TY - JOUR AU - Oraveczné Gyöngyösi, Eszter AU - László, Brigitta AU - Szalmás, Anita AU - Kónya, József AU - Veress, György TI - Transcriptional activity of the long control region in human papillomavirus type 33 intratype variants JF - VIROLOGY JOURNAL J2 - VIROL J VL - 20 PY - 2023 IS - 1 SN - 1743-422X DO - 10.1186/s12985-023-02114-y UR - https://m2.mtmt.hu/api/publication/34066112 ID - 34066112 LA - English DB - MTMT ER - TY - CHAP AU - Veress, György ED - Takács, Mária TI - A vírusok terjedése T2 - Orvosi virológia PB - Medicina Könyvkiadó CY - Budapest SN - 9789632268484 PY - 2022 SP - 28 EP - 34 PG - 7 UR - https://m2.mtmt.hu/api/publication/33131237 ID - 33131237 LA - Hungarian DB - MTMT ER - TY - CHAP AU - Veress, György ED - Takács, Mária TI - A vírusok szaporodása T2 - Orvosi virológia PB - Medicina Könyvkiadó CY - Budapest SN - 9789632268484 PY - 2022 SP - 19 EP - 27 PG - 9 UR - https://m2.mtmt.hu/api/publication/33131235 ID - 33131235 LA - Hungarian DB - MTMT ER - TY - CHAP AU - Veress, György ED - Takács, Mária TI - A vírusok taxonómiája T2 - Orvosi virológia PB - Medicina Könyvkiadó CY - Budapest SN - 9789632268484 PY - 2022 SP - 10 EP - 18 PG - 9 UR - https://m2.mtmt.hu/api/publication/33131230 ID - 33131230 LA - Hungarian DB - MTMT ER - TY - CHAP AU - Veress, György ED - Takács, Mária TI - A vírusok kémiai összetétele és szerkezete T2 - Orvosi virológia PB - Medicina Könyvkiadó CY - Budapest SN - 9789632268484 PY - 2022 SP - 3 EP - 9 PG - 7 UR - https://m2.mtmt.hu/api/publication/33131208 ID - 33131208 LA - Hungarian DB - MTMT ER - TY - JOUR AU - László, Brigitta AU - Antal, László AU - Oraveczné Gyöngyösi, Eszter AU - Szalmás, Anita AU - Póliska, Szilárd AU - Veress, György AU - Kónya, József TI - Coordinated action of human papillomavirus type 16 E6 and E7 oncoproteins on competitive endogenous RNA (ceRNA) network members in primary human keratinocytes JF - BMC CANCER J2 - BMC CANCER VL - 21 PY - 2021 IS - 1 SN - 1471-2407 DO - 10.1186/s12885-021-08361-y UR - https://m2.mtmt.hu/api/publication/32061682 ID - 32061682 LA - English DB - MTMT ER - TY - JOUR AU - Oraveczné Gyöngyösi, Eszter AU - Szalmás, Anita AU - Kónya, József AU - Veress, György TI - Orientation-dependent toxic effect of human papillomavirus type 33 long control region DNA in Escherichia coli cells JF - VIRUS GENES J2 - VIRUS GENES VL - 56 PY - 2020 IS - 3 SP - 298 EP - 305 PG - 8 SN - 0920-8569 DO - 10.1007/s11262-020-01754-4 UR - https://m2.mtmt.hu/api/publication/31306115 ID - 31306115 LA - English DB - MTMT ER - TY - CONF AU - Veress, György AU - Kónya, József AU - Oraveczné Gyöngyösi, Eszter TI - Orientation-dependent toxic effect of human papillomavirus type 33 long control region DNA in Escherichia coli cells T2 - Acta Microbiologica et Immunologica Hungarica Volume 66 Supplement 1 PB - Akadémiai Kiadó C1 - Budapest T3 - Acta Microbiologia et Immunologica Hungarica Supplement, ISSN 1217-8950 ; 66/1. PY - 2019 SP - 109 EP - 110 PG - 2 UR - https://m2.mtmt.hu/api/publication/33542809 ID - 33542809 LA - English DB - MTMT ER - TY - CONF AU - Oraveczné Gyöngyösi, Eszter AU - Szalmás, Anita AU - László, Brigitta AU - Kónya, József AU - Veress, György ED - Károly, Márialigeti ED - Orsolya, Dobay TI - PHYLOGENETIC ANALYSIS OF HUMAN PAPILLOMAVIRUS (HPV) 33 LONG CONTROL REGION (LCR) T2 - Abstracts of the 5th Central European Forum for Microbiology PY - 2017 SP - 24 UR - https://m2.mtmt.hu/api/publication/30648034 ID - 30648034 AB - High-risk HPVs (HPV 16, 18, 31, 33, 45, 52, 58, etc.) are the etiological agents of cervix carcinoma. The LCR of the virus genome has a very important role in the regulation of the viral replication and transcription, and contains several transcription factor binding sites. The intratypic nucleotide variants of HPVs has different oncogenic potential, as we could see in the case of HPV 16, HPV 18 and HPV 31, but this phenomenon has not been investigated in the case of other high-risk types, such as HPV 33. The goal of this study was to see the natural genetic variants of HPV 33 in Hungary, and to investigate the functional differences between the variants. Exfoliated cell samples were collected from the cervix of HPV 33 positive women with cytological and colposcopical abnormalities. After DNA isolation, HPV 33 LCR specific PCR was performed on the specimens and the PCR products were sequenced with the PCR primers. Multiple sequence alignment and phylogenetic analysis were carried out on the sequences. The sequences of our samples were compared to HPV 33 variants published in the literature. Several variants were identified from our samples with single nucleotide changes and a 79 bp deletion. According to the constructed phylogenetic tree, our variants belongs to the A lineage, A1 and A2 sublineages, which are the most frequent lineages in Europe. The nucleotide changes in the LCR can affect transcription factor binding sites and might result in altered transcriptional activity of the regulatory region. So, after cloning the HPV 33 variants into luciferase reporter plasmids, we are planning the functional analysis of the LCR with transient transfection experiments and luciferase tests. LA - English DB - MTMT ER - TY - JOUR AU - Ferenczi, Annamária AU - Oraveczné Gyöngyösi, Eszter AU - Szalmás, Anita AU - László, Brigitta AU - Kónya, József AU - Veress, György TI - Phylogenetic and functional analysis of sequence variation of human papillomavirus type 31 E6 and E7 oncoproteins JF - INFECTION GENETICS AND EVOLUTION J2 - INFECT GENET EVOL VL - 43 PY - 2016 SP - 94 EP - 100 PG - 7 SN - 1567-1348 DO - 10.1016/j.meegid.2016.05.020 UR - https://m2.mtmt.hu/api/publication/3065386 ID - 3065386 N1 - In Press, Available online 16 May 2016 LA - English DB - MTMT ER -