@article{MTMT:35201713, title = {A quick balance assessment tool for all clinical settings: validity and reliability of the Hungarian version of the activities-specific balance confidence scale}, url = {https://m2.mtmt.hu/api/publication/35201713}, author = {Ruszin-Perecz, Brigitta and Makai, Alexandra and Pozsgai, Miklós and Csizmadiáné Nusser, Nóra and Pál, Endre and Kovács, Norbert and Janszky, József Vladimír and Járomi, Melinda and Sebők, Ágnes}, doi = {10.1080/09593985.2024.2396074}, journal-iso = {PHYSIOTHER THEOR PR}, journal = {PHYSIOTHERAPY THEORY AND PRACTICE}, unique-id = {35201713}, issn = {0959-3985}, year = {2024}, eissn = {1532-5040}, orcid-numbers = {Makai, Alexandra/0000-0002-1907-120X; Kovács, Norbert/0000-0002-7332-9240; Janszky, József Vladimír/0000-0001-6100-832X} } @article{MTMT:35172480, title = {Management of autoimmune temporal lobe epilepsy with GAD65 antibody: four case reports}, url = {https://m2.mtmt.hu/api/publication/35172480}, author = {Janszky, József Vladimír and Bóné, Beáta and Karádi, Kázmér and Barsi, Péter and Juhos, Vera and Berta, Anikó and Trischlerné Gyimesi, Csilla and Tényi, Dalma and Horváth, Réka}, doi = {10.5603/pjnns.98738}, journal-iso = {NEUROL NEUROCHIR POL}, journal = {NEUROLOGIA I NEUROCHIRURGIA POLSKA}, volume = {58}, unique-id = {35172480}, issn = {0028-3843}, abstract = {Aim of study. Glutamate decarboxylase (GAD) enzyme can be a target intracellular antigen in autoimmune focal epilepsy. GAD65 antibody is in found patients diagnosed with drug-refractory temporal lobe epilepsy (TLE). We explore the clinical features of the disease and therapeutic options. Material and methods. We present the cases of four TLE patients, two of them with type 1 diabetes. All of them were drug-resistant and therefore underwent presurgical evaluation, which revealed GAD65 antibody positivity. We discuss the four GAD65 antibody positive temporal lobe epilepsy patients' electroclinical data, the treatments, and their effectiveness. Results. One of them became seizure-free after right anterior temporal lobe resection, two of them did not show significant improvement with immunmodulatory agents, and the fourth patient with the shortest duration of disease had significant improvement in seizure status and normalisation of cognitive status with IVIg therapy. Conclusions and clinical implications. Our cases show that the earlier a GAD65 antibody is detected, the greater the chance of achieving seizure freedom or improvements in both seizure and cognitive status with immunomodulatory agents. However, in some cases, surgery may also bring seizure freedom, but with a risk of cognitive deterioration.}, keywords = {GLUTAMIC-ACID DECARBOXYLASE; drug-refractory epilepsy; GAD 65 antibody; immunomodulation in focal epilepsy}, year = {2024}, eissn = {1897-4260}, pages = {453-458}, orcid-numbers = {Janszky, József Vladimír/0000-0001-6100-832X; Barsi, Péter/0000-0002-3574-9973} } @{MTMT:34823733, title = {Poszttraumás convulsiók}, url = {https://m2.mtmt.hu/api/publication/34823733}, author = {Janszky, József Vladimír}, booktitle = {Súlyos baleseti agysérültek ellátása}, unique-id = {34823733}, year = {2024}, pages = {181-182}, orcid-numbers = {Janszky, József Vladimír/0000-0001-6100-832X} } @article{MTMT:34800559, title = {Prevalence of celebrity worship: Development and application of the short version of the Celebrity Attitude Scale (CAS-7) on a large-scale representative sample}, url = {https://m2.mtmt.hu/api/publication/34800559}, author = {Zsila, Ágnes and McCutcheon, Lynn E. and Horváth, Rita and Urbán, Róbert and Paksi, Borbála and Darnai, Gergely and Janszky, József Vladimír and Demetrovics, Zsolt}, doi = {10.1556/2006.2024.00019}, journal-iso = {J BEHAV ADDICT}, journal = {JOURNAL OF BEHAVIORAL ADDICTIONS}, volume = {13}, unique-id = {34800559}, issn = {2062-5871}, year = {2024}, eissn = {2063-5303}, pages = {463-472}, orcid-numbers = {Zsila, Ágnes/0000-0002-8291-5997; Horváth, Rita/0009-0005-2662-2136; Urbán, Róbert/0000-0002-2058-5937; Paksi, Borbála/0000-0002-3616-2867; Darnai, Gergely/0000-0002-7042-8059; Janszky, József Vladimír/0000-0001-6100-832X; Demetrovics, Zsolt/0000-0001-5604-7551} } @article{MTMT:34733371, title = {104-week efficacy and safety of cipaglucosidase alfa plus miglustat in adults with late-onset Pompe disease. a phase III open-label extension study (ATB200-07).}, url = {https://m2.mtmt.hu/api/publication/34733371}, author = {Schoser, Benedikt and Kishnani, Priya S and Bratkovic, Drago and Byrne, Barry J and Claeys, Kristl G and Díaz-Manera, Jordi and Laforêt, Pascal and Roberts, Mark and Toscano, Antonio and van der Ploeg, Ans T and Castelli, Jeff and Goldman, Mitchell and Holdbrook, Fred and Sitaraman Das, Sheela and Wasfi, Yasmine and Mozaffar, Tahseen}, doi = {10.1007/s00415-024-12236-0}, journal-iso = {J NEUROL}, journal = {JOURNAL OF NEUROLOGY}, volume = {271}, unique-id = {34733371}, issn = {0340-5354}, abstract = {The phase III double-blind PROPEL study compared the novel two-component therapy cipaglucosidase alfa + miglustat (cipa + mig) with alglucosidase alfa + placebo (alg + pbo) in adults with late-onset Pompe disease (LOPD). This ongoing open-label extension (OLE; NCT04138277) evaluates long-term safety and efficacy of cipa + mig. Outcomes include 6-min walk distance (6MWD), forced vital capacity (FVC), creatine kinase (CK) and hexose tetrasaccharide (Hex4) levels, patient-reported outcomes and safety. Data are reported as change from PROPEL baseline to OLE week 52 (104 weeks post-PROPEL baseline). Of 118 patients treated in the OLE, 81 continued cipa + mig treatment from PROPEL (cipa + mig group; 61 enzyme replacement therapy [ERT] experienced prior to PROPEL; 20 ERT naïve) and 37 switched from alg + pbo to cipa + mig (switch group; 29 ERT experienced; 8 ERT naive). Mean (standard deviation [SD]) change in % predicted 6MWD from baseline to week 104 was + 3.1 (8.1) for cipa + mig and - 0.5 (7.8) for the ERT-experienced switch group, and + 8.6 (8.6) for cipa + mig and + 8.9 (11.7) for the ERT-naïve switch group. Mean (SD) change in % predicted FVC was - 0.6 (7.5) for cipa + mig and - 3.8 (6.2) for the ERT-experienced switch group, and - 4.8 (6.5) and - 3.1 (6.7), respectively, in ERT-naïve patients. CK and Hex4 levels improved in both treatment groups by week 104 with cipa + mig treatment. Three patients discontinued the OLE due to infusion-associated reactions. No new safety signals were identified. Cipa + mig treatment up to 104 weeks was associated with overall maintained improvements (6MWD, biomarkers) or stabilization (FVC) from baseline with continued durability, and was well tolerated, supporting long-term benefits for patients with LOPD.Trial registration number: NCT04138277; trial start date: December 18, 2019.}, keywords = {Glycogen Storage Disease Type II; Myozyme; alpha glucosidase; Lysosomal storage disorders; N-BUTYLDEOXYNOJIRIMYCIN}, year = {2024}, eissn = {1432-1459}, pages = {2810-2823}, orcid-numbers = {Janszky, József Vladimír/0000-0001-6100-832X; Molnár, Mária Judit/0000-0001-9350-1864} } @article{MTMT:34420912, title = {Altered functional brain networks in problematic smartphone and social media use: resting-state fMRI study}, url = {https://m2.mtmt.hu/api/publication/34420912}, author = {Áfra, Eszter and Janszky, József Vladimír and Perlaki, Gábor and Orsi, Gergely and Nagy, Szilvia Anett and Arató, Ákos and Szente, Anna Tímea and Alhour, Husamalddin Ali Mohammad and Kis-Jakab, Gréta and Darnai, Gergely}, doi = {10.1007/s11682-023-00825-y}, journal-iso = {BRAIN IMAGING BEHAV}, journal = {BRAIN IMAGING AND BEHAVIOR}, volume = {18}, unique-id = {34420912}, issn = {1931-7557}, abstract = {Nowadays, the limitless availability to the World Wide Web can lead to general Internet misuse and dependence. Currently, smartphone and social media use belong to the most prevalent Internet-related behavioral addiction forms. However, the neurobiological background of these Internet-related behavioral addictions is not sufficiently explored. In this study, these addiction forms were assessed with self-reported questionnaires. Resting-state functional magnetic resonance imaging was acquired for all participants ( n = 59, 29 males) to examine functional brain networks. The resting-state networks that were discovered using independent component analysis were analyzed to estimate within network differences. Significant negative associations with social media addiction and smartphone addiction were found in the language network, the lateral visual networks, the auditory network, the sensorimotor network, the executive network and the frontoparietal network. These results suggest that problematic smartphone and social media use are associated with sensory processing and higher cognitive functioning .}, year = {2024}, eissn = {1931-7565}, pages = {292-301}, orcid-numbers = {Janszky, József Vladimír/0000-0001-6100-832X; Nagy, Szilvia Anett/0000-0001-6483-9209; Alhour, Husamalddin Ali Mohammad/0000-0001-5841-1652} } @article{MTMT:34226087, title = {Structural neural correlates of mental fatigue and reward-induced improvement in performance}, url = {https://m2.mtmt.hu/api/publication/34226087}, author = {Matuz, András and Darnai, Gergely and Zsidó, András Norbert and Janszky, József Vladimír and Csathó, Árpád}, doi = {10.1007/s42977-023-00187-y}, journal-iso = {BIOL FUTURA}, journal = {BIOLOGIA FUTURA}, volume = {75}, unique-id = {34226087}, issn = {2676-8615}, abstract = {Neuroimaging studies investigating the association between mental fatigue (henceforth fatigue) and brain physiology have identified many brain regions that may underly the cognitive changes induced by fatigue. These studies focused on the functional changes and functional connectivity of the brain relating to fatigue. The structural correlates of fatigue, however, have received little attention. To fill this gap, this study explored the associations of fatigue with cortical thickness of frontal and parietal regions. In addition, we aimed to explore the associations between reward-induced improvement in performance and neuroanatomical markers in fatigued individuals. Thirty-nine healthy volunteers performed the psychomotor vigilance task for 15 min (i.e., 3 time-on-task blocks of 5 min) out of scanner; followed by an additional rewarded block of the task lasting 5 min. Baseline high-resolution T1-weigthed MR images were obtained. Reaction time increased with time-on-task but got faster again in the rewarded block. Participants’ subjective fatigue increased during task performance. In addition, we found that higher increase in subjective mental fatigue was associated with the cortical thickness of the following areas: bilateral precuneus, right precentral gyrus; right pars triangularis and left superior frontal gyrus. Our results suggest that individual differences in subjective mental fatigue may be explained by differences in the degree of cortical thickness of areas that are associated with motor processes, executive functions, intrinsic alertness and are parts of the default mode network.}, year = {2024}, eissn = {2676-8607}, pages = {93-104}, orcid-numbers = {Zsidó, András Norbert/0000-0003-0506-6861; Janszky, József Vladimír/0000-0001-6100-832X} } @article{MTMT:34113102, title = {Gray Matter Changes Following Mild COVID-19 : An MR Morphometric Study in Healthy Young People}, url = {https://m2.mtmt.hu/api/publication/34113102}, author = {Perlaki, Gábor and Darnai, Gergely and Arató, Ákos and Alhour, Husamalddin Ali Mohammad and Szente, Anna Tímea and Áfra, Eszter and Nagy, Szilvia Anett and Horváth, Réka and Kovács, Norbert and Dóczi, Tamás Péter and Orsi, Gergely and Janszky, József Vladimír}, doi = {10.1002/jmri.28970}, journal-iso = {JMRI - J MAGN RESON IM}, journal = {JOURNAL OF MAGNETIC RESONANCE IMAGING}, volume = {59}, unique-id = {34113102}, issn = {1053-1807}, abstract = {Although COVID-19 is primarily an acute respiratory infection, 5%-40% of patients develop late and prolonged symptoms with frequent neurological complaints, known as long COVID syndrome. The presentation of the disease suggests that COVID infection may cause functional and/or morphological central nervous system alterations, but studies published in the literature report contradictory findings.To investigate the chronic effects of COVID-19 on cerebral grey matter in a group of young patients without comorbidities, with mild course of COVID infection and no medical complaints at the time of examination.Prospective.Thirty-eight young (age = 26.6 ± 5.0 years; male/female = 14/24), adult participants who recovered from mild COVID infection without a history of clinical long COVID and 37 healthy control subjects (age = 25.9 ± 2.8 years; male/female = 14/23).Three Tesla, 3D T1-weighted magnetization-prepared rapid gradient-echo, 2D T2-weighted turbo spin-echo.MRI-based morphometry and volumetry along with neuropsychological testing and self-assessed questionnaire.Fisher's exact test, Mann-Whitney U-test, and multiple linear regression analyses were used to assess differences between COVID and healthy control groups. P < 0.05 was used as cutoff for significance.In the COVID group, significantly lower bilateral mean cortical thickness (left/right-hemisphere: 2.51 ± 0.06 mm vs. 2.56 ± 0.07 mm, η2 p = 0.102/2.50 ± 0.06 mm vs. 2.54 ± 0.07 mm, η2 p = 0.101), lower subcortical gray matter (57881 ± 3998 mm3 vs. 60470 ± 5211 mm3 , η2 p = 0.100) and lower right olfactory bulb volume (52.28 ± 13.55 mm3 vs. 60.98 ± 15.8 mm3 , η2 p = 0.078) were found. In patients with moderate to severe anosmia, cortical thickness was significantly lower bilaterally, as compared to patients without olfactory function loss (left/right-hemisphere: 2.50 ± 0.06 mm vs. 2.56 ± 0.05 mm, η2 = 0.173/2.49 ± 0.06 mm vs. 2.55 ± 0.05 mm, η2 = 0.189). Using further exploratory analysis, significantly reduced cortical thickness was detected locally in the right lateral orbitofrontal cortex in the COVID group (2.53 ± 0.10 mm vs. 2.60 ± 0.09 mm, η2 p = 0.112).Even without any subjective or objective neurological complaints at the time of the MR scan, subjects in the COVID group showed gray matter alterations in cortical thickness and subcortical gray matter volume.2 TECHNICAL EFFICACY: Stage 3.}, keywords = {Brain; morphometry; cortical thickness; SARS-CoV-2}, year = {2024}, eissn = {1522-2586}, pages = {2152-2161}, orcid-numbers = {Alhour, Husamalddin Ali Mohammad/0000-0001-5841-1652; Nagy, Szilvia Anett/0000-0001-6483-9209; Kovács, Norbert/0000-0002-7332-9240; Janszky, József Vladimír/0000-0001-6100-832X} } @misc{MTMT:35293613, title = {Altered h-current in cortical interneurons of drug-resistant epileptic patients}, url = {https://m2.mtmt.hu/api/publication/35293613}, author = {Szőcs, Szilárd and Kovács, Tamás and Henn-Mike, Nóra and Tóth, Márton and Agócs-Laboda, Ágnes and Dóczi, Tamás Péter and Horváth, Zsolt and Janszky, József Vladimír and Varga, Csaba}, unique-id = {35293613}, year = {2023}, orcid-numbers = {Janszky, József Vladimír/0000-0001-6100-832X} } @misc{MTMT:34123923, title = {Amikor a haszon (még) ellensúlyozza a kockázatot: Egy LECIG kezelésben részesülő Parkinson-kóros beteg esete}, url = {https://m2.mtmt.hu/api/publication/34123923}, author = {Pintér, Dávid and Harmat, Márk and Rohonczi, Mirtill and Aschermann, Zsuzsanna and Janszky, József Vladimír and Kovács, Norbert}, unique-id = {34123923}, year = {2023}, orcid-numbers = {Janszky, József Vladimír/0000-0001-6100-832X; Kovács, Norbert/0000-0002-7332-9240} }