@article{MTMT:34824919,
	title = {Anti-Nociceptive Effects of Sphingomyelinase and Methyl-Beta-Cyclodextrin in the Icilin-Induced Mouse Pain Model},
	url = {https://m2.mtmt.hu/api/publication/34824919},
	author = {Horváth, Ádám and Steib, Anita and Nehr-Majoros, Andrea Kinga and Kántás, Boglárka and Király, Ágnes and Racskó, Márk and Tóth, Balázs István and Szánti-Pintér, Eszter and Kudová, Eva and Skodáné Földes, Rita and Helyes, Zsuzsanna and Szőke, Éva},
	doi = {10.3390/ijms25094637},
	journal-iso = {INT J MOL SCI},
	journal = {INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES},
	volume = {25},
	unique-id = {34824919},
	issn = {1661-6596},
	abstract = {The thermo- and pain-sensitive Transient Receptor Potential Melastatin 3 and 8 (TRPM3 and TRPM8) ion channels are functionally associated in the lipid rafts of the plasma membrane. We have already described that cholesterol and sphingomyelin depletion, or inhibition of sphingolipid biosynthesis decreased the TRPM8 but not the TRPM3 channel opening on cultured sensory neurons. We aimed to test the effects of lipid raft disruptors on channel activation on TRPM3- and TRPM8-expressing HEK293T cells in vitro, as well as their potential analgesic actions in TRPM3 and TRPM8 channel activation involving acute pain models in mice. CHO cell viability was examined after lipid raft disruptor treatments and their effects on channel activation on channel expressing HEK293T cells by measurement of cytoplasmic Ca2+ concentration were monitored. The effects of treatments were investigated in Pregnenolone-Sulphate-CIM-0216-evoked and icilin-induced acute nocifensive pain models in mice. Cholesterol depletion decreased CHO cell viability. Sphingomyelinase and methyl-beta-cyclodextrin reduced the duration of icilin-evoked nocifensive behavior, while lipid raft disruptors did not inhibit the activity of recombinant TRPM3 and TRPM8. We conclude that depletion of sphingomyelin or cholesterol from rafts can modulate the function of native TRPM8 receptors. Furthermore, sphingolipid cleavage provided superiority over cholesterol depletion, and this method can open novel possibilities in the management of different pain conditions.},
	keywords = {PAIN; cholesterol; Sphingomyelinase; lipid raft; methyl-beta-cyclodextrin; transient receptor potential},
	year = {2024},
	eissn = {1422-0067},
	orcid-numbers = {Szánti-Pintér, Eszter/0000-0001-8263-9884; Skodáné Földes, Rita/0000-0002-9810-1509}
}

@article{MTMT:34724767,
	title = {Catalyst- and excess reagent recycling in aza-Michael additions},
	url = {https://m2.mtmt.hu/api/publication/34724767},
	author = {Maksó, Lilla and Szele, Boglárka and Ispán, Dávid and Gömöry, Ágnes and Mahó, Sándor and Skodáné Földes, Rita},
	doi = {10.1039/D3OB02073H},
	journal-iso = {ORG BIOMOL CHEM},
	journal = {ORGANIC & BIOMOLECULAR CHEMISTRY},
	volume = {2024},
	unique-id = {34724767},
	issn = {1477-0520},
	abstract = {The use of a [bmim][BF 4 ]/ n Bu-TMG solvent/catalyst mixture was shown to facilitate the recycling of solvents, catalysts and unreacted N-heterocycles (used in excess) in the aza-Michael reaction of various N-heterocycles with a steroidal substrate.},
	year = {2024},
	eissn = {1477-0539},
	orcid-numbers = {Maksó, Lilla/0000-0002-2023-8222; Ispán, Dávid/0000-0002-6698-0078; Skodáné Földes, Rita/0000-0002-9810-1509}
}

@article{MTMT:34400217,
	title = {Urea-Functionalized Heterocycles: Structure, Hydrogen Bonding and Applications},
	url = {https://m2.mtmt.hu/api/publication/34400217},
	author = {Keszei, Soma József and Váradi, Márk and Skodáné Földes, Rita},
	doi = {10.3390/molecules28237757},
	journal-iso = {MOLECULES},
	journal = {MOLECULES},
	volume = {28},
	unique-id = {34400217},
	issn = {1420-3049},
	abstract = {Ureido-heterocycles exhibiting different triple- and quadruple H-bonding patterns are useful building blocks in the construction of supramolecular polymers, self-healing materials, stimuli-responsive devices, catalysts and sensors. The heterocyclic group may provide hydrogen bond donor/acceptor sites to supplement those in the urea core, and they can also bind metals and can be modified by pH, redox reactions or irradiation. In the present review, the main structural features of these derivatives are discussed, including the effect of tautomerization and conformational isomerism on self-assembly and complex formation. Some examples of their use as building blocks in different molecular architectures and supramolecular polymers, with special emphasis on biomedical applications, are presented. The role of the heterocyclic functionality in catalytic and sensory applications is also outlined.},
	year = {2023},
	eissn = {1420-3049},
	orcid-numbers = {Skodáné Földes, Rita/0000-0002-9810-1509}
}

@article{MTMT:34074424,
	title = {Diols Speed Up Guanidine Base Catalysed Claisen‐Schmidt Condensation to Produce New 15‐Arylidene Steroids},
	url = {https://m2.mtmt.hu/api/publication/34074424},
	author = {Ispán, Dávid and Küzdő, Áron and Fonyó, Máté and Gömöry, Ágnes and Tumanov, Nikolay and Wouters, Johan and Mahó, Sándor and Lendvay, György and Skodáné Földes, Rita},
	doi = {10.1002/ejoc.202300560},
	journal-iso = {EUR J ORG CHEM},
	journal = {EUROPEAN JOURNAL OF ORGANIC CHEMISTRY},
	volume = {26},
	unique-id = {34074424},
	issn = {1434-193X},
	abstract = {Considerable acceleration was observed in the guanidine-base catalysed Claisen-Schmidt condensation of benzaldehyde and a 17α-methyl-18-nor-5α,13α-androstan-16-one (1) in the presence of ethylene glycol. Rate-enhancement effects of various alcohols and diols were compared. In quantum chemical calculations, coordination of the carbonyl group of the substrate was found to reduce the potential barrier to the proton transfer from the α carbon and thus facilitate the formation of the anion that attacks the aldehyde. Both the experiments and the calculations showed that diols enhance the reactivity more efficiently than alcohols. Ethylene glycol/guanidine-base mixtures were found to be efficient catalysts and solvents in the synthesis of a range of new 17α-methyl-18-nor-13α-15-arylidene steroids. This solvent mixture has a further advantage: the crude products can be isolated by simple extraction after introduction of CO2. It is also shown that by the proper choice of the base, the base/diol mixture can be recycled.},
	year = {2023},
	eissn = {1099-0690},
	orcid-numbers = {Ispán, Dávid/0000-0002-6698-0078; Gömöry, Ágnes/0000-0001-5216-0135; Lendvay, György/0000-0002-2150-0376; Skodáné Földes, Rita/0000-0002-9810-1509}
}

@article{MTMT:33045643,
	title = {Synthesis of 3-Aryl- and 3-Alkynylbenzofurans in the Presence of a Supported Palladium Catalyst},
	url = {https://m2.mtmt.hu/api/publication/33045643},
	author = {Nagy, Enikő and Nagymihaly, Zoltan and Kollár, László and Fonyó, Máté and Skodáné Földes, Rita},
	doi = {10.1055/a-1914-0423},
	journal-iso = {SYNTHESIS-STUTTGART},
	journal = {SYNTHESIS-STUTTGART},
	volume = {55},
	unique-id = {33045643},
	issn = {0039-7881},
	abstract = {Suzuki and Sonogashira coupling reactions of 3-iodo-2-phenylbenzofuran, leading to the corresponding 3-aryl- and 3-alkynyl derivatives, respectively, were carried out using a silica supported pyridinium ionic liquid based heterogeneous catalyst. Under optimized reactions conditions, arylboronic acids with either electron withdrawing or -donating substituents as well as terminal alkynes with aromatic or aliphatic groups could be coupled to the benzofuran skeleton efficiently. The application of this catalyst made it possible to carry out the reaction under phosphine-free and, in case of the Sonogashira coupling, under copper-free conditions. The catalyst retained its activity in at least 7 subsequent runs in both types of reactions. Palladium leaching of less than 1% of the original amount used in the catalytic reaction was observed under optimized conditions in most cases. The methodology was applied successfully in the synthesis of nine different 3-aryl- and ten different 3-alkynyl benzofuran derivatives in moderate to high yields.},
	year = {2023},
	eissn = {1437-210X},
	pages = {131-140},
	orcid-numbers = {Fonyó, Máté/0000-0002-3966-4387; Skodáné Földes, Rita/0000-0002-9810-1509}
}

@article{MTMT:33549245,
	title = {Az átmenetifém-organikus kémia és a homogén katalízis hazai megteremtője: Markó László (1928–2022)},
	url = {https://m2.mtmt.hu/api/publication/33549245},
	author = {Skodáné Földes, Rita and Kollár, László},
	journal-iso = {MAGY KEM LAP},
	journal = {MAGYAR KÉMIKUSOK LAPJA},
	volume = {77},
	unique-id = {33549245},
	issn = {0025-0163},
	year = {2022},
	eissn = {1588-1199},
	pages = {278-280},
	orcid-numbers = {Skodáné Földes, Rita/0000-0002-9810-1509}
}

@article{MTMT:33319199,
	title = {Electrochemical Corrosion Studies of Low-Alloyed Carbon Steel in Acidic Methylimidazolium Derivate Ionic Liquids with Varying Water Content},
	url = {https://m2.mtmt.hu/api/publication/33319199},
	author = {Lukács, Zoltán and Molnár, Ferenc and Skodáné Földes, Rita and Hancsók, Jenő and Kristóf, Tamás},
	doi = {10.5006/4183},
	journal-iso = {CORROSION-US},
	journal = {CORROSION},
	volume = {78},
	unique-id = {33319199},
	issn = {0010-9312},
	abstract = {The application of ionic liquids (ILs) in a wide range of technologies requires a thorough evaluation of their corrosion behavior to typical structural steels. In this work, the corrosion effects of two acidic-type methylimidazolium derivates (potential catalyst candidates) on low-alloyed carbon steel were studied with electrochemical methods (potentiodynamic polarization and electrochemical impedance spectroscopy [EIS]). The ILs cause moderate corrosion around 0.1 mm/y at water content up to 10‰ and severe corrosion around 1 mm/y at 100‰, which underlines that before industrial applications of ILs systematic corrosion studies should be performed as part of the process design. With both ILs we found that the cathodic process exhibited apparently good linear Tafel slopes in the cathodic polarization range but in the anodic range the IL with the hydrogensulfate anion showed an active-passive transition only at the highest water concentration. In this series at lower water concentrations, under 100‰, a model assuming a potential-independent anodic current rate correctly matched with the polarization data. The EIS measurement data showed chaotic, but reproducible deviations in the low-frequency range, which were interpreted as the effect of the timely variation of distribution parameters and they apparently did not affect the charge transfer parameters essentially.},
	year = {2022},
	eissn = {1938-159X},
	pages = {1203-1215},
	orcid-numbers = {Lukács, Zoltán/0000-0003-3283-6665; Skodáné Földes, Rita/0000-0002-9810-1509; Hancsók, Jenő/0000-0003-1959-7604; Kristóf, Tamás/0000-0002-3261-7078}
}

@article{MTMT:33284467,
	title = {Synthetic methods towards steroid-ferrocene conjugates},
	url = {https://m2.mtmt.hu/api/publication/33284467},
	author = {Váradi, Márk and Skodáné Földes, Rita},
	doi = {10.24820/ark.5550190.p011.885},
	journal-iso = {ARKIVOC},
	journal = {ARKIVOC},
	volume = {2022},
	unique-id = {33284467},
	issn = {1551-7012},
	year = {2022},
	eissn = {1551-7004},
	pages = {197-239},
	orcid-numbers = {Skodáné Földes, Rita/0000-0002-9810-1509}
}

@article{MTMT:33271926,
	title = {Synthesis of Novel Ferrocene-Benzofuran Hybrids via Palladium- and Copper-Catalyzed Reactions},
	url = {https://m2.mtmt.hu/api/publication/33271926},
	author = {Nagy, Enikő and Váradi, Márk and Nagymihaly, Zoltan and Kollár, László and Kovács, Krisztina and Andreidesz, Kitti and Gömöry, Ágnes and Tumanov, Nikolay and Wouters, Johan and Skodáné Földes, Rita},
	doi = {10.3390/inorganics10110205},
	journal-iso = {INORGANICS},
	journal = {INORGANICS},
	volume = {10},
	unique-id = {33271926},
	abstract = {The combination of the ferrocene skeleton with pharmacophores often leads to molecules with interesting biological properties. Five ferrocene-benzofuran hybrids of different structures were synthesized by transition metal catalyzed reactions. The efficiency of both homogeneous and heterogeneous catalytic methods was tested. The products were characterized using 1H, 13C NMR and FTIR spectroscopy, HRMS and cyclic voltammetry. The structure of one of the new compounds was also proved with X-ray crystallography. The new hybrids showed moderate cytotoxicity on MCF-7 and MDA-MB-231 cell lines. It is remarkable that the less curable MDA-MB-231 cell line was more sensitive to treatment with three ferrocene derivatives.},
	year = {2022},
	eissn = {2304-6740},
	orcid-numbers = {Gömöry, Ágnes/0000-0001-5216-0135; Tumanov, Nikolay/0000-0001-6898-9036; Wouters, Johan/0000-0002-4920-6857; Skodáné Földes, Rita/0000-0002-9810-1509}
}

@article{MTMT:33049993,
	title = {Synthesis of Steroidal Thioethers via [HDBU][OAc]-Mediated Michael Addition of Thiols to 16-Dehydropregnenolone},
	url = {https://m2.mtmt.hu/api/publication/33049993},
	author = {Maksó, Lilla and Kovács, Krisztina and Andreidesz, Kitti and Gömöry, Ágnes and Mahó, Sándor and Skodáné Földes, Rita},
	doi = {10.1002/slct.202200967},
	journal-iso = {CHEMISTRYSELECT},
	journal = {CHEMISTRYSELECT},
	volume = {7},
	unique-id = {33049993},
	issn = {2365-6549},
	year = {2022},
	eissn = {2365-6549},
	orcid-numbers = {Maksó, Lilla/0000-0002-2023-8222; Gömöry, Ágnes/0000-0001-5216-0135; Skodáné Földes, Rita/0000-0002-9810-1509}
}