TY  - JOUR
AU  - Vámos, Orsolya
AU  - Komora, Péter
AU  - Gede, Noémi
AU  - Hegyi, Péter
AU  - Kelemen, Kata
AU  - Varga, Gábor
AU  - Mikulás, Krisztina Ágnes
AU  - Kerémi, Beáta
AU  - Kispélyi, Ida Barbara
TI  - The effect of nicotine-containing products on peri-implant tissues : A systematic review and network meta-analysis
JF  - NICOTINE AND TOBACCO RESEARCH
J2  - NICOTINE TOB RES
PY  - 2024
SN  - 1462-2203
DO  - 10.1093/ntr/ntae085
UR  - https://m2.mtmt.hu/api/publication/34801787
ID  - 34801787
AB  - Smokers have a higher chance of developing peri-implant diseases and are therefore considered an at-risk population. Our aim was to compare peri-implant characteristics in users of electronic cigarettes (EC), waterpipes (WP), cigarettes (CS), smokeless tobacco (ST), and non-smokers (non-users of any nicotine and tobacco product; NS).A systematic search of four electronic databases (PubMed, EMBASE, Web of Science, CENTRAL) was performed until April 2023, restricted to English language. Thirty-nine observational studies were included in the qualitative synthesis, of which 32 studies were included in a Bayesian network meta-analysis. Using a predesigned form, two researchers independently collected data about marginal bone loss (MBL), probing pocket depth (PPD), plaque index (PI), bleeding on probing (BOP), modified plaque index (mPI), probing pocket depth > 4mm (PPD>4), gingival index (GI), peri-implant sulcular fluid (PISF) volume, and TNF-α and IL-1β levels. QUIPS and CINeMA were used to evaluate the risk of bias and certainty of evidence.NS had the smallest MBL. Most nicotine-containing product users had significantly higher MBL (CS, MD:1.34 CrI: 0.85, 1.79; WP, MD:1.58 CrI: 0.84, 2.35; ST, MD:2.53, CrI: 1.20, 3.87) than NS. EC did not show significant difference compared to NS (MD:0.52 CrI: -0.33, 1.36). In secondary outcomes NS were ranked in first place. Subset analysis based on smoking habit, implant duration, and maintenance control revealed no differences in ranking probability.Most nicotine-containing product users presented worse peri-implant parameters compared to non-smokers, while EC users did not show significant differences to NS in many outcomes.Alternative nicotine-containing products are gaining popularity and are often considered less harmful by the general public compared to traditional cigarettes. This is the first network meta-analysis comparing users of four nicotine-containing products and non-smokers. This study shows that CS, WP and ST have a detrimental effect on the overall health of peri-implant tissues. EC users also presented inferior parameters compared to NS, however, the difference was not significant in many outcomes. It is essential to educate patients who are using nicotine-containing products, and to provide proper maintenance and appropriate cessation support. Well-designed multi-armed studies are needed for direct comparison of different products, including heated tobacco products. Greater transparency of confounding factors is needed regarding smoking habit and oral hygiene.
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Olah, Csilla
AU  - Kubik, András
AU  - Mátrai, Péter
AU  - Engh, Marie Anne
AU  - Barna, Viktória
AU  - Hegyi, Péter
AU  - Reis, Henning
AU  - Nyirády, Péter
AU  - Szarvas, Tibor
TI  - Estimation of the incidence of urachal cancer : A systematic review and meta-analysis of registry-based studies
JF  - UROLOGIC ONCOLOGY: SEMINARS AND ORIGINAL INVESTIGATIONS
J2  - UROL ONCOL SEMIN ORI INV
PY  - 2024
SN  - 1078-1439
DO  - 10.1016/j.urolonc.2024.03.011
UR  - https://m2.mtmt.hu/api/publication/34801778
ID  - 34801778
AB  - Urachal cancer (UrC) is a rare disease with limited availability of representative incidence and clinical data. Although, the prevalence is accounting for less than 1% of bladder tumors, the 5-year survival rate is around only 50% for patients with resectable tumors, and even worse for patients with metastatic disease. Due to the lack of comprehensive prospective studies, our current knowledge of UrC is still limited.The present study aimed to summarize the available registry-based studies with unselected UrC patients to evaluate its incidence and clinicopathological characteristics.We conducted a systematic literature search of registry-based UrC publications on the 15th of May 2023 in 5 databases, which identified 4,748 publications. After duplicate removal and selection by 2 independent investigators, 6 publications proved to be appropriate for the final meta-analysis. Estimated incidence and clinicopathological parameters were extracted.Estimated incidence ranged between 0.022 and 0.060/ 100.000 person-years, with the highest occurrence in Japan and the lowest in Canada, while the random effect model calculated an overall incidence rate of 0.04 (95%CI: 0.03-0.05) 100.000 person-years. The median age at first diagnosis was 60 years (range: 58-64). The female to male ratio was 2:3. Lymph node or distant metastases were present in 9% and 14% of patients. The predominant tumour type was adenocarcinoma (86%) followed by urothelial carcinoma (12%) and squamous cell carcinoma (2%). The 5-year survival rate was 51.0% with 95%CI: 45.2-57.4.Our study provides an up-to-date comparison of estimated incidence rates between 6 countries of 3 continents based on rigorously selected registry-based studies. The results suggest low incidence rates for UrC with considerable geographic differences. The present meta-analysis provides unbiased registry-based data on the incidence, clinicopathological parameters and survival of UrC.
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Giaccherini, M
AU  - Rende, M
AU  - Gentiluomo, M
AU  - Corradi, C
AU  - Archibugi, L
AU  - Ermini, S
AU  - Maiello, E
AU  - Morelli, L
AU  - van Eijck, C H J
AU  - Cavestro, G M
AU  - Schneider, M
AU  - Mickevicius, A
AU  - Adamonis, K
AU  - Basso, D
AU  - Hlavac, V
AU  - Gioffreda, D
AU  - Talar-Wojnarowska, R
AU  - Schöttker, B
AU  - Lovecek, M
AU  - Vanella, G
AU  - Gazouli, M
AU  - Uno, M
AU  - Malecka-Wojciesko, E
AU  - Vodicka, P
AU  - Goetz, M
AU  - Bijlsma, M F
AU  - Petrone, M C
AU  - Bazzocchi, F
AU  - Kiudelis, M
AU  - Szentesi, Andrea Ildikó
AU  - Carrara, S
AU  - Nappo, G
AU  - Brenner, H
AU  - Milanetto, A C
AU  - Soucek, P
AU  - Katzke, V
AU  - Peduzzi, G
AU  - Rizzato, C
AU  - Pasquali, C
AU  - Chen, X
AU  - Capurso, G
AU  - Hackert, T
AU  - Bueno-de-Mesquita, B
AU  - Uzunoglu, F G G
AU  - Hegyi, Péter
AU  - Greenhalf, W
AU  - Theodoropoulos, G E E
AU  - Sperti, C
AU  - Perri, F
AU  - Oliverius, M
AU  - Mambrini, A
AU  - Tavano, F
AU  - Farinella, R
AU  - Arcidiacono, P G
AU  - Lucchesi, M
AU  - Bunduc, Stefania
AU  - Kupcinskas, J
AU  - Di Franco, G
AU  - Stocker, S
AU  - Neoptolemos, J P
AU  - Bambi, F
AU  - Jamroziak, K
AU  - Testoni, S G G
AU  - Aoki, M N
AU  - Mohelnikova-Duchonova, B
AU  - Izbicki, J R
AU  - Pezzilli, R
AU  - Lawlor, R T
AU  - Kauffmann, E F
AU  - López de Maturana, E
AU  - Malats, N
AU  - Canzian, F
AU  - Campa, D
TI  - A pleiotropy scan to discover new susceptibility loci for pancreatic ductal adenocarcinoma
JF  - MUTAGENESIS
J2  - MUTAGENESIS
PY  - 2024
SN  - 0267-8357
DO  - 10.1093/mutage/geae012
UR  - https://m2.mtmt.hu/api/publication/34797929
ID  - 34797929
AB  - Pleiotropic variants (i.e., genetic polymorphisms influencing more than one phenotype) are often associated with cancer risk. A scan of pleiotropic variants was successfully conducted ten years ago in relation to pancreatic ductal adenocarcinoma susceptibility. However, in the last decade, genetic association studies performed on several human traits have greatly increased the number of known pleiotropic variants. Based on the hypothesis that variants already associated with a least one trait have a higher probability of association with other traits, 61,052 variants reported to be associated by at least one genome wide association study (GWAS) with at least one human trait were tested in the present study consisting of two phases (discovery and validation), comprising a total of 16,055 pancreatic ductal adenocarcinoma (PDAC) cases and 212,149 controls. The meta-analysis of the two phases showed two loci (10q21.1-rs4948550 (P=6.52×10-5) and 7q36.3-rs288762 (P=3.03×10-5) potentially associated with PDAC risk. 10q21.1-rs4948550 shows a high degree of pleiotropy and it is also associated with colorectal cancer risk while 7q36.3-rs288762 is situated 28,558 base pairs upstream of the Sonic Hedgehog (SHH) gene, which is involved in the cell differentiation process and PDAC etiopathogenesis. In conclusion, none of the single nucleotide polymorphisms (SNPs) showed a formally statistically significant association after correction for multiple testing. However, given their pleiotropic nature and association with various human traits including colorectal cancer, the two SNPs showing the best associations with PDAC risk merit further investigation through fine mapping and ad hoc functional studies.
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Huszár, Zsolt
AU  - Engh, Marie Anne
AU  - Pavlekovics, Márk
AU  - Sato, Tomoya
AU  - Steenkamp, Yalea
AU  - Hanseeuw, Bernard
AU  - Terebessy, Tamás
AU  - Molnár, Zsolt
AU  - Hegyi, Péter
AU  - Csukly, Gábor
TI  - Risk of conversion to mild cognitive impairment or dementia among subjects with amyloid and tau pathology : a systematic review and meta-analysis
JF  - ALZHEIMERS RESEARCH & THERAPY
J2  - ALZHEIMERS RES THER
VL  - 16
PY  - 2024
IS  - 1
PG  - 19
SN  - 1758-9193
DO  - 10.1186/s13195-024-01455-2
UR  - https://m2.mtmt.hu/api/publication/34797928
ID  - 34797928
N1  - Meta-Analysis; Systematic Review; Journal Article; Review
AB  - Measurement of beta-amyloid (Aβ) and phosphorylated tau (p-tau) levels offers the potential for early detection of neurocognitive impairment. Still, the probability of developing a clinical syndrome in the presence of these protein changes (A+ and T+) remains unclear. By performing a systematic review and meta-analysis, we investigated the risk of mild cognitive impairment (MCI) or dementia in the non-demented population with A+ and A- alone and in combination with T+ and T- as confirmed by PET or cerebrospinal fluid examination.A systematic search of prospective and retrospective studies investigating the association of Aβ and p-tau with cognitive decline was performed in three databases (MEDLINE via PubMed, EMBASE, and CENTRAL) on January 9, 2024. The risk of bias was assessed using the Cochrane QUIPS tool. Odds ratios (OR) and Hazard Ratios (HR) were pooled using a random-effects model. The effect of neurodegeneration was not studied due to its non-specific nature.A total of 18,162 records were found, and at the end of the selection process, data from 36 cohorts were pooled (n= 7,793). Compared to the unexposed group, the odds ratio (OR) for conversion to dementia in A+ MCI patients was 5.18 [95% CI 3.93; 6.81]. In A+ CU subjects, the OR for conversion to MCI or dementia was 5.79 [95% CI 2.88; 11.64]. Cerebrospinal fluid Aβ42 or Aβ42/40 analysis and amyloid PET imaging showed consistent results. The OR for conversion in A+T+ MCI subjects (11.60 [95% CI 7.96; 16.91]) was significantly higher than in A+T- subjects (2.73 [95% CI 1.65; 4.52]). The OR for A-T+ MCI subjects was non-significant (1.47 [95% CI 0.55; 3.92]). CU subjects with A+T+ status had a significantly higher OR for conversion (13.46 [95% CI 3.69; 49.11]) than A+T- subjects (2.04 [95% CI 0.70; 5.97]). Meta-regression showed that the ORs for Aβ exposure decreased with age in MCI. (beta = -0.04 [95% CI -0.03 to -0.083]).Identifying Aβ-positive individuals, irrespective of the measurement technique employed (CSF or PET), enables the detection of the most at-risk population before disease onset, or at least at a mild stage. The inclusion of tau status in addition to Aβ, especially in A+T+ cases, further refines the risk assessment. Notably, the higher odds ratio associated with Aβ decreases with age.The study was registered in PROSPERO (ID: CRD42021288100).
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Turan, Caner
AU  - Kovács, Emőke Henrietta
AU  - Szabó, László
AU  - Atakan, Işıl
AU  - Dembrovszky, Fanni
AU  - Ocskay, Klementina
AU  - Váncsa, Szilárd
AU  - Hegyi, Péter
AU  - Zubek, László
AU  - Molnár, Zsolt
TI  - The Effect of Preoperative Administration of Glucocorticoids on the Postoperative Complication Rate in Liver Surgery : A Systematic Review and Meta-Analysis of Randomized Controlled Trials
JF  - JOURNAL OF CLINICAL MEDICINE
J2  - J CLIN MED
VL  - 13
PY  - 2024
IS  - 7
PG  - 15
SN  - 2077-0383
DO  - 10.3390/jcm13072097
UR  - https://m2.mtmt.hu/api/publication/34797927
ID  - 34797927
AB  - Background: Glucocorticoids may grant a protective effect against postoperative complications. The evidence on their efficacy, however, has been inconclusive thus far. We investigated the effects of preoperatively administered glucocorticoids on the overall postoperative complication rate, and on liver function recovery in patients undergoing major liver surgery. Methods: We performed a systematic literature search on PubMed, Embase, and CENTRAL in October 2021, and repeated the search in April 2023. Pre-study protocol was registered on PROSPERO (ID: CRD42021284559). Studies investigating patients undergoing liver resections or transplantation who were administered glucocorticoids preoperatively and reported postoperative complications were eligible. Meta-analyses were performed using META and DMETAR packages in R with a random effects model. Risk of bias was assessed using RoB2. Results: The selection yielded 11 eligible randomized controlled trials (RCTs) with 964 patients. Data from nine RCTs (n = 837) revealed a tendency toward a lower overall complication rate with glucocorticoid administration (odds ratio: 0.71; 95% confidence interval: 0.38-1.31, p = 0.23), but it was not statistically significant. Data pooled from seven RCTs showed a significant reduction in wound infections with glucocorticoid administration [odds ratio: 0.64; 95% confidence interval: 0.45-0.92 p = 0.02]. Due to limited data availability, meta-analysis of liver function recovery parameters was not possible. Conclusions: The preoperative administration of glucocorticoids did not significantly reduce the overall postoperative complication rate. Future clinical trials should investigate homogenous patient populations with a specific focus on postoperative liver recovery.
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Hernádfői , Márk Viktor
AU  - Koch, Dóra Kornélia
AU  - Kói, Tamás
AU  - Imrei, Marcell
AU  - Nagy, Rita
AU  - Máté, Vanda
AU  - Garai, Réka
AU  - Donnet, Jessica
AU  - Balogh, József
AU  - Kovács, Gábor
AU  - Párniczky, Andrea
AU  - Hegyi, Péter
AU  - Garami, Miklós
TI  - Burden of Childhood Cancer and the Social and Economic Challenges in Adulthood
JF  - JAMA PEDIATRICS
J2  - JAMA PEDIATR
VL  - in
PY  - 2024
IS  - press
SN  - 2168-6203
DO  - 10.1001/jamapediatrics.2024.0642
UR  - https://m2.mtmt.hu/api/publication/34792056
ID  - 34792056
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Weninger, Viktor
AU  - Agócs, Gergely
AU  - Kovács, Norbert
AU  - Váncsa, Szilárd
AU  - Hergár, Luca
AU  - Baek, Chan Ju
AU  - Hegyi, Péter
AU  - Holnapy, Gergely
AU  - Skaliczki, Gábor
TI  - Hyaluronate acid plus platelet-rich plasma is superior to steroids for pain relief less than 6 months using injection therapy of partial rotator cuff tears : A systematic review and network meta-analysis
JF  - ARTHROSCOPY-THE JOURNAL OF ARTHROSCOPIC AND RELATED SURGERY
J2  - ARTHROSCOPY
PY  - 2024
SN  - 0749-8063
DO  - 10.1016/j.arthro.2024.03.035
UR  - https://m2.mtmt.hu/api/publication/34788583
ID  - 34788583
AB  - We conducted our network meta-analysis to compare the efficacy of the steroid injections to other injectable therapies in partial-thickness rotator cuff tears (PTRCTs).A systematic literature search was performed until October 25, 2021 in three databases (CENTRAL, Embase, MEDLINE). Eligible studies compared the efficacy of steroid, hyaluronic acid (HA), platelet-rich plasma (PRP), the combination of HA and PRP (HA+PRP), and adipose-derived regenerative cells (ADRC) in RC tears. The primary outcomes were the Visual Analogue Scale (VAS), Constant Murley Score (CMS), and American Shoulder and Elbow Surgeons Standardized Shoulder Assessment Form. Using paired and network meta-analysis, we calculated pooled mean differences (MDs) with 95% confidence intervals (CIs).We included a total of seven articles in the quantitative synthesis. In shorter periods, the HA+PRP combination was superior to the other substances we investigated (HA+PRP: VAS (0-4 weeks): MD: -0.99 [CI = -1.62, -0.36]; CMS (0-3 months): 20.56 [CI = 16.18, 24.94]. This combination was followed by the use of HA or PRP alone, depending on the duration of follow-up and the outcome being studied. In our study, short-term results suggest that saline is superior to steroids for partial tears, but this trend is reversed at six-month follow-up.Our results suggest the combination of HA and PRP to be a more effective therapeutic option for partial RC ruptures for short terms, but there is no significant difference after 6 months.II, Included of Level of Evidence studies I-II.
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - de Jonge, Robert
AU  - Máté, Miklós
AU  - Kovács, Norbert
AU  - Imrei, Marcell
AU  - Pap, Károly
AU  - Agócs, Gergely
AU  - Váncsa, Szilárd
AU  - Hegyi, Péter
AU  - Pánics, Gergely
TI  - Nonoperative Treatment as an Option for Isolated Anterior Cruciate Ligament Injury : A Systematic Review and Meta-analysis
JF  - ORTHOPAEDIC JOURNAL OF SPORTS MEDICINE
J2  - ORTHOP J SPORTS MED
VL  - 12
PY  - 2024
IS  - 4
PG  - 9
SN  - 2325-9671
DO  - 10.1177/23259671241239665
UR  - https://m2.mtmt.hu/api/publication/34788581
ID  - 34788581
AB  - An anterior cruciate ligament (ACL) tear is a risk factor for early osteoarthritis (OA) onset. Generally, ACL reconstruction (ACLR) is associated with better outcomes. However, there is a lack of evidence regarding the effect of operative versus nonoperative treatment for preventing premature knee OA in isolated ACL tears while achieving good functional outcomes.The purpose of the study was to compare the outcomes of ACLR to primarily nonoperative management of isolated ACL tears. It was hypothesized that the outcomes between treatment types would be similar.Systematic review; Level of evidence, 3.This systematic review was registered on the International Prospective Register of Systematic Reviews (PROSPERO) (registration No. CRD42021285901) and was conducted according to the Cochrane Handbook guidelines. We systematically searched for randomized and nonrandomized studies that compared ACLR with nonoperative treatments in isolated ACL tears in 3 databases until October 25, 2021. The risk of bias and quality of evidence of the included studies was assessed in accordance with the Cochrane guidelines. The primary outcome was radiologic signs of OA, and the secondary outcomes were functional parameters. Using the common effects model, we calculated pooled mean differences (MDs) and odds ratios (ORs) with 95% CIs.Five studies-2 randomized controlled trials (RCTs) and 3 retrospective non-RCTs-were included. There was a moderate risk of bias in 2 studies and a serious risk of bias in 1 study. The quality of evidence was rated low because of the higher risk of bias and inconsistency. Nonoperatively treated knees showed a trend toward lower odds of developing radiological signs of OA (OR, 1.84 [95% CI, 0.90 to 3.75]); however, surgically reconstructed knees had significantly better stability (MD, -2.44 [95% CI, -3.21 to -1.66 ]) and a trend toward better but clinically not meaningful Lysholm scores (MD, 2.88 [95% CI, -1.09 to 6.85]). The qualitative synthesis showed that surgical reconstruction was protective against subsequent injuries but not superior when returning to previous activity levels or various functional tests.Findings indicated that there is no certain evidence that ACLR for an isolated ACL tear is superior to nonoperative treatment. Clinicians should consider nonoperative treatments with a well-designed rehabilitative program as a primary option. However, these findings must be interpreted with caution because of low study quality and high risk of bias.
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Zimonyi, Nóra
AU  - Kói, Tamás
AU  - Dombrádi, Viktor
AU  - Imrei, Marcell
AU  - Nagy, Rita
AU  - Pulay, Márk Ágoston
AU  - Lang, Zsolt
AU  - Hegyi, Péter
AU  - Takács, Zsófia K.
AU  - Túri, Ibolya
TI  - Comparison of Executive Function Skills between Patients with Cerebral Palsy and Typically Developing Populations: A Systematic Review and Meta-Analysis
JF  - JOURNAL OF CLINICAL MEDICINE
J2  - J CLIN MED
VL  - 13
PY  - 2024
IS  - 7
PG  - 16
SN  - 2077-0383
DO  - 10.3390/jcm13071867
UR  - https://m2.mtmt.hu/api/publication/34783850
ID  - 34783850
N1  - * Megosztott szerzőség
Tamás Kói thanks the National Research, Development and Innovation Office—NKFIH K120706 for their support.
AB  - Background: Children with CP show deficits in executive function compared to their typically developing peers, based on the majority of the available evidence. However, the magnitude of these deficits, as well as the proportions of the shortfalls in the three main components, have not yet been examined. This is the first meta-analysis to synthesize evidence on the magnitude of differences between patients with cerebral palsy (CP) and typically developing populations in different components of executive function skills (working memory, inhibitory control and cognitive flexibility), and thus makes recommendations on which areas of executive functioning are in greatest need of intervention. Methods: We conducted a systematic literature search of four databases for studies that measured executive functions in these two groups until 31 August 2023. We calculated the standardized mean difference (Hedges’ g), an average effect size overall, and for the three components of executive function skills separately, we used several moderator analyses, including methodological differences between the primary studies. Results: Fifteen articles were included in the meta-analysis. The average mean difference in executive functioning overall was large (g+ = −0.82). Furthermore, large significant differences were found in working memory (g+ = −0.92) and inhibitory control (g+ = −0.82) and a moderate difference was identified in cognitive flexibility (g+ = −0.57). In addition, results of moderator analyses reveal the importance of a rigorous matching of control group participants and CP patients. Conclusions: The results demonstrate a severe impairment in all executive functions among CP patients compared to typically developing peers, which do not decrease over time.
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Masszi, Richárd
AU  - Zsigmond, Előd-János
AU  - Ehrenberger, Réka
AU  - Turan, Caner
AU  - Fehérvári, Péter
AU  - Teutsch, Brigitta
AU  - Molnár, Zsolt
AU  - Drobni, Zsófia
AU  - Vágó, Hajnalka
AU  - Hegyi, Péter
AU  - Merkely, Béla Péter
AU  - Kosztin, Annamária
TI  - Evaluating the predictive value of late gadolinium enhancement assessed by cardiac magnetic resonance on sudden cardiac death in patients selected for implantable cardioverter defibrillator and cardiac resynchronization therapy implantation: a systematic review and meta-analysis
JF  - CLINICAL RESEARCH IN CARDIOLOGY
J2  - CLIN RES CARDIOL
PY  - 2024
SN  - 1861-0684
DO  - 10.1007/s00392-024-02441-2
UR  - https://m2.mtmt.hu/api/publication/34780183
ID  - 34780183
N1  - Centre for Translational Medicine, Semmelweis University, Budapest, 1085, Hungary            
            Heart and Vascular Center, Semmelweis University, 68 Városmajor Street, Budapest, 1122, Hungary            
            Department of Cardiology, Military Hospital – State Health Centre, Budapest, Hungary            
            Doctoral School of Clinical Medicine, University of Szeged, Szeged, Hungary            
            Department of Anesthesiology and Intensive Therapy, Semmelweis University, Budapest, Hungary            
            Department of Biostatistics, University of Veterinary Medicine, Budapest, Hungary            
            Institute for Translational Medicine, Medical School, University of Pécs, Pécs, 7623, Hungary            
            Department of Sports Medicine, Semmelweis University, Budapest, Hungary            
            Institute of Pancreatic Diseases, Semmelweis University, Budapest, 1083, Hungary            
            Export Date: 17 April 2024            
            Correspondence Address: Merkely, B.; Heart and Vascular Center, 68 Városmajor Street, Hungary; email: merkely.study@gmail.com
LA  - English
DB  - MTMT
ER  -