@article{MTMT:34833996,
	title = {A Systematic Review and Meta-Analysis of microRNA Profiling Studies in Chronic Kidney Diseases},
	url = {https://m2.mtmt.hu/api/publication/34833996},
	author = {Gantsetseg, Garmaa and Bunduc, Stefania and Kói, Tamás and Hegyi, Péter and Csupor, Dezső and Dariimaa, Ganbat and Dembrovszky, Fanni and Meznerics, Fanni Adél and Ailar, Nasirzadeh and Cristina, Barbagallo and Kökény, Gábor},
	doi = {10.3390/ncrna10030030},
	journal-iso = {NON-CODING RNA},
	journal = {NON-CODING RNA},
	volume = {10},
	unique-id = {34833996},
	year = {2024},
	eissn = {2311-553X},
	orcid-numbers = {Gantsetseg, Garmaa/0000-0001-9631-8635; Hegyi, Péter/0000-0003-0399-7259; Csupor, Dezső/0000-0002-4088-3333; Dembrovszky, Fanni/0000-0001-6953-3591; Kökény, Gábor/0000-0002-0345-6914}
}

@article{MTMT:34825011,
	title = {Imiquimod Is Effective in Reducing Cervical Intraepithelial Neoplasia : A Systematic Review and Meta-Analysis},
	url = {https://m2.mtmt.hu/api/publication/34825011},
	author = {Hamar, Balázs and Teutsch, Brigitta and Hoffmann, Eszter and Hegyi, Péter and Harnos, Andrea and Nyirády, Péter and Hunka, Zsombor and Ács, Nándor and Bánhidy, Ferenc and Melczer, Zsolt},
	doi = {10.3390/cancers16081610},
	journal-iso = {CANCERS},
	journal = {CANCERS},
	volume = {16},
	unique-id = {34825011},
	abstract = {Topical Imiquimod is an immune response modifier approved for the off-label use of vulvar intraepithelial neoplasia. We conducted this systematic review and meta-analysis to investigate the efficacy and safety of Imiquimod in treating cervical intraepithelial neoplasia (CIN) and human papillomavirus (HPV)-positive patients.The study was prospectively registered (CRD420222870) and involved a comprehensive systematic search of five medical databases on 10 October 2022. We included articles that assessed the use of Imiquimod in cervical dysplasia and HPV-positive patients. Pooled proportions, risk ratios (RRs), and corresponding 95% confidence intervals (CIs) were calculated using a random effects model to generate summary estimates. Statistical heterogeneity was assessed using I2 tested by the Cochran Q tests.Eight articles reported on 398 patients who received Imiquimod out of 672 patients. Among CIN-2-3 patients, we observed a pooled regression rate of 61% (CI: 0.46-0.75; I2: 77%). When compared, Imiquimod was inferior to conization (RR: 0.62; CI: 0.42-0.92; I2: 64%). The HPV clearance rate in women who completed Imiquimod treatment was 60% (CI: 0.31-0.81; I2: 57%). The majority of side effects reported were mild to moderate in severity.Our findings indicate that topical Imiquimod is safe and effective in reducing cervical intraepithelial neoplasia and promoting HPV clearance. However, it was found to be inferior compared to conization. Imiquimod could be considered a potential medication for high-grade CIN patients and should be incorporated into guidelines for treating cervical dysplasia.},
	keywords = {imiquimod; HPV; Cervical cancer; gynecologic cancer risk reduction},
	year = {2024},
	eissn = {2072-6694},
	orcid-numbers = {Teutsch, Brigitta/0000-0002-9530-7886; Hegyi, Péter/0000-0003-0399-7259}
}

@article{MTMT:34801787,
	title = {The effect of nicotine-containing products on peri-implant tissues : A systematic review and network meta-analysis},
	url = {https://m2.mtmt.hu/api/publication/34801787},
	author = {Vámos, Orsolya and Komora, Péter and Gede, Noémi and Hegyi, Péter and Kelemen, Kata and Varga, Gábor and Mikulás, Krisztina Ágnes and Kerémi, Beáta and Kispélyi, Ida Barbara},
	doi = {10.1093/ntr/ntae085},
	journal-iso = {NICOTINE TOB RES},
	journal = {NICOTINE AND TOBACCO RESEARCH},
	unique-id = {34801787},
	issn = {1462-2203},
	abstract = {Smokers have a higher chance of developing peri-implant diseases and are therefore considered an at-risk population. Our aim was to compare peri-implant characteristics in users of electronic cigarettes (EC), waterpipes (WP), cigarettes (CS), smokeless tobacco (ST), and non-smokers (non-users of any nicotine and tobacco product; NS).A systematic search of four electronic databases (PubMed, EMBASE, Web of Science, CENTRAL) was performed until April 2023, restricted to English language. Thirty-nine observational studies were included in the qualitative synthesis, of which 32 studies were included in a Bayesian network meta-analysis. Using a predesigned form, two researchers independently collected data about marginal bone loss (MBL), probing pocket depth (PPD), plaque index (PI), bleeding on probing (BOP), modified plaque index (mPI), probing pocket depth > 4mm (PPD>4), gingival index (GI), peri-implant sulcular fluid (PISF) volume, and TNF-α and IL-1β levels. QUIPS and CINeMA were used to evaluate the risk of bias and certainty of evidence.NS had the smallest MBL. Most nicotine-containing product users had significantly higher MBL (CS, MD:1.34 CrI: 0.85, 1.79; WP, MD:1.58 CrI: 0.84, 2.35; ST, MD:2.53, CrI: 1.20, 3.87) than NS. EC did not show significant difference compared to NS (MD:0.52 CrI: -0.33, 1.36). In secondary outcomes NS were ranked in first place. Subset analysis based on smoking habit, implant duration, and maintenance control revealed no differences in ranking probability.Most nicotine-containing product users presented worse peri-implant parameters compared to non-smokers, while EC users did not show significant differences to NS in many outcomes.Alternative nicotine-containing products are gaining popularity and are often considered less harmful by the general public compared to traditional cigarettes. This is the first network meta-analysis comparing users of four nicotine-containing products and non-smokers. This study shows that CS, WP and ST have a detrimental effect on the overall health of peri-implant tissues. EC users also presented inferior parameters compared to NS, however, the difference was not significant in many outcomes. It is essential to educate patients who are using nicotine-containing products, and to provide proper maintenance and appropriate cessation support. Well-designed multi-armed studies are needed for direct comparison of different products, including heated tobacco products. Greater transparency of confounding factors is needed regarding smoking habit and oral hygiene.},
	keywords = {tobacco; cigarette smoking; smokeless tobacco; Peri-implantitis; E-cigarette; waterpipe; peri-implant parameters},
	year = {2024},
	eissn = {1469-994X},
	orcid-numbers = {Komora, Péter/0000-0002-1436-7781; Hegyi, Péter/0000-0003-0399-7259; Varga, Gábor/0000-0002-5506-8198; Mikulás, Krisztina Ágnes/0000-0002-0259-9761; Kerémi, Beáta/0000-0003-4000-9440; Kispélyi, Ida Barbara/0000-0002-0530-0905}
}

@article{MTMT:34801778,
	title = {Estimation of the incidence of urachal cancer : A systematic review and meta-analysis of registry-based studies},
	url = {https://m2.mtmt.hu/api/publication/34801778},
	author = {Olah, Csilla and Kubik, András and Mátrai, Péter and Engh, Marie Anne and Barna, Viktória and Hegyi, Péter and Reis, Henning and Nyirády, Péter and Szarvas, Tibor},
	doi = {10.1016/j.urolonc.2024.03.011},
	journal-iso = {UROL ONCOL SEMIN ORI INV},
	journal = {UROLOGIC ONCOLOGY: SEMINARS AND ORIGINAL INVESTIGATIONS},
	unique-id = {34801778},
	issn = {1078-1439},
	abstract = {Urachal cancer (UrC) is a rare disease with limited availability of representative incidence and clinical data. Although, the prevalence is accounting for less than 1% of bladder tumors, the 5-year survival rate is around only 50% for patients with resectable tumors, and even worse for patients with metastatic disease. Due to the lack of comprehensive prospective studies, our current knowledge of UrC is still limited.The present study aimed to summarize the available registry-based studies with unselected UrC patients to evaluate its incidence and clinicopathological characteristics.We conducted a systematic literature search of registry-based UrC publications on the 15th of May 2023 in 5 databases, which identified 4,748 publications. After duplicate removal and selection by 2 independent investigators, 6 publications proved to be appropriate for the final meta-analysis. Estimated incidence and clinicopathological parameters were extracted.Estimated incidence ranged between 0.022 and 0.060/ 100.000 person-years, with the highest occurrence in Japan and the lowest in Canada, while the random effect model calculated an overall incidence rate of 0.04 (95%CI: 0.03-0.05) 100.000 person-years. The median age at first diagnosis was 60 years (range: 58-64). The female to male ratio was 2:3. Lymph node or distant metastases were present in 9% and 14% of patients. The predominant tumour type was adenocarcinoma (86%) followed by urothelial carcinoma (12%) and squamous cell carcinoma (2%). The 5-year survival rate was 51.0% with 95%CI: 45.2-57.4.Our study provides an up-to-date comparison of estimated incidence rates between 6 countries of 3 continents based on rigorously selected registry-based studies. The results suggest low incidence rates for UrC with considerable geographic differences. The present meta-analysis provides unbiased registry-based data on the incidence, clinicopathological parameters and survival of UrC.},
	keywords = {Incidence; EPIDEMIOLOGY; REGISTRY; Adenocarcinoma; bladder cancer; urachal cancer; Urachus carcinoma},
	year = {2024},
	eissn = {1873-2496},
	orcid-numbers = {Kubik, András/0000-0001-6901-9701; Engh, Marie Anne/0000-0003-4269-5130; Hegyi, Péter/0000-0003-0399-7259; Nyirády, Péter/0000-0002-7037-4919; Szarvas, Tibor/0000-0002-6321-0799}
}

@article{MTMT:34797929,
	title = {A pleiotropy scan to discover new susceptibility loci for pancreatic ductal adenocarcinoma},
	url = {https://m2.mtmt.hu/api/publication/34797929},
	author = {Giaccherini, M and Rende, M and Gentiluomo, M and Corradi, C and Archibugi, L and Ermini, S and Maiello, E and Morelli, L and van Eijck, C H J and Cavestro, G M and Schneider, M and Mickevicius, A and Adamonis, K and Basso, D and Hlavac, V and Gioffreda, D and Talar-Wojnarowska, R and Schöttker, B and Lovecek, M and Vanella, G and Gazouli, M and Uno, M and Malecka-Wojciesko, E and Vodicka, P and Goetz, M and Bijlsma, M F and Petrone, M C and Bazzocchi, F and Kiudelis, M and Szentesi, Andrea Ildikó and Carrara, S and Nappo, G and Brenner, H and Milanetto, A C and Soucek, P and Katzke, V and Peduzzi, G and Rizzato, C and Pasquali, C and Chen, X and Capurso, G and Hackert, T and Bueno-de-Mesquita, B and Uzunoglu, F G G and Hegyi, Péter and Greenhalf, W and Theodoropoulos, G E E and Sperti, C and Perri, F and Oliverius, M and Mambrini, A and Tavano, F and Farinella, R and Arcidiacono, P G and Lucchesi, M and Bunduc, Stefania and Kupcinskas, J and Di Franco, G and Stocker, S and Neoptolemos, J P and Bambi, F and Jamroziak, K and Testoni, S G G and Aoki, M N and Mohelnikova-Duchonova, B and Izbicki, J R and Pezzilli, R and Lawlor, R T and Kauffmann, E F and López de Maturana, E and Malats, N and Canzian, F and Campa, D},
	doi = {10.1093/mutage/geae012},
	journal-iso = {MUTAGENESIS},
	journal = {MUTAGENESIS},
	unique-id = {34797929},
	issn = {0267-8357},
	abstract = {Pleiotropic variants (i.e., genetic polymorphisms influencing more than one phenotype) are often associated with cancer risk. A scan of pleiotropic variants was successfully conducted ten years ago in relation to pancreatic ductal adenocarcinoma susceptibility. However, in the last decade, genetic association studies performed on several human traits have greatly increased the number of known pleiotropic variants. Based on the hypothesis that variants already associated with a least one trait have a higher probability of association with other traits, 61,052 variants reported to be associated by at least one genome wide association study (GWAS) with at least one human trait were tested in the present study consisting of two phases (discovery and validation), comprising a total of 16,055 pancreatic ductal adenocarcinoma (PDAC) cases and 212,149 controls. The meta-analysis of the two phases showed two loci (10q21.1-rs4948550 (P=6.52×10-5) and 7q36.3-rs288762 (P=3.03×10-5) potentially associated with PDAC risk. 10q21.1-rs4948550 shows a high degree of pleiotropy and it is also associated with colorectal cancer risk while 7q36.3-rs288762 is situated 28,558 base pairs upstream of the Sonic Hedgehog (SHH) gene, which is involved in the cell differentiation process and PDAC etiopathogenesis. In conclusion, none of the single nucleotide polymorphisms (SNPs) showed a formally statistically significant association after correction for multiple testing. However, given their pleiotropic nature and association with various human traits including colorectal cancer, the two SNPs showing the best associations with PDAC risk merit further investigation through fine mapping and ad hoc functional studies.},
	keywords = {single nucleotide polymorphism; genetic susceptibility; Pancreatic cancer; Pleiotropy},
	year = {2024},
	eissn = {1464-3804},
	orcid-numbers = {Szentesi, Andrea Ildikó/0000-0003-2097-6927; Hegyi, Péter/0000-0003-0399-7259}
}

@article{MTMT:34797928,
	title = {Risk of conversion to mild cognitive impairment or dementia among subjects with amyloid and tau pathology : a systematic review and meta-analysis},
	url = {https://m2.mtmt.hu/api/publication/34797928},
	author = {Huszár, Zsolt and Engh, Marie Anne and Pavlekovics, Márk and Sato, Tomoya and Steenkamp, Yalea and Hanseeuw, Bernard and Terebessy, Tamás and Molnár, Zsolt and Hegyi, Péter and Csukly, Gábor},
	doi = {10.1186/s13195-024-01455-2},
	journal-iso = {ALZHEIMERS RES THER},
	journal = {ALZHEIMERS RESEARCH & THERAPY},
	volume = {16},
	unique-id = {34797928},
	issn = {1758-9193},
	abstract = {Measurement of beta-amyloid (Aβ) and phosphorylated tau (p-tau) levels offers the potential for early detection of neurocognitive impairment. Still, the probability of developing a clinical syndrome in the presence of these protein changes (A+ and T+) remains unclear. By performing a systematic review and meta-analysis, we investigated the risk of mild cognitive impairment (MCI) or dementia in the non-demented population with A+ and A- alone and in combination with T+ and T- as confirmed by PET or cerebrospinal fluid examination.A systematic search of prospective and retrospective studies investigating the association of Aβ and p-tau with cognitive decline was performed in three databases (MEDLINE via PubMed, EMBASE, and CENTRAL) on January 9, 2024. The risk of bias was assessed using the Cochrane QUIPS tool. Odds ratios (OR) and Hazard Ratios (HR) were pooled using a random-effects model. The effect of neurodegeneration was not studied due to its non-specific nature.A total of 18,162 records were found, and at the end of the selection process, data from 36 cohorts were pooled (n= 7,793). Compared to the unexposed group, the odds ratio (OR) for conversion to dementia in A+ MCI patients was 5.18 [95% CI 3.93; 6.81]. In A+ CU subjects, the OR for conversion to MCI or dementia was 5.79 [95% CI 2.88; 11.64]. Cerebrospinal fluid Aβ42 or Aβ42/40 analysis and amyloid PET imaging showed consistent results. The OR for conversion in A+T+ MCI subjects (11.60 [95% CI 7.96; 16.91]) was significantly higher than in A+T- subjects (2.73 [95% CI 1.65; 4.52]). The OR for A-T+ MCI subjects was non-significant (1.47 [95% CI 0.55; 3.92]). CU subjects with A+T+ status had a significantly higher OR for conversion (13.46 [95% CI 3.69; 49.11]) than A+T- subjects (2.04 [95% CI 0.70; 5.97]). Meta-regression showed that the ORs for Aβ exposure decreased with age in MCI. (beta = -0.04 [95% CI -0.03 to -0.083]).Identifying Aβ-positive individuals, irrespective of the measurement technique employed (CSF or PET), enables the detection of the most at-risk population before disease onset, or at least at a mild stage. The inclusion of tau status in addition to Aβ, especially in A+T+ cases, further refines the risk assessment. Notably, the higher odds ratio associated with Aβ decreases with age.The study was registered in PROSPERO (ID: CRD42021288100).},
	keywords = {DEMENTIA; Alzheimer's disease; beta-Amyloid; MILD COGNITIVE IMPAIRMENT; PHOSPHORYLATED TAU},
	year = {2024},
	eissn = {1758-9193},
	orcid-numbers = {Engh, Marie Anne/0000-0003-4269-5130; Terebessy, Tamás/0000-0002-7494-6064; Hegyi, Péter/0000-0003-0399-7259; Csukly, Gábor/0000-0002-5006-9407}
}

@article{MTMT:34797927,
	title = {The Effect of Preoperative Administration of Glucocorticoids on the Postoperative Complication Rate in Liver Surgery : A Systematic Review and Meta-Analysis of Randomized Controlled Trials},
	url = {https://m2.mtmt.hu/api/publication/34797927},
	author = {Turan, Caner and Kovács, Emőke Henrietta and Szabó, László and Atakan, Işıl and Dembrovszky, Fanni and Ocskay, Klementina and Váncsa, Szilárd and Hegyi, Péter and Zubek, László and Molnár, Zsolt},
	doi = {10.3390/jcm13072097},
	journal-iso = {J CLIN MED},
	journal = {JOURNAL OF CLINICAL MEDICINE},
	volume = {13},
	unique-id = {34797927},
	abstract = {Background: Glucocorticoids may grant a protective effect against postoperative complications. The evidence on their efficacy, however, has been inconclusive thus far. We investigated the effects of preoperatively administered glucocorticoids on the overall postoperative complication rate, and on liver function recovery in patients undergoing major liver surgery. Methods: We performed a systematic literature search on PubMed, Embase, and CENTRAL in October 2021, and repeated the search in April 2023. Pre-study protocol was registered on PROSPERO (ID: CRD42021284559). Studies investigating patients undergoing liver resections or transplantation who were administered glucocorticoids preoperatively and reported postoperative complications were eligible. Meta-analyses were performed using META and DMETAR packages in R with a random effects model. Risk of bias was assessed using RoB2. Results: The selection yielded 11 eligible randomized controlled trials (RCTs) with 964 patients. Data from nine RCTs (n = 837) revealed a tendency toward a lower overall complication rate with glucocorticoid administration (odds ratio: 0.71; 95% confidence interval: 0.38-1.31, p = 0.23), but it was not statistically significant. Data pooled from seven RCTs showed a significant reduction in wound infections with glucocorticoid administration [odds ratio: 0.64; 95% confidence interval: 0.45-0.92 p = 0.02]. Due to limited data availability, meta-analysis of liver function recovery parameters was not possible. Conclusions: The preoperative administration of glucocorticoids did not significantly reduce the overall postoperative complication rate. Future clinical trials should investigate homogenous patient populations with a specific focus on postoperative liver recovery.},
	keywords = {glucocorticoid; liver surgery; perioperative mangement},
	year = {2024},
	eissn = {2077-0383},
	orcid-numbers = {Dembrovszky, Fanni/0000-0001-6953-3591; Ocskay, Klementina/0000-0001-5848-2506; Váncsa, Szilárd/0000-0002-9347-8163; Hegyi, Péter/0000-0003-0399-7259; Zubek, László/0000-0003-0583-3290}
}

@article{MTMT:34792056,
	title = {Burden of Childhood Cancer and the Social and Economic Challenges in Adulthood},
	url = {https://m2.mtmt.hu/api/publication/34792056},
	author = {Hernádfői , Márk Viktor and Koch, Dóra Kornélia and Kói, Tamás and Imrei, Marcell and Nagy, Rita and Máté, Vanda and Garai, Réka and Donnet, Jessica and Balogh, József and Kovács, Gábor and Párniczky, Andrea and Hegyi, Péter and Garami, Miklós},
	doi = {10.1001/jamapediatrics.2024.0642},
	journal-iso = {JAMA PEDIATR},
	journal = {JAMA PEDIATRICS},
	volume = {in},
	unique-id = {34792056},
	issn = {2168-6203},
	year = {2024},
	eissn = {2168-6211},
	orcid-numbers = {Imrei, Marcell/0000-0003-0175-7462; Nagy, Rita/0000-0002-2663-4912; Máté, Vanda/0000-0003-1105-9692; Garai, Réka/0000-0001-6201-764X; Kovács, Gábor/0000-0001-9924-1645; Hegyi, Péter/0000-0003-0399-7259; Garami, Miklós/0000-0003-4298-2746}
}

@article{MTMT:34788583,
	title = {Hyaluronate acid plus platelet-rich plasma is superior to steroids for pain relief less than 6 months using injection therapy of partial rotator cuff tears : A systematic review and network meta-analysis},
	url = {https://m2.mtmt.hu/api/publication/34788583},
	author = {Weninger, Viktor and Agócs, Gergely and Kovács, Norbert and Váncsa, Szilárd and Hergár, Luca and Baek, Chan Ju and Hegyi, Péter and Holnapy, Gergely and Skaliczki, Gábor},
	doi = {10.1016/j.arthro.2024.03.035},
	journal-iso = {ARTHROSCOPY},
	journal = {ARTHROSCOPY-THE JOURNAL OF ARTHROSCOPIC AND RELATED SURGERY},
	unique-id = {34788583},
	issn = {0749-8063},
	abstract = {We conducted our network meta-analysis to compare the efficacy of the steroid injections to other injectable therapies in partial-thickness rotator cuff tears (PTRCTs).A systematic literature search was performed until October 25, 2021 in three databases (CENTRAL, Embase, MEDLINE). Eligible studies compared the efficacy of steroid, hyaluronic acid (HA), platelet-rich plasma (PRP), the combination of HA and PRP (HA+PRP), and adipose-derived regenerative cells (ADRC) in RC tears. The primary outcomes were the Visual Analogue Scale (VAS), Constant Murley Score (CMS), and American Shoulder and Elbow Surgeons Standardized Shoulder Assessment Form. Using paired and network meta-analysis, we calculated pooled mean differences (MDs) with 95% confidence intervals (CIs).We included a total of seven articles in the quantitative synthesis. In shorter periods, the HA+PRP combination was superior to the other substances we investigated (HA+PRP: VAS (0-4 weeks): MD: -0.99 [CI = -1.62, -0.36]; CMS (0-3 months): 20.56 [CI = 16.18, 24.94]. This combination was followed by the use of HA or PRP alone, depending on the duration of follow-up and the outcome being studied. In our study, short-term results suggest that saline is superior to steroids for partial tears, but this trend is reversed at six-month follow-up.Our results suggest the combination of HA and PRP to be a more effective therapeutic option for partial RC ruptures for short terms, but there is no significant difference after 6 months.II, Included of Level of Evidence studies I-II.},
	keywords = {rotator cuff; Conservative therapy; Injection therapy; subacromial injection; shoulder surgery; partial rotator cuff tear},
	year = {2024},
	eissn = {1526-3231},
	orcid-numbers = {Weninger, Viktor/0000-0001-8192-4632; Agócs, Gergely/0000-0003-2489-3790; Váncsa, Szilárd/0000-0002-9347-8163; Hegyi, Péter/0000-0003-0399-7259; Skaliczki, Gábor/0000-0002-8555-5114}
}

@article{MTMT:34788581,
	title = {Nonoperative Treatment as an Option for Isolated Anterior Cruciate Ligament Injury : A Systematic Review and Meta-analysis},
	url = {https://m2.mtmt.hu/api/publication/34788581},
	author = {de Jonge, Robert and Máté, Miklós and Kovács, Norbert and Imrei, Marcell and Pap, Károly and Agócs, Gergely and Váncsa, Szilárd and Hegyi, Péter and Pánics, Gergely},
	doi = {10.1177/23259671241239665},
	journal-iso = {ORTHOP J SPORTS MED},
	journal = {ORTHOPAEDIC JOURNAL OF SPORTS MEDICINE},
	volume = {12},
	unique-id = {34788581},
	abstract = {An anterior cruciate ligament (ACL) tear is a risk factor for early osteoarthritis (OA) onset. Generally, ACL reconstruction (ACLR) is associated with better outcomes. However, there is a lack of evidence regarding the effect of operative versus nonoperative treatment for preventing premature knee OA in isolated ACL tears while achieving good functional outcomes.The purpose of the study was to compare the outcomes of ACLR to primarily nonoperative management of isolated ACL tears. It was hypothesized that the outcomes between treatment types would be similar.Systematic review; Level of evidence, 3.This systematic review was registered on the International Prospective Register of Systematic Reviews (PROSPERO) (registration No. CRD42021285901) and was conducted according to the Cochrane Handbook guidelines. We systematically searched for randomized and nonrandomized studies that compared ACLR with nonoperative treatments in isolated ACL tears in 3 databases until October 25, 2021. The risk of bias and quality of evidence of the included studies was assessed in accordance with the Cochrane guidelines. The primary outcome was radiologic signs of OA, and the secondary outcomes were functional parameters. Using the common effects model, we calculated pooled mean differences (MDs) and odds ratios (ORs) with 95% CIs.Five studies-2 randomized controlled trials (RCTs) and 3 retrospective non-RCTs-were included. There was a moderate risk of bias in 2 studies and a serious risk of bias in 1 study. The quality of evidence was rated low because of the higher risk of bias and inconsistency. Nonoperatively treated knees showed a trend toward lower odds of developing radiological signs of OA (OR, 1.84 [95% CI, 0.90 to 3.75]); however, surgically reconstructed knees had significantly better stability (MD, -2.44 [95% CI, -3.21 to -1.66 ]) and a trend toward better but clinically not meaningful Lysholm scores (MD, 2.88 [95% CI, -1.09 to 6.85]). The qualitative synthesis showed that surgical reconstruction was protective against subsequent injuries but not superior when returning to previous activity levels or various functional tests.Findings indicated that there is no certain evidence that ACLR for an isolated ACL tear is superior to nonoperative treatment. Clinicians should consider nonoperative treatments with a well-designed rehabilitative program as a primary option. However, these findings must be interpreted with caution because of low study quality and high risk of bias.},
	keywords = {RECONSTRUCTION; Cartilage; surgery; KNEE; anterior cruciate ligament; Conservative; nonoperative},
	year = {2024},
	eissn = {2325-9671},
	orcid-numbers = {Imrei, Marcell/0000-0003-0175-7462; Pap, Károly/0000-0003-1063-4026; Agócs, Gergely/0000-0003-2489-3790; Váncsa, Szilárd/0000-0002-9347-8163; Hegyi, Péter/0000-0003-0399-7259; Pánics, Gergely/0000-0002-4504-3923}
}