, orcid-numbers = {Tanács, Dániel/0000-0003-1011-8638; Berkecz, Róbert/0000-0002-9076-2177; Shahmohammadi, Sayeh/0000-0001-7681-5458; Forró, Enikő/0000-0001-6796-3889; Ilisz, István/0000-0001-8282-457X} } @article{MTMT:33025006, title = {Enzymatic Strategies for the Preparation of Pharmaceutically Important Amino Acids through Hydrolysis of Amino Carboxylic Esters and Lactams}, url = {https://m2.mtmt.hu/api/publication/33025006}, author = {Forró, Enikő and Fülöp, Ferenc}, doi = {10.2174/0929867329666220718123153}, journal-iso = {CURR MED CHEM}, journal = {CURRENT MEDICINAL CHEMISTRY}, volume = {29}, unique-id = {33025006}, issn = {0929-8673}, year = {2022}, eissn = {1875-533X}, pages = {6218-6227}, orcid-numbers = {Forró, Enikő/0000-0001-6796-3889; Fülöp, Ferenc/0000-0003-1066-5287} } @article{MTMT:32936379, title = {Macrocyclic glycopeptides- and derivatized cyclofructan-based chiral stationary phases for the enantioseparation of fluorinated ß-phenylalanine analogs}, url = {https://m2.mtmt.hu/api/publication/32936379}, author = {Tanács, Dániel and Berkecz, Róbert and Shahmohammadi, Sayeh and Forró, Enikő and Armstrong, Daniel W. and Péter, Antal and Ilisz, István}, doi = {10.1016/j.jpba.2022.114912}, journal-iso = {J PHARMACEUT BIOMED ANAL}, journal = {JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS}, volume = {219}, unique-id = {32936379}, issn = {0731-7085}, year = {2022}, eissn = {1873-264X}, orcid-numbers = {Tanács, Dániel/0000-0003-1011-8638; Berkecz, Róbert/0000-0002-9076-2177; Shahmohammadi, Sayeh/0000-0001-7681-5458; Forró, Enikő/0000-0001-6796-3889; Ilisz, István/0000-0001-8282-457X} } @article{MTMT:32787510, title = {Green Strategies for the Preparation of Enantiomeric 5–8-Membered Carbocyclic β-Amino Acid Derivatives through CALB-Catalyzed Hydrolysis}, url = {https://m2.mtmt.hu/api/publication/32787510}, author = {Shahmohammadi, Sayeh and Faragó, Tünde and Palkó, Márta and Forró, Enikő}, doi = {10.3390/molecules27082600}, journal-iso = {MOLECULES}, journal = {MOLECULES}, volume = {27}, unique-id = {32787510}, issn = {1420-3049}, year = {2022}, eissn = {1420-3049}, orcid-numbers = {Shahmohammadi, Sayeh/0000-0001-7681-5458; Faragó, Tünde/0000-0002-3052-8258; Palkó, Márta/0000-0002-8265-7377; Forró, Enikő/0000-0001-6796-3889} } @article{MTMT:32741660, title = {Enantioselective high-performance liquid chromatographic separation of fluorinated ß- phenylalanine derivatives utilizing Cinchona alkaloid-based ion-exchanger chiral stationary phases. Enantioselective separation of fluorinated ß-phenylalanine derivatives}, url = {https://m2.mtmt.hu/api/publication/32741660}, author = {Németi, Gábor and Berkecz, Róbert and Shahmohammadi, Sayeh and Forró, Enikő and Lindner, Wolfgang and Péter, Antal and Ilisz, István}, doi = {10.1016/j.chroma.2022.462974}, journal-iso = {J CHROMATOGR A}, journal = {JOURNAL OF CHROMATOGRAPHY A}, volume = {1670}, unique-id = {32741660}, issn = {0021-9673}, year = {2022}, eissn = {1873-3778}, orcid-numbers = {Németi, Gábor/0000-0001-7312-8353; Berkecz, Róbert/0000-0002-9076-2177; Shahmohammadi, Sayeh/0000-0001-7681-5458; Forró, Enikő/0000-0001-6796-3889; Ilisz, István/0000-0001-8282-457X} } @article{MTMT:32069177, title = {Cinchona-alkaloid-based zwitterionic chiral stationary phases as potential tools for high-performance liquid chromatographic enantioseparation of cationic compounds of pharmaceutical relevance}, url = {https://m2.mtmt.hu/api/publication/32069177}, author = {Tanács, Dániel and Bajtai, Attila and Berkecz, Róbert and Forró, Enikő and Fülöp, Ferenc and Lindner, Wolfgang and Péter, Antal and Ilisz, István}, doi = {10.1002/jssc.202100264}, journal-iso = {J SEP SCI}, journal = {JOURNAL OF SEPARATION SCIENCE}, volume = {44}, unique-id = {32069177}, issn = {1615-9306}, year = {2021}, eissn = {1615-9314}, pages = {2735-2743}, orcid-numbers = {Tanács, Dániel/0000-0003-1011-8638; Bajtai, Attila/0000-0002-8054-6526; Berkecz, Róbert/0000-0002-9076-2177; Forró, Enikő/0000-0001-6796-3889; Fülöp, Ferenc/0000-0003-1066-5287; Ilisz, István/0000-0001-8282-457X} } @article{MTMT:31959792, title = {High-performance liquid chromatographic evaluation of strong cation exchanger-based chiral stationary phases focusing on stationary phase characteristics and mobile phase effects employing enantiomers of tetrahydro-ß-carboline and 1,2,3,4-tetrahydroisoquinoline analogs}, url = {https://m2.mtmt.hu/api/publication/31959792}, author = {Bajtai, Attila and Tanács, Dániel and Berkecz, Róbert and Forró, Enikő and Fülöp, Ferenc and Lindner, Wolfgang and Péter, Antal and Ilisz, István}, doi = {10.1016/j.chroma.2021.462121}, journal-iso = {J CHROMATOGR A}, journal = {JOURNAL OF CHROMATOGRAPHY A}, volume = {1644}, unique-id = {31959792}, issn = {0021-9673}, year = {2021}, eissn = {1873-3778}, orcid-numbers = {Bajtai, Attila/0000-0002-8054-6526; Tanács, Dániel/0000-0003-1011-8638; Berkecz, Róbert/0000-0002-9076-2177; Forró, Enikő/0000-0001-6796-3889; Fülöp, Ferenc/0000-0003-1066-5287; Ilisz, István/0000-0001-8282-457X} }