@article{MTMT:34768350,
	title = {Simulation of gap junction formation reveals critical role of Cys disulfide redox state in connexin hemichannel docking},
	url = {https://m2.mtmt.hu/api/publication/34768350},
	author = {Héja, László and Simon, Ágnes and Kardos, Julianna},
	doi = {10.1186/s12964-023-01439-z},
	journal-iso = {CELL COMM SIGN},
	journal = {CELL COMMUNICATION AND SIGNALING},
	volume = {22},
	unique-id = {34768350},
	issn = {1478-811X},
	year = {2024},
	eissn = {1478-811X}
}

@article{MTMT:34718118,
	title = {GABA fluctuations driven by astrocytic Glu-GABA exchange explain synaptic acuity},
	url = {https://m2.mtmt.hu/api/publication/34718118},
	author = {Héja, László and Kardos, Julianna},
	doi = {10.46439/signaling.1.016},
	journal-iso = {Cell Signal},
	journal = {Cell Signaling},
	volume = {1},
	unique-id = {34718118},
	year = {2023},
	eissn = {2837-8253},
	pages = {76-80}
}

@article{MTMT:33031938,
	title = {Putrescine Intensifies Glu/GABA Exchange Mechanism and Promotes Early Termination of Seizures},
	url = {https://m2.mtmt.hu/api/publication/33031938},
	author = {Kovács, Zsolt and Skatchkov, Serguei N. and Szabó, Zsolt and Qahtan, Saif and Méndez-González, Miguel P. and Malpica-Nieves, Christian J. and Eaton, Misty J. and Kardos, Julianna and Héja, László},
	doi = {10.3390/ijms23158191},
	journal-iso = {INT J MOL SCI},
	journal = {INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES},
	volume = {23},
	unique-id = {33031938},
	issn = {1661-6596},
	year = {2022},
	eissn = {1422-0067},
	orcid-numbers = {Kovács, Zsolt/0000-0001-8571-5686; Szabó, Zsolt/0000-0002-2902-743X; Méndez-González, Miguel P./0000-0003-0079-4042; Malpica-Nieves, Christian J./0000-0001-6778-408X}
}

@article{MTMT:32612048,
	title = {Connexons coupling to gap junction channel: Potential role for extracellular protein stabilization centers},
	url = {https://m2.mtmt.hu/api/publication/32612048},
	author = {Héja, László and Simon, Ágnes and Szabó, Zsolt and Kardos, Julianna},
	doi = {10.3390/biom12010049},
	journal-iso = {BIOMOLECULES},
	journal = {BIOMOLECULES},
	volume = {12},
	unique-id = {32612048},
	issn = {2218-273X},
	abstract = {Connexin (Cx) proteins establish intercellular gap junction channels (Cx GJCs) through coupling of two apposed hexameric Cx hemichannels (Cx HCs, connexons). Pre-and post-GJ interfaces consist of extracellular EL1 and EL2 loops, each with three conserved cysteines. Previously, we reported that known peptide inhibitors, mimicking a variety of Cx43 sequences, appear non-selective when binding to homomeric Cx43 vs. Cx36 GJC homology model subtypes. In pursuit of finding potentially Cx subtype-specific inhibitors of connexon-connexon coupling, we aimed at to understand better how the GJ interface is formed. Here we report on the discovery of Cx GJC subtype-specific protein stabilization centers (SCs) featuring GJ interface architecture. First, the Cx43 GJC homology model, embedded in two opposed membrane bilayers, has been devised. Next, we endorsed the fluctuation dynamics of SCs of the interface domain of Cx43 GJC by applying standard molecular dynamics under open and closed cystine disulfide bond (CS-SC) preconditions. The simulations confirmed the major role of of the unique trans-GJ SC pattern comprising conserved (55N, 56T) and non-conserved (57Q) residues of the apposed EL1 loops in the stabilization of the GJC complex. Importantly, clusters of SC patterns residing close to the GJ interface domain appear to orient the interface formation via the numerous SCs between EL1 and EL2. These include central54CS-S198C or61CS-S192C contacts with residues 53R, 54C, 55N, 197D, 199F or 64V, 191P, respectively. In addition, we revealed that GJC interface formation is favoured when the psi dihedral angle of the nearby 193P residue is stable around 180◦ and the interface SCs disappear when this angle moves to the 0◦ to −45◦ range. The potential of the association of non-conserved residues with SC motifs in connexon-connexon coupling makes the development of Cx subtype-specific inhibitors viable. © 2021 by the authors. Licensee MDPI, Basel, Switzerland.},
	keywords = {ARTICLE; human; membrane protein; nonhuman; PROTEIN FUNCTION; molecular dynamics; computer model; gap junction protein; disulfide bond; Connexin 43; Cystine; bilayer membrane; connexon; Close/open disulfide bonds precon-ditions; Cx43 GJC with two membranes; Cystine disulfide related GJ SC patterns; Fluctuation dynamics of protein stabilization centres (SCs); GJ architecture; Subtype-specific SC motifs},
	year = {2022},
	eissn = {2218-273X},
	orcid-numbers = {Szabó, Zsolt/0000-0002-2902-743X}
}

@article{MTMT:32578354,
	title = {Critical Role of Astrocytic Polyamine and GABA Metabolism in Epileptogenesis},
	url = {https://m2.mtmt.hu/api/publication/32578354},
	author = {Kovács, Zsolt and Skatchkov, Serguei N. and Veh, Rüdiger W. and Szabó, Zsolt and Németh, Krisztina and Szabó, Pál Tamás and Kardos, Julianna and Héja, László},
	doi = {10.3389/fncel.2021.787319},
	journal-iso = {FRONT CELL NEUROSCI},
	journal = {FRONTIERS IN CELLULAR NEUROSCIENCE},
	volume = {15},
	unique-id = {32578354},
	issn = {1662-5102},
	year = {2022},
	eissn = {1662-5102},
	orcid-numbers = {Kovács, Zsolt/0000-0001-8571-5686; Szabó, Zsolt/0000-0002-2902-743X; Szabó, Pál Tamás/0000-0003-2260-4641}
}

@article{MTMT:31971626,
	title = {Dual Role for Astroglial Copper-Assisted Polyamine Metabolism during Intense Network Activity},
	url = {https://m2.mtmt.hu/api/publication/31971626},
	author = {Szabó, Zsolt and Péter, Márton and Héja, László and Kardos, Julianna},
	doi = {10.3390/biom11040604},
	journal-iso = {BIOMOLECULES},
	journal = {BIOMOLECULES},
	volume = {11},
	unique-id = {31971626},
	issn = {2218-273X},
	year = {2021},
	eissn = {2218-273X},
	orcid-numbers = {Szabó, Zsolt/0000-0002-2902-743X; Kardos, Julianna/0000-0001-9873-7155}
}

@article{MTMT:31925857,
	title = {Spontaneous Ca2+ Fluctuations Arise in Thin Astrocytic Processes With Real 3D Geometry},
	url = {https://m2.mtmt.hu/api/publication/31925857},
	author = {Héja, László and Szabó, Zsolt and Péter, Márton and Kardos, Julianna},
	doi = {10.3389/fncel.2021.617989},
	journal-iso = {FRONT CELL NEUROSCI},
	journal = {FRONTIERS IN CELLULAR NEUROSCIENCE},
	volume = {15},
	unique-id = {31925857},
	issn = {1662-5102},
	year = {2021},
	eissn = {1662-5102},
	orcid-numbers = {Szabó, Zsolt/0000-0002-2902-743X}
}

@article{MTMT:31795296,
	title = {Peptide Binding Sites of Connexin Proteins},
	url = {https://m2.mtmt.hu/api/publication/31795296},
	author = {Simon, Ágnes and Magyar, Csaba and Héja, László and Kardos, Julianna},
	doi = {10.3390/chemistry2030042},
	journal-iso = {CHEMISTRY},
	journal = {CHEMISTRY},
	volume = {2},
	unique-id = {31795296},
	year = {2020},
	eissn = {2624-8549},
	pages = {662-673},
	orcid-numbers = {Magyar, Csaba/0000-0002-5023-6180}
}

@article{MTMT:31123982,
	title = {NCX activity generates spontaneous Ca2+ oscillations in the astrocytic leaflet microdomain},
	url = {https://m2.mtmt.hu/api/publication/31123982},
	author = {Héja, László and Kardos, Julianna},
	doi = {10.1016/j.ceca.2019.102137},
	journal-iso = {CELL CALCIUM},
	journal = {CELL CALCIUM},
	volume = {86},
	unique-id = {31123982},
	issn = {0143-4160},
	abstract = {The synergy between synaptic Glu release and astrocytic Glu-Na+ symport is essential to the signalling function of the tripartite synapse. Here we used kinetic data of astrocytic Glu transporters (EAAT) and the Na+/Ca2+ exchanger (NCX) to simulate Glu release, Glu uptake and subsequent Na+ and Ca2+ dynamics in the astrocytic leaflet microdomain following single release event. Model simulations show that Glu-Na+ symport differently affect intracellular [Na+] in synapses with different extent of astrocytic coverage. Surprisingly, NCX activity alone has been shown to generate markedly stable, spontaneous Ca2+ oscillation in the astrocytic leaflet. These on-going oscillations appear when NCX operates either in the forward or reverse direction. We conjecture that intrinsic NCX activity may play a prominent role in the generation of astrocytic Ca2+ oscillations. © 2019 The Authors},
	keywords = {ARTICLE; priority journal; nonhuman; brain region; Sodium ion; Calcium ion; nerve cell; glutamic acid; amino acid transport; molecular dynamics; Calcium Signaling; ASTROCYTE; anion exchange; intracellular transport; Na+/Ca2+ exchange; CA2+ OSCILLATIONS; membrane microdomain; Astrocytic Glu-Na+ symport; Astrocytic leaflet; Glu-Na+ symport; Synaptic Glu release; membrane leaflet},
	year = {2020},
	eissn = {1532-1991}
}

@article{MTMT:31096625,
	title = {Astrocytic gap junctions differentially affect seizures in absence and temporal lobe epilepsy models},
	url = {https://m2.mtmt.hu/api/publication/31096625},
	author = {Vincze, R. and Péter, Márton and Szabó, Zsolt and Kardos, Julianna and Kovács, Zsolt and Héja, László},
	journal-iso = {GLIA},
	journal = {GLIA},
	volume = {67},
	unique-id = {31096625},
	issn = {0894-1491},
	year = {2019},
	eissn = {1098-1136},
	pages = {E710-E711},
	orcid-numbers = {Szabó, Zsolt/0000-0002-2902-743X; Kovács, Zsolt/0000-0001-8571-5686}
}