TY - CONF AU - Bencsik, Péter AU - Gömöri, Kamilla AU - Pósa, Bence AU - Kenyeres, Éva AU - Szabados, Tamara AU - Ágg, Bence AU - Váradi, Barnabás AU - Tóth, Viktória AU - Ágoston, Gergely AU - Leprán, István AU - Hamdani, Nazha AU - Görbe, Anikó AU - Ferdinandy, Péter TI - MICRORNA‐MRNA BIOINFORMATICS TARGET PREDICTION IN A RAT MODEL OF VOLUME OVERLOAD‐INDUCED LEFT VENTRICULAR HYPERTROPHY T2 - FAMÉ 2023 PY - 2023 SP - 58 EP - 58 PG - 1 UR - https://m2.mtmt.hu/api/publication/34152354 ID - 34152354 LA - English DB - MTMT ER - TY - JOUR AU - Bencsik, Péter AU - Pósa, Bence AU - Gömöri, Kamilla AU - Szabados, Tamara AU - Ágg, Bence Károly AU - Váradi, Barnabás AU - Ágoston, Gergely AU - Leprán, István AU - Hamdani, Nazha AU - Ferdinandy, Péter AU - Görbe, Anikó TI - Új, potenciális gyógyszertámadáspontok azonosítása volumenterhelés-indukálta bal kamrai hipertrófiában mikroRNS-mRNS bioinformatikai célpont predikcióval JF - CARDIOLOGIA HUNGARICA J2 - CARDIOL HUNG VL - 53 PY - 2023 IS - Suppl. A SP - A306 EP - A306 PG - 1 SN - 0133-5596 UR - https://m2.mtmt.hu/api/publication/33834109 ID - 33834109 LA - English DB - MTMT ER - TY - JOUR AU - Gömöri, Kamilla AU - Herwig, Melissa AU - Hassoun, Roua AU - Budde, Heidi AU - Mostafi, Nusratul AU - Delalat, Simin AU - Modi, Suvasini AU - Begovic, Merima AU - Szabados, Tamara AU - Pipis, Judit AU - Morvay, Nikolett AU - Leprán, István AU - Kovács, Árpád AU - Mügge, Andreas AU - Ferdinandy, Péter AU - Görbe, Anikó AU - Bencsik, Péter AU - Hamdani, Nazha TI - Altered Cellular Protein Quality Control System Modulates Cardiomyocyte Function in Volume Overload-Induced Hypertrophy JF - ANTIOXIDANTS J2 - ANTIOXIDANTS-BASEL VL - 11 PY - 2022 IS - 11 PG - 16 SN - 2076-3921 DO - 10.3390/antiox11112210 UR - https://m2.mtmt.hu/api/publication/33228699 ID - 33228699 AB - Volume-induced hypertrophy is one of the risk factors for cardiac morbidity and mortality. In addition, mechanical and metabolic dysfunction, aging, and cellular redox balance are also contributing factors to the disease progression. In this study, we used volume overload (VO), which was induced by an aortocaval fistula in 2-month-old male Wistar rats, and sham-operated animals served as control. Functional parameters were measured by transthoracic echocardiography at termination 4- or 8-months after VO. The animals showed hypertrophic remodeling that was accompanied by mechanical dysfunction and increased cardiomyocyte stiffness. These alterations were reversible upon treatment with glutathione. Cardiomyocyte dysfunction was associated with elevated oxidative stress markers with unchanged inflammatory signaling pathways. In addition, we observed altered phosphorylation status of small heat shock proteins 27 and 70 and diminished protease expression caspases 3 compared to the matched control group, indicating an impaired protein quality control system. Such alterations might be attributed to the increased oxidative stress as anticipated from the enhanced titin oxidation, ubiquitination, and the elevation in oxidative stress markers. Our study showed an early pathological response to VO, which manifests in cardiomyocyte mechanical dysfunction and dysregulated signaling pathways associated with enhanced oxidative stress and an impaired protein quality control system. LA - English DB - MTMT ER - TY - JOUR AU - Gömöri, Kamilla AU - Herwig, Melissa AU - Budde, Heidi AU - Hassoun, Roua AU - Mostafi, Nusratul AU - Zhazykbayeva, Saltanat AU - Sieme, Marcel AU - Modi, Suvasini AU - Szabados, Tamara AU - Pipis, Judit AU - Morvay, Nikolett AU - Leprán, István AU - Ágoston, Gergely AU - Baczkó, István AU - Kovács, Árpád AU - Mügge, Andreas AU - Ferdinandy, Péter AU - Görbe, Anikó AU - Bencsik, Péter AU - Hamdani, Nazha TI - Ca2+/calmodulin-dependent protein kinase II and protein kinase G oxidation contributes to impaired sarcomeric proteins in hypertrophy model JF - ESC HEART FAILURE J2 - ESC HEART FAIL VL - 9 PY - 2022 IS - 4 SP - 2585 EP - 2600 PG - 16 SN - 2055-5822 DO - 10.1002/ehf2.13973 UR - https://m2.mtmt.hu/api/publication/32830295 ID - 32830295 AB - Volume overload (VO) induced hypertrophy is one of the hallmarks to the development of heart diseases. Understanding the compensatory mechanisms involved in this process might help preventing the disease progression.Therefore, the present study used 2 months old Wistar rats, which underwent an aortocaval fistula to develop VO-induced hypertrophy. The animals were subdivided into four different groups, two sham operated animals served as age-matched controls and two groups with aortocaval fistula. Echocardiography was performed prior termination after 4- and 8-month. Functional and molecular changes of several sarcomeric proteins and their signalling pathways involved in the regulation and modulation of cardiomyocyte function were investigated.The model was characterized with preserved ejection fraction in all groups and with elevated heart/body weight ratio, left/right ventricular and atrial weight at 4- and 8-month, which indicates VO-induced hypertrophy. In addition, 8-months groups showed increased left ventricular internal diameter during diastole, RV internal diameter, stroke volume and velocity-time index compared with their age-matched controls. These changes were accompanied by increased Ca2+ sensitivity and titin-based cardiomyocyte stiffness in 8-month VO rats compared with other groups. The altered cardiomyocyte mechanics was associated with phosphorylation deficit of sarcomeric proteins cardiac troponin I, myosin binding protein C and titin, also accompanied with impaired signalling pathways involved in phosphorylation of these sarcomeric proteins in 8-month VO rats compared with age-matched control group. Impaired protein phosphorylation status and dysregulated signalling pathways were associated with significant alterations in the oxidative status of both kinases CaMKII and PKG explaining by this the elevated Ca2+ sensitivity and titin-based cardiomyocyte stiffness and perhaps the development of hypertrophy.Our findings showed VO-induced cardiomyocyte dysfunction via deranged phosphorylation of myofilament proteins and signalling pathways due to increased oxidative state of CaMKII and PKG and this might contribute to the development of hypertrophy. LA - English DB - MTMT ER - TY - JOUR AU - Kui, Péter AU - Polyák, Alexandra Júlia AU - Morvay, Nikolett AU - Tiszlavicz, László AU - Nagy, Norbert AU - Ördög, Balázs AU - Takács, Hedvig AU - Leprán, István AU - Farkas, András AU - Papp, Gyula AU - Jost, Norbert László AU - Varró, András AU - Baczkó, István AU - Farkas, Attila TI - Long-Term Endurance Exercise Training Alters Repolarization in a New Rabbit Athlete’s Heart Model JF - FRONTIERS IN PHYSIOLOGY J2 - FRONT PHYSIOL VL - 12 PY - 2022 PG - 14 SN - 1664-042X DO - 10.3389/fphys.2021.741317 UR - https://m2.mtmt.hu/api/publication/32670331 ID - 32670331 N1 - Department of Pharmacology and Pharmacotherapy, Albert Szent-Györgyi Medical School, University of Szeged, Szeged, Hungary Department of Internal Medicine, Albert Szent-Györgyi Medical School, University of Szeged, Szeged, Hungary ELKH-SZTE Working Group of Cardiovascular Pharmacology, Szeged, Hungary Department of Pathology, Albert Szent-Györgyi Medical School, University of Szeged, Szeged, Hungary Department of Pharmacology and Pharmacotherapy, Interdisciplinary Excellence Centre, Albert Szent-Györgyi Medical School, University of Szeged, Szeged, Hungary Export Date: 17 March 2022 Correspondence Address: Varró, A.; Department of Pharmacology and Pharmacotherapy, Hungary; email: varro.andras@med.u-szeged.hu LA - English DB - MTMT ER - TY - CHAP AU - Váczi, S AU - Leprán, István AU - Ónody, R AU - Földesi, Imre AU - Deli, M AU - Mezei, Zsófia ED - Rakonczay, Zoltán ED - Kiss, Lóránd TI - Ex vivo effects of sigma-1 receptor agonist on function of rat platelets in different animal models T2 - Proceedings of the EFOP-3.6.2-16-2017-00006 (LIVE LONGER) project PB - University of Szeged CY - Szeged SN - 9789633067642 PY - 2020 SP - 87 UR - https://m2.mtmt.hu/api/publication/31641356 ID - 31641356 LA - English DB - MTMT ER - TY - CHAP AU - Morvay, Nikolett AU - Varró, András AU - Baczkó, István AU - Leprán, István ED - Djuric, D ED - Jakovljevic, V TI - Effects of polyunsaturated fatty acid-rich diet and chronic fibrate pretreatment in a rat heart failure model T2 - 6th Meeting of European Section and 7th Meeting of North American Section of the International Academy of Cardiovascular Sciences (IACS) Cardiometabolic Diseases: How new research may lead to new cardioprotective therapy PB - University of Kragujevac, Faculty of Medical Sciences CY - Kragujevac SN - 9788677601362 PY - 2019 SP - 168 UR - https://m2.mtmt.hu/api/publication/30827298 ID - 30827298 LA - English DB - MTMT ER - TY - CONF AU - Mezei, Zsófia AU - Váczi, Sándor AU - Puskás, Ákos AU - Tobak, Myrtill AU - Nagy, Tamás AU - Horváth, Krisztián AU - Réda, Beáta AU - Szabó, Gyula AU - Siska, Andrea AU - Földesi, Imre AU - Leprán, István TI - Sigma-1 receptor agonista hatása a telített zsírsav dús diétás, szívelégtelen patkányok vérlemezkéinek eikozanoid szintézisére T2 - Magyar Élettani Társaság 2018. évi Vándorgyűlése : előadás és poszter absztraktok PY - 2018 PG - 1 UR - https://m2.mtmt.hu/api/publication/31173182 ID - 31173182 LA - Hungarian DB - MTMT ER - TY - CONF AU - Nagy, Tamás István AU - Török, Viktória AU - Horváth, Krisztián AU - Leprán, István AU - Váczi, Sándor AU - Szabó, Gyula AU - Mezei, Zsófia TI - Vérlemezkék arachidonsav metabolizmusának változása szívelégtelenség hatására patkányban T2 - Magyar Élettani Társaság 2018. évi Vándorgyűlése : előadás és poszter absztraktok PY - 2018 PG - 2 UR - https://m2.mtmt.hu/api/publication/31173174 ID - 31173174 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Polyák, Alexandra Júlia AU - Kui, Péter AU - Morvay, Nikolett AU - Leprán, István AU - Ágoston, Gergely AU - Varga, Albert AU - Nagy, Norbert AU - Baczkó, István AU - Farkas, András AU - Papp, Gyula AU - Varró, András AU - Farkas, Attila TI - Long-term endurance training-induced cardiac adaptation in new rabbit and dog animal models of the human athlete’s heart JF - REVIEWS IN CARDIOVASCULAR MEDICINE J2 - REV CARDIOVASC MED VL - 19 PY - 2018 IS - 4 SP - 135 EP - 142 PG - 8 SN - 1530-6550 DO - 10.31083/j.rcm.2018.04.4161 UR - https://m2.mtmt.hu/api/publication/30670028 ID - 30670028 N1 - Second Department of Medicine and Cardiology Centre, University of Szeged, Szeged, H-6725, Hungary MTA-SZTE Research Group for Cardiovascular Pharmacology, Hungarian Academy of Sciences, Szeged, H-6720, Hungary Department of Pharmacology and Pharmacotherapy, University of Szeged, Szeged, H-6720, Hungary Institute of Family Medicine, University of SzegedH-6720, Hungary Cited By :1 Export Date: 4 November 2019 CODEN: RCMEC Correspondence Address: Varró, A.; MTA-SZTE Research Group for Cardiovascular Pharmacology, Hungarian Academy of SciencesHungary; email: varro.andras@med.u-szeged.hu Chemicals/CAS: atropine, 51-55-8, 55-48-1; dofetilide, 115256-11-6; testosterone, 58-22-0; Androgens; Anti-Arrhythmia Agents Second Department of Medicine and Cardiology Centre, University of Szeged, Szeged, H-6725, Hungary MTA-SZTE Research Group for Cardiovascular Pharmacology, Hungarian Academy of Sciences, Szeged, H-6720, Hungary Department of Pharmacology and Pharmacotherapy, University of Szeged, Szeged, H-6720, Hungary Institute of Family Medicine, University of SzegedH-6720, Hungary Cited By :2 Export Date: 10 December 2019 CODEN: RCMEC Correspondence Address: Varró, A.; MTA-SZTE Research Group for Cardiovascular Pharmacology, Hungarian Academy of SciencesHungary; email: varro.andras@med.u-szeged.hu Chemicals/CAS: atropine, 51-55-8, 55-48-1; dofetilide, 115256-11-6; testosterone, 58-22-0; Androgens; Anti-Arrhythmia Agents Second Department of Medicine and Cardiology Centre, University of Szeged, Szeged, H-6725, Hungary MTA-SZTE Research Group for Cardiovascular Pharmacology, Hungarian Academy of Sciences, Szeged, H-6720, Hungary Department of Pharmacology and Pharmacotherapy, University of Szeged, Szeged, H-6720, Hungary Institute of Family Medicine, University of SzegedH-6720, Hungary Cited By :2 Export Date: 27 January 2020 CODEN: RCMEC Correspondence Address: Varró, A.; MTA-SZTE Research Group for Cardiovascular Pharmacology, Hungarian Academy of SciencesHungary; email: varro.andras@med.u-szeged.hu Chemicals/CAS: atropine, 51-55-8, 55-48-1; dofetilide, 115256-11-6; testosterone, 58-22-0; Androgens; Anti-Arrhythmia Agents Second Department of Medicine and Cardiology Centre, University of Szeged, Szeged, H-6725, Hungary MTA-SZTE Research Group for Cardiovascular Pharmacology, Hungarian Academy of Sciences, Szeged, H-6720, Hungary Department of Pharmacology and Pharmacotherapy, University of Szeged, Szeged, H-6720, Hungary Institute of Family Medicine, University of SzegedH-6720, Hungary Cited By :2 Export Date: 13 February 2020 CODEN: RCMEC Correspondence Address: Varró, A.; MTA-SZTE Research Group for Cardiovascular Pharmacology, Hungarian Academy of SciencesHungary; email: varro.andras@med.u-szeged.hu Chemicals/CAS: atropine, 51-55-8, 55-48-1; dofetilide, 115256-11-6; testosterone, 58-22-0; Androgens; Anti-Arrhythmia Agents Second Department of Medicine and Cardiology Centre, University of Szeged, Szeged, H-6725, Hungary MTA-SZTE Research Group for Cardiovascular Pharmacology, Hungarian Academy of Sciences, Szeged, H-6720, Hungary Department of Pharmacology and Pharmacotherapy, University of Szeged, Szeged, H-6720, Hungary Institute of Family Medicine, University of SzegedH-6720, Hungary Cited By :2 Export Date: 14 February 2020 CODEN: RCMEC Correspondence Address: Varró, A.; MTA-SZTE Research Group for Cardiovascular Pharmacology, Hungarian Academy of SciencesHungary; email: varro.andras@med.u-szeged.hu Chemicals/CAS: atropine, 51-55-8, 55-48-1; dofetilide, 115256-11-6; testosterone, 58-22-0; Androgens; Anti-Arrhythmia Agents Second Department of Medicine and Cardiology Centre, University of Szeged, Szeged, H-6725, Hungary MTA-SZTE Research Group for Cardiovascular Pharmacology, Hungarian Academy of Sciences, Szeged, H-6720, Hungary Department of Pharmacology and Pharmacotherapy, University of Szeged, Szeged, H-6720, Hungary Institute of Family Medicine, University of SzegedH-6720, Hungary Cited By :3 Export Date: 10 July 2020 CODEN: RCMEC Correspondence Address: Varró, A.; MTA-SZTE Research Group for Cardiovascular Pharmacology, Hungarian Academy of SciencesHungary; email: varro.andras@med.u-szeged.hu Cited By :2 Export Date: 23 April 2020 Second Department of Medicine and Cardiology Centre, University of Szeged, Szeged, H-6725, Hungary MTA-SZTE Research Group for Cardiovascular Pharmacology, Hungarian Academy of Sciences, Szeged, H-6720, Hungary Department of Pharmacology and Pharmacotherapy, University of Szeged, Szeged, H-6720, Hungary Institute of Family Medicine, University of SzegedH-6720, Hungary Cited By :5 Export Date: 13 April 2021 CODEN: RCMEC Correspondence Address: Varró, A.; MTA-SZTE Research Group for Cardiovascular Pharmacology, Hungary; email: varro.andras@med.u-szeged.hu Chemicals/CAS: atropine, 51-55-8, 55-48-1; dofetilide, 115256-11-6; testosterone, 58-22-0; Androgens; Anti-Arrhythmia Agents Second Department of Medicine and Cardiology Centre, University of Szeged, Szeged, H-6725, Hungary MTA-SZTE Research Group for Cardiovascular Pharmacology, Hungarian Academy of Sciences, Szeged, H-6720, Hungary Department of Pharmacology and Pharmacotherapy, University of Szeged, Szeged, H-6720, Hungary Institute of Family Medicine, University of SzegedH-6720, Hungary Cited By :5 Export Date: 16 April 2021 CODEN: RCMEC Correspondence Address: Varró, A.; MTA-SZTE Research Group for Cardiovascular Pharmacology, Hungary; email: varro.andras@med.u-szeged.hu Chemicals/CAS: atropine, 51-55-8, 55-48-1; dofetilide, 115256-11-6; testosterone, 58-22-0; Androgens; Anti-Arrhythmia Agents Second Department of Medicine and Cardiology Centre, University of Szeged, Szeged, H-6725, Hungary MTA-SZTE Research Group for Cardiovascular Pharmacology, Hungarian Academy of Sciences, Szeged, H-6720, Hungary Department of Pharmacology and Pharmacotherapy, University of Szeged, Szeged, H-6720, Hungary Institute of Family Medicine, University of SzegedH-6720, Hungary Cited By :5 Export Date: 17 May 2021 CODEN: RCMEC Correspondence Address: Varró, A.; MTA-SZTE Research Group for Cardiovascular Pharmacology, Hungary; email: varro.andras@med.u-szeged.hu Chemicals/CAS: atropine, 51-55-8, 55-48-1; dofetilide, 115256-11-6; testosterone, 58-22-0; Androgens; Anti-Arrhythmia Agents LA - English DB - MTMT ER -