@article{MTMT:31825377,
	title = {Cariprazine modulates sleep architecture in rats},
	url = {https://m2.mtmt.hu/api/publication/31825377},
	author = {Nyitrai, Gabriella and Kiss, Béla and Farkas, Bence and Balázs, O. and Diószegi, P. and Lendvai, Balázs and Czurkó, András},
	doi = {10.1177/0269881120981378},
	journal-iso = {J PSYCHOPHARMACOL},
	journal = {JOURNAL OF PSYCHOPHARMACOLOGY},
	volume = {35},
	unique-id = {31825377},
	issn = {0269-8811},
	year = {2021},
	eissn = {1461-7285},
	pages = {303-310},
	orcid-numbers = {Czurkó, András/0000-0002-1985-7296}
}

@article{MTMT:31613493,
	title = {Chronic stepwise cerebral hypoperfusion differentially induces synaptic proteome changes in the frontal cortex, occipital cortex, and hippocampus in rats},
	url = {https://m2.mtmt.hu/api/publication/31613493},
	author = {Tukacs, Vanda and Mittli, Dániel Árpád and Györffy, Balázs and Hunyadi-Gulyás Éva, Csilla and Hlatky, Dávid and Tóth, Vilmos and Ravasz, Lilla and Medzihradszky F., Katalin and Nyitrai, Gabriella and Czurkó, András and Juhász, Gábor Dénes and Kardos, József and Kékesi, Adrienna Katalin},
	doi = {10.1038/s41598-020-72868-w},
	journal-iso = {SCI REP},
	journal = {SCIENTIFIC REPORTS},
	volume = {10},
	unique-id = {31613493},
	issn = {2045-2322},
	year = {2020},
	eissn = {2045-2322},
	orcid-numbers = {Györffy, Balázs/0000-0003-0654-0641; Czurkó, András/0000-0002-1985-7296; Juhász, Gábor Dénes/0000-0002-0849-6931; Kardos, József/0000-0002-2135-2932; Kékesi, Adrienna Katalin/0000-0003-3042-4878}
}

@article{MTMT:30816395,
	title = {Purkinje cell number-correlated cerebrocerebellar circuit anomaly in the valproate model of autism},
	url = {https://m2.mtmt.hu/api/publication/30816395},
	author = {Spisák, Tamás and Román, Viktor and Papp, Edit and Kedves, Rita and Sághy, Katalin and Csölle, Cecília and Varga, Anita and Gajári, Dávid and Nyitrai, Gabriella and Spisák, Zsófia and Kincses, Zsigmond Tamás and Lévay, György István and Lendvai, Balázs and Czurkó, András},
	doi = {10.1038/s41598-019-45667-1},
	journal-iso = {SCI REP},
	journal = {SCIENTIFIC REPORTS},
	volume = {9},
	unique-id = {30816395},
	issn = {2045-2322},
	abstract = {While cerebellar alterations may play a crucial role in the development of core autism spectrum disorder (ASD) symptoms, their pathophysiology on the function of cerebrocerebellar circuit loops is largely unknown. We combined multimodal MRI (9.4 T) brain assessment of the prenatal rat valproate (VPA) model and correlated immunohistological analysis of the cerebellar Purkinje cell number to address this question. We hypothesized that a suitable functional MRI (fMRI) paradigm might show some altered activity related to disrupted cerebrocerebellar information processing. Two doses of maternal VPA (400 and 600 mg/kg, s.c.) were used. The higher VPA dose induced 3% smaller whole brain volume, the lower dose induced 2% smaller whole brain volume and additionally a focal gray matter density decrease in the cerebellum and brainstem. Increased cortical BOLD responses to whisker stimulation were detected in both VPA groups, but it was more pronounced and extended to cerebellar regions in the 400 mg/kg VPA group. Immunohistological analysis revealed a decreased number of Purkinje cells in both VPA groups. In a detailed analysis, we revealed that the Purkinje cell number interacts with the cerebral BOLD response distinctively in the two VPA groups that highlights atypical function of the cerebrocerebellar circuit loops with potential translational value as an ASD biomarker.},
	year = {2019},
	eissn = {2045-2322},
	orcid-numbers = {Kincses, Zsigmond Tamás/0000-0002-1442-4475; Czurkó, András/0000-0002-1985-7296}
}

@article{MTMT:3400976,
	title = {Stepwise occlusion of the carotid arteries of the rat. MRI assessment of the effect of donepezil and hypoperfusion-induced brain atrophy and white matter microstructural changes},
	url = {https://m2.mtmt.hu/api/publication/3400976},
	author = {Nyitrai, Gabriella and Spisák, Tamás and Spisák, Z and Gajári, D and Diószegi, P and Kincses, Zsigmond Tamás and Czurkó, András},
	doi = {10.1371/journal.pone.0198265},
	journal-iso = {PLOS ONE},
	journal = {PLOS ONE},
	volume = {13},
	unique-id = {3400976},
	issn = {1932-6203},
	abstract = {Bilateral common carotid artery occlusion (BCCAo) in the rat is a widely used animal model of vascular dementia and a valuable tool for preclinical pharmacological drug testing, although the varying degrees of acute focal ischemic lesions it induces could interfere with its translational value. Recently, a modification to the BCCAo model, the stepwise occlusion of the two carotid arteries, has been introduced. To acquire objective translatable measures, we used longitudinal multimodal magnetic resonance imaging (MRI) to assess the effects of semi-chronic (8 days) donepezil treatment in this model, with half of the Wistar rats receiving the treatment one week after the stepwise BCCAo. With an ultrahigh field MRI, we measured high-resolution anatomy, diffusion tensor imaging, cerebral blood flow measurements and functional MRI in response to whisker stimulation, to evaluate both the structural and functional effects of the donepezil treatment and stepwise BCCAo up to 5 weeks post-occlusion. While no large ischemic lesions were detected, atrophy in the striatum and in the neocortex, along with widespread white matter microstructural changes, were found. Donepezil ameliorated the transient drop in the somatosensory BOLD response in distant cortical areas, as detected 2 weeks after the occlusion but the drug had no effect on the long term structural changes. Our results demonstrate a measurable functional MRI effect of the donepezil treatment and the importance of diffusion MRI and voxel based morphometry (VBM) analysis in the translational evaluation of the rat BCCAo model.},
	year = {2018},
	eissn = {1932-6203},
	orcid-numbers = {Kincses, Zsigmond Tamás/0000-0002-1442-4475; Czurkó, András/0000-0002-1985-7296}
}

@article{MTMT:2932290,
	title = {Bilayer Charge Reversal and Modification of Lipid Organization by Dendrimers as Observed by Sum-Frequency Vibrational Spectroscopy},
	url = {https://m2.mtmt.hu/api/publication/2932290},
	author = {Keszthelyi, Tamás and Holló, Gábor and Nyitrai, Gabriella and Kardos, Julianna and Héja, László},
	doi = {10.1021/acs.langmuir.5b00734},
	journal-iso = {LANGMUIR},
	journal = {LANGMUIR},
	volume = {31},
	unique-id = {2932290},
	issn = {0743-7463},
	abstract = {Polyamidoamine (PAMAM) dendrimers are hyper-branched, nanosized polymers with promising biomedical applications as nanocarriers in targeted drug delivery and gene therapy. For the development of safe dendrimer-based biomedical applications it is necessary to gain an understanding of the detailed mechanism of the interactions of both cationic and anionic dendrimers with cell membranes. To characterize dendrimer membrane interactions we applied solid-supported lipid bilayers as biomembrane models and utilized infrared visible sum-frequency vibrational spectroscopy to independently probe the interactions of cationic G5-NH2 and anionic G4.5-COONa dendrimers with the two leaflets of the lipid bilayers. Interaction with both dendrimers led to changes in the interfacial water structure and charge density as evidenced by the changes in the OH band intensities in the sum-frequency spectra of the bilayers. Interaction with the G5-NH2 dendrimer also led to a unique inversion of the sign of the OH-stretch amplitudes, in addition to a decrease in their absolute values. We suggest that the positively charged amino groups on the G5-NH2 dendrimer surface bind to the negatively charged bilayer, while uncompensated positive charges not involved in the binding cause a reversal of the electric field and thus an opposite orientation of the interfacial water molecules. More subtle but nonetheless significant changes were seen in the relative magnitudes of the CH amplitudes. The methyl antisymmetric to symmetric stretch amplitude ratios are altered, implying changes in the tilt angles of the phospholipid alkyl chains. The conformational order of the phospholipid alkyl chains of both leaflets is also influenced by the G5-NH2 dendrimer while G4.5-COONa has no effect on the alkyl chain conformation.},
	year = {2015},
	eissn = {1520-5827},
	pages = {7815-7825},
	orcid-numbers = {Holló, Gábor/0000-0001-9920-4801}
}

@article{MTMT:2540335,
	title = {GLIAL GABA TRANSPORTERS DOWNREGULATE ENHANCED NEURONAL ACTIVITY},
	url = {https://m2.mtmt.hu/api/publication/2540335},
	author = {Kékesi, Orsolya Sára and Nyitrai, Gabriella and Szabó, Pál Tamás and Fiáth, Richárd and Ulbert, István and Kardos, Julianna and Héja, László},
	journal-iso = {GLIA},
	journal = {GLIA},
	volume = {61},
	unique-id = {2540335},
	issn = {0894-1491},
	year = {2013},
	eissn = {1098-1136},
	pages = {S122-S123},
	orcid-numbers = {Szabó, Pál Tamás/0000-0003-2260-4641; Fiáth, Richárd/0000-0001-8732-2691; Ulbert, István/0000-0001-9941-9159}
}

@article{MTMT:2305528,
	title = {Sodium selective ion channel formation in living cell membranes by polyamidoamine dendrimer},
	url = {https://m2.mtmt.hu/api/publication/2305528},
	author = {Nyitrai, Gabriella and Keszthelyi, Tamás and Bóta, Attila and Simon, Ágnes and Tőke, Orsolya and Horváth, Gergő and Pál, Ildikó and Kardos, Julianna and Héja, László},
	doi = {10.1016/j.bbamem.2013.04.004},
	journal-iso = {BBA-BIOMEMBRANES},
	journal = {BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES},
	volume = {1828},
	unique-id = {2305528},
	issn = {0005-2736},
	year = {2013},
	eissn = {1879-2642},
	pages = {1873-1880},
	orcid-numbers = {Pál, Ildikó/0000-0003-2124-9967}
}

@article{MTMT:2305501,
	title = {Polyamidoamine dendrimer impairs mitochondrial oxidation in brain tissue},
	url = {https://m2.mtmt.hu/api/publication/2305501},
	author = {Nyitrai, Gabriella and Héja, László and Jablonkai, István and Pál, Ildikó and Benéné Visy, Júlia and Kardos, Julianna},
	doi = {10.1186/1477-3155-11-9},
	journal-iso = {J NANOBIOTECHNOL},
	journal = {JOURNAL OF NANOBIOTECHNOLOGY},
	volume = {11},
	unique-id = {2305501},
	abstract = {Background: The potential nanocarrier polyamidoamine (PAMAM) generation 5 (G5-NH2) dendrimer has been shown to evoke lasting neuronal depolarization and cell death in a concentration-dependent manner. In this study we explored the early progression of G5-NH2 action in brain tissue on neuronal and astroglial cells.Results: In order to describe early mechanisms of G5-NH2 dendrimer action in brain tissue we assessed G5-NH2 trafficking, free intracellular Ca2+ and mitochondrial membrane potential (ΨMITO) changes in the rat hippocampal slice by microfluorimetry. With the help of fluorescent dye conjugated G5-NH2, we observed predominant appearance of the dendrimer in the plasma membrane of pyramidal neurons and glial cells within 30 min. Under this condition, G5-NH2 evoked robust intracellular Ca2+ enhancements and ΨMITO depolarization both in pyramidal neurons and astroglial cells. Intracellular Ca2+ enhancements clearly preceded ΨMITO depolarization in astroglial cells. Comparing activation dynamics, neurons and glia showed prevalence of lasting and transient ΨMITO depolarization, respectively. Transient as opposed to lasting ΨMITO changes to short-term G5-NH2 application suggested better survival of astroglia, as observed in the CA3 stratum radiatum area. We also showed that direct effect of G5-NH2 on astroglial ΨMITO was significantly enhanced by neuron-astroglia interaction, subsequent to G5-NH2 evoked neuronal activation.Conclusion: These findings indicate that the interaction of the PAMAM dendrimer with the plasma membrane leads to robust activation of neurons and astroglial cells, leading to mitochondrial depolarization. Distinguishable dynamics of mitochondrial depolarization in neurons and astroglia suggest that the enhanced mitochondrial depolarization followed by impaired oxidative metabolism of neurons may be the primary basis of neurotoxicity. © 2013 Nyitrai et al.; licensee BioMed Central Ltd.},
	keywords = {brain tissue; Nanotoxicity; PAMAM dendrimer; Mitochondrial depolarization; Calcium enhancement},
	year = {2013},
	eissn = {1477-3155},
	orcid-numbers = {Pál, Ildikó/0000-0003-2124-9967}
}

@article{MTMT:2222611,
	title = {Neuronal and Astroglial Correlates Underlying Spatiotemporal Intrinsic Optical Signal in the Rat Hippocampal Slice},
	url = {https://m2.mtmt.hu/api/publication/2222611},
	author = {Pál, Ildikó and Nyitrai, Gabriella and Kardos, Julianna and Héja, László},
	doi = {10.1371/journal.pone.0057694},
	journal-iso = {PLOS ONE},
	journal = {PLOS ONE},
	volume = {8},
	unique-id = {2222611},
	issn = {1932-6203},
	year = {2013},
	eissn = {1932-6203},
	orcid-numbers = {Pál, Ildikó/0000-0003-2124-9967}
}

@article{MTMT:2060849,
	title = {Assessing toxicity of polyamidoamine dendrimers by neuronal signaling functions},
	url = {https://m2.mtmt.hu/api/publication/2060849},
	author = {Nyitrai, Gabriella and Kékesi, Orsolya Sára and Pál, Ildikó and Keglevich, Péter and Csíki, Zsuzsanna and Fügedi, Péter and Simon, Ágnes and Fitos, Ilona and Németh, Krisztina and Benéné Visy, Júlia and Tárkányi, Gábor and Kardos, Julianna},
	doi = {10.3109/17435390.2011.591511},
	journal-iso = {NANOTOXICOLOGY},
	journal = {NANOTOXICOLOGY},
	volume = {6},
	unique-id = {2060849},
	issn = {1743-5390},
	keywords = {Brain; CELLS; DELIVERY; GROWTH; CYTOTOXICITY; NANOPARTICLES; Phosphate; internalization; MOLECULAR SIMULATION; CARRIERS; PAMAM dendrimers; imaging cell death; beta-D-glucopyranose-conjugation; polycationic and polyanionic PAMAM dendrimers; Functional neurotoxicity indicators},
	year = {2012},
	eissn = {1743-5404},
	pages = {576-586},
	orcid-numbers = {Pál, Ildikó/0000-0003-2124-9967}
}