@{MTMT:32524104, title = {1,3-Oxazines and Their Benzo Derivatives}, url = {https://m2.mtmt.hu/api/publication/32524104}, author = {Lázár, László and Fülöp, Ferenc}, booktitle = {Comprehensive Heterocylic Chemistry IV}, doi = {10.1016/B978-0-12-818655-8.00008-1}, unique-id = {32524104}, year = {2022}, pages = {416-479}, orcid-numbers = {Lázár, László/0000-0002-2135-8496; Fülöp, Ferenc/0000-0003-1066-5287} } @article{MTMT:32123857, title = {Novel High Affinity Sigma-1 Receptor Ligands from Minimal Ensemble Docking-Based Virtual Screening}, url = {https://m2.mtmt.hu/api/publication/32123857}, author = {Dvorácskó, Szabolcs and Lázár, László and Fülöp, Ferenc and Palkó, Márta and Zalán, Zita and Penke, Botond and Fülöp, Lívia and Tömböly, Csaba and Bogár, Ferenc}, doi = {10.3390/ijms22158112}, journal-iso = {INT J MOL SCI}, journal = {INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES}, volume = {22}, unique-id = {32123857}, issn = {1661-6596}, year = {2021}, eissn = {1422-0067}, orcid-numbers = {Lázár, László/0000-0002-2135-8496; Fülöp, Ferenc/0000-0003-1066-5287; Palkó, Márta/0000-0002-8265-7377; Zalán, Zita/0000-0002-7146-3024; Penke, Botond/0000-0003-0938-0567; Fülöp, Lívia/0000-0002-8010-0129; Bogár, Ferenc/0000-0002-0611-1452} } @article{MTMT:3283042, title = {Synthesis of 2-(hetero)arylquinazolinones in aqueous media}, url = {https://m2.mtmt.hu/api/publication/3283042}, author = {Magyar, Tímea and Miklós, Ferenc and Lázár, László and Fülöp, Ferenc}, doi = {10.24820/ark.5550190.p009.894}, journal-iso = {ARKIVOC}, journal = {ARKIVOC}, volume = {2016}, unique-id = {3283042}, issn = {1551-7012}, abstract = {Mechanochemical treatment of N-unsubstituted or N-methyl anthranilamide with benzaldehyde yielded their Schiff bases derivatives which could be easily cyclized to the corresponding 2-phenyl- 2,3-dihydroquinazolinones via thermal rearrangement in water. On the basis of the above findings, an eco-friendly method was applied to prepare quinazolin-4(1H)-one derivatives from anthranilamides and a number of (hetero) aryl aldehydes. Heating the aqueous mixture of starting compounds to 90 degrees C resulted in the products in 81-94% yields. All products precipitated from the reaction mixture and were isolated by simply filtration. No further work-up or purification was necessary.}, keywords = {ACID; ONE-POT SYNTHESIS; WATER; EFFICIENT SYNTHESIS; Mild; SOLVENT-FREE CONDITIONS; Mechanochemical; Aqueous; Environmentally friendly methods; Ball-milling reactions; Recyclable catalyst; 2,3-DIHYDROQUINAZOLIN-4(1H)-ONE DERIVATIVES; HETEROCYCLIC RINGS}, year = {2016}, eissn = {1551-7004}, pages = {247-258}, orcid-numbers = {Lázár, László/0000-0002-2135-8496; Fülöp, Ferenc/0000-0003-1066-5287} } @book{MTMT:3123383, title = {Laboratory investigations in pharmaceutical chemistry}, url = {https://m2.mtmt.hu/api/publication/3123383}, author = {Lázár, László and Miklós, Ferenc and Palkó, Márta and Szakonyi, Zsolt and Zalán, Zita}, editor = {Fülöp, Ferenc and Lázár, László and Szakonyi, Zsolt}, publisher = {SZTE}, unique-id = {3123383}, year = {2015}, orcid-numbers = {Lázár, László/0000-0002-2135-8496; Szakonyi, Zsolt/0000-0003-2432-8409; Zalán, Zita/0000-0002-7146-3024; Fülöp, Ferenc/0000-0003-1066-5287; Lázár, László/0000-0002-2135-8496; Szakonyi, Zsolt/0000-0003-2432-8409} } @book{MTMT:3123382, title = {Gyógyszerészi kémia gyakorlatok}, url = {https://m2.mtmt.hu/api/publication/3123382}, author = {Lázár, László and Miklós, Ferenc and Palkó, Márta and Szakonyi, Zsolt and Zalán, Zita}, editor = {Lázár, László and Fülöp, Ferenc}, publisher = {SZTE}, unique-id = {3123382}, year = {2015}, orcid-numbers = {Lázár, László/0000-0002-2135-8496; Szakonyi, Zsolt/0000-0003-2432-8409; Zalán, Zita/0000-0002-7146-3024; Lázár, László/0000-0002-2135-8496; Fülöp, Ferenc/0000-0003-1066-5287} } @article{MTMT:2968580, title = {High-performance liquid chromatographic separation of unusual β3-amino acid enantiomers in different chromatographic modes on Cinchona alkaloid-based zwitterionic chiral stationary phases}, url = {https://m2.mtmt.hu/api/publication/2968580}, author = {Ilisz, István and Grecsó, Nóra and Papoušek, R and Pataj, Zoltán and Barták, P and Lázár, László and Fülöp, Ferenc and Lindner, W and Péter, Antal}, doi = {10.1007/s00726-015-2006-1}, journal-iso = {AMINO ACIDS}, journal = {AMINO ACIDS}, volume = {47}, unique-id = {2968580}, issn = {0939-4451}, abstract = {Polar-ionic and hydro-organic mobile phase mode of high-performance liquid chromatographic separations of 23 sterically constrained primary β3-amino acid enantiomers containing, alkyl, aryl or heteroaryl side-chains were carried out by using newly developed Cinchona alkaloid-based zwitterionic chiral selectors and the stationary phases Chiralpak ZWIX(+)™ and ZWIX(-)™. In the polar-ionic mode, the effects of the composition of the bulk solvent and the natures of the co- and counter-ions, while in the hydro-organic mode, the effects of the pH, the counter-ion concentration and the structures of the analytes were investigated. The separations of the enantiomers of these 23 primary β3-amino acids, which can be classified as a series of quasi- (pseudo-) homologs, were optimized in both chromatographic modes. The elution sequence was determined in most cases and a reversal of elution order on ZWIX(+)™ and ZWIX(-)™ column was observed. On the basis of this intermolecular recognition model between the selectors and the given enantiomers an indirect assignment of the resolved enantiomer via chromatography is proposed. © 2015 Springer-Verlag Wien.}, keywords = {HPLC; enantiomer separation; β3-amino acids; Cinchona alkaloid-based zwitterionic columns}, year = {2015}, eissn = {1438-2199}, pages = {2279-2291}, orcid-numbers = {Ilisz, István/0000-0001-8282-457X; Grecsó, Nóra/0000-0003-4323-1872; Lázár, László/0000-0002-2135-8496; Fülöp, Ferenc/0000-0003-1066-5287} } @article{MTMT:2847135, title = {Application of a Ball Milling Technique for the Condensation of Anthranilic Hydrazides with Aromatic Aldehydes Towards 4-Quinazolinone Derivatives}, url = {https://m2.mtmt.hu/api/publication/2847135}, author = {Magyar, T and Miklós, Ferenc and Lázár, László and Fülöp, Ferenc}, doi = {10.1007/s10593-014-1611-3}, journal-iso = {CHEM HETEROCYCL COM+}, journal = {CHEMISTRY OF HETEROCYCLIC COMPOUNDS}, volume = {50}, unique-id = {2847135}, issn = {0009-3122}, abstract = {An environmentally friendly method was applied to prepare anthranilic hydrazones and quinazolin-4(1H)-ones from anthranilic hydrazides and a number of aldehydes in solventless medium. The condensations proceeded smoothly under ball milling conditions at room temperature, and the products were obtained in high purity and yield.}, keywords = {Quinazolinones; mechanochemistry; HYDRAZIDES; solventless reactions; ball milling reactions}, year = {2015}, eissn = {1573-8353}, pages = {1463-1469}, orcid-numbers = {Lázár, László/0000-0002-2135-8496; Fülöp, Ferenc/0000-0003-1066-5287} } @article{MTMT:2833797, title = {Synthesis of novel 13a-(ω-aminoalkyl)-8-oxoberbines by means of reaction of homophthalic anhydride with 1-substituted 3,4-dihydroisoquinolines. An unexpected formation of a pyrrolo[3,4-i]berbindione}, url = {https://m2.mtmt.hu/api/publication/2833797}, author = {Stanoeva, E and Georgieva, A and Avramova, S and Burdzhiev, N and Lázár, László}, doi = {10.1002/jhet.1965}, journal-iso = {J HETEROCYCLIC CHEM}, journal = {JOURNAL OF HETEROCYCLIC CHEMISTRY}, volume = {52}, unique-id = {2833797}, issn = {0022-152X}, abstract = {The reaction of 1-[o-(N-acylated amino)alkyl]-3,4-dihydroisoquinolines (7a-e) with homophthalic anhydride (1) leads to the formation of 8-oxo-13a-[(N-acylated amino)alkyl]-8H-dibenzo[a,g]quinolizine- 13-carboxylic acids (8a-e) with predomination of cis diastereomers, together with small amount of trans-8a. cis-13a-[(N-Cbzaminomethyl)]-8-oxo-dibenzoquinolizine-13-carboxylic acid (8a) cyclized to the unknown dibenzo[a,g]pyrrolo[3,4-i]quinolizinedione (10) upon moderate heating in methanol.}, year = {2015}, eissn = {1943-5193}, pages = {130-135}, orcid-numbers = {Lázár, László/0000-0002-2135-8496} } @article{MTMT:2833796, title = {Comparison of the separation performances of cinchona alkaloid-based zwitterionic stationary phases in the enantioseparation of β2- And β3-amino acids}, url = {https://m2.mtmt.hu/api/publication/2833796}, author = {Ilisz, István and Grecsó, Nóra and Misicka, A and Tymecka, D and Lázár, László and Lindner, W and Péter, Antal}, doi = {10.3390/molecules20010070}, journal-iso = {MOLECULES}, journal = {MOLECULES}, volume = {20}, unique-id = {2833796}, issn = {1420-3049}, abstract = {The enantiomers of twelve unusual β2- and β3-homoamino acids containing the same side-chains were separated on chiral stationary phases containing a quinine- or quinidine-based zwitterionic ion-exchanger as chiral selector. The effects of the mobile phase composition, the nature and concentration of the acid and base additives and temperature on the separations were investigated. The changes in standard enthalpy, Δ(ΔH° ), entropy, Δ(ΔS° ), and free energy, Δ(ΔG° ), were calculated from the linear van't Hoff plots derived from the ln α vs. 1/T curves in the studied temperature range (10-50 °C). The values of the thermodynamic parameters depended on the nature of the selectors, the structures of the analytes, and the positions of the substituents on the analytes. A comparison of the zwitterionic stationary phases revealed that the quinidine-based ZWIX(-)™ column exhibited much better selectivity for both β2- and β 3-amino acids than the quinine-based ZWIX(+)™ column, and the separation performances of both the ZWIX(+)™ and ZWIX(-)™ columns were better for β2-amino acids. The elution sequence was determined in some cases and was observed to be R < S and S < R on the ZWIX(+)™ and ZWIX(-)™ columns, respectively.}, keywords = {column liquid chromatography; β2-Amino acids; β3-amino acids; Cinchona alkaloid-based chiral stationary phases}, year = {2015}, eissn = {1420-3049}, pages = {70-87}, orcid-numbers = {Ilisz, István/0000-0001-8282-457X; Grecsó, Nóra/0000-0003-4323-1872; Lázár, László/0000-0002-2135-8496} } @book{MTMT:3329849, title = {New pyridazinone and pyridone compounds}, url = {https://m2.mtmt.hu/api/publication/3329849}, author = {Pihlavisto, Marjo and Smith, David and Juhakoski, Auni and Fülöp, Ferenc and Lázár, László and Szatmári, István and Miklós, Ferenc and Szakonyi, Zsolt and Kiss, Loránd and Palkó, Márta}, unique-id = {3329849}, year = {2014}, orcid-numbers = {Fülöp, Ferenc/0000-0003-1066-5287; Lázár, László/0000-0002-2135-8496; Szatmári, István/0000-0002-8571-5229; Szakonyi, Zsolt/0000-0003-2432-8409; Palkó, Márta/0000-0002-8265-7377} }