TY - JOUR AU - Romeo, Alessia AU - Nochta-Kazsoki, Adrienn Katalin AU - Musumeci, Teresa AU - Zelkó, Romána TI - A Clinical, Pharmacological, and Formulation Evaluation of Melatonin in the Treatment of Ocular Disorders—A Systematic Review JF - INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES J2 - INT J MOL SCI VL - 25 PY - 2024 IS - 7 PG - 21 SN - 1661-6596 DO - 10.3390/ijms25073999 UR - https://m2.mtmt.hu/api/publication/34768534 ID - 34768534 N1 - Submission received: 27 February 2024 / Revised: 25 March 2024 / Accepted: 1 April 2024 / Published: 3 April 2024 AB - Melatonin’s cytoprotective properties may have therapeutic implications in treating ocular diseases like glaucoma and age-related macular degeneration. Literature data suggest that melatonin could potentially protect ocular tissues by decreasing the production of free radicals and pro-inflammatory mediators. This study aims to summarize the screened articles on melatonin’s clinical, pharmacological, and formulation evaluation in treating ocular disorders. The identification of relevant studies on the topic in focus was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA 2020) guidelines. The studies were searched in the following databases and web search engines: Pubmed, Scopus, Science Direct, Web of Science, Reaxys, Google Scholar, Google Patents, Espacenet, and Patentscope. The search time interval was 2013–2023, with the following keywords: melatonin AND ocular OR ophthalmic AND formulation OR insert AND disease. Our key conclusion was that using melatonin-loaded nano-delivery systems enabled the improved permeation of the molecule into intraocular tissues and assured controlled release profiles. Although preclinical studies have demonstrated the efficacy of developed formulations, a considerable gap has been observed in the clinical translation of the results. To overcome this failure, revising the preclinical experimental phase might be useful by selecting endpoints close to clinical ones. LA - English DB - MTMT ER - TY - JOUR AU - Csorba, Anita AU - Katona, Gábor AU - Budai-Szűcs, Mária AU - Balogh Weiser, Diána AU - Molnár, P. AU - Maka, Erika AU - Nochta-Kazsoki, Adrienn Katalin AU - Vajna, Márton Antal AU - Zelkó, Romána AU - Nagy, Zoltán Zsolt AU - Balogh, György Tibor TI - A Comparative Pharmacokinetic Study for Cysteamine-Containing Eye Drops as an Orphan Topical Therapy in Cystinosis JF - INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES J2 - INT J MOL SCI VL - 25 PY - 2024 IS - 3 PG - 14 SN - 1661-6596 DO - 10.3390/ijms25031623 UR - https://m2.mtmt.hu/api/publication/34538437 ID - 34538437 N1 - Department of Ophthalmology, Semmelweis University, Mária Street 39, Budapest, H-1085, Hungary Institute of Pharmaceutical Technology and Regulatory Affairs, Faculty of Pharmacy, University of Szeged, Eötvös Street 6, Szeged, H-6720, Hungary Department of Physical Chemistry and Materials Science, Faculty of Chemical Technology and Biotechnology, Budapest University of Technology and Economics, Műegyetem rkp. 3, Budapest, H-1111, Hungary Molteam Llc., Mélyfúró Street 4, Budapest, H-1151, Hungary University Pharmacy Department of Pharmacy Administration, Semmelweis University, Hőgyes Endre Street 7-9, Budapest, H-1092, Hungary Department of Pharmaceutical Chemistry, Semmelweis University, Hőgyes Endre Street 7-9, Budapest, H-1092, Hungary Export Date: 23 February 2024 Correspondence Address: Csorba, A.; Department of Ophthalmology, Mária Street 39, Hungary; email: csorba.anita@semmelweis-univ.hu Correspondence Address: Balogh, G.T.; Department of Pharmaceutical Chemistry, Hőgyes Endre Street 7-9, Hungary; email: balogh.gyorgy.tibor@semmelweis.hu LA - English DB - MTMT ER - TY - JOUR AU - Zelkó, Romána TI - Innovatív gyógyszerformák és összetett hatóanyag-leadó rendszerek JF - ORVOSKÉPZÉS J2 - ORVOSKÉPZÉS VL - 98 PY - 2023 IS - 3 SP - 740 EP - 743 PG - 4 SN - 0030-6037 UR - https://m2.mtmt.hu/api/publication/34434109 ID - 34434109 N1 - A cikk Richter Gedeon emlékérem és jutalomdíjban részesült LA - Hungarian DB - MTMT ER - TY - JOUR AU - Lőrinczy, Lilla AU - Turbucz, Béla AU - Hankó, Balázs AU - Zelkó, Romána TI - Managing Antibiotic Shortages in Inpatient Care - A Review of Recent Years in Comparison with the Hungarian Status JF - ANTIBIOTICS J2 - ANTIBIOTICS-BASEL VL - 12 PY - 2023 IS - 12 PG - 14 SN - 2079-6382 DO - 10.3390/antibiotics12121704 UR - https://m2.mtmt.hu/api/publication/34421579 ID - 34421579 LA - English DB - MTMT ER - TY - JOUR AU - MAGRAMANE, Sabrina AU - Vlahovic, Kristina AU - Gordon, Péter AU - Kállai-Szabó, Nikolett AU - Zelkó, Romána AU - Antal, István AU - Farkas, Dóra TI - Inhalation Dosage Forms: A Focus on Dry Powder Inhalers and Their Advancements JF - PHARMACEUTICALS J2 - PHARMACEUTICALS-BASE VL - 16 PY - 2023 IS - 12 PG - 48 SN - 1424-8247 DO - 10.3390/ph16121658 UR - https://m2.mtmt.hu/api/publication/34405975 ID - 34405975 N1 - Department of Pharmaceutics, Semmelweis University, Hőgyes Str. 7, Budapest, H-1092, Hungary Department of Electronics Technology, Budapest University of Technology and Economics, Egry J. Str. 18, Budapest, H-1111, Hungary Department of Pharmacy Administration, Semmelweis University, Hőgyes Str. 7–9, Budapest, H-1092, Hungary Export Date: 14 March 2024 Correspondence Address: Kállai-Szabó, N.; Department of Pharmaceutics, Hőgyes Str. 7, Hungary; email: kallai.nikolett@semmelweis.hu Correspondence Address: Farkas, D.; Department of Pharmaceutics, Hőgyes Str. 7, Hungary; email: farkas.dora@semmelweis.hu AB - In this review, an extensive analysis of dry powder inhalers (DPIs) is offered, focusing on their characteristics, formulation, stability, and manufacturing. The advantages of pulmonary delivery were investigated, as well as the significance of the particle size in drug deposition. The preparation of DPI formulations was also comprehensively explored, including physico-chemical characterization of powders, powder processing techniques, and formulation considerations. In addition to manufacturing procedures, testing methods were also discussed, providing insights into the development and evaluation of DPI formulations. This review also explores the design basics and critical attributes specific to DPIs, highlighting the significance of their optimization to achieve an effective inhalation therapy. Additionally, the morphology and stability of 3 DPI capsules (Spiriva, Braltus, and Onbrez) were investigated, offering valuable insights into the properties of these formulations. Altogether, these findings contribute to a deeper understanding of DPIs and their development, performance, and optimization of inhalation dosage forms. LA - English DB - MTMT ER - TY - JOUR AU - Safaa, Mohammed Omer AU - Nagy, Nándor AU - Szőcs, Emőke AU - Kádár, Szabina AU - Völgyi, Gergely AU - Pinke, Balázs AU - Mészáros, László AU - Katona, Gábor AU - Vincze, Anna AU - Dormán, Péter AU - Nagy, Zoltán Zsolt AU - Balogh, György Tibor AU - Nochta-Kazsoki, Adrienn Katalin AU - Zelkó, Romána TI - Development of innovative electrospun nepafenac-loaded nanofibers-based ophthalmic inserts JF - INTERNATIONAL JOURNAL OF PHARMACEUTICS J2 - INT J PHARM VL - 647 PY - 2023 PG - 13 SN - 0378-5173 DO - 10.1016/j.ijpharm.2023.123554 UR - https://m2.mtmt.hu/api/publication/34225112 ID - 34225112 N1 - University Pharmacy Department of Pharmacy Administration, Semmelweis University, Hőgyes Endre Street 7-9, Budapest, H-1092, Hungary Department of Anatomy, Histology and Embryology Semmelweis University, Tűzoltó Street 58, Budapest, H-1094, Hungary Department of Organic Chemistry and Technology, Faculty of Chemical Technology and Biotechnology, Budapest University of Technology and Economics, Műegyetem Rkp. 3, Budapest, H-1111, Hungary Department of Pharmaceutical Chemistry, Semmelweis University, Hőgyes Endre Street 9, Budapest, H-1092, Hungary Department of Polymer Engineering, Faculty of Mechanical Engineering, Budapest University of Technology and Economics, Műegyetem Rkp. 3, Budapest, H-1111, Hungary Institute of Pharmaceutical Technology and Regulatory Affairs, University of Szeged, Eötvös u. 6, Szeged, H-6720, Hungary Department of Chemical and Environmental Process Engineering, Budapest University of Technology and Economics, Műegyetem Rkp. 3, Budapest, H-1111, Hungary Department of Ophthalmology, Semmelweis University, Ma ́ria Street 39, Budapest, 1085, Hungary Export Date: 1 March 2024 CODEN: IJPHD Correspondence Address: Kazsoki, A.; University Pharmacy Department of Pharmacy Administration, Hőgyes Endre Street 7-9, Hungary; email: kazsoki.adrienn@semmelweis.hu Chemicals/CAS: 2 hydroxypropyl beta cyclodextrin, 94035-02-6, 128446-35-5; nepafenac, 78281-72-8; poloxamer, 9003-11-6; polyvinyl alcohol, 37380-95-3, 9002-89-5 Tradenames: nevanac Manufacturers: TCI, Japan LA - English DB - MTMT ER - TY - CONF AU - Benkő, Beáta Mária AU - Tóth, Gergő AU - Tóth, Bence AU - I. Szabó, Zoltán AU - Szente, Lajos AU - Szabó, Edina AU - Zelkó, Romána AU - Sebe, István TI - Inclusion complexation of the novel antipsoriatic drug apremilast with cyclodextrins T2 - EUROCD 2023 7th European Cyclodextrin Conference PY - 2023 PG - 2 UR - https://m2.mtmt.hu/api/publication/34163455 ID - 34163455 N1 - https://www.cyclodextrinconference.com/wp-content/uploads/2023/07/EuroCD-2023-Scientific-Program-5.pdf LA - English DB - MTMT ER - TY - JOUR AU - Tóth, Gergő D. AU - Kállai-Szabó, Nikolett AU - Lengyel, Miléna AU - Süvegh, Károly AU - Ender, Ferenc AU - Katona, Gábor AU - Nochta-Kazsoki, Adrienn Katalin AU - Zelkó, Romána AU - Antal, István AU - Balogh, György Tibor AU - Balogh Weiser, Diána TI - Nanoformulation of lipase from Porcine pancreas by electrospinning as a novel alternative for enzyme-based per os therapies JF - JOURNAL OF MOLECULAR LIQUIDS J2 - J MOL LIQ VL - 389 PY - 2023 PG - 13 SN - 0167-7322 DO - 10.1016/j.molliq.2023.122819 UR - https://m2.mtmt.hu/api/publication/34096036 ID - 34096036 N1 - Department of Physical Chemistry and Materials Science, Budapest University of Technology and Economics, Műegyetem rkp. 3, Budapest, H-1111, Hungary Department of Pharmaceutics, Semmelweis University, Hőgyes E. Street 7–9, Budapest, H-1092, Hungary Eötvös Loránd University Laboratory of Nuclear Chemistry, P.O. Box 32, Budapest, H-1518, Hungary Department of Electron Devices, Budapest University of Technology and Economics, Műegyetem rkp. 3, Budapest, H-1111, Hungary Spinsplit Llc., Vend u. 17, Budapest, H-1025, Hungary Institute of Pharmaceutical Technology and Regulatory Affairs, Faculty of Pharmacy, University of Szeged, Eötvös u. 6, Szeged, H-6720, Hungary University Pharmacy, Department of Pharmacy Administration, Faculty of Pharmaceutical Sciences, Semmelweis University, Hőgyes E. Street 7–9, Budapest, H-1092, Hungary Department of Pharmaceutical Chemistry, Faculty of Pharmaceutical Sciences, Semmelweis University, Hőgyes E. Street 7–9, Budapest, H-1092, Hungary Department of Chemical and Environmental Process Engineering, Budapest University of Technology and Economics, Budapest, H-1111, Hungary Department of Organic Chemistry and Technology, Budapest University of Technology and Economics, Műegyetem rkp. 3, Budapest, H-1111, Hungary Export Date: 20 February 2024 CODEN: JMLID Correspondence Address: Antal, I.; Department of Pharmaceutical Chemistry, Hőgyes E. Street 7–9, Hungary; email: antal.istvan@semmelweis.hu LA - English DB - MTMT ER - TY - JOUR AU - Al Assaf, Sarah AU - Kleiner, Dénes AU - Zelkó, Romána AU - Hankó, Balázs TI - Type 2 Diabetes Patients’ Views of Local Pharmacists and Fulfilment with Pharmaceutical Diabetes Care in Syria’s Latakia Governorate: An Online Survey Research JF - HEALTHCARE J2 - HEALTHCARE-BASEL VL - 11 PY - 2023 IS - 12 PG - 16 SN - 2227-9032 DO - 10.3390/healthcare11121720 UR - https://m2.mtmt.hu/api/publication/34010969 ID - 34010969 N1 - Export Date: 12 April 2024 Correspondence Address: Zelkó, R.; University Pharmacy, Hungary; email: zelko.romana@semmelweis.hu LA - English DB - MTMT ER - TY - JOUR AU - Romeo, A AU - Nochta-Kazsoki, Adrienn Katalin AU - Safaa, Mohammed Omer AU - Pinke, B AU - Mészáros, László AU - Musumeci, T AU - Zelkó, Romána TI - Formulation and Characterization of Electrospun Nanofibers for Melatonin Ocular Delivery JF - PHARMACEUTICS J2 - PHARMACEUTICS VL - 15 PY - 2023 IS - 4 PG - 17 SN - 1999-4923 DO - 10.3390/pharmaceutics15041296 UR - https://m2.mtmt.hu/api/publication/33763666 ID - 33763666 LA - English DB - MTMT ER -