TY - JOUR AU - Horváth, Ádám AU - Steib, Anita AU - Nehr-Majoros, Andrea Kinga AU - Kántás, Boglárka AU - Király, Ágnes AU - Racskó, Márk AU - Tóth, Balázs István AU - Szánti-Pintér, Eszter AU - Kudová, Eva AU - Skodáné Földes, Rita AU - Helyes, Zsuzsanna AU - Szőke, Éva TI - Anti-Nociceptive Effects of Sphingomyelinase and Methyl-Beta-Cyclodextrin in the Icilin-Induced Mouse Pain Model JF - INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES J2 - INT J MOL SCI VL - 25 PY - 2024 IS - 9 PG - 13 SN - 1661-6596 DO - 10.3390/ijms25094637 UR - https://m2.mtmt.hu/api/publication/34824919 ID - 34824919 AB - The thermo- and pain-sensitive Transient Receptor Potential Melastatin 3 and 8 (TRPM3 and TRPM8) ion channels are functionally associated in the lipid rafts of the plasma membrane. We have already described that cholesterol and sphingomyelin depletion, or inhibition of sphingolipid biosynthesis decreased the TRPM8 but not the TRPM3 channel opening on cultured sensory neurons. We aimed to test the effects of lipid raft disruptors on channel activation on TRPM3- and TRPM8-expressing HEK293T cells in vitro, as well as their potential analgesic actions in TRPM3 and TRPM8 channel activation involving acute pain models in mice. CHO cell viability was examined after lipid raft disruptor treatments and their effects on channel activation on channel expressing HEK293T cells by measurement of cytoplasmic Ca2+ concentration were monitored. The effects of treatments were investigated in Pregnenolone-Sulphate-CIM-0216-evoked and icilin-induced acute nocifensive pain models in mice. Cholesterol depletion decreased CHO cell viability. Sphingomyelinase and methyl-beta-cyclodextrin reduced the duration of icilin-evoked nocifensive behavior, while lipid raft disruptors did not inhibit the activity of recombinant TRPM3 and TRPM8. We conclude that depletion of sphingomyelin or cholesterol from rafts can modulate the function of native TRPM8 receptors. Furthermore, sphingolipid cleavage provided superiority over cholesterol depletion, and this method can open novel possibilities in the management of different pain conditions. LA - English DB - MTMT ER - TY - JOUR AU - Maksó, Lilla AU - Szele, Boglárka AU - Ispán, Dávid AU - Gömöry, Ágnes AU - Mahó, Sándor AU - Skodáné Földes, Rita TI - Catalyst- and excess reagent recycling in aza-Michael additions JF - ORGANIC & BIOMOLECULAR CHEMISTRY J2 - ORG BIOMOL CHEM VL - 2024 PY - 2024 SN - 1477-0520 DO - 10.1039/D3OB02073H UR - https://m2.mtmt.hu/api/publication/34724767 ID - 34724767 AB - The use of a [bmim][BF 4 ]/ n Bu-TMG solvent/catalyst mixture was shown to facilitate the recycling of solvents, catalysts and unreacted N-heterocycles (used in excess) in the aza-Michael reaction of various N-heterocycles with a steroidal substrate. LA - English DB - MTMT ER - TY - JOUR AU - Keszei, Soma József AU - Váradi, Márk AU - Skodáné Földes, Rita TI - Urea-Functionalized Heterocycles: Structure, Hydrogen Bonding and Applications JF - MOLECULES J2 - MOLECULES VL - 28 PY - 2023 IS - 23 SN - 1420-3049 DO - 10.3390/molecules28237757 UR - https://m2.mtmt.hu/api/publication/34400217 ID - 34400217 AB - Ureido-heterocycles exhibiting different triple- and quadruple H-bonding patterns are useful building blocks in the construction of supramolecular polymers, self-healing materials, stimuli-responsive devices, catalysts and sensors. The heterocyclic group may provide hydrogen bond donor/acceptor sites to supplement those in the urea core, and they can also bind metals and can be modified by pH, redox reactions or irradiation. In the present review, the main structural features of these derivatives are discussed, including the effect of tautomerization and conformational isomerism on self-assembly and complex formation. Some examples of their use as building blocks in different molecular architectures and supramolecular polymers, with special emphasis on biomedical applications, are presented. The role of the heterocyclic functionality in catalytic and sensory applications is also outlined. LA - English DB - MTMT ER - TY - JOUR AU - Ispán, Dávid AU - Küzdő, Áron AU - Fonyó, Máté AU - Gömöry, Ágnes AU - Tumanov, Nikolay AU - Wouters, Johan AU - Mahó, Sándor AU - Lendvay, György AU - Skodáné Földes, Rita TI - Diols Speed Up Guanidine Base Catalysed Claisen‐Schmidt Condensation to Produce New 15‐Arylidene Steroids JF - EUROPEAN JOURNAL OF ORGANIC CHEMISTRY J2 - EUR J ORG CHEM VL - 26 PY - 2023 IS - 34 PG - 10 SN - 1434-193X DO - 10.1002/ejoc.202300560 UR - https://m2.mtmt.hu/api/publication/34074424 ID - 34074424 AB - Considerable acceleration was observed in the guanidine-base catalysed Claisen-Schmidt condensation of benzaldehyde and a 17α-methyl-18-nor-5α,13α-androstan-16-one (1) in the presence of ethylene glycol. Rate-enhancement effects of various alcohols and diols were compared. In quantum chemical calculations, coordination of the carbonyl group of the substrate was found to reduce the potential barrier to the proton transfer from the α carbon and thus facilitate the formation of the anion that attacks the aldehyde. Both the experiments and the calculations showed that diols enhance the reactivity more efficiently than alcohols. Ethylene glycol/guanidine-base mixtures were found to be efficient catalysts and solvents in the synthesis of a range of new 17α-methyl-18-nor-13α-15-arylidene steroids. This solvent mixture has a further advantage: the crude products can be isolated by simple extraction after introduction of CO2. It is also shown that by the proper choice of the base, the base/diol mixture can be recycled. LA - English DB - MTMT ER - TY - JOUR AU - Nagy, Enikő AU - Nagymihaly, Zoltan AU - Kollár, László AU - Fonyó, Máté AU - Skodáné Földes, Rita TI - Synthesis of 3-Aryl- and 3-Alkynylbenzofurans in the Presence of a Supported Palladium Catalyst JF - SYNTHESIS-STUTTGART J2 - SYNTHESIS-STUTTGART VL - 55 PY - 2023 IS - 01 SP - 131 EP - 140 PG - 10 SN - 0039-7881 DO - 10.1055/a-1914-0423 UR - https://m2.mtmt.hu/api/publication/33045643 ID - 33045643 AB - Suzuki and Sonogashira coupling reactions of 3-iodo-2-phenylbenzofuran, leading to the corresponding 3-aryl- and 3-alkynyl derivatives, respectively, were carried out using a silica supported pyridinium ionic liquid based heterogeneous catalyst. Under optimized reactions conditions, arylboronic acids with either electron withdrawing or -donating substituents as well as terminal alkynes with aromatic or aliphatic groups could be coupled to the benzofuran skeleton efficiently. The application of this catalyst made it possible to carry out the reaction under phosphine-free and, in case of the Sonogashira coupling, under copper-free conditions. The catalyst retained its activity in at least 7 subsequent runs in both types of reactions. Palladium leaching of less than 1% of the original amount used in the catalytic reaction was observed under optimized conditions in most cases. The methodology was applied successfully in the synthesis of nine different 3-aryl- and ten different 3-alkynyl benzofuran derivatives in moderate to high yields. LA - English DB - MTMT ER - TY - JOUR AU - Skodáné Földes, Rita AU - Kollár, László TI - Az átmenetifém-organikus kémia és a homogén katalízis hazai megteremtője: Markó László (1928–2022) JF - MAGYAR KÉMIKUSOK LAPJA J2 - MAGY KEM LAP VL - 77 PY - 2022 IS - 9 SP - 278 EP - 280 PG - 2 SN - 0025-0163 UR - https://m2.mtmt.hu/api/publication/33549245 ID - 33549245 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Lukács, Zoltán AU - Molnár, Ferenc AU - Skodáné Földes, Rita AU - Hancsók, Jenő AU - Kristóf, Tamás TI - Electrochemical Corrosion Studies of Low-Alloyed Carbon Steel in Acidic Methylimidazolium Derivate Ionic Liquids with Varying Water Content JF - CORROSION J2 - CORROSION-US VL - 78 PY - 2022 IS - 12 SP - 1203 EP - 1215 PG - 13 SN - 0010-9312 DO - 10.5006/4183 UR - https://m2.mtmt.hu/api/publication/33319199 ID - 33319199 AB - The application of ionic liquids (ILs) in a wide range of technologies requires a thorough evaluation of their corrosion behavior to typical structural steels. In this work, the corrosion effects of two acidic-type methylimidazolium derivates (potential catalyst candidates) on low-alloyed carbon steel were studied with electrochemical methods (potentiodynamic polarization and electrochemical impedance spectroscopy [EIS]). The ILs cause moderate corrosion around 0.1 mm/y at water content up to 10‰ and severe corrosion around 1 mm/y at 100‰, which underlines that before industrial applications of ILs systematic corrosion studies should be performed as part of the process design. With both ILs we found that the cathodic process exhibited apparently good linear Tafel slopes in the cathodic polarization range but in the anodic range the IL with the hydrogensulfate anion showed an active-passive transition only at the highest water concentration. In this series at lower water concentrations, under 100‰, a model assuming a potential-independent anodic current rate correctly matched with the polarization data. The EIS measurement data showed chaotic, but reproducible deviations in the low-frequency range, which were interpreted as the effect of the timely variation of distribution parameters and they apparently did not affect the charge transfer parameters essentially. LA - English DB - MTMT ER - TY - JOUR AU - Váradi, Márk AU - Skodáné Földes, Rita TI - Synthetic methods towards steroid-ferrocene conjugates JF - ARKIVOC J2 - ARKIVOC VL - 2022 PY - 2022 IS - 3 SP - 197 EP - 239 PG - 43 SN - 1551-7012 DO - 10.24820/ark.5550190.p011.885 UR - https://m2.mtmt.hu/api/publication/33284467 ID - 33284467 LA - English DB - MTMT ER - TY - JOUR AU - Nagy, Enikő AU - Váradi, Márk AU - Nagymihaly, Zoltan AU - Kollár, László AU - Kovács, Krisztina AU - Andreidesz, Kitti AU - Gömöry, Ágnes AU - Tumanov, Nikolay AU - Wouters, Johan AU - Skodáné Földes, Rita TI - Synthesis of Novel Ferrocene-Benzofuran Hybrids via Palladium- and Copper-Catalyzed Reactions JF - INORGANICS J2 - INORGANICS VL - 10 PY - 2022 IS - 11 PG - 16 SN - 2304-6740 DO - 10.3390/inorganics10110205 UR - https://m2.mtmt.hu/api/publication/33271926 ID - 33271926 AB - The combination of the ferrocene skeleton with pharmacophores often leads to molecules with interesting biological properties. Five ferrocene-benzofuran hybrids of different structures were synthesized by transition metal catalyzed reactions. The efficiency of both homogeneous and heterogeneous catalytic methods was tested. The products were characterized using 1H, 13C NMR and FTIR spectroscopy, HRMS and cyclic voltammetry. The structure of one of the new compounds was also proved with X-ray crystallography. The new hybrids showed moderate cytotoxicity on MCF-7 and MDA-MB-231 cell lines. It is remarkable that the less curable MDA-MB-231 cell line was more sensitive to treatment with three ferrocene derivatives. LA - English DB - MTMT ER - TY - JOUR AU - Maksó, Lilla AU - Kovács, Krisztina AU - Andreidesz, Kitti AU - Gömöry, Ágnes AU - Mahó, Sándor AU - Skodáné Földes, Rita TI - Synthesis of Steroidal Thioethers via [HDBU][OAc]-Mediated Michael Addition of Thiols to 16-Dehydropregnenolone JF - CHEMISTRYSELECT J2 - CHEMISTRYSELECT VL - 7 PY - 2022 IS - 29 PG - 5 SN - 2365-6549 DO - 10.1002/slct.202200967 UR - https://m2.mtmt.hu/api/publication/33049993 ID - 33049993 LA - English DB - MTMT ER -