@article{MTMT:35220164,
	title = {Embryonic Leucine Promotes Early Postnatal Growth via mTOR Signalling in Japanese Quails},
	url = {https://m2.mtmt.hu/api/publication/35220164},
	author = {Ndunguru, Sawadi Fransisco and Gebrehaweria Kidane, Reda and Csernus, Brigitta and Knop, Renáta and Lugata, James Kachungwa and Szabó, Csaba and Lendvai, Ádám Zoltán and Czeglédi, Levente},
	doi = {10.3390/ani14172596},
	journal-iso = {ANIMALS-BASEL},
	journal = {ANIMALS},
	volume = {14},
	unique-id = {35220164},
	abstract = {Nutritional cues during embryonic development can alter developmental trajectories and affect postnatal growth. However, the specific mechanisms by which nutrients influence avian growth remain largely unknown. Amino acids can directly interact with the nutrient-sensing pathways, such as the insulin-like growth factor 1 (IGF-1)/mechanistic target of rapamycin (mTOR) pathways, which are known to regulate growth. We examined the effects of embryonic leucine on gene expression and phenotypic growth in Japanese quails by injecting 2.5 mg leucine or saline (control) into Japanese quail eggs on the tenth day of incubation and incubating them under standard conditions. The treatment groups had similar hatching success and size at hatching. However, between 3 and 7 days post-hatching, quails treated with embryonic leucine showed increased growth in body mass and wing, tarsus, head, and intestinal lengths, lasting up to 21 days. The hepatic expression of IGF1, IGF1R, mTOR, and RPS6K1 was upregulated in leucine-treated quails, while the expression of FOXO1 remained unaffected. In conclusion, a subtle increase in embryonic leucine may induce developmental programming effects in Japanese quail by interacting with the IGF-1/mTOR nutrient-sensing pathway to promote growth. This study highlights the role of embryonic amino acids as crucial nutrients for enhancing growth. It provides valuable insight into nutrient intervention strategies during embryonic development to potentially improve poultry growth performance.},
	year = {2024},
	eissn = {2076-2615},
	orcid-numbers = {Lendvai, Ádám Zoltán/0000-0002-8953-920X}
}

@article{MTMT:35166359,
	title = {Trophic guilds differ in blood glucose concentrations: a phylogenetic comparative analysis in birds},
	url = {https://m2.mtmt.hu/api/publication/35166359},
	author = {Szarka, Endre Zoltán and Lendvai, Ádám Zoltán},
	doi = {10.1098/rspb.2023.2655},
	journal-iso = {P ROY SOC B-BIOL SCI},
	journal = {PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES},
	volume = {291},
	unique-id = {35166359},
	issn = {0962-8452},
	abstract = {Glucose is a central metabolic compound used as an energy source across all animal taxa. There is high interspecific variation in glucose concentration between taxa, the origin and the consequence of which remain largely unknown. Nutrition may affect glucose concentrations because carbohydrate content of different food sources may determine the importance of metabolic pathways in the organism. Birds sustain high glucose concentrations that may entail the risks of oxidative damage. We collected glucose concentration and life-history data from 202 bird species from 171 scientific publications, classified them into seven trophic guilds and analysed the data with a phylogenetically controlled model. We show that glucose concentration is negatively associated with body weight and is significantly associated with trophic guilds with a moderate phylogenetic signal. After controlling for allometry, glucose concentrations were highest in carnivorous birds, which rely on high rates of gluconeogenesis to maintain their glycaemia, and lowest in frugivorous/nectarivorous species, which take in carbohydrates directly. However, trophic guilds with different glucose concentrations did not differ in lifespan. These results link nutritional ecology to physiology and suggest that at the macroevolutionary scale, species requiring constantly elevated glucose concentrations may have additional adaptations to avoid the risks associated with high glycaemia.},
	year = {2024},
	eissn = {1471-2954},
	orcid-numbers = {Lendvai, Ádám Zoltán/0000-0002-8953-920X}
}

@article{MTMT:35155022,
	title = {Urban house finches are more resistant to the effects of artificial light at night},
	url = {https://m2.mtmt.hu/api/publication/35155022},
	author = {Hutton, P. and Lendvai, Ádám Zoltán and Németh, J. and McGraw, K.J.},
	doi = {10.1016/j.scitotenv.2024.174525},
	journal-iso = {SCI TOTAL ENVIRON},
	journal = {SCIENCE OF THE TOTAL ENVIRONMENT},
	volume = {946},
	unique-id = {35155022},
	issn = {0048-9697},
	year = {2024},
	eissn = {1879-1026},
	orcid-numbers = {Lendvai, Ádám Zoltán/0000-0002-8953-920X}
}

@article{MTMT:35117298,
	title = {Author Correction: Dietary restriction reveals sex-specific expression of the mTOR pathway genes in Japanese quails},
	url = {https://m2.mtmt.hu/api/publication/35117298},
	author = {Gebrehaweria Kidane, Reda and Ndunguru, Sawadi Fransisco and Csernus, Brigitta and Knop, Renáta and Lugata, James Kachungwa and Szabó, Csaba and Czeglédi, Levente and Lendvai, Ádám Zoltán},
	doi = {10.1038/s41598-024-63532-8},
	journal-iso = {SCI REP},
	journal = {SCIENTIFIC REPORTS},
	volume = {14},
	unique-id = {35117298},
	issn = {2045-2322},
	year = {2024},
	eissn = {2045-2322},
	orcid-numbers = {Lendvai, Ádám Zoltán/0000-0002-8953-920X}
}

@article{MTMT:35083305,
	title = {IGF-1 induces sex-specific oxidative damage and mortality in a songbird},
	url = {https://m2.mtmt.hu/api/publication/35083305},
	author = {Lendvai, Ádám Zoltán and Tóth, Zsófia and Katharina, Mahr and Janka, Pénzes and Sarah, Vogel-Kindgen and Bruno, A. Gander and Vágási, István Csongor},
	doi = {10.1007/s00442-024-05587-y},
	journal-iso = {OECOLOGIA},
	journal = {OECOLOGIA},
	volume = {205},
	unique-id = {35083305},
	issn = {0029-8549},
	year = {2024},
	eissn = {1432-1939},
	pages = {561-570},
	orcid-numbers = {Lendvai, Ádám Zoltán/0000-0002-8953-920X}
}

@{MTMT:35059208,
	title = {The effect of mtor and related signaling pathway on ageing in birds},
	url = {https://m2.mtmt.hu/api/publication/35059208},
	author = {Mequanint, Gashew and Lendvai, Ádám Zoltán and Czeglédi, Levente},
	booktitle = {21st Wellmann International Scientific Conference},
	unique-id = {35059208},
	year = {2024},
	pages = {34-35},
	orcid-numbers = {Lendvai, Ádám Zoltán/0000-0002-8953-920X}
}

@article{MTMT:34914296,
	title = {Sex‐specific effects of dietary restriction on physiological variables in Japanese quails},
	url = {https://m2.mtmt.hu/api/publication/34914296},
	author = {Gebrehaweria Kidane, Reda and Ndunguru, Sawadi Fransisco and Csernus, Brigitta and Lugata, James Kachungwa and Knop, Renáta and Szabó, Csaba and Czeglédi, Levente and Lendvai, Ádám Zoltán},
	doi = {10.1002/ece3.11405},
	journal-iso = {ECOL EVOL},
	journal = {ECOLOGY AND EVOLUTION},
	volume = {14},
	unique-id = {34914296},
	issn = {2045-7758},
	abstract = {Nutritional limitation is a common phenomenon in nature that leads to trade‐offs among processes competing for limited resources. These trade‐offs are mediated by changes in physiological traits such as growth factors and circulating lipids. However, studies addressing the sex‐specific effect of nutritional deficiency on these physiological variables are limited in birds. We used dietary restriction to mimic the depletion of resources to various degrees and investigated sex‐specific effects on circulating levels of insulin‐like growth factor 1 (IGF‐1) and triglycerides in Japanese quails ( Coturnix japonica ) subjected to ad libitum, 20%, 30% or 40% restriction of their daily requirement, for 2 weeks. We also explored the association of both physiological variables with body mass and egg production. While dietary restriction showed no effects on circulating IGF‐1, this hormone exhibited a marked sexual difference, with females having 64.7% higher IGF‐1 levels than males. Dietary restriction significantly reduced plasma triglyceride levels in both sexes. Females showed more than six‐fold higher triglyceride levels than males. Triglyceride levels were positively associated with body mass in females while showed not association in males. Overall, our findings revealed sex‐specific expression of physiological variables under dietary restriction conditions, which coincide with body size.},
	year = {2024},
	eissn = {2045-7758},
	orcid-numbers = {Lendvai, Ádám Zoltán/0000-0002-8953-920X}
}

@{MTMT:34794891,
	title = {Expression of nutrient sensing genes mediate the effect of dietary unpredictability in Japanese quails},
	url = {https://m2.mtmt.hu/api/publication/34794891},
	author = {Gebrehaweria Kidane, Reda and Ndunguru, Sawadi Fransisco and Csernus, Brigitta and Szabó, Csaba and Czeglédi, Levente and Lendvai, Ádám Zoltán},
	booktitle = {II. Magyar Agrártudományi Doktoranduszok Szimpóziuma 2024},
	unique-id = {34794891},
	year = {2024},
	pages = {27},
	orcid-numbers = {Lendvai, Ádám Zoltán/0000-0002-8953-920X}
}

@article{MTMT:34786100,
	title = {Dietary restriction reveals sex-specific expression of the mTOR pathway genes in Japanese quails},
	url = {https://m2.mtmt.hu/api/publication/34786100},
	author = {Gebrehaweria Kidane, Reda and Ndunguru, Sawadi Fransisco and Csernus, Brigitta and Knop, Renáta and Lugata, James Kachungwa and Szabó, Csaba and Czeglédi, Levente and Lendvai, Ádám Zoltán},
	doi = {10.1038/s41598-024-58487-9},
	journal-iso = {SCI REP},
	journal = {SCIENTIFIC REPORTS},
	volume = {14},
	unique-id = {34786100},
	issn = {2045-2322},
	abstract = {Limited resources affect an organism’s physiology through the conserved metabolic pathway, the mechanistic target of rapamycin (mTOR). Males and females often react differently to nutritional limitation, but whether it leads to differential mTOR pathway expression remains unknown. Recently, we found that dietary restriction (DR) induced significant changes in the expression of mTOR pathway genes in female Japanese quails ( Coturnix japonica ). We simultaneously exposed 32 male and female Japanese quails to either 20%, 30%, 40% restriction or ad libitum feeding for 14 days and determined the expression of six key genes of the mTOR pathway in the liver to investigate sex differences in the expression patterns. We found that DR significantly reduced body mass, albeit the effect was milder in males compared to females. We observed sex-specific liver gene expression. DR downregulated mTOR expression more in females than in males. Under moderate DR, ATG9A and RPS6K1 expressions were increased more in males than in females. Like females, body mass in males was correlated positively with mTOR and IGF1, but negatively with ATG9A and RS6K1 expressions. Our findings highlight that sexes may cope with nutritional deficits differently and emphasise the importance of considering sexual differences in studies of dietary restriction.},
	year = {2024},
	eissn = {2045-2322},
	orcid-numbers = {Lendvai, Ádám Zoltán/0000-0002-8953-920X}
}

@article{MTMT:34785047,
	title = {Dietary restriction and life-history trade-offs: insights into mTOR pathway regulation and reproductive investment in Japanese quails},
	url = {https://m2.mtmt.hu/api/publication/34785047},
	author = {Gebrehaweria Kidane, Reda and Ndunguru, Sawadi Fransisco and Csernus, Brigitta and Tóthné Gulyás, Gabriella and Knop, Renáta and Szabó, Csaba and Czeglédi, Levente and Lendvai, Ádám Zoltán},
	doi = {10.1242/jeb.247064},
	journal-iso = {J EXP BIOL},
	journal = {JOURNAL OF EXPERIMENTAL BIOLOGY},
	volume = {227},
	unique-id = {34785047},
	issn = {0022-0949},
	abstract = {Resources are needed for growth, reproduction and survival, and organisms must trade-off limited resources among competing processes. Nutritional availability in organisms is sensed and monitored by nutrient-sensing pathways that can trigger physiological changes or alter gene expression. Previous studies have proposed that one such signalling pathway, the mechanistic target of rapamycin (mTOR), underpins a form of adaptive plasticity when individuals encounter constraints in their energy budget. Despite the fundamental importance of this process in evolutionary biology, how nutritional limitation is regulated through the expression of genes governing this pathway and its consequential effects on fitness remains understudied, particularly in birds. We used dietary restriction to simulate resource depletion and examined its effects on body mass, reproduction and gene expression in Japanese quails (Coturnix japonica). Quails were subjected to feeding 20%, 30%, 40% restriction levels or ad libitum for two weeks. All restricted groups exhibited reduced body mass, whereas reductions in the number and mass of eggs were observed only under more severe restrictions. Additionally, dietary restriction led to decreased expression of mTOR and insulin-like growth factor 1 (IGF1), whereas the ribosomal protein S6 kinase 1 (RPS6K1) and autophagy-related genes (ATG9A and ATG5) were upregulated. The pattern in which mTOR respond to restriction was similar to what has been seen in body mass. Regardless of the treatment, proportionally higher reproductive investment was associated with individual variation in mTOR expression. These findings reveal the connection between dietary intake and the expression of mTOR and related genes in this pathway.},
	keywords = {reproduction; Gene Expression; resource allocation; MTOR PATHWAY; Coturnix japonica; KEY WORDS: Dietary restriction},
	year = {2024},
	eissn = {1477-9145},
	orcid-numbers = {Lendvai, Ádám Zoltán/0000-0002-8953-920X}
}