TY - CHAP AU - Lázár, László AU - Fülöp, Ferenc ED - Black, David StC ED - Cossy, Janine ED - Stevens, Christian V TI - 1,3-Oxazines and Their Benzo Derivatives T2 - Comprehensive Heterocylic Chemistry IV PB - Elsevier Ltd. CY - Amsterdam SN - 9780128186565 PY - 2022 SP - 416 EP - 479 PG - 64 DO - 10.1016/B978-0-12-818655-8.00008-1 UR - https://m2.mtmt.hu/api/publication/32524104 ID - 32524104 N1 - Cited By :1 Export Date: 1 February 2023 LA - English DB - MTMT ER - TY - JOUR AU - Dvorácskó, Szabolcs AU - Lázár, László AU - Fülöp, Ferenc AU - Palkó, Márta AU - Zalán, Zita AU - Penke, Botond AU - Fülöp, Lívia AU - Tömböly, Csaba AU - Bogár, Ferenc TI - Novel High Affinity Sigma-1 Receptor Ligands from Minimal Ensemble Docking-Based Virtual Screening JF - INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES J2 - INT J MOL SCI VL - 22 PY - 2021 IS - 15 PG - 17 SN - 1661-6596 DO - 10.3390/ijms22158112 UR - https://m2.mtmt.hu/api/publication/32123857 ID - 32123857 LA - English DB - MTMT ER - TY - JOUR AU - Magyar, Tímea AU - Miklós, Ferenc AU - Lázár, László AU - Fülöp, Ferenc TI - Synthesis of 2-(hetero)arylquinazolinones in aqueous media JF - ARKIVOC J2 - ARKIVOC VL - 2016 PY - 2016 IS - 6 SP - 247 EP - 258 PG - 12 SN - 1551-7012 DO - 10.24820/ark.5550190.p009.894 UR - https://m2.mtmt.hu/api/publication/3283042 ID - 3283042 N1 - Funding Agency and Grant Number: Hungarian Research FoundationOrszagos Tudomanyos Kutatasi Alapprogramok (OTKA) [OTKA K-115731] Funding text: We are grateful to the Hungarian Research Foundation (OTKA K-115731) for financial support. Part number: 6 AB - Mechanochemical treatment of N-unsubstituted or N-methyl anthranilamide with benzaldehyde yielded their Schiff bases derivatives which could be easily cyclized to the corresponding 2-phenyl- 2,3-dihydroquinazolinones via thermal rearrangement in water. On the basis of the above findings, an eco-friendly method was applied to prepare quinazolin-4(1H)-one derivatives from anthranilamides and a number of (hetero) aryl aldehydes. Heating the aqueous mixture of starting compounds to 90 degrees C resulted in the products in 81-94% yields. All products precipitated from the reaction mixture and were isolated by simply filtration. No further work-up or purification was necessary. LA - English DB - MTMT ER - TY - BOOK AU - Lázár, László AU - Miklós, Ferenc AU - Palkó, Márta AU - Szakonyi, Zsolt AU - Zalán, Zita ED - Fülöp, Ferenc ED - Lázár, László ED - Szakonyi, Zsolt TI - Laboratory investigations in pharmaceutical chemistry ET - 0 PB - Szegedi Tudományegyetem (SZTE) CY - Szeged PY - 2015 UR - https://m2.mtmt.hu/api/publication/3123383 ID - 3123383 LA - English DB - MTMT ER - TY - BOOK AU - Lázár, László AU - Miklós, Ferenc AU - Palkó, Márta AU - Szakonyi, Zsolt AU - Zalán, Zita ED - Lázár, László ED - Fülöp, Ferenc TI - Gyógyszerészi kémia gyakorlatok ET - 0 PB - Szegedi Tudományegyetem (SZTE) CY - Szeged PY - 2015 UR - https://m2.mtmt.hu/api/publication/3123382 ID - 3123382 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Ilisz, István AU - Grecsó, Nóra AU - Papoušek, R AU - Pataj, Zoltán AU - Barták, P AU - Lázár, László AU - Fülöp, Ferenc AU - Lindner, W AU - Péter, Antal TI - High-performance liquid chromatographic separation of unusual β3-amino acid enantiomers in different chromatographic modes on Cinchona alkaloid-based zwitterionic chiral stationary phases JF - AMINO ACIDS J2 - AMINO ACIDS VL - 47 PY - 2015 IS - 11 SP - 2279 EP - 2291 PG - 13 SN - 0939-4451 DO - 10.1007/s00726-015-2006-1 UR - https://m2.mtmt.hu/api/publication/2968580 ID - 2968580 N1 - Funding Agency and Grant Number: Hungarian National Science Foundation [OTKA K 108847]; Ministry of Education, Youth and Sports of the Czech RepublicMinistry of Education, Youth & Sports - Czech Republic [NPU LO 1305]; Operational Program "Education for Competitiveness" [CZ.1.07/2.3.00/30.0041]; Palacky University in Olomouc [IGA_PrF_2014031] Funding text: This work was supported by Hungarian National Science Foundation grant OTKA K 108847. AP gratefully acknowledges the support of Pilar Franco (Chiral Technologies Europe) for the Chiralpak columns. RP, PZ and PB gratefully acknowledge the support of the Ministry of Education, Youth and Sports of the Czech Republic (NPU LO 1305), Operational Program "Education for Competitiveness" (CZ.1.07/2.3.00/30.0041), and Palacky University in Olomouc (IGA_PrF_2014031). AB - Polar-ionic and hydro-organic mobile phase mode of high-performance liquid chromatographic separations of 23 sterically constrained primary β3-amino acid enantiomers containing, alkyl, aryl or heteroaryl side-chains were carried out by using newly developed Cinchona alkaloid-based zwitterionic chiral selectors and the stationary phases Chiralpak ZWIX(+)™ and ZWIX(-)™. In the polar-ionic mode, the effects of the composition of the bulk solvent and the natures of the co- and counter-ions, while in the hydro-organic mode, the effects of the pH, the counter-ion concentration and the structures of the analytes were investigated. The separations of the enantiomers of these 23 primary β3-amino acids, which can be classified as a series of quasi- (pseudo-) homologs, were optimized in both chromatographic modes. The elution sequence was determined in most cases and a reversal of elution order on ZWIX(+)™ and ZWIX(-)™ column was observed. On the basis of this intermolecular recognition model between the selectors and the given enantiomers an indirect assignment of the resolved enantiomer via chromatography is proposed. © 2015 Springer-Verlag Wien. LA - English DB - MTMT ER - TY - JOUR AU - Magyar, T AU - Miklós, Ferenc AU - Lázár, László AU - Fülöp, Ferenc TI - Application of a Ball Milling Technique for the Condensation of Anthranilic Hydrazides with Aromatic Aldehydes Towards 4-Quinazolinone Derivatives JF - CHEMISTRY OF HETEROCYCLIC COMPOUNDS J2 - CHEM HETEROCYCL COM+ VL - 50 PY - 2015 IS - 10 SP - 1463 EP - 1469 PG - 7 SN - 0009-3122 DO - 10.1007/s10593-014-1611-3 UR - https://m2.mtmt.hu/api/publication/2847135 ID - 2847135 N1 - A Springer oldalán és a WoS-ban más az oldalszám: 1464-1470. A rekordon a Scopus és a fulltext PDF oldalszámai lettek rögzítve. AB - An environmentally friendly method was applied to prepare anthranilic hydrazones and quinazolin-4(1H)-ones from anthranilic hydrazides and a number of aldehydes in solventless medium. The condensations proceeded smoothly under ball milling conditions at room temperature, and the products were obtained in high purity and yield. LA - English DB - MTMT ER - TY - JOUR AU - Stanoeva, E AU - Georgieva, A AU - Avramova, S AU - Burdzhiev, N AU - Lázár, László TI - Synthesis of novel 13a-(ω-aminoalkyl)-8-oxoberbines by means of reaction of homophthalic anhydride with 1-substituted 3,4-dihydroisoquinolines. An unexpected formation of a pyrrolo[3,4-i]berbindione JF - JOURNAL OF HETEROCYCLIC CHEMISTRY J2 - J HETEROCYCLIC CHEM VL - 52 PY - 2015 IS - 1 SP - 130 EP - 135 PG - 6 SN - 0022-152X DO - 10.1002/jhet.1965 UR - https://m2.mtmt.hu/api/publication/2833797 ID - 2833797 AB - The reaction of 1-[o-(N-acylated amino)alkyl]-3,4-dihydroisoquinolines (7a-e) with homophthalic anhydride (1) leads to the formation of 8-oxo-13a-[(N-acylated amino)alkyl]-8H-dibenzo[a,g]quinolizine- 13-carboxylic acids (8a-e) with predomination of cis diastereomers, together with small amount of trans-8a. cis-13a-[(N-Cbzaminomethyl)]-8-oxo-dibenzoquinolizine-13-carboxylic acid (8a) cyclized to the unknown dibenzo[a,g]pyrrolo[3,4-i]quinolizinedione (10) upon moderate heating in methanol. LA - English DB - MTMT ER - TY - JOUR AU - Ilisz, István AU - Grecsó, Nóra AU - Misicka, A AU - Tymecka, D AU - Lázár, László AU - Lindner, W AU - Péter, Antal TI - Comparison of the separation performances of cinchona alkaloid-based zwitterionic stationary phases in the enantioseparation of β2- And β3-amino acids JF - MOLECULES J2 - MOLECULES VL - 20 PY - 2015 IS - 1 SP - 70 EP - 87 PG - 18 SN - 1420-3049 DO - 10.3390/molecules20010070 UR - https://m2.mtmt.hu/api/publication/2833796 ID - 2833796 N1 - Funding Agency and Grant Number: Hungarian National Science Foundation [OTKA K 108847] Funding text: This work was supported by Hungarian National Science Foundation grant OTKA K 108847. The support of Pilar Franco (Chiral Technologies Europe) in providing the Chiralpak columns is gratefully acknowledged. AB - The enantiomers of twelve unusual β2- and β3-homoamino acids containing the same side-chains were separated on chiral stationary phases containing a quinine- or quinidine-based zwitterionic ion-exchanger as chiral selector. The effects of the mobile phase composition, the nature and concentration of the acid and base additives and temperature on the separations were investigated. The changes in standard enthalpy, Δ(ΔH° ), entropy, Δ(ΔS° ), and free energy, Δ(ΔG° ), were calculated from the linear van't Hoff plots derived from the ln α vs. 1/T curves in the studied temperature range (10-50 °C). The values of the thermodynamic parameters depended on the nature of the selectors, the structures of the analytes, and the positions of the substituents on the analytes. A comparison of the zwitterionic stationary phases revealed that the quinidine-based ZWIX(-)™ column exhibited much better selectivity for both β2- and β 3-amino acids than the quinine-based ZWIX(+)™ column, and the separation performances of both the ZWIX(+)™ and ZWIX(-)™ columns were better for β2-amino acids. The elution sequence was determined in some cases and was observed to be R < S and S < R on the ZWIX(+)™ and ZWIX(-)™ columns, respectively. LA - English DB - MTMT ER - TY - PAT AU - Pihlavisto, Marjo AU - Smith, David AU - Juhakoski, Auni AU - Fülöp, Ferenc AU - Lázár, László AU - Szatmári, István AU - Miklós, Ferenc AU - Szakonyi, Zsolt AU - Kiss, Loránd AU - Palkó, Márta TI - New pyridazinone and pyridone compounds PY - 2014 UR - https://m2.mtmt.hu/api/publication/3329849 ID - 3329849 LA - English DB - MTMT ER -