TY - JOUR AU - Ruszin-Perecz, Brigitta AU - Makai, Alexandra AU - Pozsgai, Miklós AU - Csizmadiáné Nusser, Nóra AU - Pál, Endre AU - Kovács, Norbert AU - Janszky, József Vladimír AU - Járomi, Melinda AU - Sebők, Ágnes TI - A quick balance assessment tool for all clinical settings: validity and reliability of the Hungarian version of the activities-specific balance confidence scale JF - PHYSIOTHERAPY THEORY AND PRACTICE J2 - PHYSIOTHER THEOR PR PY - 2024 PG - 10 SN - 0959-3985 DO - 10.1080/09593985.2024.2396074 UR - https://m2.mtmt.hu/api/publication/35201713 ID - 35201713 N1 - Funding Agency and Grant Number: New National Excellence Program of the Ministry of Human Capacities, Hungary [UNKP-20-2-I-PTE-835] Funding text: The work was supported by the New National Excellence Program of the Ministry of Human Capacities, Hungary [UNKP-20-2-I-PTE-835]. LA - English DB - MTMT ER - TY - JOUR AU - Janszky, József Vladimír AU - Bóné, Beáta AU - Karádi, Kázmér AU - Barsi, Péter AU - Juhos, Vera AU - Berta, Anikó AU - Trischlerné Gyimesi, Csilla AU - Tényi, Dalma AU - Horváth, Réka TI - Management of autoimmune temporal lobe epilepsy with GAD65 antibody: four case reports JF - NEUROLOGIA I NEUROCHIRURGIA POLSKA J2 - NEUROL NEUROCHIR POL VL - 58 PY - 2024 IS - 4 SP - 453 EP - 458 PG - 6 SN - 0028-3843 DO - 10.5603/pjnns.98738 UR - https://m2.mtmt.hu/api/publication/35172480 ID - 35172480 N1 - Short Communication AB - Aim of study. Glutamate decarboxylase (GAD) enzyme can be a target intracellular antigen in autoimmune focal epilepsy. GAD65 antibody is in found patients diagnosed with drug-refractory temporal lobe epilepsy (TLE). We explore the clinical features of the disease and therapeutic options. Material and methods. We present the cases of four TLE patients, two of them with type 1 diabetes. All of them were drug-resistant and therefore underwent presurgical evaluation, which revealed GAD65 antibody positivity. We discuss the four GAD65 antibody positive temporal lobe epilepsy patients' electroclinical data, the treatments, and their effectiveness. Results. One of them became seizure-free after right anterior temporal lobe resection, two of them did not show significant improvement with immunmodulatory agents, and the fourth patient with the shortest duration of disease had significant improvement in seizure status and normalisation of cognitive status with IVIg therapy. Conclusions and clinical implications. Our cases show that the earlier a GAD65 antibody is detected, the greater the chance of achieving seizure freedom or improvements in both seizure and cognitive status with immunomodulatory agents. However, in some cases, surgery may also bring seizure freedom, but with a risk of cognitive deterioration. LA - English DB - MTMT ER - TY - CHAP AU - Janszky, József Vladimír ED - Vámos, Zoltán TI - Poszttraumás convulsiók T2 - Súlyos baleseti agysérültek ellátása PB - Medicina Könyvkiadó CY - Budapest SN - 9789632269177 PY - 2024 SP - 181 EP - 182 PG - 2 UR - https://m2.mtmt.hu/api/publication/34823733 ID - 34823733 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Zsila, Ágnes AU - McCutcheon, Lynn E. AU - Horváth, Rita AU - Urbán, Róbert AU - Paksi, Borbála AU - Darnai, Gergely AU - Janszky, József Vladimír AU - Demetrovics, Zsolt TI - Prevalence of celebrity worship: Development and application of the short version of the Celebrity Attitude Scale (CAS-7) on a large-scale representative sample JF - JOURNAL OF BEHAVIORAL ADDICTIONS J2 - J BEHAV ADDICT VL - 13 PY - 2024 IS - 2 SP - 463 EP - 472 PG - 10 SN - 2062-5871 DO - 10.1556/2006.2024.00019 UR - https://m2.mtmt.hu/api/publication/34800559 ID - 34800559 N1 - Institute of Psychology, Pázmány Péter Catholic UniversityBudapest, Hungary Institute of Psychology, ELTE Eötvös Loránd UniversityBudapest, Hungary 3North American Journal of Psychology, Winter Garden, FL, United States 4Doctoral School of Psychology, ELTE Eötvös Loránd UniversityBudapest, Hungary Institute of Education, ELTE Eötvös Loránd UniversityBudapest, Hungary Department of Behavioural Sciences, Medical School, University of Pécs, Pécs, Hungary Department of Neurology, Medical School, University of Pécs, Pécs, Hungary 8HUN-REN-PTE Clinical Neuroscience MR Research Group, Pécs, Hungary 9Centre of Excellence in Responsible Gaming, University of Gibraltar, Gibraltar 10College of Education, Psychology and Social Work, Flinders University, Adelaide, Australia Export Date: 26 July 2024 LA - English DB - MTMT ER - TY - JOUR AU - Schoser, Benedikt AU - Kishnani, Priya S AU - Bratkovic, Drago AU - Byrne, Barry J AU - Claeys, Kristl G AU - Díaz-Manera, Jordi AU - Laforêt, Pascal AU - Roberts, Mark AU - Toscano, Antonio AU - van der Ploeg, Ans T AU - Castelli, Jeff AU - Goldman, Mitchell AU - Holdbrook, Fred AU - Sitaraman Das, Sheela AU - Wasfi, Yasmine AU - Mozaffar, Tahseen ED - Sebok, Agnes / Collaborator ED - Pestronk, Alan / Collaborator ED - Dominovic-Kovacevic, Aleksandra / Collaborator ED - Khan, Aneal / Collaborator ED - Koritnik, Blaž / Collaborator ED - Tard, Celine / Collaborator ED - Lindberg, Christopher / Collaborator ED - Quinn, Colin / Collaborator ED - Eldridge, Crystal / Collaborator ED - Bodkin, Cynthia / Collaborator ED - Reyes-Leiva, David / Collaborator ED - Hughes, Derralynn / Collaborator ED - Stefanescu, Ela / Collaborator ED - Salort-Campana, Emmanuelle / Collaborator ED - Butler, Ernest / Collaborator ED - Bouhour, Francoise / Collaborator ED - Kim, Gee / Collaborator ED - Papadimas, George Konstantinos / Collaborator ED - Parenti, Giancarlo / Collaborator ED - Bartosik-Psujek, Halina / Collaborator ED - Kushlaf, Hani / Collaborator ED - Akihiro, Hashiguchi / Collaborator ED - Lau, Heather / Collaborator ED - Pedro, Helio / Collaborator ED - Andersen, Henning / Collaborator ED - Amartino, Hernan / Collaborator ED - Shiraishi, Hideaki / Collaborator ED - Kobayashi, Hiroshi / Collaborator ED - Tarnev, Ivaylo / Collaborator ED - Vengoechea, Jaime / Collaborator ED - Avelar, Jennifer / Collaborator ED - Shin, Jin-Hong / Collaborator ED - Nevin, John / Collaborator ED - Cauci, Jonathan / Collaborator ED - Alonso-Pérez, Jorge / Collaborator ED - Janszky, József Vladimír / Collaborator ED - Berthy, Julie / Collaborator ED - Kornblum, Cornelia / Collaborator ED - Gutschmidt, Kristina / Collaborator ED - Molnár, Mária Judit / Collaborator ED - Wencel, Marie / Collaborator ED - Tarnopolsky, Mark / Collaborator ED - Boentert, Matthias / Collaborator ED - Tchan, Michel / Collaborator ED - Freimer, Miriam / Collaborator ED - Longo, Nicola / Collaborator ED - Abreu, Nicolas / Collaborator ED - Vidal-Fernandez, Nuria / Collaborator ED - Musumeci, Olimpia / Collaborator ED - Goker-Alpan, Ozlem / Collaborator ED - Deegan, Patrick / Collaborator ED - Clemens, Paula R / Collaborator ED - Roxburgh, Richard / Collaborator ED - Henderson, Robert / Collaborator ED - Hopkin, Robert / Collaborator ED - Sacconi, Sabrina / Collaborator ED - Fecarotta, Simona / Collaborator ED - Attarian, Shahram / Collaborator ED - Wenninger, Stephan / Collaborator ED - Dearmey, Stephanie / Collaborator ED - Hiwot, Tarekegn / Collaborator ED - Burrow, Thomas / Collaborator ED - Ruck, Tobias / Collaborator ED - Sawada, Tomo / Collaborator ED - Laszlo, Vescei / Collaborator ED - Löscher, Wolfgang / Collaborator ED - Chien, Yin-Hsiu / Collaborator TI - 104-week efficacy and safety of cipaglucosidase alfa plus miglustat in adults with late-onset Pompe disease. a phase III open-label extension study (ATB200-07). TS - a phase III open-label extension study (ATB200-07). JF - JOURNAL OF NEUROLOGY J2 - J NEUROL VL - 271 PY - 2024 SP - 2810 EP - 2823 PG - 14 SN - 0340-5354 DO - 10.1007/s00415-024-12236-0 UR - https://m2.mtmt.hu/api/publication/34733371 ID - 34733371 N1 - Friedrich-Baur-Institute at the Department of Neurology, LMU University Hospital, LMU Munich, Munich, Germany Duke University Medical Center, Durham, NC, United States PARC Research Clinic, Royal Adelaide Hospital, Adelaide, SA, Australia University of Florida, Gainesville, FL, United States Department of Neurology, University Hospitals Leuven, Leuven, Belgium Laboratory for Muscle Diseases and Neuropathies, Department of Neurosciences, KU Leuven, Leuven, Belgium John Walton Muscular Dystrophy Research Centre, Newcastle University International Centre for Life, Newcastle Upon Tyne, United Kingdom Neurology Department, Nord/Est/Île-de-France Neuromuscular Reference Center, FHU PHENIX, Raymond-Poincaré Hospital, AP-HP, Garches, France Salford Royal NHS Foundation Trust, Salford, United Kingdom ERN-NMD Center for Neuromuscular Disorders of Messina, Department of Clinical and Experimental Medicine, University of Messina, Messina, Italy Erasmus MC University Medical Center, Rotterdam, Netherlands Amicus Therapeutics, Inc, Princeton, NJ, United States Department of Neurology, University of California, Irvine, CA, United States Cited By :1 Export Date: 26 July 2024 CODEN: JNRYA Correspondence Address: Schoser, B.; Friedrich-Baur-Institute at the Department of Neurology, Germany; email: benedikt.schoser@med.uni-muenchen.de AB - The phase III double-blind PROPEL study compared the novel two-component therapy cipaglucosidase alfa + miglustat (cipa + mig) with alglucosidase alfa + placebo (alg + pbo) in adults with late-onset Pompe disease (LOPD). This ongoing open-label extension (OLE; NCT04138277) evaluates long-term safety and efficacy of cipa + mig. Outcomes include 6-min walk distance (6MWD), forced vital capacity (FVC), creatine kinase (CK) and hexose tetrasaccharide (Hex4) levels, patient-reported outcomes and safety. Data are reported as change from PROPEL baseline to OLE week 52 (104 weeks post-PROPEL baseline). Of 118 patients treated in the OLE, 81 continued cipa + mig treatment from PROPEL (cipa + mig group; 61 enzyme replacement therapy [ERT] experienced prior to PROPEL; 20 ERT naïve) and 37 switched from alg + pbo to cipa + mig (switch group; 29 ERT experienced; 8 ERT naive). Mean (standard deviation [SD]) change in % predicted 6MWD from baseline to week 104 was + 3.1 (8.1) for cipa + mig and - 0.5 (7.8) for the ERT-experienced switch group, and + 8.6 (8.6) for cipa + mig and + 8.9 (11.7) for the ERT-naïve switch group. Mean (SD) change in % predicted FVC was - 0.6 (7.5) for cipa + mig and - 3.8 (6.2) for the ERT-experienced switch group, and - 4.8 (6.5) and - 3.1 (6.7), respectively, in ERT-naïve patients. CK and Hex4 levels improved in both treatment groups by week 104 with cipa + mig treatment. Three patients discontinued the OLE due to infusion-associated reactions. No new safety signals were identified. Cipa + mig treatment up to 104 weeks was associated with overall maintained improvements (6MWD, biomarkers) or stabilization (FVC) from baseline with continued durability, and was well tolerated, supporting long-term benefits for patients with LOPD.Trial registration number: NCT04138277; trial start date: December 18, 2019. LA - English DB - MTMT ER - TY - JOUR AU - Áfra, Eszter AU - Janszky, József Vladimír AU - Perlaki, Gábor AU - Orsi, Gergely AU - Nagy, Szilvia Anett AU - Arató, Ákos AU - Szente, Anna Tímea AU - Alhour, Husamalddin Ali Mohammad AU - Kis-Jakab, Gréta AU - Darnai, Gergely TI - Altered functional brain networks in problematic smartphone and social media use: resting-state fMRI study JF - BRAIN IMAGING AND BEHAVIOR J2 - BRAIN IMAGING BEHAV VL - 18 PY - 2024 IS - 2 SP - 292 EP - 301 PG - 10 SN - 1931-7557 DO - 10.1007/s11682-023-00825-y UR - https://m2.mtmt.hu/api/publication/34420912 ID - 34420912 AB - Nowadays, the limitless availability to the World Wide Web can lead to general Internet misuse and dependence. Currently, smartphone and social media use belong to the most prevalent Internet-related behavioral addiction forms. However, the neurobiological background of these Internet-related behavioral addictions is not sufficiently explored. In this study, these addiction forms were assessed with self-reported questionnaires. Resting-state functional magnetic resonance imaging was acquired for all participants ( n = 59, 29 males) to examine functional brain networks. The resting-state networks that were discovered using independent component analysis were analyzed to estimate within network differences. Significant negative associations with social media addiction and smartphone addiction were found in the language network, the lateral visual networks, the auditory network, the sensorimotor network, the executive network and the frontoparietal network. These results suggest that problematic smartphone and social media use are associated with sensory processing and higher cognitive functioning . LA - English DB - MTMT ER - TY - JOUR AU - Matuz, András AU - Darnai, Gergely AU - Zsidó, András Norbert AU - Janszky, József Vladimír AU - Csathó, Árpád TI - Structural neural correlates of mental fatigue and reward-induced improvement in performance JF - BIOLOGIA FUTURA J2 - BIOL FUTURA VL - 75 PY - 2024 SP - 93 EP - 104 PG - 12 SN - 2676-8615 DO - 10.1007/s42977-023-00187-y UR - https://m2.mtmt.hu/api/publication/34226087 ID - 34226087 N1 - Export Date: 26 July 2024 Correspondence Address: Matuz, A.; Department of Behavioural Sciences, Hungary; email: andras.matuz@aok.pte.hu AB - Neuroimaging studies investigating the association between mental fatigue (henceforth fatigue) and brain physiology have identified many brain regions that may underly the cognitive changes induced by fatigue. These studies focused on the functional changes and functional connectivity of the brain relating to fatigue. The structural correlates of fatigue, however, have received little attention. To fill this gap, this study explored the associations of fatigue with cortical thickness of frontal and parietal regions. In addition, we aimed to explore the associations between reward-induced improvement in performance and neuroanatomical markers in fatigued individuals. Thirty-nine healthy volunteers performed the psychomotor vigilance task for 15 min (i.e., 3 time-on-task blocks of 5 min) out of scanner; followed by an additional rewarded block of the task lasting 5 min. Baseline high-resolution T1-weigthed MR images were obtained. Reaction time increased with time-on-task but got faster again in the rewarded block. Participants’ subjective fatigue increased during task performance. In addition, we found that higher increase in subjective mental fatigue was associated with the cortical thickness of the following areas: bilateral precuneus, right precentral gyrus; right pars triangularis and left superior frontal gyrus. Our results suggest that individual differences in subjective mental fatigue may be explained by differences in the degree of cortical thickness of areas that are associated with motor processes, executive functions, intrinsic alertness and are parts of the default mode network. LA - English DB - MTMT ER - TY - JOUR AU - Perlaki, Gábor AU - Darnai, Gergely AU - Arató, Ákos AU - Alhour, Husamalddin Ali Mohammad AU - Szente, Anna Tímea AU - Áfra, Eszter AU - Nagy, Szilvia Anett AU - Horváth, Réka AU - Kovács, Norbert AU - Dóczi, Tamás Péter AU - Orsi, Gergely AU - Janszky, József Vladimír TI - Gray Matter Changes Following Mild COVID-19 : An MR Morphometric Study in Healthy Young People JF - JOURNAL OF MAGNETIC RESONANCE IMAGING J2 - JMRI - J MAGN RESON IM VL - 59 PY - 2024 IS - 6 SP - 2152 EP - 2161 PG - 10 SN - 1053-1807 DO - 10.1002/jmri.28970 UR - https://m2.mtmt.hu/api/publication/34113102 ID - 34113102 N1 - * Megosztott szerzőség AB - Although COVID-19 is primarily an acute respiratory infection, 5%-40% of patients develop late and prolonged symptoms with frequent neurological complaints, known as long COVID syndrome. The presentation of the disease suggests that COVID infection may cause functional and/or morphological central nervous system alterations, but studies published in the literature report contradictory findings.To investigate the chronic effects of COVID-19 on cerebral grey matter in a group of young patients without comorbidities, with mild course of COVID infection and no medical complaints at the time of examination.Prospective.Thirty-eight young (age = 26.6 ± 5.0 years; male/female = 14/24), adult participants who recovered from mild COVID infection without a history of clinical long COVID and 37 healthy control subjects (age = 25.9 ± 2.8 years; male/female = 14/23).Three Tesla, 3D T1-weighted magnetization-prepared rapid gradient-echo, 2D T2-weighted turbo spin-echo.MRI-based morphometry and volumetry along with neuropsychological testing and self-assessed questionnaire.Fisher's exact test, Mann-Whitney U-test, and multiple linear regression analyses were used to assess differences between COVID and healthy control groups. P < 0.05 was used as cutoff for significance.In the COVID group, significantly lower bilateral mean cortical thickness (left/right-hemisphere: 2.51 ± 0.06 mm vs. 2.56 ± 0.07 mm, η2 p = 0.102/2.50 ± 0.06 mm vs. 2.54 ± 0.07 mm, η2 p = 0.101), lower subcortical gray matter (57881 ± 3998 mm3 vs. 60470 ± 5211 mm3 , η2 p = 0.100) and lower right olfactory bulb volume (52.28 ± 13.55 mm3 vs. 60.98 ± 15.8 mm3 , η2 p = 0.078) were found. In patients with moderate to severe anosmia, cortical thickness was significantly lower bilaterally, as compared to patients without olfactory function loss (left/right-hemisphere: 2.50 ± 0.06 mm vs. 2.56 ± 0.05 mm, η2 = 0.173/2.49 ± 0.06 mm vs. 2.55 ± 0.05 mm, η2 = 0.189). Using further exploratory analysis, significantly reduced cortical thickness was detected locally in the right lateral orbitofrontal cortex in the COVID group (2.53 ± 0.10 mm vs. 2.60 ± 0.09 mm, η2 p = 0.112).Even without any subjective or objective neurological complaints at the time of the MR scan, subjects in the COVID group showed gray matter alterations in cortical thickness and subcortical gray matter volume.2 TECHNICAL EFFICACY: Stage 3. LA - English DB - MTMT ER - TY - GEN AU - Szőcs, Szilárd AU - Kovács, Tamás AU - Henn-Mike, Nóra AU - Tóth, Márton AU - Agócs-Laboda, Ágnes AU - Dóczi, Tamás Péter AU - Horváth, Zsolt AU - Janszky, József Vladimír AU - Varga, Csaba TI - Altered h-current in cortical interneurons of drug-resistant epileptic patients PY - 2023 UR - https://m2.mtmt.hu/api/publication/35293613 ID - 35293613 LA - English DB - MTMT ER - TY - GEN AU - Pintér, Dávid AU - Harmat, Márk AU - Rohonczi, Mirtill AU - Aschermann, Zsuzsanna AU - Janszky, József Vladimír AU - Kovács, Norbert TI - Amikor a haszon (még) ellensúlyozza a kockázatot: Egy LECIG kezelésben részesülő Parkinson-kóros beteg esete PY - 2023 UR - https://m2.mtmt.hu/api/publication/34123923 ID - 34123923 LA - Hungarian DB - MTMT ER -