@article{MTMT:34089134,
	title = {Real-Life Efficacy of Tofacitinib in Various Situations in Ulcerative Colitis. A Retrospective Worldwide Multicenter Collaborative Study},
	url = {https://m2.mtmt.hu/api/publication/34089134},
	author = {Resál, Tamás and Bacsur, Péter and Keresztes, Csilla and Bálint, Anita and Bor, Renáta and Fábián, Anna and Farkas, Bernadett and Katsanos, Kostas and Michalopoylos, George and Ribaldone, Davide Giuseppe and Attauabi, Mohamed and Zhao, Mirabella and Barak, Hadar Amir and Yanai, Henit and Bezzio, Cristina and Rispo, Antonio and Castiglione, Fabiana and Bar-Gil Shitrit, Ariella and Pugliese, Daniela and Armuzzi, Alessandro and Savarino, Edoardo Vincenzo and Kolar, Martin and Lukáš, Milan and Chashkova, Elena and Filip, Rafał and Rozieres, Aurore and Nancey, Stéphane and Krznarić, Željko and Schäfer, Eszter and Szamosi, A and Sarlós, Patrícia and Franko, Matej and Drobne, David and Knyazev, Oleg V and Kagramanova, Anna V and Limdi, Jimmy and Wetwittayakhlang, Panu and Lakatos, Péter László and Maharshak, Nitsan and Bannon, Lian and Nyári, Tibor András and Szepes, Zoltán and Farkas, Klaudia and Molnár, Tamás},
	doi = {10.1093/ibd/izad135},
	journal-iso = {INFLAMM BOWEL DIS},
	journal = {INFLAMMATORY BOWEL DISEASES},
	volume = {In press},
	unique-id = {34089134},
	issn = {1078-0998},
	abstract = {Tofacitinib (TFB) appears to be effective in the treatment of ulcerative colitis (UC); however, available real-world studies are limited by cohort size. TFB could be an option in the treatment of acute severe ulcerative colitis (ASUC). We aimed to investigate efficacy and safety of TFB in moderate-to-severe colitis and ASUC.This retrospective, international cohort study enrolling UC patients with ≥6-week follow-up period was conducted from February 1 to July 31, 2022. Indications were categorized as ASUC and chronic activity (CA). Baseline demographic and clinical data were obtained. Steroid-free remission (SFR), colectomy, and safety data were analyzed.A total of 391 UC patients (median age 38 [interquartile range, 28-47] years; follow-up period 26 [interquartile range, 14-52] weeks) were included. A total of 27.1% received TFB in ASUC. SFR rates were 23.7% (ASUC: 26.0%, CA: 22.8%) at week 12 and 41.1% (ASUC: 34.2%, CA: 43.5%) at week 52. The baseline partial Mayo score (odds ratio [OR], 0.850; P = .006) was negatively associated with week 12 SFR, while biologic-naïve patients (OR, 2.078; P = .04) more likely achieved week 52 SFR. The colectomy rate at week 52 was higher in ASUC group (17.6% vs 5.7%; P < .001) and decreased with age (OR, 0.94; P = .013). A total of 67 adverse events were reported, and 17.9% resulted in cessation of TFB. One case of thromboembolic event was reported.TFB is effective in both studied indications. TFB treatment resulted in high rates of SFR in the short and long terms. Higher baseline disease activity and previous biological therapies decreased efficacy. No new adverse event signals were found.},
	keywords = {Tofacitinib; acute severe ulcerative colitis; moderate-to severe ulcerative colitis},
	year = {2024},
	eissn = {1536-4844},
	orcid-numbers = {Resál, Tamás/0000-0002-3842-9094; Bacsur, Péter/0000-0002-8534-0068; Bálint, Anita/0000-0002-3624-896X; Bor, Renáta/0000-0001-9393-5240; Fábián, Anna/0000-0002-0824-7476; Sarlós, Patrícia/0000-0002-5086-9455; Lakatos, Péter László/0000-0002-3948-6488; Nyári, Tibor András/0000-0001-8900-6641; Szepes, Zoltán/0000-0002-9466-8719; Farkas, Klaudia/0000-0003-0599-182X; Molnár, Tamás/0000-0002-4913-7599}
}

@inproceedings{MTMT:34449586,
	title = {A külső halálozások alakulása Magyarországon a 15 év alatti populációban 2000 és 2021 között},
	url = {https://m2.mtmt.hu/api/publication/34449586},
	author = {Urfi, Zsanett Gabriella and Nyári, Tibor András and Lantos, Tamás},
	booktitle = {Orvosi informatika. A XXXVI. Neumann Kollokvium konferencia-kiadványa},
	unique-id = {34449586},
	year = {2023},
	pages = {127-132},
	orcid-numbers = {Nyári, Tibor András/0000-0001-8900-6641}
}

@{MTMT:34426094,
	title = {Impact of neoadjuvant FLOT treatment of advanced gastric and gastroesophageal junction cancer following surgical therapy},
	url = {https://m2.mtmt.hu/api/publication/34426094},
	author = {Paszt, Attila and Simonka, Zsolt and Budai, Krisztina and Horváth, Zoltán and Erdos, Marton and Vas, Márton Árpád and Ottlakán, Aurél and Nyári, Tibor András and Szepes, Zoltán and Uhercsák, Gabriella and Maráz, Anikó and Torday, László and Tiszlavicz, László and Oláh, Judit Magdolna and Lázár, György ifj},
	booktitle = {Surgical and Oncological Updates in the Management of Gastric Cancer: the Role of Neoadjuvant Therapy and Minimally Invasive Surgery},
	unique-id = {34426094},
	year = {2023},
	pages = {56-68},
	orcid-numbers = {Paszt, Attila/0000-0002-1637-8652; Simonka, Zsolt/0000-0002-3490-226X; Horváth, Zoltán/0000-0002-9790-4975; Ottlakán, Aurél/0000-0002-7743-7775; Nyári, Tibor András/0000-0001-8900-6641; Szepes, Zoltán/0000-0002-9466-8719; Maráz, Anikó/0000-0002-2018-8413; Torday, László/0000-0002-2911-5499; Tiszlavicz, László/0000-0003-1134-6587; Lázár, György ifj/0000-0001-7155-2978}
}

@article{MTMT:34104677,
	title = {The value of PLA2R antigen and IgG subclass staining relative to anti-PLA2R seropositivity in the differential diagnosis of membranous nephropathy},
	url = {https://m2.mtmt.hu/api/publication/34104677},
	author = {Bajcsi, Dóra and Bitó, László and Turkevi-Nagy, Sándor and Nyári, Tibor András and Kemény, Éva and Légrády, Péter and Ábrahám, György and Iványi, Béla},
	doi = {10.1186/s12882-023-03273-4},
	journal-iso = {BMC NEPHROL},
	journal = {BMC NEPHROLOGY},
	volume = {24},
	unique-id = {34104677},
	issn = {1471-2369},
	abstract = {The diagnostic performance of PLA2R and IgG subclass staining of kidney biopsies relative to anti-PLA2R seropositivity in the differentiation of primary and secondary membranous nephropathy (pMN, sMN) was examined. Besides PLA2R staining - which has a lower specificity than anti-PLA2R antibody serology - there is insufficient knowledge to decide which IgG1-4 subtype immunohistological patterns (IgG4-dominance, IgG4-dominance/IgG1-IgG4-codominance or IgG4-dominance/IgG4-codominance with any IgG subtype) could be used to distinguish between pMN and sMN.87 consecutive Hungarian patients (84 Caucasians, 3 Romas) with the biopsy diagnosis of MN were classified clinically as pMN (n = 63) or sMN (n = 24). The PLA2R and IgG subclass staining was part of the diagnostic protocol. Anti-PLA2R antibodies were determined by an indirect immunofluorescence test in 74 patients with disease activity.For pMN, the sensitivity of anti-PLA2R seropositivity was 61.1%, and the specificity was 90.0%; and similar values for PLA2R staining were 81.0%, and 66.7%, respectively. In all stages of pMN, IgG4-dominance was the dominant subclass pattern, while the second most frequent was IgG3/IgG4-codominance. The sensitivity and specificity scores were: IgG4-dominance 52.2% and 91.7%, IgG4-dominance/IgG3-IgG4-codominance 76.2% and 87.5%, IgG4-dominance/IgG1-IgG4-codominance 64.2% and 75%, and IgG4-dominance/codominance with any IgG subclass 92.1% and 70.8%, respectively. Anti-PLA2R seropositivity, glomerular PLA2R, and IgG4-dominance/codominance significantly correlated with each other. The IgG4 subclass was rarely encountered in sMN.In our series, IgG4-dominance had the highest specificity in the differentiation of MN, just as high as that for anti-PLA2R seropositivity. The specificity values of PLA2R staining and IgG4-dominance/codominance with any IgG subclass or IgG4-dominance/IgG1-IgG4 codominance were ≤ 75%. Apart from IgG4 dominance, IgG4-dominance/IgG3-IgG4-codominance also had good statistical value in differentiating pMN from sMN. As IgG subclass switching during the progression of pMN was not the feature of our cohort, pMN in Hungarian patients is presumed to be an IgG4-related disorder right from the start. Although anti-PLA2R seropositivity has become the cornerstone for diagnosing pMN, if a kidney biopsy evaluation is conducted, besides the staining of PLA2R antigen, the evaluation of IgG subclasses provides relevant information for a differential diagnosis. Even in cases with IgG4-dominance, however, malignancy should be thoroughly checked.},
	keywords = {SPECIFICITY; Membranous nephropathy; IgG subclass; anti-PLA2R antibodies; IgG4-dominance; PLA2R antigen},
	year = {2023},
	eissn = {1471-2369},
	orcid-numbers = {Nyári, Tibor András/0000-0001-8900-6641; Ábrahám, György/0000-0002-2272-2317}
}

@{MTMT:33775804,
	title = {Effect of maternal pregestational BMI on the development of gestational diabetes mellitus},
	url = {https://m2.mtmt.hu/api/publication/33775804},
	author = {Rachamim, Y and Altojay, A and Nyári, Tibor András and Németh, Gábor László and Surányi, Andrea},
	booktitle = {Abstract Book 5th RECOOP International Student and 18th RECOOP Bridges in Life Sciences Conferences},
	unique-id = {33775804},
	abstract = {Introduction: The purpose of this study was to investigate the effect of maternal pregestational body mass index (preBMI) on development of gestational diabetes mellitus (GDM).
		Methods: A retrospective case control study was conducted for pregnancies during the 2-year study period. Women were separated into three groups: normal pregnancy (N=145), preGDM (N=27), GDM (N=41). According to the BMI categories of WHO, pregnants were classified as normal weight (18.5-24.9 kg/m2) or obese (≥30 kg/m2).
		Diagnostic criteria for preGDM and GDM were based on the guidelines of the Hungarian College of Obstetrics and Gynecology. The Hungarian guideline adopted the National Institute for Health and Care Excellence. (NICE Guideline 3).
		The oral glucose tolerance test (OGTT) was applied as a screening and diagnostic tool for diabetes. In the test, 75 grams of glucose solution was consumed by the pregnant woman after an 8-hour period of fasting. The glucose level in samples of maternal serum was measured at the start (0 min) and after 120 min. Diagnostic criteria for GDM were: fasting blood glucose level (at 0 min) ≥ 5.6 mmol/l and/or postprandial blood glucose level (at 120 min) ≥ 7.8 mmol/l. 
		If women before subsequent pregnancy had been affected by diabetes mellitus (DM), the OGTT was not performed, but dietary treatment was administered. Patients suffering from preGDM used insulin for treating the disease before pregnancy. High risk pregnancies with respect to GDM were screened with OGTT between the 16th-18th week of gestation, and when the result was below the limit, OGTT was repeated between the 24th-28th week of gestation.
		Results: The prevalence of pregestational obesity among pregnant women was 25.82% (55/213) [normal: 3.45% (5/145), preGDM: 66.67% (18/27), GDM: 78.05% (32/41)].
		Discussion: In women with pregestational obesity increased risk for developing GDM can be detected, that leads to a significantly higher risk for adverse perinatal outcome in Hungary.
		Conclusion: Pregestational obesity is a risk for developing GDM.},
	year = {2023},
	pages = {70},
	orcid-numbers = {Nyári, Tibor András/0000-0001-8900-6641; Németh, Gábor László/0000-0003-1829-3457; Surányi, Andrea/0000-0002-1168-7261}
}

@{MTMT:33775774,
	title = {Effect of maternal pregestational BMI on perinatal outcomes in pregestational and gestational diabetes},
	url = {https://m2.mtmt.hu/api/publication/33775774},
	author = {Kolcsár, Bálint and Altorjay, Ábel Tamás and Nyári, Tibor András and Németh, Gábor László and Surányi, Andrea},
	booktitle = {Abstract Book 5th RECOOP International Student and 18th RECOOP Bridges in Life Sciences Conferences},
	unique-id = {33775774},
	abstract = {Introduction: The purpose of this study was to investigate the effect of maternal pregestational body mass index (preBMI) on perinatal outcomes in pregestational diabetes mellitus (preGDM) and in gestational diabetes mellitus GDM.
		Methods: A retrospective case control study was conducted for pregnancies during the 2-year study period. Women were separated into three groups: normal pregnancy (N=145), preGDM (N=27), GDM (N=41). According to the BMI categories of WHO, pregnants were classified as normal weight (18.5-24.9 kg/m2) or obese (≥30 kg/m2).
		Diagnostic criteria for preGDM and GDM were based on the guidelines of the Hungarian College of Obstetrics and Gynecology. The Hungarian guideline adopted the National Institute for Health and Care Excellence. (NICE Guideline 3).
		We examined the following pregnancy and neonatal outcomes: Cesarean section, perinatal complications (breathing problem, hypoglycemia, polycythemia), birth weight, birth length, 1-minute, 5-minute and 10-minute Apgar scores, admission to the neonatal intensive care unit (NICU) and umbilical cord arterial pH.
		Results: Transmission to the neonatal intensive unit was 22.53% (48/213) with an increased rate in diabetic groups [GDM: 41.46% (17/41), preGDM: 14.81% (4/27)] compared to healthy controls [13.79% (20/145)]. The average rate of perinatal complications was the highest in GDM group (16.98%) compared to control (14.19%) and preGDM (5.56%) groups. The risk of perinatal complications was elevated in diabetic groups (GDM; preGDM) compared to the control group (aOR: 4.52,95% CI:2.20-9.27). It was demonstrated that obese women are more likely to have perinatal complications (preGDM: aOR 1.17,95% CI:0.72-2.82; GDM: aOR77.77 95% CI:27.42-220.51).
		Discussion: In women affected by GDM we can detect even higher risk for adverse perinatal outcome in Hungary.
		Conclusion: Pregestational obesity is a risk for perinatal complications.},
	year = {2023},
	pages = {69},
	orcid-numbers = {Altorjay, Ábel Tamás/0000-0002-9052-8671; Nyári, Tibor András/0000-0001-8900-6641; Németh, Gábor László/0000-0003-1829-3457; Surányi, Andrea/0000-0002-1168-7261}
}

@article{MTMT:33729458,
	title = {Impact of neoadjuvant FLOT treatment of advanced gastric and gastroesophageal junction cancer following surgical therapy},
	url = {https://m2.mtmt.hu/api/publication/33729458},
	author = {Paszt, Attila and Simonka, Zsolt and Budai, Krisztina and Horváth, Zoltán and Erdos, Marton and Vas, Márton Árpád and Ottlakán, Aurél and Nyári, Tibor András and Szepes, Zoltán and Uhercsák, Gabriella and Maráz, Anikó and Torday, László and Tiszlavicz, László and Oláh, Judit Magdolna and Lázár, György ifj},
	doi = {10.3389/fsurg.2023.1148984},
	journal-iso = {FRONT SURG},
	journal = {FRONTIERS IN SURGERY},
	volume = {10},
	unique-id = {33729458},
	year = {2023},
	eissn = {2296-875X},
	orcid-numbers = {Paszt, Attila/0000-0002-1637-8652; Simonka, Zsolt/0000-0002-3490-226X; Horváth, Zoltán/0000-0002-9790-4975; Ottlakán, Aurél/0000-0002-7743-7775; Nyári, Tibor András/0000-0001-8900-6641; Szepes, Zoltán/0000-0002-9466-8719; Maráz, Anikó/0000-0002-2018-8413; Torday, László/0000-0002-2911-5499; Tiszlavicz, László/0000-0003-1134-6587; Lázár, György ifj/0000-0001-7155-2978}
}

@misc{MTMT:33685481,
	title = {Az anyai pregesztációs testtömegindex hatása a perinatális kimenetelre pregesztációs és terhességi diabetes mellitusban},
	url = {https://m2.mtmt.hu/api/publication/33685481},
	author = {Kolcsár, Bálint and Altorjay, Ábel Tamás and Nyári, Tibor András and Németh, Gábor László and Surányi, Andrea},
	unique-id = {33685481},
	year = {2023},
	orcid-numbers = {Altorjay, Ábel Tamás/0000-0002-9052-8671; Nyári, Tibor András/0000-0001-8900-6641; Németh, Gábor László/0000-0003-1829-3457; Surányi, Andrea/0000-0002-1168-7261}
}

@article{MTMT:33649494,
	title = {ONEST (Observers Needed to Evaluate Subjective Tests) Analysis of Stromal Tumour-Infiltrating Lymphocytes (sTILs) in Breast Cancer and Its Limitations},
	url = {https://m2.mtmt.hu/api/publication/33649494},
	author = {Cserni, Bálint Gábor and Kilmartin, Darren and O’Loughlin, Mark and Andreu, Xavier and Bagó-Horváth, Zsuzsanna and Bianchi, Simonetta and Chmielik, Ewa and Figueiredo, Paulo and Floris, Giuseppe and Foschini, Maria Pia and Kovács, Anikó and Heikkilä, Päivi and Kulka, Janina and Laenkholm, Anne-Vibeke and Liepniece-Karele, Inta and Marchiò, Caterina and Provenzano, Elena and Regitnig, Peter and Reiner, Angelika and Ryška, Aleš and Sapino, Anna and Stovgaard, Elisabeth Specht and Quinn, Cecily and Zolota, Vasiliki and Webber, Mark and Glynn, Sharon A. and Bori, Rita and Csörgő, Erika and Oláh, Orsolya and Pancsa, Tamás and Sejben, Anita and Sejben, István and Vörös, András and Zombori, Tamás and Nyári, Tibor András and Callagy, Grace and Cserni, Gábor},
	doi = {10.3390/cancers15041199},
	journal-iso = {CANCERS},
	journal = {CANCERS},
	volume = {15},
	unique-id = {33649494},
	abstract = {Tumour-infiltrating lymphocytes (TILs) reflect antitumour immunity. Their evaluation of histopathology specimens is influenced by several factors and is subject to issues of reproducibility. ONEST (Observers Needed to Evaluate Subjective Tests) helps in determining the number of observers that would be sufficient for the reliable estimation of inter-observer agreement of TIL categorisation. This has not been explored previously in relation to TILs. ONEST analyses, using an open-source software developed by the first author, were performed on TIL quantification in breast cancers taken from two previous studies. These were one reproducibility study involving 49 breast cancers, 23 in the first circulation and 14 pathologists in the second circulation, and one study involving 100 cases and 9 pathologists. In addition to the estimates of the number of observers required, other factors influencing the results of ONEST were examined. The analyses reveal that between six and nine observers (range 2–11) are most commonly needed to give a robust estimate of reproducibility. In addition, the number and experience of observers, the distribution of values around or away from the extremes, and outliers in the classification also influence the results. Due to the simplicity and the potentially relevant information it may give, we propose ONEST to be a part of new reproducibility analyses.},
	year = {2023},
	eissn = {2072-6694},
	orcid-numbers = {Bianchi, Simonetta/0000-0002-2605-4758; Foschini, Maria Pia/0000-0001-7079-7260; Kovács, Anikó/0000-0001-7711-4418; Kulka, Janina/0000-0001-6498-5943; Marchiò, Caterina/0000-0003-2024-6131; Regitnig, Peter/0000-0002-1371-1595; Stovgaard, Elisabeth Specht/0000-0002-5784-3610; Glynn, Sharon A./0000-0003-1459-2580; Oláh, Orsolya/0000-0002-5731-4030; Sejben, Anita/0000-0002-9434-2989; Vörös, András/0000-0001-6837-0567; Zombori, Tamás/0000-0002-0654-563X; Nyári, Tibor András/0000-0001-8900-6641; Cserni, Gábor/0000-0003-1344-7744}
}

@inproceedings{MTMT:33575313,
	title = {Gyerekkori daganatos betegségek morbiditásának és mortalitásának vizsgálata Magyarországon 1999-2021 között},
	url = {https://m2.mtmt.hu/api/publication/33575313},
	author = {Németh, Kristóf and Nyári, Tibor András},
	booktitle = {Az egészségügyi informatika COVID előtt és COVID után - A XXXV. Neumann Kollokvium konferencia kiadványa},
	unique-id = {33575313},
	year = {2022},
	pages = {173-176},
	orcid-numbers = {Nyári, Tibor András/0000-0001-8900-6641}
}