TY - JOUR AU - Varga, Alexandra Edit AU - Márton, Éva AU - Penyige, András AU - Balogh, István AU - Nagy, Bálint AU - Szilágyi-Bónizs, Melinda TI - Study the significance of miR-30 family members in ovarian cancer JF - EUROPEAN JOURNAL OF HUMAN GENETICS J2 - EUR J HUM GENET VL - 31 PY - 2023 IS - S1 SP - 547 EP - 547 PG - 1 SN - 1018-4813 UR - https://m2.mtmt.hu/api/publication/34738118 ID - 34738118 LA - English DB - MTMT ER - TY - JOUR AU - Márton, Éva AU - Varga, Alexandra Edit AU - Penyige, András AU - Nagy, Bálint AU - Széles, Lajos AU - Balogh, István AU - Szilágyi-Bónizs, Melinda TI - Study the role of miR200s in the estrogen response of ovarian cells JF - EUROPEAN JOURNAL OF HUMAN GENETICS J2 - EUR J HUM GENET VL - 31 PY - 2023 IS - S1 SP - 556 EP - 556 PG - 1 SN - 1018-4813 UR - https://m2.mtmt.hu/api/publication/34736761 ID - 34736761 LA - English DB - MTMT ER - TY - JOUR AU - Varga, Alexandra Edit AU - Márton, Éva AU - Grimplinyi, Fatime AU - Takács, Balint AU - Penyige, András AU - Széles, Lajos AU - Balogh, István AU - Nagy, Bálint AU - Szilágyi-Bónizs, Melinda TI - Comparative analysis of transcriptomic changes including mRNA and microRNA expression induced by xenoestrogens in ovarian cells JF - EUROPEAN JOURNAL OF HUMAN GENETICS J2 - EUR J HUM GENET VL - 31 PY - 2023 IS - S1 SP - 547 EP - 547 PG - 1 SN - 1018-4813 UR - https://m2.mtmt.hu/api/publication/34732826 ID - 34732826 LA - English DB - MTMT ER - TY - JOUR AU - Soltész, Beáta AU - Lukács, János AU - Németh , Nikolett AU - Penyige, András AU - Póka, Róbert AU - Balogh, István AU - Nagy, Bálint TI - Comparative analyses of long non-coding RNA and associated microRNAs expression in plasma and ovarian tissue samples of patients with ovarian cancer JF - EUROPEAN JOURNAL OF HUMAN GENETICS J2 - EUR J HUM GENET VL - 31 PY - 2023 IS - S1 SP - 566 EP - 567 PG - 2 SN - 1018-4813 UR - https://m2.mtmt.hu/api/publication/34732470 ID - 34732470 LA - English DB - MTMT ER - TY - JOUR AU - Géczi, Dóra Anikó AU - Nagy, Bálint AU - Szilágyi-Bónizs, Melinda AU - Penyige, András AU - Klekner, Álmos AU - Virga, József AU - Birkó, Zsuzsanna TI - Analysis of circulating miRNA profile in plasma sapmles of glioblastoma patients JF - EUROPEAN JOURNAL OF HUMAN GENETICS J2 - EUR J HUM GENET VL - 31 PY - 2023 IS - S1 SP - 546 EP - 547 PG - 2 SN - 1018-4813 UR - https://m2.mtmt.hu/api/publication/34732037 ID - 34732037 LA - English DB - MTMT ER - TY - JOUR AU - Gombos, Gréta AU - Németh , Nikolett AU - Pös, Ondrej AU - Styk, Jakub AU - Buglyó, Gergely AU - Szemes, Tomas AU - Danihel, Ludovit AU - Nagy, Bálint AU - Balogh, István AU - Soltész, Beáta TI - New Possible Ways to Use Exosomes in Diagnostics and Therapy via JAK/STAT Pathways JF - PHARMACEUTICS J2 - PHARMACEUTICS VL - 15 PY - 2023 IS - 7 SP - 1904 SN - 1999-4923 DO - 10.3390/pharmaceutics15071904 UR - https://m2.mtmt.hu/api/publication/34071266 ID - 34071266 AB - Exosomes have the potential to be the future of personalized diagnostics and therapy. They are nano-sized particles between 30 and 100 nm flowing in the extracellular milieu, where they mediate cell–cell communication and participate in immune system regulation. Tumor-derived exosomes (TDEs) secreted from different types of cancer cells are the key regulators of the tumor microenvironment. With their immune suppressive cargo, TDEs prevent the antitumor immune response, leading to reduced effectiveness of cancer treatment by promoting a pro-tumorigenic microenvironment. Involved signaling pathways take part in the regulation of tumor proliferation, differentiation, apoptosis, and angiogenesis. Signal transducers and activators of transcription factors (STATs) and Janus kinase (JAK) signaling pathways are crucial in malignancies and autoimmune diseases alike, and their potential to be manipulated is currently the focus of interest. In this review, we aim to discuss exosomes, TDEs, and the JAK/STAT pathways, along with mediators like interleukins, tripartite motif proteins, and interferons. LA - English DB - MTMT ER - TY - JOUR AU - Pös, Ondrej AU - Styk, Jakub AU - Buglyó, Gergely AU - Zeman, Michal AU - Lukyova, Lydia AU - Bernatova, Kamila AU - Hrckova Turnova, Evelina AU - Rendek, Tomas AU - Csók, Ádám AU - Repiska, Vanda AU - Nagy, Bálint AU - Szemes, Tomas TI - Cross-Kingdom Interaction of miRNAs and Gut Microbiota with Non-Invasive Diagnostic and Therapeutic Implications in Colorectal Cancer JF - INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES J2 - INT J MOL SCI VL - 24 PY - 2023 IS - 13 SN - 1661-6596 DO - 10.3390/ijms241310520 UR - https://m2.mtmt.hu/api/publication/34050539 ID - 34050539 AB - Colorectal cancer (CRC) has one of the highest incidences among all types of malignant diseases, affecting millions of people worldwide. It shows slow progression, making it preventable. However, this is not the case due to shortcomings in its diagnostic and management procedure and a lack of effective non-invasive biomarkers for screening. Here, we discuss CRC-associated microRNAs (miRNAs) and gut microbial species with potential as CRC diagnostic and therapy biomarkers. We provide rich evidence of cross-kingdom miRNA-mediated interactions between the host and gut microbiome. miRNAs have emerged with the ability to shape the composition and dynamics of gut microbiota. Intestinal microbes can uptake miRNAs, which in turn influence microbial growth and provide the ability to regulate the abundance of various microbial species. In the context of CRC, targeting miRNAs could aid in manipulating the balance of the microbiota. Our findings suggest the need for correlation analysis between the composition of the gut microbiome and the miRNA expression profile. LA - English DB - MTMT ER - TY - JOUR AU - Márton, Éva AU - Varga, Alexandra Edit AU - Penyige, András AU - Birkó, Zsuzsanna AU - Balogh, István AU - Nagy, Bálint AU - Szilágyi-Bónizs, Melinda TI - Comparative Analysis of Transcriptomic Changes including mRNA and microRNA Expression Induced by the Xenoestrogens Zearalenone and Bisphenol A in Human Ovarian Cells JF - TOXINS J2 - TOXINS VL - 15 PY - 2023 IS - 2 SN - 2072-6651 DO - 10.3390/toxins15020140 UR - https://m2.mtmt.hu/api/publication/33687572 ID - 33687572 AB - Xenoestrogens are natural or synthetic compounds that mimic the effect of endogenous estrogens and might cause cancer. We aimed to compare the global transcriptomic response to zearalenone (ZEA; mycotoxin) and bisphenol A (BPA; plastic additive) with the effect of physiological estradiol (E2) in the PEO1 human ovarian cell line by mRNA and microRNA sequencing. Estrogen exposure induced remarkable transcriptomic changes: 308, 288 and 63 genes were upregulated (log2FC > 1); 292, 260 and 45 genes were downregulated (log2FC < −1) in response to E2 (10 nM), ZEA (10 nM) and BPA (100 nM), respectively. Furthermore, the expression of 13, 11 and 10 miRNAs changed significantly (log2FC > 1, or log2FC < −1) after exposure to E2, ZEA and BPA, respectively. Functional enrichment analysis of the significantly differentially expressed genes and miRNAs revealed several pathways related to the regulation of cell proliferation and migration. The effect of E2 and ZEA was highly comparable: 407 genes were coregulated by these molecules. We could identify 83 genes that were regulated by all three treatments that might have a significant role in the estrogen response of ovarian cells. Furthermore, the downregulation of several miRNAs (miR-501-5p, let-7a-2-3p, miR-26a-2-3p, miR-197-5p and miR-582-3p) was confirmed by qPCR, which might support the proliferative effect of estrogens in ovarian cells. LA - English DB - MTMT ER - TY - JOUR AU - Styk, Jakub AU - Pös, Zuzana AU - Pös, Ondrej AU - Radvanszky, Jan AU - Turnova, Evelina Hrckova AU - Buglyó, Gergely AU - Klimova, Daniela AU - Budis, Jaroslav AU - Repiska, Vanda AU - Nagy, Bálint AU - Szemes, Tomas TI - Microsatellite instability assessment is instrumental for Predictive, Preventive and Personalised Medicine: status quo and outlook JF - EPMA JOURNAL J2 - EPMA J VL - 14 PY - 2023 IS - 1 SP - 143 EP - 165 PG - 23 SN - 1878-5077 DO - 10.1007/s13167-023-00312-w UR - https://m2.mtmt.hu/api/publication/33594324 ID - 33594324 AB - A form of genomic alteration called microsatellite instability (MSI) occurs in a class of tandem repeats (TRs) called microsatellites (MSs) or short tandem repeats (STRs) due to the failure of a post-replicative DNA mismatch repair (MMR) system. Traditionally, the strategies for determining MSI events have been low-throughput procedures that typically require assessment of tumours as well as healthy samples. On the other hand, recent large-scale pan-tumour studies have consistently highlighted the potential of massively parallel sequencing (MPS) on the MSI scale. As a result of recent innovations, minimally invasive methods show a high potential to be integrated into the clinical routine and delivery of adapted medical care to all patients. Along with advances in sequencing technologies and their ever-increasing cost-effectiveness, they may bring about a new era of Predictive, Preventive and Personalised Medicine (3PM). In this paper, we offered a comprehensive analysis of high-throughput strategies and computational tools for the calling and assessment of MSI events, including whole-genome, whole-exome and targeted sequencing approaches. We also discussed in detail the detection of MSI status by current MPS blood-based methods and we hypothesised how they may contribute to the shift from conventional medicine to predictive diagnosis, targeted prevention and personalised medical services. Increasing the efficacy of patient stratification based on MSI status is crucial for tailored decision-making. Contextually, this paper highlights drawbacks both at the technical level and those embedded deeper in cellular/molecular processes and future applications in routine clinical testing. LA - English DB - MTMT ER - TY - JOUR AU - Soltész, Beáta AU - Pös, Ondrej AU - Wlachovska, Zuzana AU - Budis, Jaroslav AU - Hekel, Rastislav AU - Strieskova, Lucia AU - Liptak, Jana Bozenka AU - Krampl, Werner AU - Styk, Jakub AU - Németh , Nikolett AU - Keserű, Judit Szilvia AU - Jenei, Adrienn AU - Buglyó, Gergely AU - Klekner, Álmos AU - Nagy, Bálint AU - Szemes, Tomas TI - Mitochondrial DNA copy number changes, heteroplasmy, and mutations in plasma-derived exosomes and brain tissue of glioblastoma patients JF - MOLECULAR AND CELLULAR PROBES J2 - MOL CELL PROBE VL - 66 PY - 2022 PG - 6 SN - 0890-8508 DO - 10.1016/j.mcp.2022.101875 UR - https://m2.mtmt.hu/api/publication/33291817 ID - 33291817 LA - English DB - MTMT ER -