@{MTMT:34756881, title = {Az ergoszterin bioszintézis útvonal csonkolásának fiziológiára gyakorolt hatásának vizsgálata Mucor lusitanicus-ban}, url = {https://m2.mtmt.hu/api/publication/34756881}, author = {Rafael, Bence and Jánvári, Zsófia and Molnár, Anna and Kiss, Karina and Kovács, Vanda and Szebenyi, Csilla and Abu Saleem, Tammam Khaliefeh Siliman and Nagy, Gábor and Szekeres, András and Varga, Mónika and Vágvölgyi, Csaba and Papp, Tamás}, booktitle = {III. Természettudományok helyzete hazánkban Egyetemtől a munkaerőpiacig Workshop: Absztraktfüzet}, unique-id = {34756881}, year = {2024}, pages = {46-48}, orcid-numbers = {Nagy, Gábor/0000-0002-7871-6098; Szekeres, András/0000-0003-1651-4623; Vágvölgyi, Csaba/0000-0003-0009-7773; Papp, Tamás/0000-0001-8211-5431} } @{MTMT:34756662, title = {Intelligens peptidek: mesterséges intelligencia felhasználása a peptaibolok kutatásában}, url = {https://m2.mtmt.hu/api/publication/34756662}, author = {Rozsnyói, Ákos and Balázs, Dóra Krisztina and Tyagi, Chetna and Terna, Gergő and Szekeres, András and Vágvölgyi, Csaba and Marik, Tamás and Kredics, László}, booktitle = {III. Természettudományok helyzete hazánkban Egyetemtől a munkaerőpiacig Workshop: Absztraktfüzet}, unique-id = {34756662}, year = {2024}, pages = {32-33}, orcid-numbers = {Tyagi, Chetna/0000-0001-7067-4770; Szekeres, András/0000-0003-1651-4623; Vágvölgyi, Csaba/0000-0003-0009-7773; Marik, Tamás/0000-0002-0434-5685; Kredics, László/0000-0002-8837-3973} } @{MTMT:34756649, title = {Water solubility of fungal peptaibols and its effect on their bioactivity}, url = {https://m2.mtmt.hu/api/publication/34756649}, author = {Terna, Gergő and Tyagi, Chetna and Balázs, Dóra Krisztina and Rozsnyói, Ákos and Szekeres, András and Varga, Mónika and Vágvölgyi, Csaba and Kredics, László and Marik, Tamás}, booktitle = {III. Természettudományok helyzete hazánkban Egyetemtől a munkaerőpiacig Workshop: Absztraktfüzet}, unique-id = {34756649}, year = {2024}, pages = {29-31}, orcid-numbers = {Tyagi, Chetna/0000-0001-7067-4770; Szekeres, András/0000-0003-1651-4623; Vágvölgyi, Csaba/0000-0003-0009-7773; Kredics, László/0000-0002-8837-3973; Marik, Tamás/0000-0002-0434-5685} } @article{MTMT:34729405, title = {The mycoremediation potential of the armillarioids: a comparative genomics analysis(vol11, :1189640, 2023)}, url = {https://m2.mtmt.hu/api/publication/34729405}, author = {Champramary, Simang and Indic, Boris and Szucs, Attila and Tyagi, Chetna and Languar, Omar and Hasan, K M Faridul and Szekeres, András and Vágvölgyi, Csaba and Kredics, László and Sipos, György}, doi = {10.3389/fbioe.2024.1370053}, journal-iso = {FRONT BIOENG BIOTECHNOL}, journal = {FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY}, volume = {12}, unique-id = {34729405}, issn = {2296-4185}, keywords = {BIODEGRADATION; Mycoremediation; White-rot; armillarioids; benzoate 4-monooxygenase; phylogenetic principal component analysis}, year = {2024}, eissn = {2296-4185}, orcid-numbers = {Hasan, K M Faridul/0000-0003-4126-374X; Szekeres, András/0000-0003-1651-4623; Vágvölgyi, Csaba/0000-0003-0009-7773; Kredics, László/0000-0002-8837-3973; Sipos, György/0000-0002-6666-1384} } @{MTMT:34727848, title = {JÁROMSPÓRÁS GOMBÁK ERGOSZTERIN BIOSZINTÉZISE: BETEKINTÉS A METABOLOMIKÁBA ÉS A GÉNEXPRESSZIÓBA}, url = {https://m2.mtmt.hu/api/publication/34727848}, author = {Rafael, Bence and Jánvári, Zsófia and Molnár, Anna and Varga, Mónika and Szekeres, András and Vágvölgyi, Csaba and Nagy, Gábor and Papp, Tamás}, booktitle = {Biotechnológiai Szakmai Nap Absztraktfüzet}, unique-id = {34727848}, year = {2024}, pages = {43-44}, orcid-numbers = {Szekeres, András/0000-0003-1651-4623; Vágvölgyi, Csaba/0000-0003-0009-7773; Nagy, Gábor/0000-0002-7871-6098; Papp, Tamás/0000-0001-8211-5431} } @CONFERENCE{MTMT:34439948, title = {Comprehensive examination of peptaibol compounds and preparation of their future agricultural application}, url = {https://m2.mtmt.hu/api/publication/34439948}, author = {Balázs, Dóra Krisztina and Rozsnyói, Ákos and Marik, Tamás and Szekeres, András and Vágvölgyi, Csaba and Tyagi, Chetna and Kredics, László}, booktitle = {CEESME Central and Eastern Europe Symposium on Microbial Ecology}, unique-id = {34439948}, year = {2023}, pages = {44.}, orcid-numbers = {Marik, Tamás/0000-0002-0434-5685; Szekeres, András/0000-0003-1651-4623; Vágvölgyi, Csaba/0000-0003-0009-7773; Tyagi, Chetna/0000-0001-7067-4770; Kredics, László/0000-0002-8837-3973} } @CONFERENCE{MTMT:34439538, title = {Comprehensive investigation of peptaibols produced by Trichoderma fungal species to establish their practical application}, url = {https://m2.mtmt.hu/api/publication/34439538}, author = {Balázs, Dóra Krisztina and Marik, Tamás and Rozsnyói, Ákos and Szekeres, András and Vágvölgyi, Csaba and Tyagi, Chetna and Kredics, László}, booktitle = {Abstracts of the 19th International Congress of the Hungarian Society for Microbiology}, unique-id = {34439538}, year = {2023}, pages = {55.}, orcid-numbers = {Marik, Tamás/0000-0002-0434-5685; Szekeres, András/0000-0003-1651-4623; Vágvölgyi, Csaba/0000-0003-0009-7773; Tyagi, Chetna/0000-0001-7067-4770; Kredics, László/0000-0002-8837-3973} } @misc{MTMT:34437902, title = {Comprehensive investigation of the structure- activity relationships of peptaibols from the Trichoderma species}, url = {https://m2.mtmt.hu/api/publication/34437902}, author = {Balázs, Dóra Krisztina and Rozsnyói, Ákos and Marik, Tamás and Szekeres, András and Vágvölgyi, Csaba and Kredics, László and Tyagi, Chetna}, unique-id = {34437902}, year = {2023}, orcid-numbers = {Marik, Tamás/0000-0002-0434-5685; Szekeres, András/0000-0003-1651-4623; Vágvölgyi, Csaba/0000-0003-0009-7773; Kredics, László/0000-0002-8837-3973; Tyagi, Chetna/0000-0001-7067-4770} } @article{MTMT:34409078, title = {Modeling the Effect on a Novel Fungal Peptaibol Placed in an All-Atom Bacterial Membrane Mimicking System via Accelerated Molecular Dynamics Simulations}, url = {https://m2.mtmt.hu/api/publication/34409078}, author = {Tyagi, Chetna and Marik, Tamás and Szekeres, András and Vágvölgyi, Csaba and Kredics, László and Ötvös, Ferenc}, doi = {10.3390/life13122288}, journal-iso = {LIFE-BASEL}, journal = {LIFE-BASEL}, volume = {13}, unique-id = {34409078}, abstract = {We previously reported on a novel peptaibol, named Tripleurin XIIc (TPN), an 18-residue long sequence produced by the fungus Trichoderma pleuroti. We elucidated its 3D structure via classical and accelerated molecular dynamics simulation (aMD) methods and reported the folding dynamics of TPN in water and chloroform solvents. Peptaibols, in general, are insoluble in water, as they are amphipathic and may prefer hydrophobic environments like transmembrane regions. In this study, we attempted to use aMD simulations to model an all-atom bacterial membrane system while placing a TPN molecule in its vicinity. The results highlighted that TPN was able to introduce some disorder into the membrane and caused lipid clustering. It could also enter the transmembrane region from the water-bilayer interface. The structural dynamics of TPN in the transmembrane region revealed a single energetically stable conformation similar to the one obtained from water and chloroform solvent simulations reported by us previously. However, this linear structure was found to be at the local energy minimum (stable) in water but at a metastable intermediate state (higher energy) in chloroform. Therefore, it could be said that the water solvent can be successfully used for folding simulations of peptaibols.}, year = {2023}, eissn = {2075-1729}, orcid-numbers = {Tyagi, Chetna/0000-0001-7067-4770; Marik, Tamás/0000-0002-0434-5685; Szekeres, András/0000-0003-1651-4623; Vágvölgyi, Csaba/0000-0003-0009-7773; Kredics, László/0000-0002-8837-3973} } @article{MTMT:34409072, title = {Acquired Triazole Resistance Alters Pathogenicity-Associated Features in Candida auris in an Isolate-Dependent Manner}, url = {https://m2.mtmt.hu/api/publication/34409072}, author = {Bohner, Flóra and Papp, Csaba Gergő and Takács, Tamás and Varga, Mónika and Szekeres, András and Nosanchuk, Joshua D. and Vágvölgyi, Csaba and Tóth, Renáta and Gácser, Attila}, doi = {10.3390/jof9121148}, journal-iso = {J FUNGI}, journal = {JOURNAL OF FUNGI}, volume = {9}, unique-id = {34409072}, abstract = {Fluconazole resistance is commonly encountered in Candida auris, and the yeast frequently displays resistance to other standard drugs, which severely limits the number of effective therapeutic agents against this emerging pathogen. In this study, we aimed to investigate the effect of acquired azole resistance on the viability, stress response, and virulence of this species. Fluconazole-, posaconazole-, and voriconazole- resistant strains were generated from two susceptible C. auris clinical isolates (0381, 0387) and compared under various conditions. Several evolved strains became pan-azole-resistant, as well as echinocandin-cross-resistant. While being pan-azole-resistant, the 0381-derived posaconazole-evolved strain colonized brain tissue more efficiently than any other strain, suggesting that fitness cost is not necessarily a consequence of resistance development in C. auris. All 0387-derived evolved strains carried a loss of function mutation (R160S) in BCY1, an inhibitor of the PKA pathway. Sequencing data also revealed that posaconazole treatment can result in ERG3 mutation in C. auris. Despite using the same mechanisms to generate the evolved strains, both genotype and phenotype analysis highlighted that the development of resistance was unique for each strain. Our data suggest that C. auris triazole resistance development is a highly complex process, initiated by several pleiotropic factors.}, year = {2023}, eissn = {2309-608X}, orcid-numbers = {Papp, Csaba Gergő/0000-0003-4450-0667; Szekeres, András/0000-0003-1651-4623; Nosanchuk, Joshua D./0000-0001-9905-5754; Vágvölgyi, Csaba/0000-0003-0009-7773; Tóth, Renáta/0000-0001-7395-0689} }