@article{MTMT:33254004, title = {Decreasing effects of protein kinase inhibitors on the expression of NOS2 and inflammatory cytokines and on phagocytosis in rat peritoneal macrophages is partly related to repolarization}, url = {https://m2.mtmt.hu/api/publication/33254004}, author = {Hrabák, András and Bőgel, Gábor and Murányi, József and Tamási, Viola and Németh, Krisztina and Szokol, Bálint and Kukor, Zoltán and Kardon Tamás, Zoltán and Őrfi, László}, doi = {10.1016/j.molimm.2022.11.002}, journal-iso = {MOL IMMUNOL}, journal = {MOLECULAR IMMUNOLOGY}, volume = {153}, unique-id = {33254004}, issn = {0161-5890}, year = {2023}, eissn = {1872-9142}, pages = {10-24}, orcid-numbers = {Hrabák, András/0000-0002-7818-6509; Bőgel, Gábor/0000-0002-7677-6855; Tamási, Viola/0000-0001-7419-5603; Németh, Krisztina/0000-0002-3825-2137; Kukor, Zoltán/0000-0002-7250-2160; Őrfi, László/0000-0001-6149-2385} } @article{MTMT:33034057, title = {Effect of Pravastatin and Simvastatin on the Reduction of Cytochrome C.}, url = {https://m2.mtmt.hu/api/publication/33034057}, author = {Csomó, Krisztián Benedek and Belik, Andrea and Hrabák, András and Kovács, Bence Géza and Fábián, Orsolya and Valent, Sándor and Varga, Gábor and Kukor, Zoltán}, doi = {10.3390/jpm12071121}, journal-iso = {J PERS MED}, journal = {JOURNAL OF PERSONALIZED MEDICINE}, volume = {12}, unique-id = {33034057}, abstract = {Statins are used to treat hypercholesterolemia, with several pleiotropic effects. Alongside their positive effects (for example, decreasing blood pressure), they can also bring about negative effects/symptoms (such as myopathy). Their main mechanism of action is inducing apoptosis, the key step being the release of cytochrome c from the mitochondria. This can be facilitated by oxidative stress, through which glutathione is oxidized. In this research, glutathione was used as a respiratory substrate to measure the mitochondrial oxygen consumption of rat liver with an O2 electrode. The reduction of cytochrome c was monitored photometrically. Hydrophilic (pravastatin) and lipophilic (simvastatin) statins were used for the measurements. Pravastatin reduces the reduction of cytochrome c and the oxygen consumption of the mitochondria, while simvastatin, on the other hand, increases the reduction of cytochrome c and the mitochondrial oxygen consumption. The results make it seem probable that statins influence the mitochondrial oxygen consumption through cytochrome c. Simvastatin could enhance the oxidizing capacity of free cytochrome c, thereby increasing oxidative stress and thus facilitating apoptosis. The observed effects could further the understanding of the mechanism of action of statins and thereby aid in constructing optimal statin therapy for every patient.}, keywords = {APOPTOSIS; Cytochrome c; PREECLAMPSIA; hypercholesterolemia; Statins; mitochondrial oxygen consumption}, year = {2022}, eissn = {2075-4426}, orcid-numbers = {Csomó, Krisztián Benedek/0000-0002-3749-6391; Belik, Andrea/0000-0002-8146-2009; Hrabák, András/0000-0002-7818-6509; Kovács, Bence Géza/0000-0002-5578-1858; Valent, Sándor/0000-0003-1098-1861; Varga, Gábor/0000-0002-5506-8198; Kukor, Zoltán/0000-0002-7250-2160} } @article{MTMT:32574856, title = {Production of NOS2 and inflammatory cytokines is reduced by selected protein kinase inhibitors with partial repolarization of HL-60 derived and human blood macrophages}, url = {https://m2.mtmt.hu/api/publication/32574856}, author = {Bőgel, Gábor and Murányi, József and Szokol, Bálint and Kukor, Zoltán and Móra , István András and Kardon Tamás, Zoltán and Őrfi, László and Hrabák, András}, doi = {10.1016/j.heliyon.2021.e08670}, journal-iso = {HELIYON}, journal = {HELIYON}, volume = {8}, unique-id = {32574856}, year = {2022}, eissn = {2405-8440}, orcid-numbers = {Bőgel, Gábor/0000-0002-7677-6855; Kukor, Zoltán/0000-0002-7250-2160; Őrfi, László/0000-0001-6149-2385; Hrabák, András/0000-0002-7818-6509} } @article{MTMT:32534532, title = {Characterization of oxidation of glutathione by cytochrome c}, url = {https://m2.mtmt.hu/api/publication/32534532}, author = {Csomó, Krisztián Benedek and Alasztics, Bálint and Sándor, A. P. and Belik, Andrea and Varga, Gábor and Hrabák, András and Kukor, Zoltán}, doi = {10.1007/s10863-021-09926-z}, journal-iso = {J BIOENERG BIOMEMBR}, journal = {JOURNAL OF BIOENERGETICS AND BIOMEMBRANES}, volume = {54}, unique-id = {32534532}, issn = {0145-479X}, year = {2022}, eissn = {1573-6881}, pages = {1-8}, orcid-numbers = {Csomó, Krisztián Benedek/0000-0002-3749-6391; Alasztics, Bálint/0000-0002-4011-8439; Belik, Andrea/0000-0002-8146-2009; Varga, Gábor/0000-0002-5506-8198; Hrabák, András/0000-0002-7818-6509; Kukor, Zoltán/0000-0002-7250-2160} } @article{MTMT:30929732, title = {Pravastatin induces NO synthesis by enhancing microsomal arginine uptake in healthy and preeclamptic placentas}, url = {https://m2.mtmt.hu/api/publication/30929732}, author = {Pánczél, Zita and Kukor, Zoltán and Supák, Dorina and Kovács, Bence Géza and Kecskeméti, András and Czizel, Rita and Djurecz, Magdolna and Alasztics, Bálint and Csomó, Krisztián Benedek and Hrabák, András and Valent, Sándor}, doi = {10.1186/s12884-019-2507-0}, journal-iso = {BMC PREGNANCY CHILDB}, journal = {BMC PREGNANCY AND CHILDBIRTH}, volume = {19}, unique-id = {30929732}, issn = {1471-2393}, year = {2019}, eissn = {1471-2393}, orcid-numbers = {Pánczél, Zita/0000-0003-4496-6280; Kukor, Zoltán/0000-0002-7250-2160; Kovács, Bence Géza/0000-0002-5578-1858; Kecskeméti, András/0000-0001-5314-3927; Alasztics, Bálint/0000-0002-4011-8439; Csomó, Krisztián Benedek/0000-0002-3749-6391; Hrabák, András/0000-0002-7818-6509; Valent, Sándor/0000-0003-1098-1861} } @{MTMT:30556140, title = {Lipidek anyagcseréje}, url = {https://m2.mtmt.hu/api/publication/30556140}, author = {Hrabák, András}, booktitle = {Biokémia, molekuláris és sejtbiológia}, unique-id = {30556140}, year = {2018}, pages = {304-338}, orcid-numbers = {Hrabák, András/0000-0002-7818-6509} } @{MTMT:3105245, title = {Is Arginine Truly a “Miracle Molecule” ?: A Critical Evaluation of Nutritional Arginine Supplementation from a Biochemical Point of View}, url = {https://m2.mtmt.hu/api/publication/3105245}, author = {Hrabák, András and Kukor, Zoltán}, booktitle = {L-Arginine: Structure, Dietary Sources and Beneficial Effects}, unique-id = {3105245}, year = {2016}, pages = {1-46}, orcid-numbers = {Hrabák, András/0000-0002-7818-6509; Kukor, Zoltán/0000-0002-7250-2160} } @article{MTMT:3102371, title = {17-beta-estradiol Decreases Neutrophil Superoxide Production through Rac1}, url = {https://m2.mtmt.hu/api/publication/3102371}, author = {Marczell, István and Hrabák, András and Nyírő, Gábor and Patócs, Attila Balázs and Stark, Júlia and Dinya, Elek and Kukor, Zoltán and Tóth, Sára and Tulassay, Zsolt and Rácz, Károly and Békési, Gábor}, doi = {10.1055/s-0042-105556}, journal-iso = {EXP CLIN ENDOCR DIAB}, journal = {EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES}, volume = {124}, unique-id = {3102371}, issn = {0947-7349}, abstract = {Neutrophil granulocytes form the biggest free radical producing system of the human body. The importance of this system in atherosclerotic plaque formation and other free radical mediated disorders is confirmed by both in vivo and in vitro studies. Estrogen's effect on free radical production involves multiple estrogen receptors and occurs both on transcriptional and on protein phosphorylational level. Estrogen decreases the superoxide production of neutrophil granulocytes in such a short time frame it is unlikely to be mediated by transcription regulation. We investigated the underlying mechanism through which the mentioned estrogen effect takes place using an immunabsorption-based method. Phosphorylation data of 43 different messenger proteins were used for pathway analysis. The newly identified pathway involved largely second messengers from previously described non-genomic estrogen effects and affected superoxide production via Rac1 - an important regulator of free radical production and chemotaxis. Selective inhibition of the participating second messengers altered superoxide production in the predicted direction confirming that this pathway is at least partly responsible for the effect of 17-beta-estradiol on chemoattractant induced superoxide production.}, year = {2016}, eissn = {1439-3646}, pages = {588-592}, orcid-numbers = {Hrabák, András/0000-0002-7818-6509; Nyírő, Gábor/0000-0002-0248-0007; Patócs, Attila Balázs/0000-0001-7506-674X; Dinya, Elek/0000-0002-2620-8649; Kukor, Zoltán/0000-0002-7250-2160; Tóth, Sára/0000-0001-9852-0458; Tulassay, Zsolt/0000-0003-2452-6640; Békési, Gábor/0000-0002-1142-1930} } @{MTMT:2892042, title = {Lipidek anyagcseréje}, url = {https://m2.mtmt.hu/api/publication/2892042}, author = {Hrabák, András}, booktitle = {Biokémia, molekuláris és sejtbiológia}, unique-id = {2892042}, year = {2015}, pages = {262-297}, orcid-numbers = {Hrabák, András/0000-0002-7818-6509} } @book{MTMT:2820555, title = {Molekuláris biológiai módszerek 2. bővített kiadás. Egészségügyi mérnökhallgatók számára}, url = {https://m2.mtmt.hu/api/publication/2820555}, isbn = {9789633311578}, author = {Hrabák, András}, publisher = {Semmelweis Kiadó és Multimédia Stúdió Kft.}, unique-id = {2820555}, year = {2014}, orcid-numbers = {Hrabák, András/0000-0002-7818-6509} }