@article{MTMT:32558272,
	title = {100 éves a Debreceni Egyetem Orvosi Vegytani Intézete},
	url = {https://m2.mtmt.hu/api/publication/32558272},
	author = {Dombrádi, Viktor Béla},
	journal-iso = {BIOKÉMIA},
	journal = {BIOKÉMIA: A MAGYAR BIOKÉMIAI EGYESÜLET FOLYÓIRATA},
	volume = {XLV},
	unique-id = {32558272},
	issn = {0133-8455},
	year = {2021},
	eissn = {2060-8152},
	pages = {33-43}
}

@article{MTMT:32282187,
	title = {Biophysical experiments reveal a protective role of protein phosphatase Z1 against oxidative damage of the cell membrane in Candida albicans},
	url = {https://m2.mtmt.hu/api/publication/32282187},
	author = {Hajdu, Tímea and Szabó, Krisztina and Jakab, Ágnes and Pócsi, István and Dombrádi, Viktor Béla and Nagy, Péter},
	doi = {10.1016/j.freeradbiomed.2021.09.020},
	journal-iso = {FREE RADICAL BIO MED},
	journal = {FREE RADICAL BIOLOGY AND MEDICINE},
	volume = {176},
	unique-id = {32282187},
	issn = {0891-5849},
	year = {2021},
	eissn = {1873-4596},
	pages = {222-227},
	orcid-numbers = {Nagy, Péter/0000-0002-7466-805X}
}

@article{MTMT:32120842,
	title = {The Negative Effect of Protein Phosphatase Z1 Deletion on the Oxidative Stress Tolerance of Candida albicans Is Synergistic with Betamethasone Exposure},
	url = {https://m2.mtmt.hu/api/publication/32120842},
	author = {Jakab, Ágnes and Emri, Tamás and Csillag, Kinga Karola and Szabó, Anita and Nagy, Fruzsina and Baranyai, Edina and Sajtos, Zsófi and Géczi, Dóra Anikó and Antal, Károly and Kovács, Renátó and Szabó, Krisztina and Dombrádi, Viktor Béla and Pócsi, István},
	doi = {10.3390/jof7070540},
	journal-iso = {J FUNGI},
	journal = {JOURNAL OF FUNGI},
	volume = {7},
	unique-id = {32120842},
	abstract = {The glucocorticoid betamethasone (BM) has potent anti-inflammatory and immunosuppressive effects; however, it increases the susceptibility of patients to superficial Candida infections. Previously we found that this disadvantageous side effect can be counteracted by menadione sodium bisulfite (MSB) induced oxidative stress treatment. The fungus specific protein phosphatase Z1 (CaPpz1) has a pivotal role in oxidative stress response of Candida albicans and was proposed as a potential antifungal drug target. The aim of this study was to investigate the combined effects of CaPPZ1 gene deletion and MSB treatment in BM pre-treated C. albicans cultures. We found that the combined treatment increased redox imbalance, enhanced the specific activities of antioxidant enzymes, and reduced the growth in cappz1 mutant (KO) strain. RNASeq data demonstrated that the presence of BM markedly elevated the number of differentially expressed genes in the MSB treated KO cultures. Accumulation of reactive oxygen species, increased iron content and fatty acid oxidation, as well as the inhibiting ergosterol biosynthesis and RNA metabolic processes explain, at least in part, the fungistatic effect caused by the combined stress exposure. We suggest that the synergism between MSB treatment and CaPpz1 inhibition could be considered in developing of a novel combinatorial antifungal strategy accompanying steroid therapy.},
	keywords = {PLASMA; RESISTANCE; GENE-EXPRESSION; SUSCEPTIBILITY; YEAST; microbiology; Fungi; glucocorticoid; Candida albicans; menadione; menadione; ATPASE; stress response; ANTIFUNGAL THERAPY; Combinatorial stress; Oxidative stress; protein phosphatase Z1; HOST COPPER},
	year = {2021},
	eissn = {2309-608X},
	orcid-numbers = {Antal, Károly/0000-0001-8993-3314}
}

@article{MTMT:32089120,
	title = {Egy gombaspecifikus enzim, a protein foszfatáz Z jellemzése},
	url = {https://m2.mtmt.hu/api/publication/32089120},
	author = {Dombrádi, Viktor Béla},
	journal-iso = {BIOKÉMIA},
	journal = {BIOKÉMIA: A MAGYAR BIOKÉMIAI EGYESÜLET FOLYÓIRATA},
	volume = {XLV},
	unique-id = {32089120},
	issn = {0133-8455},
	year = {2021},
	eissn = {2060-8152},
	pages = {22-35}
}

@article{MTMT:31815661,
	title = {The phosphatome of opportunistic pathogen Candida species},
	url = {https://m2.mtmt.hu/api/publication/31815661},
	author = {Szabó, Krisztina and Miskei, Márton and Farkas, Ilona and Dombrádi, Viktor Béla},
	doi = {10.1016/j.fbr.2020.12.002},
	journal-iso = {FUNG BIOL REV},
	journal = {FUNGAL BIOLOGY REVIEWS},
	volume = {35},
	unique-id = {31815661},
	issn = {1749-4613},
	abstract = {Several Candida species, the best known example of which is Candida albicans, are opportunistic human pathogens that are responsible for frequent nosocomial infections. A worrisome aspect of the currently available treatments of candidemia is the steady development of resistance to antifungals among these potentially life threatening fungi. Under these circumstances the search for novel drug targets is a well justified research direction. We propose that the principles of signal transduction therapy by targeting protein phosphatases can be adopted as these enzymes carry out important physiological functions in Candida. We demonstrate that C. tropicalis, C. albicans, C. dubliniensis, and S. cerevisiae exhibit the largest repertoire of protein phosphatases among the investigated fungi. Together with other opportunistic pathogen Candida species and the members of the Saccharomycetales order, they expanded their phosphatome by repeated gene duplications. We noted that evolution generated a set of fungus specific phosphatases which can be targeted without the danger of causing undesirable side effects in the human body. Based on the conflicting criteria of effectiveness and selectivity, we identified and characterized 7 phosphatases that are potent virulence determinants and may be utilized as potential antifungal drug targets. (C) 2020 The Authors. Published by Elsevier Ltd on behalf of British Mycological Society.},
	keywords = {EVOLUTION; PROTEIN PHOSPHATASES; Protein Domains; PATHOGENIC FUNGI; Candida albicans; Enzyme phylogeny},
	year = {2021},
	eissn = {1878-0253},
	pages = {40-51},
	orcid-numbers = {Szabó, Krisztina/0000-0002-8461-9294}
}

@CONFERENCE{MTMT:31927583,
	title = {The combined effect of the protein phosphatase Z1 gene deletion and oxidative stress on the gene expression of the glucocorticoid treated Candida albicans.},
	url = {https://m2.mtmt.hu/api/publication/31927583},
	author = {Jakab, Ágnes and Szabó, A and Emri, Tamás and Dombrádi, Viktor Béla and Pócsi, István},
	booktitle = {4th National Conference of Young Biotechnologists "FIBOK 2020" online conference : abstract book},
	unique-id = {31927583},
	year = {2020},
	pages = {79}
}

@CONFERENCE{MTMT:31799994,
	title = {The deletion of the fungus specific Cappz1 phosphatase enhances the oxidative stress sensitivity of Candida albicans in the presence of Betamethasone},
	url = {https://m2.mtmt.hu/api/publication/31799994},
	author = {Jakab, Ágnes and Emri, Tamás and Géczi, Dóra and Szabó, Anita and Antal, Károly and Szabó, Krisztina and Dombrádi, Viktor Béla and Pócsi, István},
	booktitle = {A Magyar Mikrobiológiai Társaság 2020. évi Nagygyűlése és a XIV. Fermentációs Kollokvium : Absztraktfüzet},
	unique-id = {31799994},
	year = {2020},
	pages = {15-16},
	orcid-numbers = {Antal, Károly/0000-0001-8993-3314}
}

@CONFERENCE{MTMT:31348954,
	title = {A Candida albicans allélspecifikus génexpressziójának elemzése bioinformatikai módszerekkel.},
	url = {https://m2.mtmt.hu/api/publication/31348954},
	author = {Nagy-Köteles, Csaba and Barta, Endre and Szabó, Krisztina and Jakab, Ágnes and Emri, Tamás and Nagy, Tibor and Dombrádi, Viktor Béla and Pócsi, István},
	booktitle = {Biotechnológia a Debreceni Egyetemen Tudományos Szimpózium},
	unique-id = {31348954},
	year = {2019},
	pages = {38-38},
	orcid-numbers = {Barta, Endre/0000-0002-6753-0714}
}

@article{MTMT:30925993,
	title = {Deletion of the fungus specific protein phosphatase Z1 exaggerates the oxidative stress response in Candida albicans},
	url = {https://m2.mtmt.hu/api/publication/30925993},
	author = {Szabó, Krisztina and Jakab, Ágnes and Póliska, Szilárd and Petrényi, Katalin and Kovács, Katalin and Issa, Lama Hasan Bou and Emri, Tamás and Pócsi, István and Dombrádi, Viktor Béla},
	doi = {10.1186/s12864-019-6252-6},
	journal-iso = {BMC GENOMICS},
	journal = {BMC GENOMICS},
	volume = {20},
	unique-id = {30925993},
	issn = {1471-2164},
	year = {2019},
	eissn = {1471-2164}
}

@article{MTMT:30748158,
	title = {Synergistic action of protein phosphatase Z1 deletion and oxidative stress in the opportunistic pathogen Candida albicans},
	url = {https://m2.mtmt.hu/api/publication/30748158},
	author = {Szabó, Krisztina and Jakab, Ágnes and Póliska, Szilárd and Petrényi, K and Kovács, K and Lama, Hasan Bou Issa and Emri, Tamás and Pócsi, István and Dombrádi, Viktor Béla},
	journal-iso = {ACTA MICROBIOL IMMUNOL HUNG},
	journal = {ACTA MICROBIOLOGICA ET IMMUNOLOGICA HUNGARICA},
	volume = {66},
	unique-id = {30748158},
	issn = {1217-8950},
	year = {2019},
	eissn = {1588-2640},
	pages = {193}
}