@article{MTMT:34738118,
	title = {Study the significance of miR-30 family members in ovarian cancer},
	url = {https://m2.mtmt.hu/api/publication/34738118},
	author = {Varga, Alexandra Edit and Márton, Éva and Penyige, András and Balogh, István and Nagy, Bálint and Szilágyi-Bónizs, Melinda},
	journal-iso = {EUR J HUM GENET},
	journal = {EUROPEAN JOURNAL OF HUMAN GENETICS},
	volume = {31},
	unique-id = {34738118},
	issn = {1018-4813},
	year = {2023},
	eissn = {1476-5438},
	pages = {547-547},
	orcid-numbers = {Nagy, Bálint/0000-0002-0295-185X}
}

@article{MTMT:34736761,
	title = {Study the role of miR200s in the estrogen response of ovarian cells},
	url = {https://m2.mtmt.hu/api/publication/34736761},
	author = {Márton, Éva and Varga, Alexandra Edit and Penyige, András and Nagy, Bálint and Széles, Lajos and Balogh, István and Szilágyi-Bónizs, Melinda},
	journal-iso = {EUR J HUM GENET},
	journal = {EUROPEAN JOURNAL OF HUMAN GENETICS},
	volume = {31},
	unique-id = {34736761},
	issn = {1018-4813},
	year = {2023},
	eissn = {1476-5438},
	pages = {556-556},
	orcid-numbers = {Nagy, Bálint/0000-0002-0295-185X}
}

@article{MTMT:34732826,
	title = {Comparative analysis of transcriptomic changes including mRNA and microRNA expression induced by xenoestrogens in ovarian cells},
	url = {https://m2.mtmt.hu/api/publication/34732826},
	author = {Varga, Alexandra Edit and Márton, Éva and Grimplinyi, Fatime and Takács, Balint and Penyige, András and Széles, Lajos and Balogh, István and Nagy, Bálint and Szilágyi-Bónizs, Melinda},
	journal-iso = {EUR J HUM GENET},
	journal = {EUROPEAN JOURNAL OF HUMAN GENETICS},
	volume = {31},
	unique-id = {34732826},
	issn = {1018-4813},
	year = {2023},
	eissn = {1476-5438},
	pages = {547-547},
	orcid-numbers = {Nagy, Bálint/0000-0002-0295-185X}
}

@article{MTMT:34732470,
	title = {Comparative analyses of long non-coding RNA and associated microRNAs expression in plasma and ovarian tissue samples of patients with ovarian cancer},
	url = {https://m2.mtmt.hu/api/publication/34732470},
	author = {Soltész, Beáta and Lukács, János and Németh , Nikolett and Penyige, András and Póka, Róbert and Balogh, István and Nagy, Bálint},
	journal-iso = {EUR J HUM GENET},
	journal = {EUROPEAN JOURNAL OF HUMAN GENETICS},
	volume = {31},
	unique-id = {34732470},
	issn = {1018-4813},
	year = {2023},
	eissn = {1476-5438},
	pages = {566-567},
	orcid-numbers = {Nagy, Bálint/0000-0002-0295-185X}
}

@article{MTMT:34732037,
	title = {Analysis of circulating miRNA profile in plasma sapmles of glioblastoma patients},
	url = {https://m2.mtmt.hu/api/publication/34732037},
	author = {Géczi, Dóra Anikó and Nagy, Bálint and Szilágyi-Bónizs, Melinda and Penyige, András and Klekner, Álmos and Virga, József and Birkó, Zsuzsanna},
	journal-iso = {EUR J HUM GENET},
	journal = {EUROPEAN JOURNAL OF HUMAN GENETICS},
	volume = {31},
	unique-id = {34732037},
	issn = {1018-4813},
	year = {2023},
	eissn = {1476-5438},
	pages = {546-547},
	orcid-numbers = {Nagy, Bálint/0000-0002-0295-185X}
}

@article{MTMT:34071266,
	title = {New Possible Ways to Use Exosomes in Diagnostics and Therapy via JAK/STAT Pathways},
	url = {https://m2.mtmt.hu/api/publication/34071266},
	author = {Gombos, Gréta and Németh , Nikolett and Pös, Ondrej and Styk, Jakub and Buglyó, Gergely and Szemes, Tomas and Danihel, Ludovit and Nagy, Bálint and Balogh, István and Soltész, Beáta},
	doi = {10.3390/pharmaceutics15071904},
	journal-iso = {PHARMACEUTICS},
	journal = {PHARMACEUTICS},
	volume = {15},
	unique-id = {34071266},
	issn = {1999-4923},
	abstract = {Exosomes have the potential to be the future of personalized diagnostics and therapy. They are nano-sized particles between 30 and 100 nm flowing in the extracellular milieu, where they mediate cell–cell communication and participate in immune system regulation. Tumor-derived exosomes (TDEs) secreted from different types of cancer cells are the key regulators of the tumor microenvironment. With their immune suppressive cargo, TDEs prevent the antitumor immune response, leading to reduced effectiveness of cancer treatment by promoting a pro-tumorigenic microenvironment. Involved signaling pathways take part in the regulation of tumor proliferation, differentiation, apoptosis, and angiogenesis. Signal transducers and activators of transcription factors (STATs) and Janus kinase (JAK) signaling pathways are crucial in malignancies and autoimmune diseases alike, and their potential to be manipulated is currently the focus of interest. In this review, we aim to discuss exosomes, TDEs, and the JAK/STAT pathways, along with mediators like interleukins, tripartite motif proteins, and interferons.},
	year = {2023},
	eissn = {1999-4923},
	pages = {1904},
	orcid-numbers = {Gombos, Gréta/0009-0006-8062-8560; Pös, Ondrej/0000-0003-2491-2285; Styk, Jakub/0000-0002-5717-3522; Buglyó, Gergely/0000-0001-5994-2658; Nagy, Bálint/0000-0002-0295-185X}
}

@article{MTMT:34050539,
	title = {Cross-Kingdom Interaction of miRNAs and Gut Microbiota with Non-Invasive Diagnostic and Therapeutic Implications in Colorectal Cancer},
	url = {https://m2.mtmt.hu/api/publication/34050539},
	author = {Pös, Ondrej and Styk, Jakub and Buglyó, Gergely and Zeman, Michal and Lukyova, Lydia and Bernatova, Kamila and Hrckova Turnova, Evelina and Rendek, Tomas and Csók, Ádám and Repiska, Vanda and Nagy, Bálint and Szemes, Tomas},
	doi = {10.3390/ijms241310520},
	journal-iso = {INT J MOL SCI},
	journal = {INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES},
	volume = {24},
	unique-id = {34050539},
	issn = {1661-6596},
	abstract = {Colorectal cancer (CRC) has one of the highest incidences among all types of malignant diseases, affecting millions of people worldwide. It shows slow progression, making it preventable. However, this is not the case due to shortcomings in its diagnostic and management procedure and a lack of effective non-invasive biomarkers for screening. Here, we discuss CRC-associated microRNAs (miRNAs) and gut microbial species with potential as CRC diagnostic and therapy biomarkers. We provide rich evidence of cross-kingdom miRNA-mediated interactions between the host and gut microbiome. miRNAs have emerged with the ability to shape the composition and dynamics of gut microbiota. Intestinal microbes can uptake miRNAs, which in turn influence microbial growth and provide the ability to regulate the abundance of various microbial species. In the context of CRC, targeting miRNAs could aid in manipulating the balance of the microbiota. Our findings suggest the need for correlation analysis between the composition of the gut microbiome and the miRNA expression profile.},
	year = {2023},
	eissn = {1422-0067},
	orcid-numbers = {Pös, Ondrej/0000-0003-2491-2285; Buglyó, Gergely/0000-0001-5994-2658; Nagy, Bálint/0000-0002-0295-185X}
}

@article{MTMT:33687572,
	title = {Comparative Analysis of Transcriptomic Changes including mRNA and microRNA Expression Induced by the Xenoestrogens Zearalenone and Bisphenol A in Human Ovarian Cells},
	url = {https://m2.mtmt.hu/api/publication/33687572},
	author = {Márton, Éva and Varga, Alexandra Edit and Penyige, András and Birkó, Zsuzsanna and Balogh, István and Nagy, Bálint and Szilágyi-Bónizs, Melinda},
	doi = {10.3390/toxins15020140},
	journal-iso = {TOXINS},
	journal = {TOXINS},
	volume = {15},
	unique-id = {33687572},
	issn = {2072-6651},
	abstract = {Xenoestrogens are natural or synthetic compounds that mimic the effect of endogenous estrogens and might cause cancer. We aimed to compare the global transcriptomic response to zearalenone (ZEA; mycotoxin) and bisphenol A (BPA; plastic additive) with the effect of physiological estradiol (E2) in the PEO1 human ovarian cell line by mRNA and microRNA sequencing. Estrogen exposure induced remarkable transcriptomic changes: 308, 288 and 63 genes were upregulated (log2FC > 1); 292, 260 and 45 genes were downregulated (log2FC < −1) in response to E2 (10 nM), ZEA (10 nM) and BPA (100 nM), respectively. Furthermore, the expression of 13, 11 and 10 miRNAs changed significantly (log2FC > 1, or log2FC < −1) after exposure to E2, ZEA and BPA, respectively. Functional enrichment analysis of the significantly differentially expressed genes and miRNAs revealed several pathways related to the regulation of cell proliferation and migration. The effect of E2 and ZEA was highly comparable: 407 genes were coregulated by these molecules. We could identify 83 genes that were regulated by all three treatments that might have a significant role in the estrogen response of ovarian cells. Furthermore, the downregulation of several miRNAs (miR-501-5p, let-7a-2-3p, miR-26a-2-3p, miR-197-5p and miR-582-3p) was confirmed by qPCR, which might support the proliferative effect of estrogens in ovarian cells.},
	year = {2023},
	eissn = {2072-6651},
	orcid-numbers = {Nagy, Bálint/0000-0002-0295-185X}
}

@article{MTMT:33594324,
	title = {Microsatellite instability assessment is instrumental for Predictive, Preventive and Personalised Medicine: status quo and outlook},
	url = {https://m2.mtmt.hu/api/publication/33594324},
	author = {Styk, Jakub and Pös, Zuzana and Pös, Ondrej and Radvanszky, Jan and Turnova, Evelina Hrckova and Buglyó, Gergely and Klimova, Daniela and Budis, Jaroslav and Repiska, Vanda and Nagy, Bálint and Szemes, Tomas},
	doi = {10.1007/s13167-023-00312-w},
	journal-iso = {EPMA J},
	journal = {EPMA JOURNAL},
	volume = {14},
	unique-id = {33594324},
	issn = {1878-5077},
	abstract = {A form of genomic alteration called microsatellite instability (MSI) occurs in a class of tandem repeats (TRs) called microsatellites (MSs) or short tandem repeats (STRs) due to the failure of a post-replicative DNA mismatch repair (MMR) system. Traditionally, the strategies for determining MSI events have been low-throughput procedures that typically require assessment of tumours as well as healthy samples. On the other hand, recent large-scale pan-tumour studies have consistently highlighted the potential of massively parallel sequencing (MPS) on the MSI scale. As a result of recent innovations, minimally invasive methods show a high potential to be integrated into the clinical routine and delivery of adapted medical care to all patients. Along with advances in sequencing technologies and their ever-increasing cost-effectiveness, they may bring about a new era of Predictive, Preventive and Personalised Medicine (3PM). In this paper, we offered a comprehensive analysis of high-throughput strategies and computational tools for the calling and assessment of MSI events, including whole-genome, whole-exome and targeted sequencing approaches. We also discussed in detail the detection of MSI status by current MPS blood-based methods and we hypothesised how they may contribute to the shift from conventional medicine to predictive diagnosis, targeted prevention and personalised medical services. Increasing the efficacy of patient stratification based on MSI status is crucial for tailored decision-making. Contextually, this paper highlights drawbacks both at the technical level and those embedded deeper in cellular/molecular processes and future applications in routine clinical testing.},
	year = {2023},
	eissn = {1878-5085},
	pages = {143-165},
	orcid-numbers = {Styk, Jakub/0000-0002-5717-3522; Buglyó, Gergely/0000-0001-5994-2658; Nagy, Bálint/0000-0002-0295-185X}
}

@article{MTMT:33291817,
	title = {Mitochondrial DNA copy number changes, heteroplasmy, and mutations in plasma-derived exosomes and brain tissue of glioblastoma patients},
	url = {https://m2.mtmt.hu/api/publication/33291817},
	author = {Soltész, Beáta and Pös, Ondrej and Wlachovska, Zuzana and Budis, Jaroslav and Hekel, Rastislav and Strieskova, Lucia and Liptak, Jana Bozenka and Krampl, Werner and Styk, Jakub and Németh , Nikolett and Keserű, Judit Szilvia and Jenei, Adrienn and Buglyó, Gergely and Klekner, Álmos and Nagy, Bálint and Szemes, Tomas},
	doi = {10.1016/j.mcp.2022.101875},
	journal-iso = {MOL CELL PROBE},
	journal = {MOLECULAR AND CELLULAR PROBES},
	volume = {66},
	unique-id = {33291817},
	issn = {0890-8508},
	year = {2022},
	eissn = {1096-1194},
	orcid-numbers = {Buglyó, Gergely/0000-0001-5994-2658; Nagy, Bálint/0000-0002-0295-185X}
}