@article{MTMT:3402130, title = {Tyrosine kinase expression analyses in canine mammary gland tumours – A pilot study}, url = {https://m2.mtmt.hu/api/publication/3402130}, author = {Koltai, Zsófia and Szabó, Bernadett and Jakus, Judit and Vajdovich, Péter}, doi = {10.1556/004.2018.027}, journal-iso = {ACTA VET HUNG}, journal = {ACTA VETERINARIA HUNGARICA}, volume = {66}, unique-id = {3402130}, issn = {0236-6290}, year = {2018}, eissn = {1588-2705}, pages = {294-308} } @article{MTMT:3005112, title = {Genetic predisposition in patients with hypertension and normal ejection fraction to oxidative stress}, url = {https://m2.mtmt.hu/api/publication/3005112}, author = {Fazakas, Á and Szelényi, Zsuzsanna Orsolya and Szénási, Gábor and Nyírő, Gábor and Szabó, PM and Patócs, Attila Balázs and Tegze, Nárcis and Fekete, BC and Molvarec, Attila and Nagy, Bálint and Jakus, Judit and Örsi, F and Karádi, István and Vereckei, András}, doi = {10.1016/j.jash.2015.11.013}, journal-iso = {J AM SOC HYPERTENS}, journal = {JOURNAL OF THE AMERICAN SOCIETY OF HYPERTENSION}, volume = {10}, unique-id = {3005112}, issn = {1933-1711}, abstract = {The role of oxidative stress (OXS) due to myocardial nitric oxide synthase (NOS) uncoupling related to oxidative depletion of its cofactor tetrahydrobiopterin (BH4) emerged in the pathogenesis of heart failure with preserved ejection fraction. We determined the prevalence of six single nucleotide polymorphisms (SNPs) of genes encoding enzymes related to OXS, BH4 metabolism, and NOS function in ≥60-year-old 94 patients with hypertension and 18 age-matched controls with normal ejection fraction. Using echocardiography, 56/94 (60%) patients with hypertension had left ventricular (LV) diastolic dysfunction (HTDD+ group) and 38/94 (40%) patients had normal LV diastolic function (HTDD- group). Four SNPs (rs841, rs3783641, rs10483639, and rs807267) of guanosine triphosphate cyclohydrolase-1, the rate-limiting enzyme in BH4 synthesis, one (rs4880) of manganese superoxide dismutase, and one (rs1799983) of endothelial NOS genes were genotyped using real-time polymerase chain reaction method and Taqman probes. Protein carbonylation, BH4, and total biopterin levels were measured from plasma samples. No between-groups difference in minor allele frequency of SNPs was found. We calculated a genetic score indicating risk for OXS based on the minor allele frequencies of the SNPs. A high genetic risk for OXS was significantly associated with HTDD+ even after adjustment for confounding variables (odds ratio [95% confidence interval]:4.79 [1.12-20.54]; P = .035). In both patient groups protein carbonylation (P < .05 for both), plasma BH4 (P < .01 for both) and in the HTDD+ group total biopterin (P < .05) increased versus controls. In conclusion, in patients with hypertension and normal ejection fraction, a potential precursor of heart failure with preserved ejection fraction, a partly genetically determined increased OXS, seems to be associated with the presence of LV diastolic dysfunction. © 2015 American Society of Hypertension.}, keywords = {HYPERTENSION; Heart failure with preserved ejection fraction; Oxidative stress}, year = {2016}, eissn = {1878-7436}, pages = {124-132}, orcid-numbers = {Szénási, Gábor/0000-0002-7350-6091; Nyírő, Gábor/0000-0002-0248-0007; Patócs, Attila Balázs/0000-0001-7506-674X; Tegze, Nárcis/0000-0003-4437-0276; Molvarec, Attila/0000-0002-3229-3034; Nagy, Bálint/0000-0002-0295-185X; Karádi, István/0000-0002-8253-2654; Vereckei, András/0000-0001-7881-6585} } @article{MTMT:2285675, title = {Protein phosphatases but not reactive oxygen species play functional role in acute amphetamine-mediated dopamine release}, url = {https://m2.mtmt.hu/api/publication/2285675}, author = {Pásztiné Gere, Erzsébet and Jakus, Judit}, doi = {10.1007/s12013-013-9608-6}, journal-iso = {CELL BIOCHEM BIOPHYS}, journal = {CELL BIOCHEMISTRY AND BIOPHYSICS}, volume = {66}, unique-id = {2285675}, issn = {1085-9195}, year = {2013}, eissn = {1559-0283}, pages = {831-841} } @article{MTMT:2270899, title = {The effects of cocoa supplementation, caloric restriction, and regular exercise, on oxidative stress markers of brain and memory in the rat model}, url = {https://m2.mtmt.hu/api/publication/2270899}, author = {Radák, Zsolt and Silye, G and Bartha, Csaba and Jakus, Judit and Stefanovitsné Bányai, Éva and Atalay, M and Marton, Orsolya and Koltai, Erika}, doi = {10.1016/j.fct.2013.01.047}, journal-iso = {FOOD CHEM TOXICOL}, journal = {FOOD AND CHEMICAL TOXICOLOGY}, volume = {61}, unique-id = {2270899}, issn = {0278-6915}, abstract = {The effects of treadmill running (8weeks, 5 times/week, 1h/day at 27m/min), caloric restriction, and cocoa supplementation on brain function and oxidative stress markers were tested. The Morris maze test was used to appraise rat memory. Regular exercise significantly improved spatial learning performance. The level of oxidative stress was measured by the concentration of carbonylated proteins. The free radical concentration increased in brain of the training groups but not the controls. The content of reactive carbonyl derivates did not change with exercise, suggesting that the increased production of reactive oxygen species (ROS) were well tolerated in this experimental model. Caloric restriction (CR) decreased the accumulation of free radicals in the frontal lobe. The protein content of brain-derived neutrophic factors (BDNFs) was evaluated and changes did not occur either with exercise or cocoa supplementation treatments. These data did not show significant effects of the administration of cocoa (2% w/w) on the concentration of ROS, BDNF or on spatial memory. Conversely, exercise and CR can play a role in ROS generation and brain function.}, year = {2013}, eissn = {1873-6351}, pages = {36-41}, orcid-numbers = {Radák, Zsolt/0000-0003-1297-6804; Koltai, Erika/0000-0002-1370-2955} } @article{MTMT:2558905, title = {Synthesis of long-wavelength chlorins by chemical modification for methyl pyropheophorbide-a and their in vitro cell viabilities}, url = {https://m2.mtmt.hu/api/publication/2558905}, author = {Wang, JJ and Li, JZ and Jakus, Judit and Shim, YK}, doi = {10.1142/S1088424611004403}, journal-iso = {J PORPHYR PHTHALOCYA}, journal = {JOURNAL OF PORPHYRINS AND PHTHALOCYANINES}, volume = {16}, unique-id = {2558905}, issn = {1088-4246}, abstract = {A series of novel chlorophyll-a homologs with long wavelength absorption were synthesized via modification of methyl pyropheophorbide-a used as starting material. For introducing electron-withdrawing group methylenemalononitrile moiety was established on the periphery of modified chlorin by Knoevenagel reaction of malononitrile with formyl group at 3-, 15-position and 13 1-carbonyl group on the exocyclic ring. All of chlorins containing the methylenemalononitrile structure show Qy-absorption at more than 700 nm. Moreover, we have examined a preliminary in vitro photodynamic anticancer effect of these new derivatives on mouse sarcoma S-180 cell line. © 2012 World Scientific Publishing Company.}, keywords = {chemical modification; visible absorption; methyl pyropheophorbide-a; chlorin}, year = {2012}, eissn = {1099-1409}, pages = {122-129} } @article{MTMT:2200459, title = {Fotodinamikus gyógymód alkalmazása az állatorvosi onkológiában : Irodalmi áttekintés és saját tapasztalatok. Photodynamic therapy in veterinary oncology. Literature review and own experiences}, url = {https://m2.mtmt.hu/api/publication/2200459}, author = {Molnár, Péter and Horváth, Dávid and Szabó, Bernadett and Vajdovich, Péter and Jakus, Judit}, journal-iso = {MAGY ALLATORVOSOK}, journal = {MAGYAR ÁLLATORVOSOK LAPJA}, volume = {134}, unique-id = {2200459}, issn = {0025-004X}, year = {2012}, pages = {242-251} } @article{MTMT:1885646, title = {Pitfalls of peroxynitrite determination by luminescent probe in diabetic rat aorta}, url = {https://m2.mtmt.hu/api/publication/1885646}, author = {Németh, András and Stadler, Krisztián and Jakus, Judit and Vidóczy, Tamás}, doi = {10.1007/s11144-012-0427-3}, journal-iso = {REACT KINET MECH CATAL}, journal = {REACTION KINETICS MECHANISMS AND CATALYSIS}, volume = {106}, unique-id = {1885646}, issn = {1878-5190}, year = {2012}, eissn = {1878-5204}, pages = {1-10} } @article{MTMT:2558906, title = {Synthesis of novel C12-nonmethylated chlorophyll derivatives from methyl pyropheophorbide-a by allomerization and functionalization}, url = {https://m2.mtmt.hu/api/publication/2558906}, author = {Wang, J-J and Wang, P and Li, J-Z and Jakus, Judit and Shim, Y-K}, doi = {10.5012/bkcs.2011.32.9.3473}, journal-iso = {B KOR CHEM SOC}, journal = {BULLETIN OF THE KOREAN CHEMICAL SOCIETY}, volume = {32}, unique-id = {2558906}, issn = {0253-2964}, keywords = {FUNCTIONALIZATION; CHLOROPHYLL; Pyropheophorbide-a; Formylation; Allomerization; chlorin}, year = {2011}, eissn = {1229-5949}, pages = {3473-3476} } @techreport{MTMT:1654031, title = {Az 5-ala indukált fotodinamikus terápiában szerepet játszó transzportfolyamatok. Klinikumok, gyógyszertan}, url = {https://m2.mtmt.hu/api/publication/1654031}, author = {Szabó, Bernadett and Molnár, Péter and Merész, Laura and Vajdovich, Péter and Jakus, Judit}, unique-id = {1654031}, year = {2011} } @article{MTMT:1507701, title = {Kinetics of peroxynitrite formation and decay in diabetic rat aorta}, url = {https://m2.mtmt.hu/api/publication/1507701}, author = {Németh, András and Stadler, K and Jakus, Judit and Vidóczy, Tamás}, journal-iso = {OXID COMMUN}, journal = {OXIDATION COMMUNICATIONS}, volume = {34}, unique-id = {1507701}, issn = {0209-4541}, year = {2011}, pages = {128-135} }