@article{MTMT:34830215,
	title = {Diagnosis rates, therapeutic characteristics, lifestyle, and cancer screening habits of patients with diabetes mellitus in a highly deprived region in Hungary: a cross-sectional analysis},
	url = {https://m2.mtmt.hu/api/publication/34830215},
	author = {Pártos, Katalin and Major, Dávid and Dósa, Norbert Sándor and Fazekas-Pongor, Vince and Tabák, Ádám and Ungvári, Zoltán and Horváth, Ildikó and Barta, Ildikó and Pozsgai, Éva and Bodnár, Tamás and Fehér, Gergely and Lenkey, Zsófia and Fekete, Mónika and Springó, Zsolt},
	doi = {10.3389/fendo.2024.1299148},
	journal-iso = {FRONT ENDOCRINOL},
	journal = {FRONTIERS IN ENDOCRINOLOGY},
	volume = {15},
	unique-id = {34830215},
	issn = {1664-2392},
	year = {2024},
	eissn = {1664-2392},
	orcid-numbers = {Major, Dávid/0000-0002-6108-9745; Fazekas-Pongor, Vince/0000-0002-6405-4003; Tabák, Ádám/0000-0002-6234-3936; Horváth, Ildikó/0000-0001-6891-1044; Fekete, Mónika/0000-0001-8632-2120}
}

@article{MTMT:34788186,
	title = {Tumor- and circulating-free DNA methylation identifies clinically relevant small cell lung cancer subtypes},
	url = {https://m2.mtmt.hu/api/publication/34788186},
	author = {Heeke, Simon and Gay, Carl M. and Estecio, Marcos R. and Tran, Hai and Morris, Benjamin B. and Zhang, Bingnan and Tang, Ximing and Raso, Maria Gabriela and Rocha, Pedro and Lai, Siqi and Arriola, Edurne and Hofman, Paul and Hofman, Veronique and Kopparapu, Prasad and Lovly, Christine M. and Concannon, Kyle and De Sousa, Luana Guimaraes and Lewis, Whitney Elisabeth and Kondo, Kimie and Hu, Xin and Tanimoto, Azusa and Vokes, Natalie I. and Nilsson, Monique B. and Stewart, Allison and Jansen, Maarten and Horváth, Ildikó and Gaga, Mina and Panagoulias, Vasileios and Raviv, Yael and Frumkin, Danny and Wasserstrom, Adam and Shuali, Aharona and Schnabel, Catherine A. and Xi, Yuanxin and Diao, Lixia and Wang, Qi and Zhang, Jianjun and Van Loo, Peter and Wang, Jing and Wistuba, Ignacio I. and Byers, Lauren A. and Heymach, John V.},
	doi = {10.1016/j.ccell.2024.01.001},
	journal-iso = {CANCER CELL},
	journal = {CANCER CELL},
	volume = {42},
	unique-id = {34788186},
	issn = {1535-6108},
	year = {2024},
	eissn = {1878-3686},
	pages = {225-237.e5},
	orcid-numbers = {Heeke, Simon/0000-0002-5916-534X; Horváth, Ildikó/0000-0001-6891-1044}
}

@article{MTMT:34724154,
	title = {A COVID–19-fertőzéssel és -immunizációval szerzett tapasztalatok felnőtt cystás fibrosisos betegcsoportban},
	url = {https://m2.mtmt.hu/api/publication/34724154},
	author = {Örlős, Zoltán and Miklós, Zsuzsanna and Horváth, Ildikó},
	doi = {10.1556/650.2024.32994},
	journal-iso = {ORV HETIL},
	journal = {ORVOSI HETILAP},
	volume = {165},
	unique-id = {34724154},
	issn = {0030-6002},
	abstract = {Bevezetés: Habár a nem transzplantált, cystás fibrosisban szenvedő betegek többségében enyhe lefolyást mutat a COVID–19-fertőzés, a betegek kis hányadában súlyos lefolyású kórforma alakul ki. Célkitűzés: A célok között szerepelt azoknak a rizikófaktoroknak az azonosítása, amelyek megnövelik a koronavírussal fertőzött cystás fibrosisos betegek hospitalizációs igényét, emellett a betegek átoltottságát és a fertőzésben alkalmazott kezeléseket is vizsgálni kívántuk. Módszer: Az Országos Korányi Pulmonológiai Intézet Cystás Fibrosis Részlegén gondozott 145 beteg adatait elemeztük retrospektív módon a pandémia kitörése és 2022. december 31. között. Eredmények: A vizsgált időszakban a betegek 85,5%-a részesült SARS-CoV-2-alapimmunizációban, a beadott védőoltások 70,9%-a mRNS-alapú volt. A betegek 49,65%-a vészelte át a fertőzést, a fertőzöttek 13,9%-a kórházi ellátást igényelt. A súlyos lefolyású COVID–19 legfontosabb prediktora az erőltetett kilégzési másodpercvolumen (FEV 1 ) 35%-os vagy annál alacsonyabb értéke (OR: 6,25, p = 0,01). Megbeszélés: Vizsgálati eredményeink azt mutatják, hogy súlyos, kórházi ellátást igénylő COVID–19-fertőzés gyakrabban alakul ki az eleve kisebb FEV 1 -értékkel rendelkező cystás fibrosisos betegek körében. Felmérésünk alapján a felnőtt cystás fibrosisos betegek oltási fegyelme jelentősen meghaladja az országos átlagot, többségük már emlékeztető oltásban is részesült. Következtetés: A prediktorok ismerete segíthet meghatározni azokat a cystás fibrosisos betegeket, akiknél fokozott figyelem és gyors terápiás döntéshozatal szükséges COVID–19-infekció akvirálása esetén. Orv Hetil. 2024; 165(9): 332–337.},
	year = {2024},
	eissn = {1788-6120},
	pages = {332-337},
	orcid-numbers = {Miklós, Zsuzsanna/0000-0001-8577-4475; Horváth, Ildikó/0000-0001-6891-1044}
}

@article{MTMT:34720912,
	title = {Co-Morbidity Clusters in Post-COVID-19 Syndrome},
	url = {https://m2.mtmt.hu/api/publication/34720912},
	author = {Sárközi, Anna Teréz and Tornyi, Ilona and Békési, Erik and Horváth, Ildikó},
	doi = {10.3390/jcm13051457},
	journal-iso = {J CLIN MED},
	journal = {JOURNAL OF CLINICAL MEDICINE},
	volume = {13},
	unique-id = {34720912},
	abstract = {Background: Post-COVID-19 syndrome, characterized by persistent symptoms emerging more than 12 weeks after acute infection, displays diverse manifestations. This study aimed to analyze co-existing organ dysfunctions in post-COVID-19 patients and explore their potential association with the acute COVID-19 episode and functional impairment. Methods: Data from 238 patients attending post-COVID-19 outpatient care between 1 March 2021 and 1 March 2022, after previous hospitalization for acute COVID-19, were retrospectively analyzed with 80 having comprehensive mapping of organ involvement. Results: The average time between acute episode and post-COVID-19 care was 149 days. Spirometry indicated significant abnormalities in lung function. Predominant symptoms included respiratory (75%), fatigue (73%), neurological (62.5%), and ear-nose-throat issues (51.25%). Multiorgan dysfunctions were observed in 87.5% of patients, contributing to an 18.33% reduction in health quality compared to pre-acute COVID-19 levels. Subgroup analysis identified four distinct post-COVID-19 syndrome subgroups, highlighting the coexistence of respiratory and neurological disorders as potential indicators and drivers of further organ involvement. Our results reveal that most patients with post-COVID-19 syndrome suffer from multiorgan disorders. Conclusions: The presence of coexisting respiratory and neurological symptoms suggests the involvement of other organ systems as well. The complexity of multiorgan involvement requires further studies to provide insights into the different symptom clusters and identify potential targets for personalized preventive and therapeutic interventions to improve patient outcome.},
	year = {2024},
	eissn = {2077-0383},
	pages = {1457},
	orcid-numbers = {Tornyi, Ilona/0000-0003-2165-4196; Horváth, Ildikó/0000-0001-6891-1044}
}

@article{MTMT:34210255,
	title = {Low levels of endogenous anabolic androgenic steroids in females with severe asthma taking corticosteroids},
	url = {https://m2.mtmt.hu/api/publication/34210255},
	author = {Yasinska, V. and Gómez, C. and Kolmert, J. and Ericsson, M. and Pohanka, A. and James, A. and Andersson, L.I. and Sparreman-Mikus, M. and Sousa, A.R. and Riley, J.H. and Bates, S. and Bakke, P.S. and Kermani, N.Z. and Caruso, M. and Chanez, P. and Fowler, S.J. and Geiser, T. and Howarth, P.H. and Horváth, Ildikó and Krug, N. and Montuschi, P. and Sanak, M. and Behndig, A. and Shaw, D.E. and Knowles, R.G. and Dahlén, B. and van, der Zee A.-H.M. and Sterk, P.J. and Djukanovic, R. and Adcock, I.M. and Chung, K.F. and Wheelock, C.E. and Dahlén, S.-E. and Jonsson, E.W.},
	doi = {10.1183/23120541.00269-2023},
	journal-iso = {ERJ OPEN RES},
	journal = {ERJ OPEN RESEARCH},
	volume = {9},
	unique-id = {34210255},
	abstract = {Rationale Patients with severe asthma are dependent upon treatment with high doses of inhaled corticosteroids (ICS) and often also oral corticosteroids (OCS). The extent of endogenous androgenic anabolic steroid (EAAS) suppression in asthma has not previously been described in detail. The objective of the present study was to measure urinary concentrations of EAAS in relation to exogenous corticosteroid exposure. Methods Urine collected at baseline in the U-BIOPRED (Unbiased Biomarkers for the Prediction of Respiratory Disease outcomes) study of severe adult asthmatics (SA, n=408) was analysed by quantitative mass spectrometry. Data were compared to that of mild-to-moderate asthmatics (MMA, n=70) and healthy subjects (HC, n=98) from the same study. Measurements and main results The concentrations of urinary endogenous steroid metabolites were substantially lower in SA than in MMA or HC. These differences were more pronounced in SA patients with detectable urinary OCS metabolites. Their dehydroepiandrosterone sulfate (DHEA-S) concentrations were <5% of those in HC, and cortisol concentrations were below the detection limit in 75% of females and 82% of males. The concentrations of EAAS in OCS-positive patients, as well as patients on high-dose ICS only, were more suppressed in females than males (p<0.05). Low levels of DHEA were associated with features of more severe disease and were more prevalent in females (p<0.05). The association between low EAAS and corticosteroid treatment was replicated in 289 of the SA patients at follow-up after 12–18 months. Conclusion The pronounced suppression of endogenous anabolic androgens in females might contribute to sex differences regarding the prevalence of severe asthma. © The authors 2023.},
	year = {2023},
	eissn = {2312-0541},
	orcid-numbers = {Horváth, Ildikó/0000-0001-6891-1044}
}

@article{MTMT:34206422,
	title = {Oropharyngeal Microbiota Clusters in Children with Asthma or Wheeze Associate with Allergy, Blood Transcriptomic Immune Pathways, and Exacerbation Risk},
	url = {https://m2.mtmt.hu/api/publication/34206422},
	author = {Abdel-Aziz, M.I. and Thorsen, J. and Hashimoto, S. and Vijverberg, S.J.H. and Neerincx, A.H. and Brinkman, P. and Van, Aalderen W. and Stokholm, J. and Rasmussen, M.A. and Roggenbuck-Wedemeye, M. and Vissing, N.H. and Mortensen, M.S. and Brejnrod, A.D. and Fleming, L.J. and Murray, C.S. and Fowler, S.J. and Frey, U. and Bush, A. and Singer, F. and Hedlin, G. and Nordlund, B. and Shaw, D.E. and Chung, K.F. and Adcock, I.M. and Djukanovic, R. and Auffray, C. and Bansal, A.T. and Sousa, A.R. and Wagers, S.S. and Chawes, B.L. and Bønnelykke, K. and Sørensen, S.J. and Kraneveld, A.D. and Sterk, P.J. and Roberts, G. and Bisgaard, H. and Maitland-Van, Der Zee A.H. and Kolmert, J. and James, A. and Sousa, A.R. and Riley, J.H. and Bates, S. and Bakke, P.S. and Caruso, M. and Chanez, P. and Fowler, S.J. and Geiser, T. and Howarth, P. and Horváth, Ildikó and Krug, N. and Montuschi, P. and Sanak, M. and Behndig, A. and Shaw, D.E. and Knowles, R.G. and Holweg, C.T.J. and Wheelock, A.M. and Dahlen, B. and Alving, K. and Chung, K.F. and Adcock, I.M. and Sterk, P.J. and Djukanovic, R. and Dahlen, S.-E. and Wheelock, C.E. and Andersson, L. and Auffray, C. and Bisgaard, H. and De, Meulder B. and Fleming, L.J. and Frey, U. and Lutter, R. and Mumby, S. and Roberts, G. and Uddin, M. and Wagers, S.S. and Kermani, N.Z. and U-BIOPRED, Study Group},
	doi = {10.1164/rccm.202211-2107OC},
	journal-iso = {AM J RESP CRIT CARE},
	journal = {AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE},
	volume = {208},
	unique-id = {34206422},
	issn = {1073-449X},
	abstract = {Rationale: Children with preschool wheezing or school-age asthma are reported to have airway microbial imbalances. Objectives: To identify clusters in children with asthma or wheezing using oropharyngeal microbiota profiles. Methods: Oropharyngeal swabs from the U-BIOPRED (Unbiased Biomarkers for the Prediction of Respiratory Disease Outcomes) pediatric asthma or wheezing cohort were characterized using 16S ribosomal RNA gene sequencing, and unsupervised hierarchical clustering was performed on the Bray-Curtis b-diversity. Enrichment scores of the Molecular Signatures Database hallmark gene sets were computed from the blood transcriptome using gene set variation analysis. Children with severe asthma or severe wheezing were followed up for 12-18 months, with assessment of the frequency of exacerbations. Measurements and Main Results: Oropharyngeal samples from 241 children (age range, 1-17 years; 40% female) revealed four taxa-driven clusters dominated by Streptococcus, Veillonella, Rothia, and Haemophilus. The clusters showed significant differences in atopic dermatitis, grass pollen sensitization, FEV1% predicted after salbutamol, and annual asthma exacerbation frequency during follow-up. The Veillonella cluster was the most allergic and included the highest percentage of children with two or more exacerbations per year during follow-up. The oropharyngeal clusters were different in the enrichment scores of TGF-b (transforming growth factor-β) (highest in the Veillonella cluster) and Wnt/β-catenin signaling (highest in the Haemophilus cluster) transcriptomic pathways in blood (all q values ,0.05). Conclusions: Analysis of the oropharyngeal microbiota of children with asthma or wheezing identified four clusters with distinct clinical characteristics (phenotypes) that associate with risk for exacerbation and transcriptomic pathways involved in airway remodeling. This suggests that further exploration of the oropharyngeal microbiota may lead to novel pathophysiologic insights and potentially new treatment approaches. Copyright © 2023 by the American Thoracic Society.},
	keywords = {Adolescent; Female; Female; Male; Male; Humans; BLOOD; PHENOTYPE; GENETICS; ARTICLE; SENSITIZATION; human; Child; data base; risk factor; disease association; steroid; school child; major clinical study; controlled study; cohort analysis; STREPTOCOCCUS; MICROFLORA; corticosteroid; leukotriene receptor blocking agent; Forced Expiratory Volume; preschool child; lung function test; disease exacerbation; salbutamol; Asthma; Asthma; Asthma; Asthma; human tissue; wheezing; wheezing; Allergy; Hypersensitivity; Hypersensitivity; antibiotic agent; corticosteroid therapy; follow up; morbidity; transcriptomics; MICROBIAL DIVERSITY; MICROBIAL COMMUNITY; futurology; transforming growth factor beta; Atopic dermatitis; muscarinic receptor blocking agent; lung function; Transcriptome; Transcriptome; Transcriptome; long acting drug; beta adrenergic receptor stimulating agent; abnormal respiratory sound; grass pollen; Microbiota; Microbiota; RNA 16S; TGF beta signaling; veillonella; haemophilus; Hierarchical clustering; short acting drug; severe asthma; Precision Medicine; RNA sequencing; Immune signaling; Airway remodeling; Pediatric patient; Gene set variation analysis; canonical Wnt signaling; oropharyngeal swab; species dominance; Rothia; Respiratory Sounds; Oropharyngeal Microbiota},
	year = {2023},
	eissn = {1535-4970},
	pages = {142-154},
	orcid-numbers = {Horváth, Ildikó/0000-0001-6891-1044}
}

@article{MTMT:34188757,
	title = {A new perspective on the proper timing of radiotherapy during CDK4/6 inhibitor therapy in patients with “bone-only” metastatic breast cancer},
	url = {https://m2.mtmt.hu/api/publication/34188757},
	author = {Tornyi, Ilona and Árkosy, Péter and Horváth, Ildikó and Furka, Andrea},
	doi = {10.3389/pore.2023.1611369},
	journal-iso = {PATHOL ONCOL RES},
	journal = {PATHOLOGY AND ONCOLOGY RESEARCH},
	volume = {29},
	unique-id = {34188757},
	issn = {1219-4956},
	abstract = {The vast majority of hormone positive and HER2 negative advanced breast cancers can be controlled well by endocrine therapy combined with the groundbreaking use of CDK4/6 inhibitors in the metastatic first-line setting. Approximately 50%–60% of these patients have “bone-only” metastatic disease. In oligometastatic cases or if a certain number of uncontrolled lesions develop during the aforementioned therapy, ablative radiotherapy can be delivered or, in symptomatic cases, urgent irradiation is needed with palliative intent. To achieve the most effective results, parallel with good quality of life, the timing of radiotherapy must be determined precisely, taking into account that different cell cycles are involved during different treatment modalities; therefore, optimization of treatment schedules ensures longer and safer post-progression overall survival. The key question is whether the two treatment modalities are safe concurrently or whether they should be administered separately, and if so, what is the optimal sequence and why? This manuscript aims to answer this important question, with a focus on quality of life. Existing publications focus on safety and toxicity profiles, and efficacy is detailed only tangentially and minimally.},
	year = {2023},
	eissn = {1532-2807},
	pages = {1-9},
	orcid-numbers = {Horváth, Ildikó/0000-0001-6891-1044}
}

@article{MTMT:34064075,
	title = {The Role of Oxidative Stress and Antioxidants in Cardiovascular Comorbidities in COPD},
	url = {https://m2.mtmt.hu/api/publication/34064075},
	author = {Miklós, Z. and Horváth, Ildikó},
	doi = {10.3390/antiox12061196},
	journal-iso = {ANTIOXIDANTS-BASEL},
	journal = {ANTIOXIDANTS},
	volume = {12},
	unique-id = {34064075},
	year = {2023},
	eissn = {2076-3921},
	orcid-numbers = {Horváth, Ildikó/0000-0001-6891-1044}
}

@article{MTMT:33823988,
	title = {The role of inflammation in anxiety and depression in the European U-BIOPRED asthma cohorts},
	url = {https://m2.mtmt.hu/api/publication/33823988},
	author = {Hou, R. and Ye, G. and Cheng, X. and Shaw, D.E. and Bakke, P.S. and Caruso, M. and Dahlen, B. and Dahlen, S.-E. and Fowler, S.J. and Horváth, Ildikó and Howarth, P. and Krug, N. and Montuschi, P. and Sanak, M. and Sandström, T. and Auffray, C. and De, Meulder B. and Sousa, A.R. and Adcock, I.M. and Fan, Chung K. and Sterk, P.J. and Skipp, P.J. and Schofield, J. and Djukanović, R. and Weiszhar, Zsóka},
	doi = {10.1016/j.bbi.2023.04.011},
	journal-iso = {BRAIN BEHAV IMMUN},
	journal = {BRAIN BEHAVIOR AND IMMUNITY},
	volume = {111},
	unique-id = {33823988},
	issn = {0889-1591},
	year = {2023},
	eissn = {1090-2139},
	pages = {249-258},
	orcid-numbers = {Horváth, Ildikó/0000-0001-6891-1044; Szentkereszty, Márton/0000-0001-8891-8657; Tamási, Lilla/0000-0003-3477-6125}
}

@article{MTMT:33789491,
	title = {Stratification of asthma by lipidomic profiling of induced sputum supernatant},
	url = {https://m2.mtmt.hu/api/publication/33789491},
	author = {Brandsma, J. and Schofield, J.P.R. and Yang, X. and Strazzeri, F. and Barber, C. and Goss, V.M. and Koster, G. and Bakke, P.S. and Caruso, M. and Chanez, P. and Dahlén, S.-E. and Fowler, S.J. and Horváth, Ildikó and Krug, N. and Montuschi, P. and Sanak, M. and Sandström, T. and Shaw, D.E. and Chung, K.F. and Singer, F. and Fleming, L.J. and Adcock, I.M. and Pandis, I. and Bansal, A.T. and Corfield, J. and Sousa, A.R. and Sterk, P.J. and Sánchez-García, R.J. and Skipp, P.J. and Postle, A.D. and Djukanović, R.},
	doi = {10.1016/j.jaci.2023.02.032},
	journal-iso = {J ALLERGY CLIN IMMUN},
	journal = {JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY},
	volume = {152},
	unique-id = {33789491},
	issn = {0091-6749},
	year = {2023},
	eissn = {1097-6825},
	pages = {117-125},
	orcid-numbers = {Horváth, Ildikó/0000-0001-6891-1044}
}