TY - JOUR AU - Abboud, Houssam AU - Zelkó, Romána AU - Nochta-Kazsoki, Adrienn Katalin TI - A systematic review of liposomal nanofibrous scaffolds as a drug delivery system: a decade of progress in controlled release and therapeutic efficacy JF - DRUG DELIVERY : JOURNAL OF DELIVERY AND TARGETING OF THERAPEUTIC AGENTS J2 - DRUG DELIV VL - 32 PY - 2025 IS - 1 PG - 23 SN - 1071-7544 DO - 10.1080/10717544.2024.2445259 UR - https://m2.mtmt.hu/api/publication/35655586 ID - 35655586 N1 - Funding Agency and Grant Number: Semmelweis 250+ Excellence PhD Scholarship; Stipendium Hungaricum Scholarship; New National Excellence Program of the Ministry for Culture and Innovation from the source of the National Research, Development and Innovation Fund [UNKP-23-4-II-SE-22]; University Research Scholarship Programme of the Ministry for Culture and Innovation from the source of the National Research, Development and Innovation Fund [2024-2.1.1.-EKOP-2024-00004] Funding text: Houssam Abboud is grateful for the Semmelweis 250+ Excellence PhD Scholarship and Stipendium Hungaricum Scholarship. This project was supported by UNKP-23-4-II-SE-22 New National Excellence Program of the Ministry for Culture and Innovation from the source of the National Research, Development and Innovation Fund, and by the 2024-2.1.1.-EKOP-2024-00004 University Research Scholarship Programme of the Ministry for Culture and Innovation from the source of the National Research, Development and Innovation Fund. LA - English DB - MTMT ER - TY - CONF AU - Artner, Anna AU - Eőry, Ajándék AU - Hankó, Balázs AU - Torzsa, Péter AU - Zelkó, Romána TI - A gyógyszerészek szerepe az idős betegek sztatinterápiás adherenciájának javításában: egy randomizált, kontrollált vizsgálat T2 - CSALÁDORVOS KUTATÓK ORSZÁGOS SZERVEZETE - XXIII. Kongresszus PY - 2025 SP - n/a UR - https://m2.mtmt.hu/api/publication/35959609 ID - 35959609 LA - Hungarian DB - MTMT ER - TY - PAT AU - László, Ritter AU - László, Hornok AU - Mátyus, Péter AU - Zelkó, Romána AU - Andrea, Ujhelyi AU - Richárd, Balázs Kárpáti AU - Tamás, Solymosi AU - Hristos, Glavinas TI - TOPICAL AMLODIPINE SALTS FOR THE TREATMENT OF ANORECTAL DISEASES CY - Country:10001(1) PY - 2025 UR - https://m2.mtmt.hu/api/publication/36012044 ID - 36012044 LA - English DB - MTMT ER - TY - GEN AU - Nochta-Kazsoki, Adrienn Katalin AU - Abboud, Houssam AU - Zelkó, Romána TI - Development of a Multifunctional Nanofibrous Patch for Oral Aphthae Treatment. PY - 2025 UR - https://m2.mtmt.hu/api/publication/36112298 ID - 36112298 LA - English DB - MTMT ER - TY - JOUR AU - Borbás, Bence AU - Kohod, Z. AU - Kállai-Szabó, Nikolett AU - Basa, Bálint AU - Lengyel, Miléna AU - Zelkó, Romána AU - Antal, István TI - Evaluation of 3D-Printed Balls with Photopolymer Resin as Grinding Medium Used to Alternatively Reduce Warmup During Dry Milling JF - POLYMERS J2 - POLYMERS-BASEL VL - 17 PY - 2025 IS - 13 PG - 17 SN - 2073-4360 DO - 10.3390/polym17131795 UR - https://m2.mtmt.hu/api/publication/36215710 ID - 36215710 LA - English DB - MTMT ER - TY - JOUR AU - Benkő, Beáta Mária AU - Szabó, B.-I. AU - Kádár, Szabina AU - Szabó, Edina AU - Tóth, Gergő AU - Szente, Lajos AU - Tonka-Nagy, P. AU - Zelkó, Romána AU - Sebe, István TI - Development of Low-Dose Disulfiram Rectal Suppository Intended for Application in Post-Treatment Lyme Disease Syndrome JF - PHARMACEUTICS J2 - PHARMACEUTICS VL - 17 PY - 2025 IS - 7 PG - 25 SN - 1999-4923 DO - 10.3390/pharmaceutics17070849 UR - https://m2.mtmt.hu/api/publication/36216612 ID - 36216612 LA - English DB - MTMT ER - TY - JOUR AU - MAGRAMANE, Sabrina AU - Kállai-Szabó, Nikolett AU - Farkas, Dóra AU - Süvegh, Károly AU - Zelkó, Romána AU - Antal, István TI - Comparative Evaluation of Gelatin and HPMC Inhalation Capsule Shells Exposed to Simulated Humidity Conditions JF - PHARMACEUTICS J2 - PHARMACEUTICS VL - 17 PY - 2025 IS - 7 PG - 23 SN - 1999-4923 DO - 10.3390/pharmaceutics17070877 UR - https://m2.mtmt.hu/api/publication/36226846 ID - 36226846 AB - Background/Objectives: This study investigates the impact of high humidity (25 °C, 75% relative humidity) on gelatin and hydroxypropyl methylcellulose (HPMC) capsules used in dry powder inhalers (DPIs), focusing on moisture dynamics, structural responses, and mechanical performance, with an emphasis on understanding how different capsule types respond to prolonged exposure to humid conditions. Methods: Capsules were exposed to controlled humidity conditions, and moisture uptake was measured via thermal analysis. Visual observations of silica bead color changes were performed to assess moisture absorption, while surface wettability was measured using the sessile drop method. Hardness testing, mechanical deformation, and puncture tests were performed to evaluate structural and mechanical changes. Positron annihilation lifetime spectroscopy (PALS) was used to analyze free volume expansion. Results: HPMC capsules exhibited rapid moisture uptake, attributed to their lower equilibrium moisture content and ability to rearrange dynamically, preventing brittleness. In contrast, gelatin capsules showed slower moisture absorption but reached higher equilibrium levels, resulting in plasticization and softening. Mechanical testing showed that HPMC capsules retained structural integrity with minimal deformation, while gelatin capsules became softer and exhibited reduced puncture resistance. Structural analysis revealed greater free volume expansion in HPMC capsules, consistent with their amorphous nature, compared with gelatin’s semi-crystalline matrix. Conclusions: HPMC capsules demonstrated superior humidity resilience, making them more suitable for protecting moisture-sensitive active pharmaceutical ingredients (APIs) in DPI formulations. These findings underline the importance of appropriate storage conditions, as outlined in the Summary of Product Characteristics, to ensure optimal capsule performance throughout patient use. LA - English DB - MTMT ER - TY - JOUR AU - Kleiner, Dénes AU - Haghverdi, Faraz AU - Szépe, Orsolya AU - Horváth, István László AU - Sebők, Szilvia AU - Csupor, Dezső AU - Horváth, András Attila AU - Balogh, Artúr György AU - Monostory, Katalin AU - Kóbori, László AU - Balázs, Máté Ádám AU - Dank, Magdolna AU - Móczár, Csaba AU - Becze, Ádám AU - Süle, András AU - Zelkó, Romána TI - How to manage the overwhelming amount of database-detected interactions? A focus group meeting study on the management of database-detected risks of drug interactions JF - EUROPEAN JOURNAL OF HOSPITAL PHARMACY-SCIENCE AND PRACTICE J2 - EUR J HOSP PHARM SCI PRACT PY - 2025 PG - 6 SN - 2047-9956 DO - 10.1136/ejhpharm-2025-004478 UR - https://m2.mtmt.hu/api/publication/36241099 ID - 36241099 AB - Database-assisted screening may help detect the risks of drug interactions, but less than 10% of flagged interactions have clinical manifestations, potentially leading to alert fatigue among healthcare providers. To address this issue, this study aimed to develop a concise framework to support the management of database-indicated interaction risks.A grounded theory approach was used to design, evaluate and develop the framework. Participants included healthcare professionals and laypersons with experience using narrow therapeutic index medications, as well as individuals recommended by them. Two focus group discussions were conducted (N1=6 and N2=5), each lasting approximately 2 hours and following the same agenda. In one case, a follow-up one-on-one interview was held because the participant indicated further insights at the end of the session.Participants identified key decision-making questions for the framework, including the evidence base for interacting drugs, severity and documentation level of the interaction, availability of safer alternatives, and the presence of confounding factors. The framework was considered useful and, following refinement, potentially suitable for clinical implementation. A key insight was that integration into healthcare curricula is essential for achieving long-term impact. Overall, the proposed tool may assist in managing interaction risks in diverse clinical scenarios and reduce alert fatigue among healthcare professionals.Although further clinical validation is needed, the framework provides a foundation for improving the management of database-detected drug interactions. LA - English DB - MTMT ER - TY - JOUR AU - Pegah, Poursafar AU - Nochta-Kazsoki, Adrienn Katalin AU - Palcsó, Barnabás AU - Károly, Süvegh AU - Zelkó, Romána TI - Structure–dependent chlorine dioxide release from poly(acrylic acid) and hydroxyethyl cellulose hydrogels: Insights from real-time positron annihilation lifetime spectroscopy and quantum chemical calculations JF - FOOD CHEMISTRY: X J2 - FOOD CHEM X VL - 29 PY - 2025 PG - 8 SN - 2590-1575 DO - 10.1016/j.fochx.2025.102782 UR - https://m2.mtmt.hu/api/publication/36245043 ID - 36245043 LA - English DB - MTMT ER - TY - JOUR AU - Artner, Anna AU - Zelkó, Romána AU - Hankó, Balázs TI - Optimizing Statin Therapy in Older Adults: A Systematic Review of Dosing, Titration, and Combination Strategies JF - GEROSCIENCE: OFFICIAL JOURNAL OF THE AMERICAN AGING ASSOCIATION (AGE) J2 - GEROSCIENCE PY - 2025 PG - 23 SN - 2509-2715 DO - 10.1007/s11357-025-01772-w UR - https://m2.mtmt.hu/api/publication/36250637 ID - 36250637 AB - Statins are crucial in lipid-lowering therapy for reducing atherosclerotic cardiovascular disease (ASCVD) risk. However, rhabdomyolysis, a rare but severe side effect, disproportionately affects frail, older adults with polypharmacy and multiple comorbidities. Current guidelines for adjusting statin dosages in older adults lack clarity. To evaluate statin use in the geriatric population, assess benefit-risk ratios, and analyze dosage regimens through a systematic literature review. A comprehensive search was conducted in PubMed, Scopus, Web of Science, and EBSCO databases. Eleven original studies involving 566,509 patients were included. The review was registered on PROSPERO (CRD42024587259). Statin therapy was associated with a lower risk of cardiovascular disease compared to placebo. When adjusted during treatment, higher-intensity statins appeared to provide greater benefits than fixed low-dose statins, while the likelihood of side effects remained similar. Using ezetimibe and statins further improved outcomes and was linked to fewer side effects. Adherence-improving techniques were crucial, especially in older adults. Individualized statin dosing, considering titration, combination therapy, and adherence strategies, is essential for maximizing benefits and minimizing risks in older adults. While statins effectively reduce CVD risk, careful consideration of patient-specific factors is necessary when prescribing to older adults. LA - English DB - MTMT ER -