TY - JOUR AU - Koltai, Zsófia AU - Szabó, Bernadett AU - Jakus, Judit AU - Vajdovich, Péter TI - Tyrosine kinase expression analyses in canine mammary gland tumours – A pilot study JF - ACTA VETERINARIA HUNGARICA J2 - ACTA VET HUNG VL - 66 PY - 2018 IS - 2 SP - 294 EP - 308 PG - 15 SN - 0236-6290 DO - 10.1556/004.2018.027 UR - https://m2.mtmt.hu/api/publication/3402130 ID - 3402130 LA - English DB - MTMT ER - TY - JOUR AU - Fazakas, Á AU - Szelényi, Zsuzsanna Orsolya AU - Szénási, Gábor AU - Nyírő, Gábor AU - Szabó, PM AU - Patócs, Attila Balázs AU - Tegze, Nárcis AU - Fekete, BC AU - Molvarec, Attila AU - Nagy, Bálint AU - Jakus, Judit AU - Örsi, F AU - Karádi, István AU - Vereckei, András TI - Genetic predisposition in patients with hypertension and normal ejection fraction to oxidative stress JF - JOURNAL OF THE AMERICAN SOCIETY OF HYPERTENSION J2 - J AM SOC HYPERTENS VL - 10 PY - 2016 IS - 2 SP - 124 EP - 132 PG - 9 SN - 1933-1711 DO - 10.1016/j.jash.2015.11.013 UR - https://m2.mtmt.hu/api/publication/3005112 ID - 3005112 N1 - Ádám Fazekas and Zsuzsanna Szelény contributed equally to this work. AB - The role of oxidative stress (OXS) due to myocardial nitric oxide synthase (NOS) uncoupling related to oxidative depletion of its cofactor tetrahydrobiopterin (BH4) emerged in the pathogenesis of heart failure with preserved ejection fraction. We determined the prevalence of six single nucleotide polymorphisms (SNPs) of genes encoding enzymes related to OXS, BH4 metabolism, and NOS function in ≥60-year-old 94 patients with hypertension and 18 age-matched controls with normal ejection fraction. Using echocardiography, 56/94 (60%) patients with hypertension had left ventricular (LV) diastolic dysfunction (HTDD+ group) and 38/94 (40%) patients had normal LV diastolic function (HTDD- group). Four SNPs (rs841, rs3783641, rs10483639, and rs807267) of guanosine triphosphate cyclohydrolase-1, the rate-limiting enzyme in BH4 synthesis, one (rs4880) of manganese superoxide dismutase, and one (rs1799983) of endothelial NOS genes were genotyped using real-time polymerase chain reaction method and Taqman probes. Protein carbonylation, BH4, and total biopterin levels were measured from plasma samples. No between-groups difference in minor allele frequency of SNPs was found. We calculated a genetic score indicating risk for OXS based on the minor allele frequencies of the SNPs. A high genetic risk for OXS was significantly associated with HTDD+ even after adjustment for confounding variables (odds ratio [95% confidence interval]:4.79 [1.12-20.54]; P = .035). In both patient groups protein carbonylation (P < .05 for both), plasma BH4 (P < .01 for both) and in the HTDD+ group total biopterin (P < .05) increased versus controls. In conclusion, in patients with hypertension and normal ejection fraction, a potential precursor of heart failure with preserved ejection fraction, a partly genetically determined increased OXS, seems to be associated with the presence of LV diastolic dysfunction. © 2015 American Society of Hypertension. LA - English DB - MTMT ER - TY - JOUR AU - Pásztiné Gere, Erzsébet AU - Jakus, Judit TI - Protein phosphatases but not reactive oxygen species play functional role in acute amphetamine-mediated dopamine release JF - CELL BIOCHEMISTRY AND BIOPHYSICS J2 - CELL BIOCHEM BIOPHYS VL - 66 PY - 2013 IS - 3 SP - 831 EP - 841 PG - 11 SN - 1085-9195 DO - 10.1007/s12013-013-9608-6 UR - https://m2.mtmt.hu/api/publication/2285675 ID - 2285675 LA - English DB - MTMT ER - TY - JOUR AU - Radák, Zsolt AU - Silye, G AU - Bartha, Csaba AU - Jakus, Judit AU - Stefanovitsné Bányai, Éva AU - Atalay, M AU - Marton, Orsolya AU - Koltai, Erika TI - The effects of cocoa supplementation, caloric restriction, and regular exercise, on oxidative stress markers of brain and memory in the rat model JF - FOOD AND CHEMICAL TOXICOLOGY J2 - FOOD CHEM TOXICOL VL - 61 PY - 2013 SP - 36 EP - 41 PG - 6 SN - 0278-6915 DO - 10.1016/j.fct.2013.01.047 UR - https://m2.mtmt.hu/api/publication/2270899 ID - 2270899 AB - The effects of treadmill running (8weeks, 5 times/week, 1h/day at 27m/min), caloric restriction, and cocoa supplementation on brain function and oxidative stress markers were tested. The Morris maze test was used to appraise rat memory. Regular exercise significantly improved spatial learning performance. The level of oxidative stress was measured by the concentration of carbonylated proteins. The free radical concentration increased in brain of the training groups but not the controls. The content of reactive carbonyl derivates did not change with exercise, suggesting that the increased production of reactive oxygen species (ROS) were well tolerated in this experimental model. Caloric restriction (CR) decreased the accumulation of free radicals in the frontal lobe. The protein content of brain-derived neutrophic factors (BDNFs) was evaluated and changes did not occur either with exercise or cocoa supplementation treatments. These data did not show significant effects of the administration of cocoa (2% w/w) on the concentration of ROS, BDNF or on spatial memory. Conversely, exercise and CR can play a role in ROS generation and brain function. LA - English DB - MTMT ER - TY - JOUR AU - Wang, JJ AU - Li, JZ AU - Jakus, Judit AU - Shim, YK TI - Synthesis of long-wavelength chlorins by chemical modification for methyl pyropheophorbide-a and their in vitro cell viabilities JF - JOURNAL OF PORPHYRINS AND PHTHALOCYANINES J2 - J PORPHYR PHTHALOCYA VL - 16 PY - 2012 IS - 1 SP - 122 EP - 129 PG - 8 SN - 1088-4246 DO - 10.1142/S1088424611004403 UR - https://m2.mtmt.hu/api/publication/2558905 ID - 2558905 AB - A series of novel chlorophyll-a homologs with long wavelength absorption were synthesized via modification of methyl pyropheophorbide-a used as starting material. For introducing electron-withdrawing group methylenemalononitrile moiety was established on the periphery of modified chlorin by Knoevenagel reaction of malononitrile with formyl group at 3-, 15-position and 13 1-carbonyl group on the exocyclic ring. All of chlorins containing the methylenemalononitrile structure show Qy-absorption at more than 700 nm. Moreover, we have examined a preliminary in vitro photodynamic anticancer effect of these new derivatives on mouse sarcoma S-180 cell line. © 2012 World Scientific Publishing Company. LA - English DB - MTMT ER - TY - JOUR AU - Molnár, Péter AU - Horváth, Dávid AU - Szabó, Bernadett AU - Vajdovich, Péter AU - Jakus, Judit TI - Fotodinamikus gyógymód alkalmazása az állatorvosi onkológiában : Irodalmi áttekintés és saját tapasztalatok. Photodynamic therapy in veterinary oncology. Literature review and own experiences TS - Photodynamic therapy in veterinary oncology. Literature review and own experiences JF - MAGYAR ÁLLATORVOSOK LAPJA J2 - MAGY ALLATORVOSOK VL - 134 PY - 2012 IS - 4 SP - 242 EP - 251 PG - 10 SN - 0025-004X UR - https://m2.mtmt.hu/api/publication/2200459 ID - 2200459 N1 - WoS:hiba:000303370600008 2019-03-03 16:09 első szerző nem egyezik, cím nem egyezik LA - Hungarian DB - MTMT ER - TY - JOUR AU - Németh, András AU - Stadler, Krisztián AU - Jakus, Judit AU - Vidóczy, Tamás TI - Pitfalls of peroxynitrite determination by luminescent probe in diabetic rat aorta JF - REACTION KINETICS MECHANISMS AND CATALYSIS J2 - REACT KINET MECH CATAL VL - 106 PY - 2012 IS - 1 SP - 1 EP - 10 PG - 10 SN - 1878-5190 DO - 10.1007/s11144-012-0427-3 UR - https://m2.mtmt.hu/api/publication/1885646 ID - 1885646 LA - English DB - MTMT ER - TY - JOUR AU - Wang, J-J AU - Wang, P AU - Li, J-Z AU - Jakus, Judit AU - Shim, Y-K TI - Synthesis of novel C12-nonmethylated chlorophyll derivatives from methyl pyropheophorbide-a by allomerization and functionalization JF - BULLETIN OF THE KOREAN CHEMICAL SOCIETY J2 - B KOR CHEM SOC VL - 32 PY - 2011 IS - 9 SP - 3473 EP - 3476 PG - 4 SN - 0253-2964 DO - 10.5012/bkcs.2011.32.9.3473 UR - https://m2.mtmt.hu/api/publication/2558906 ID - 2558906 LA - English DB - MTMT ER - TY - GEN AU - Szabó, Bernadett AU - Molnár, Péter AU - Merész, Laura AU - Vajdovich, Péter AU - Jakus, Judit TI - Az 5-ala indukált fotodinamikus terápiában szerepet játszó transzportfolyamatok. Klinikumok, gyógyszertan TS - Klinikumok, gyógyszertan PY - 2011 UR - https://m2.mtmt.hu/api/publication/1654031 ID - 1654031 N1 - [Kutatási jelentés (belső)] LA - Hungarian DB - MTMT ER - TY - JOUR AU - Németh, András AU - Stadler, K AU - Jakus, Judit AU - Vidóczy, Tamás TI - Kinetics of peroxynitrite formation and decay in diabetic rat aorta JF - OXIDATION COMMUNICATIONS J2 - OXID COMMUN VL - 34 PY - 2011 IS - 1 SP - 128 EP - 135 PG - 8 SN - 0209-4541 UR - https://m2.mtmt.hu/api/publication/1507701 ID - 1507701 LA - English DB - MTMT ER -