TY - JOUR
AU - Gödöny, Krisztina
AU - Herczeg, Róbert
AU - Gyenesei, Attila
AU - Várnagy, Ákos
AU - Bognár, Zoltán
AU - Kovács, L. Gábor
AU - Szekeres, Júlia
AU - Mauchart, Péter
AU - Nagy, Bernadett
AU - Erostyák, János
AU - Kovács, Kálmán András
AU - Bódis, József
TI - Clinical Benefits of Decreased Photo-Oxidative Stress on Human Embryo Development
JF - MEDICAL PRINCIPLES AND PRACTICE
J2 - MED PRIN PRACT
PY - 2024
SN - 1011-7571
DO - 10.1159/000536358
UR - https://m2.mtmt.hu/api/publication/34763514
ID - 34763514
AB - Objective: Early embryonic development is characterized by rapid cell division and gene activation, making the embryo extremely sensitive to environmental influences. Light exposure can affect embryonic development through a direct toxic effect on the embryo via the generation of reactive oxygen species. In a previous study, we demonstrated the positive effect of improved light-protected embryo culture conditions implemented in our laboratory. This study aimed to investigate the changes in human embryo development under light protection during the conventional in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI). Materials and Methods: We tested the potential beneficial effect of light filters to reduce the risk of toxic effects of light. IVF outcomes were compared between two experimental conditions, light protection with red light filters versus no light protection as a control. Results: Blastocyst development rate in IVF was significantly higher in the light-protected group than in the group treated under conventional conditions (46.6 vs. 26.7%). In the case of ICSI, we obtained a similar result (44.5 vs. 31.6%). The rate of cryopreservation with at least one embryo was higher in the light-protected phase (32.8%) than in the conventionally manipulated phase (26.8%). The abortion rate was also significantly lower during the light-protected period in IVF, resulting in a higher live birth rate. Conclusions: The implementation of light protection to reduce the embryotoxic wavelengths of light in IVF centers may improve the blastocyst development rate and embryo quality while maintaining embryo safety.
LA - English
DB - MTMT
ER -
TY - CONF
AU - Pónusz-Kovács, Dalma
AU - Csákvári, Tímea
AU - Kajos, Luca Fanni
AU - Elmer, Diána
AU - Pónusz, Róbert
AU - Bódis, József
AU - Boncz, Imre
ED - Figler, Mária
ED - Karamánné Pakai, Annamária
ED - Tigyi, Zoltánné
ED - Kajos, Luca Fanni
ED - Trixler, Bettina
TI - Magyarországi területi egyenlőtlenségek elemzése a női infertilitás diagnózis esetében
T2 - Jubileumi Szakkollégiumi Konferencia: Absztrakt kötet
PB - Pécsi Tudományegyetem Egészségtudományi Kar (PTE ETK)
C1 - Pécs
SN - 9789636262402
PY - 2024
SP - 20
EP - 20
PG - 1
UR - https://m2.mtmt.hu/api/publication/34667323
ID - 34667323
LA - Hungarian
DB - MTMT
ER -
TY - GEN
AU - Bódis, József
AU - Bognár, Zoltán
AU - Csabai-Tanics, Tímea Judith
AU - Berke, József
AU - Gulyás, István Tibor
AU - Mauchart, Péter
AU - Hans-Rudolf, Tinneberg
AU - Farkas, Bálint
AU - Várnagy, Ákos
AU - Kovács, Kálmán András
TI - Detection of Ultraweak Photon Emissions from Mouse Embryos with Implications for Assisted Reproduction
PY - 2024
UR - https://m2.mtmt.hu/api/publication/34525481
ID - 34525481
LA - English
DB - MTMT
ER -
TY - GEN
AU - Berke, József
AU - Gulyás, István Tibor
AU - Bognár, Zoltán
AU - Dávid, Berke
AU - Attila, Enyedi
AU - Veronika, Kozma-Bognár
AU - Mauchart, Péter
AU - Nagy, Bernadett
AU - Várnagy, Ákos
AU - Kovács, Kálmán András
AU - Bódis, József
TI - Unique algorithm for the evaluation of embryo photon emission and viability
PY - 2024
UR - https://m2.mtmt.hu/api/publication/34525317
ID - 34525317
LA - English
DB - MTMT
ER -
TY - GEN
AU - Pónusz-Kovács, Dalma
AU - Csákvári, Tímea
AU - Kajos, Luca Fanni
AU - Elmer, Diána
AU - Pónusz, Róbert
AU - Kovács, Bettina
AU - Várnagy, Ákos
AU - Kovács, Kálmán András
AU - Bódis, József
AU - Boncz, Imre
TI - Epidemiological disease burden and annual, nationwide health insurance treatment cost of female infertility based on real-world health insurance claims data in Hungary
PY - 2024
UR - https://m2.mtmt.hu/api/publication/34525263
ID - 34525263
LA - English
DB - MTMT
ER -
TY - GEN
AU - Pónusz-Kovács, Dalma
AU - Pónusz, Róbert
AU - Kajos, Luca Fanni
AU - Csákvári, Tímea
AU - Bódis, József
AU - Boncz, Imre
TI - A női infertilitással összefüggő egészségbiztosítási kiadások elemzése Magyarországon a 2010-2019. közötti időszakban című poszter bemutatása
PY - 2023
UR - https://m2.mtmt.hu/api/publication/34506735
ID - 34506735
LA - Hungarian
DB - MTMT
ER -
TY - JOUR
AU - Nagy, Bernadett
AU - Kovács, Kálmán András
AU - Sulyok, Endre
AU - Várnagy, Ákos
AU - Bódis, József
TI - Thrombocytes and Platelet-Rich Plasma as Modulators of Reproduction and Fertility
JF - INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
J2 - INT J MOL SCI
VL - 24
PY - 2023
IS - 24
PG - 12
SN - 1661-6596
DO - 10.3390/ijms242417336
UR - https://m2.mtmt.hu/api/publication/34477408
ID - 34477408
N1 - Funding Agency and Grant Number: HUN-REN Hungarian Research Network
Funding text: We would like to thank Orvosi Hetilap for giving permission to use some content of our previous work written in Hungarian.
AB - Thrombocytes play an essential role in hemostasis and thrombosis. Moreover, the controlled activation of thrombocytes is required in reproduction and fertility. The platelet-activating factor and the controlled activation of platelets have important roles in folliculogenesis, ovulation, placental development, implantation and embryo development. Activated platelets accumulate in the follicular vessels surrounding the follicle and, due to its released soluble molecules (factors, mediators, chemokines, cytokines, neurotransmitters), locally increase oocyte maturation and hormone secretion. Furthermore, activated platelets are involved in the pathogenesis of ovarian hyperstimulation syndrome (OHSS) and preeclampsia. Low-dose aspirin can prevent OHSS during ovulation induction, while intrauterine or intraovarian administration of platelet-rich plasma (PRP) increases the endometrium thickness and receptivity as well as oocyte maturation. Activated thrombocytes rapidly release the contents of intracellular granules and have multiple adhesion molecules and receptors on their surface. Considering the numerous homeostatic endocrine functions of thrombocytes, it is reasonable to suppose a platelet-associated regulatory system (PARS) in reproduction. Although we are far from a complete understanding of the regulatory processes, the results of PARS research and the therapeutic application of aspirin and PRP during in vitro fertilization are promising.
LA - English
DB - MTMT
ER -
TY - JOUR
AU - Vass, Réka Anna
AU - Mikó, Éva
AU - Gál, Csenge
AU - Kőszegi, Tamás
AU - Vass, Csaba I
AU - Bokor, Szilvia
AU - Molnár, Dénes
AU - Funke Kiss, Simone
AU - Kovács, Kálmán András
AU - Bódis, József
AU - Ertl, Tibor
TI - The Effect of Holder Pasteurization and Different Variants on Breast Milk Antioxidants
JF - ANTIOXIDANTS
J2 - ANTIOXIDANTS-BASEL
VL - 12
PY - 2023
IS - 10
PG - 13
SN - 2076-3921
DO - 10.3390/antiox12101857
UR - https://m2.mtmt.hu/api/publication/34227655
ID - 34227655
N1 - ISSN:2076-3921
AB - After birth, breast milk (BM) is a known essential source of antioxidants for infants. We analyzed the non-enzymatic total antioxidant capacity (TAC), oxygen radical absorbance capacity (ORAC), and glutathione, calcium, transferrin, and total protein levels of human breast milk before and after Holder pasteurization (HoP).The collected donor BM samples were pasteurized with HoP.HoP decreased TAC (-12.6%), ORAC (-12.1%), transferrin (-98.3%), and total protein (-21.4%) levels; HoP did not influence the glutathione concentration, and it increased the total calcium (+25.5%) concentration. Mothers who gave birth via Cesarean section had significantly lower TAC in their BM. TAC and glutathione levels were elevated in the BM of mothers over the age of 30. BM produced in the summer had higher glutathione and calcium levels compared to BM produced in the winter. The glutathione concentration in term milk samples was significantly higher in the first two months of lactation compared to the period between the third and sixth months. The transferrin level of BM for female infants was significantly higher than the BM for boys, and mothers with a BMI above 30 had increased transferrin in their samples.Antioxidant levels in human milk are influenced by numerous factors. Environmental and maternal factors, the postpartum age at breast milk collection, and Holder pasteurization of the milk influence the antioxidant intake of the infant.
LA - English
DB - MTMT
ER -
TY - JOUR
AU - Mikó, Éva
AU - Császár, András
AU - Kovacs, Kalman
AU - Szekeres, Júlia
AU - Bódis, József
TI - The investigation of endometrial microbiota and its possible role in IVF success
JF - JOURNAL OF REPRODUCTIVE IMMUNOLOGY
J2 - J REPROD IMMUNOL
VL - 159
PY - 2023
SP - 18
EP - 18
PG - 1
SN - 0165-0378
DO - 10.1016/j.jri.2023.104034
UR - https://m2.mtmt.hu/api/publication/34214974
ID - 34214974
LA - English
DB - MTMT
ER -
TY - JOUR
AU - Joó, József Gábor
AU - Sulyok, Endre
AU - Bódis, József
AU - Kornya, László
TI - Disrupted Balance of the Oxidant–Antioxidant System in the Pathophysiology of Female Reproduction: Oxidative Stress and Adverse Pregnancy Outcomes
JF - CURRENT ISSUES IN MOLECULAR BIOLOGY
J2 - CURR ISSUES MOL BIOL
VL - 45
PY - 2023
IS - 10
SP - 8091
EP - 8111
PG - 21
SN - 1467-3037
DO - 10.3390/cimb45100511
UR - https://m2.mtmt.hu/api/publication/34196772
ID - 34196772
N1 - ISSN:1467-3045
AB - The significance of oxidative stress in the pathophysiology of male reproductive processes has been closely studied in the last two decades. Recently, it has become clear that oxidative stress can lead to numerous pathological conditions during female reproductive processes as well, contributing to the development of endometriosis, polycystic ovary syndrome and various forms of infertility. During pregnancy, physiological generation of reactive oxygen species (ROS) occurs in association with several developmental processes including oocyte maturation and implantation. An overproduction of ROS can lead to disturbances in fetal development and increases the risk for missed abortion, intrauterine growth restriction, pre-eclampsia, premature delivery and gestational diabetes. Our review focuses on the etiological role of the disrupted oxidant–antioxidant system during human gestation as it relates to adverse pregnancy outcomes.
LA - English
DB - MTMT
ER -