TY - JOUR AU - Gödöny, Krisztina AU - Herczeg, Róbert AU - Gyenesei, Attila AU - Várnagy, Ákos AU - Bognár, Zoltán AU - Kovács, L. Gábor AU - Szekeres, Júlia AU - Mauchart, Péter AU - Nagy, Bernadett AU - Erostyák, János AU - Kovács, Kálmán András AU - Bódis, József TI - Clinical Benefits of Decreased Photo-Oxidative Stress on Human Embryo Development JF - MEDICAL PRINCIPLES AND PRACTICE J2 - MED PRIN PRACT PY - 2024 SN - 1011-7571 DO - 10.1159/000536358 UR - https://m2.mtmt.hu/api/publication/34763514 ID - 34763514 AB - Objective: Early embryonic development is characterized by rapid cell division and gene activation, making the embryo extremely sensitive to environmental influences. Light exposure can affect embryonic development through a direct toxic effect on the embryo via the generation of reactive oxygen species. In a previous study, we demonstrated the positive effect of improved light-protected embryo culture conditions implemented in our laboratory. This study aimed to investigate the changes in human embryo development under light protection during the conventional in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI). Materials and Methods: We tested the potential beneficial effect of light filters to reduce the risk of toxic effects of light. IVF outcomes were compared between two experimental conditions, light protection with red light filters versus no light protection as a control. Results: Blastocyst development rate in IVF was significantly higher in the light-protected group than in the group treated under conventional conditions (46.6 vs. 26.7%). In the case of ICSI, we obtained a similar result (44.5 vs. 31.6%). The rate of cryopreservation with at least one embryo was higher in the light-protected phase (32.8%) than in the conventionally manipulated phase (26.8%). The abortion rate was also significantly lower during the light-protected period in IVF, resulting in a higher live birth rate. Conclusions: The implementation of light protection to reduce the embryotoxic wavelengths of light in IVF centers may improve the blastocyst development rate and embryo quality while maintaining embryo safety. LA - English DB - MTMT ER - TY - CONF AU - Pónusz-Kovács, Dalma AU - Csákvári, Tímea AU - Kajos, Luca Fanni AU - Elmer, Diána AU - Pónusz, Róbert AU - Bódis, József AU - Boncz, Imre ED - Figler, Mária ED - Karamánné Pakai, Annamária ED - Tigyi, Zoltánné ED - Kajos, Luca Fanni ED - Trixler, Bettina TI - Magyarországi területi egyenlőtlenségek elemzése a női infertilitás diagnózis esetében T2 - Jubileumi Szakkollégiumi Konferencia: Absztrakt kötet PB - Pécsi Tudományegyetem Egészségtudományi Kar (PTE ETK) C1 - Pécs SN - 9789636262402 PY - 2024 SP - 20 EP - 20 PG - 1 UR - https://m2.mtmt.hu/api/publication/34667323 ID - 34667323 LA - Hungarian DB - MTMT ER - TY - GEN AU - Bódis, József AU - Bognár, Zoltán AU - Csabai-Tanics, Tímea Judith AU - Berke, József AU - Gulyás, István Tibor AU - Mauchart, Péter AU - Hans-Rudolf, Tinneberg AU - Farkas, Bálint AU - Várnagy, Ákos AU - Kovács, Kálmán András TI - Detection of Ultraweak Photon Emissions from Mouse Embryos with Implications for Assisted Reproduction PY - 2024 UR - https://m2.mtmt.hu/api/publication/34525481 ID - 34525481 LA - English DB - MTMT ER - TY - GEN AU - Berke, József AU - Gulyás, István Tibor AU - Bognár, Zoltán AU - Dávid, Berke AU - Attila, Enyedi AU - Veronika, Kozma-Bognár AU - Mauchart, Péter AU - Nagy, Bernadett AU - Várnagy, Ákos AU - Kovács, Kálmán András AU - Bódis, József TI - Unique algorithm for the evaluation of embryo photon emission and viability PY - 2024 UR - https://m2.mtmt.hu/api/publication/34525317 ID - 34525317 LA - English DB - MTMT ER - TY - GEN AU - Pónusz-Kovács, Dalma AU - Csákvári, Tímea AU - Kajos, Luca Fanni AU - Elmer, Diána AU - Pónusz, Róbert AU - Kovács, Bettina AU - Várnagy, Ákos AU - Kovács, Kálmán András AU - Bódis, József AU - Boncz, Imre TI - Epidemiological disease burden and annual, nationwide health insurance treatment cost of female infertility based on real-world health insurance claims data in Hungary PY - 2024 UR - https://m2.mtmt.hu/api/publication/34525263 ID - 34525263 LA - English DB - MTMT ER - TY - GEN AU - Pónusz-Kovács, Dalma AU - Pónusz, Róbert AU - Kajos, Luca Fanni AU - Csákvári, Tímea AU - Bódis, József AU - Boncz, Imre TI - A női infertilitással összefüggő egészségbiztosítási kiadások elemzése Magyarországon a 2010-2019. közötti időszakban című poszter bemutatása PY - 2023 UR - https://m2.mtmt.hu/api/publication/34506735 ID - 34506735 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Nagy, Bernadett AU - Kovács, Kálmán András AU - Sulyok, Endre AU - Várnagy, Ákos AU - Bódis, József TI - Thrombocytes and Platelet-Rich Plasma as Modulators of Reproduction and Fertility JF - INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES J2 - INT J MOL SCI VL - 24 PY - 2023 IS - 24 PG - 12 SN - 1661-6596 DO - 10.3390/ijms242417336 UR - https://m2.mtmt.hu/api/publication/34477408 ID - 34477408 N1 - Funding Agency and Grant Number: HUN-REN Hungarian Research Network Funding text: We would like to thank Orvosi Hetilap for giving permission to use some content of our previous work written in Hungarian. AB - Thrombocytes play an essential role in hemostasis and thrombosis. Moreover, the controlled activation of thrombocytes is required in reproduction and fertility. The platelet-activating factor and the controlled activation of platelets have important roles in folliculogenesis, ovulation, placental development, implantation and embryo development. Activated platelets accumulate in the follicular vessels surrounding the follicle and, due to its released soluble molecules (factors, mediators, chemokines, cytokines, neurotransmitters), locally increase oocyte maturation and hormone secretion. Furthermore, activated platelets are involved in the pathogenesis of ovarian hyperstimulation syndrome (OHSS) and preeclampsia. Low-dose aspirin can prevent OHSS during ovulation induction, while intrauterine or intraovarian administration of platelet-rich plasma (PRP) increases the endometrium thickness and receptivity as well as oocyte maturation. Activated thrombocytes rapidly release the contents of intracellular granules and have multiple adhesion molecules and receptors on their surface. Considering the numerous homeostatic endocrine functions of thrombocytes, it is reasonable to suppose a platelet-associated regulatory system (PARS) in reproduction. Although we are far from a complete understanding of the regulatory processes, the results of PARS research and the therapeutic application of aspirin and PRP during in vitro fertilization are promising. LA - English DB - MTMT ER - TY - JOUR AU - Vass, Réka Anna AU - Mikó, Éva AU - Gál, Csenge AU - Kőszegi, Tamás AU - Vass, Csaba I AU - Bokor, Szilvia AU - Molnár, Dénes AU - Funke Kiss, Simone AU - Kovács, Kálmán András AU - Bódis, József AU - Ertl, Tibor TI - The Effect of Holder Pasteurization and Different Variants on Breast Milk Antioxidants JF - ANTIOXIDANTS J2 - ANTIOXIDANTS-BASEL VL - 12 PY - 2023 IS - 10 PG - 13 SN - 2076-3921 DO - 10.3390/antiox12101857 UR - https://m2.mtmt.hu/api/publication/34227655 ID - 34227655 N1 - ISSN:2076-3921 AB - After birth, breast milk (BM) is a known essential source of antioxidants for infants. We analyzed the non-enzymatic total antioxidant capacity (TAC), oxygen radical absorbance capacity (ORAC), and glutathione, calcium, transferrin, and total protein levels of human breast milk before and after Holder pasteurization (HoP).The collected donor BM samples were pasteurized with HoP.HoP decreased TAC (-12.6%), ORAC (-12.1%), transferrin (-98.3%), and total protein (-21.4%) levels; HoP did not influence the glutathione concentration, and it increased the total calcium (+25.5%) concentration. Mothers who gave birth via Cesarean section had significantly lower TAC in their BM. TAC and glutathione levels were elevated in the BM of mothers over the age of 30. BM produced in the summer had higher glutathione and calcium levels compared to BM produced in the winter. The glutathione concentration in term milk samples was significantly higher in the first two months of lactation compared to the period between the third and sixth months. The transferrin level of BM for female infants was significantly higher than the BM for boys, and mothers with a BMI above 30 had increased transferrin in their samples.Antioxidant levels in human milk are influenced by numerous factors. Environmental and maternal factors, the postpartum age at breast milk collection, and Holder pasteurization of the milk influence the antioxidant intake of the infant. LA - English DB - MTMT ER - TY - JOUR AU - Mikó, Éva AU - Császár, András AU - Kovacs, Kalman AU - Szekeres, Júlia AU - Bódis, József TI - The investigation of endometrial microbiota and its possible role in IVF success JF - JOURNAL OF REPRODUCTIVE IMMUNOLOGY J2 - J REPROD IMMUNOL VL - 159 PY - 2023 SP - 18 EP - 18 PG - 1 SN - 0165-0378 DO - 10.1016/j.jri.2023.104034 UR - https://m2.mtmt.hu/api/publication/34214974 ID - 34214974 LA - English DB - MTMT ER - TY - JOUR AU - Joó, József Gábor AU - Sulyok, Endre AU - Bódis, József AU - Kornya, László TI - Disrupted Balance of the Oxidant–Antioxidant System in the Pathophysiology of Female Reproduction: Oxidative Stress and Adverse Pregnancy Outcomes JF - CURRENT ISSUES IN MOLECULAR BIOLOGY J2 - CURR ISSUES MOL BIOL VL - 45 PY - 2023 IS - 10 SP - 8091 EP - 8111 PG - 21 SN - 1467-3037 DO - 10.3390/cimb45100511 UR - https://m2.mtmt.hu/api/publication/34196772 ID - 34196772 N1 - ISSN:1467-3045 AB - The significance of oxidative stress in the pathophysiology of male reproductive processes has been closely studied in the last two decades. Recently, it has become clear that oxidative stress can lead to numerous pathological conditions during female reproductive processes as well, contributing to the development of endometriosis, polycystic ovary syndrome and various forms of infertility. During pregnancy, physiological generation of reactive oxygen species (ROS) occurs in association with several developmental processes including oocyte maturation and implantation. An overproduction of ROS can lead to disturbances in fetal development and increases the risk for missed abortion, intrauterine growth restriction, pre-eclampsia, premature delivery and gestational diabetes. Our review focuses on the etiological role of the disrupted oxidant–antioxidant system during human gestation as it relates to adverse pregnancy outcomes. LA - English DB - MTMT ER -