TY - JOUR AU - Martos, Diána AU - Tuka, Bernadett AU - Tanaka, Masaru AU - Vécsei, László AU - Telegdy, Gyula TI - Memory Enhancement with Kynurenic Acid and Its Mechanisms in Neurotransmission JF - BIOMEDICINES J2 - BIOMEDICINES VL - 10 PY - 2022 IS - 4 PG - 18 SN - 2227-9059 DO - 10.3390/biomedicines10040849 UR - https://m2.mtmt.hu/api/publication/32778125 ID - 32778125 N1 - Funding Agency and Grant Number: National Scientific Research Fund [OTKA138125, TUDFO/47138-1/2019-ITM, TKP2020, 5257] Funding text: The current work was supported by National Scientific Research Fund OTKA138125, TUDFO/47138-1/2019-ITM, TKP2020 Thematic Excellence Programme 2020, University of Szeged Open Access Fund (5257). LA - English DB - MTMT ER - TY - JOUR AU - Tanaka, Masaru AU - Bohár, Zsuzsanna AU - Martos, Diána AU - Telegdy, Gyula AU - Vécsei, László TI - Antidepressant-like effects of kynurenic acid in a modified forced swim test. JF - PHARMACOLOGICAL REPORTS J2 - PHARMACOL REP VL - 72 PY - 2020 IS - 2 SP - 449 EP - 455 PG - 7 SN - 1734-1140 DO - 10.1007/s43440-020-00067-5 UR - https://m2.mtmt.hu/api/publication/31252899 ID - 31252899 N1 - MTA-SZTE, Neuroscience Research Group, Szeged, Hungary Department of Neurology, Interdisciplinary Excellence Centre, Faculty of Medicine, Albert Szent-Györgyi Health Centre, University of Szeged, Szeged, Hungary Department of Pathophysiology, Faculty of Medicine, University of Szeged, Szeged, Hungary Cited By :45 Export Date: 7 March 2024 CODEN: PRHED Correspondence Address: Tanaka, M.; MTA-SZTE, Hungary; email: tanaka.masaru.1@med.u-szeged.hu Funding details: 4639 Funding details: Emberi Eroforrások Minisztériuma, EMMI, 20391-3/2018/FEKUSTRAT Funding details: Szegedi Tudományegyetem, SZTE, GINOP 2.3.2-15-2016-00034 Funding text 1: Open access funding provided by University of Szeged (SZTE). This work was funded by GINOP 2.3.2-15-2016-00034, Ministry of Human Capacities, Hungary Grant 20391-3/2018/FEKUSTRAT and University of Szeged Open Access Fund (FundRef), Grant number 4639. We thank Ms. Jennifer Tusz, a native English speaker, for proofreading the manuscript. Funding text 2: Open access funding provided by University of Szeged (SZTE). This work was funded by GINOP 2.3.2-15-2016-00034, Ministry of Human Capacities, Hungary Grant 20391-3/2018/FEKUSTRAT and University of Szeged Open Access Fund (FundRef), Grant number 4639. We thank Ms. Jennifer Tusz, a native English speaker, for proofreading the manuscript. AB - Kynurenic acid (KYNA) is an L-tryptophan metabolite with neuromodulatory activities, regulating the release of neurotransmitters such as glutamate, dopamine (DA), and acetylcholine (Ach). Dysregulation of the kynurenine pathway has been associated with neurodegenerative, neurological, and psychological disorders such as Alzheimer's disease, Parkinson's disease, Huntington's disease, major depressive disorder, and schizophrenia.The antidepressant-like effects of KYNA were studied with a modified mouse forced swimming test (FST), and the potential involvement of the serotonin (SER), norepinephrine, DA, Ach, N-methyl-D-aspartate, or gamma-aminobutyric acid subunit A (GABAA) receptors in its antidepressant-like effect was assayed by modified combination mouse FST. In combination studies, the mice were pretreated with the respective receptor antagonist, cyproheptadine (CPH), phenoxybenzamine, yohimbine, propranolol, haloperidol (HPD), atropine, MK-801, or bicuculline (BCL).The FST revealed that KYNA reversed immobility, climbing, and swimming times, suggesting the antidepressant-like effects of KYNA. Furthermore, the combination studies showed that CPH prevented the antidepressant-like effects of KYNA on immobility, climbing, and swimming times, whereas HPD reduced climbing time and BCL influenced immobility and climbing times and prevented the effects of KYNA on swimming time.The results demonstrated, for the first time, the presence of antidepressant-like effects of KYNA in a modified mouse FST. Furthermore, modified combination FST showed that the antidepressant-like actions of KYNA strongly interacted with 5-hydroxytryptamine type 2 SER-ergic receptors, weakly interacted with D2, D3, D4 DA-ergic receptors, and interacted moderately with GABAA receptors. LA - English DB - MTMT ER - TY - JOUR AU - Buzás, András AU - Bokor, Péter AU - Balangó, Beáta AU - Pintér, Dávid AU - Palotai, Miklós AU - Simon, Balázs AU - Csabafi, Krisztina AU - Telegdy, Gyula AU - Szabó, Gyula AU - Bagosi, Zsolt TI - Changes in striatal dopamine release and locomotor activity following acute withdrawal from chronic nicotine are mediated by CRF1, but not CRF2, receptors JF - BRAIN RESEARCH J2 - BRAIN RES VL - 1706 PY - 2019 SP - 41 EP - 47 PG - 7 SN - 0006-8993 DO - 10.1016/j.brainres.2018.10.028 UR - https://m2.mtmt.hu/api/publication/30330450 ID - 30330450 N1 - Cited By :7 Export Date: 11 October 2023 CODEN: BRREA Correspondence Address: Bagosi, Z.; Department of Pathophysiology, Semmelweis str. 1, Hungary; email: bagosi.zsolt@med.u-szeged.hu LA - English DB - MTMT ER - TY - JOUR AU - Bagosi, Zsolt AU - Csabafi, Krisztina AU - Karasz, Gergely AU - Jászberényi, Miklós AU - Földesi, Imre AU - Siska, Andrea AU - Szabó, Gyula AU - Telegdy, Gyula TI - The effects of the urocortins on the hypothalamic-pituitary-adrenal axis - similarities and discordancies between rats and mice JF - PEPTIDES J2 - PEPTIDES VL - 112 PY - 2019 SP - 1 EP - 13 PG - 13 SN - 0196-9781 DO - 10.1016/j.peptides.2018.10.014 UR - https://m2.mtmt.hu/api/publication/30330445 ID - 30330445 LA - English DB - MTMT ER - TY - JOUR AU - Csabafi, Krisztina AU - Bagosi, Zsolt AU - Bodnár, Éva AU - Szakács, Júlia AU - Telegdy, Gyula AU - Szabó, Gyula TI - Kisspeptin modulates pain sensitivity of CFLP mice JF - PEPTIDES J2 - PEPTIDES VL - 105 PY - 2018 SP - 21 EP - 27 PG - 7 SN - 0196-9781 DO - 10.1016/j.peptides.2018.04.018 UR - https://m2.mtmt.hu/api/publication/27524046 ID - 27524046 LA - English DB - MTMT ER - TY - JOUR AU - Bagosi, Zsolt AU - Csabafi, Krisztina AU - Balangó, B AU - Pintér, D AU - Szolomájer-Csikos, Orsolya AU - Bozsó, Zsolt AU - Tóth, Gábor AU - Telegdy, Gyula AU - Szabó, Gyula TI - Anxiolytic- and antidepressant-like actions of Urocortin 2 and its fragments in mice JF - BRAIN RESEARCH J2 - BRAIN RES VL - 1680 PY - 2018 SP - 62 EP - 68 PG - 7 SN - 0006-8993 DO - 10.1016/j.brainres.2017.12.011 UR - https://m2.mtmt.hu/api/publication/3310034 ID - 3310034 N1 - Department of Pathophysiology, Faculty of Medicine, University of Szeged, Hungary Department of Medical Chemistry, Faculty of Medicine, University of Szeged, Hungary Cited By :3 Export Date: 11 October 2023 CODEN: BRREA Correspondence Address: Bagosi, Z.; Department of Pathophysiology, Semmelweis str. 1, Hungary; email: bagosi.zsolt@med.u-szeged.hu LA - English DB - MTMT ER - TY - JOUR AU - Bagosi, Zsolt AU - Czebely-Lenart, A AU - Karasz, G AU - Csabafi, Krisztina AU - Jászberényi, Miklós AU - Telegdy, Gyula TI - The effects of CRF and urocortins on the preference for social novelty of mice JF - BEHAVIOURAL BRAIN RESEARCH J2 - BEHAV BRAIN RES VL - 324 PY - 2017 SP - 146 EP - 154 PG - 9 SN - 0166-4328 DO - 10.1016/j.bbr.2017.02.009 UR - https://m2.mtmt.hu/api/publication/3280538 ID - 3280538 AB - The aim of the present study was to determine the role of corticotropin-releasing factor (CRF), the urocortins (UCN 1, UCN 2 and UCN 3) and their receptors (CRF1 and CRF2) in the preference for social novelty of mice. Male CFLP mice were administered intracerebroventricularly (ICV) with CRF, UCN 1, UCN 2 or UCN 3 and/or antalarmin or astressin 2B, selective antagonists of CRF1 receptor and CRF2 receptor, respectively. The mice were investigated in a Crawley social interaction test arena consisting of three chambers: an unknown female was set in the first chamber and a known female, with which the male was familiarized previously for 24 h, was set in the third chamber. First the tested male was habituated with the middle chamber for 5 min and then allowed to explore the remaining chambers for 5 min, during which the number of entries and the time of interaction were measured. CRF decreased significantly the number of entries and the time of interaction with the unknown female, but not the known female. UCN 1 decreased significantly the number of entries into the chamber of the unknown female, but not the known female, without changing the time of interaction. All decreasing effects were reversed by antalarmin, but not astressin 2B. UCN 2 and UCN 3 didn't influence significantly any of the parameters. The present study suggests that CRF and UCN 1 decrease the preference for social novelty by activating CRF1 receptor, while UCN 2 and UCN 3, activating selectively CRF2 receptor, do not participate to male-female interaction. (C) 2017 Elsevier B.V. All rights reserved. LA - English DB - MTMT ER - TY - JOUR AU - Bagosi, Zsolt AU - Karasz, G AU - Czebely-Lenart, A AU - Csabafi, Krisztina AU - Jászberényi, Miklós AU - Telegdy, Gyula TI - The effects of CRF and urocortins on the sociability of mice JF - BRAIN RESEARCH J2 - BRAIN RES VL - 1663 PY - 2017 SP - 114 EP - 122 PG - 9 SN - 0006-8993 DO - 10.1016/j.brainres.2017.03.003 UR - https://m2.mtmt.hu/api/publication/3280537 ID - 3280537 AB - The aim of our study was to determine the role of corticotropin-releasing factor (CRF), the urocortins (Ucn1, Ucn2 and Ucn3) and their receptors (CRF1 and CRF2) in the sociability of mice. Male CFLP mice were administered intracerebroventricularly (icv) with CRF and urocortins alone or in combination with antalarmin (specific CRF1 antagonist) and astressin(2B) (specific CRF2 antagonist) and then investigated in a Crawley social interaction test arena, that consists of three chambers. An unknown male in a cage was put in the first chamber and an empty cage was put in the opposite chamber. The tested male was habituated with the middle chamber for 5 min and then allowed to explore the remaining chambers for 5 min, during which the number of entries and the time of interaction were measured. Intracerebroventricular administration of CRF decreased significantly the number of entries and the time of interaction with the unknown male and these effects were blocked by antalarmin, but not astressin2B. In contrast, central administration of Ucn1 increased significantly the number of entries into the chamber of the unknown male, without changing the time of interaction and this effect was blocked by astressin2B, but not antalarmin. Central administration of Ucn2 and Ucn3 didn't influence remarkably the number of entries, but it reduced the time of interaction between the male mice. Our study suggests that CRF and Ucn1 may play important, but different roles in sociability, and that Ucn2 and Ucn3, playing similar roles, must be also involved in social interactions. (C) 2017 Elsevier B.V. All rights reserved. LA - English DB - MTMT ER - TY - CONF AU - Bagosi, Zsolt AU - Csabafi, Krisztina AU - Jászberényi, Miklós AU - Telegdy, Gyula ED - [sn], null TI - The role of CRF and the urocortins in social interaction T2 - Abstracts of the 25th Annual Meeting of the International Behavioral Neuroscience Society PY - 2016 SP - 100 EP - 101 PG - 2 UR - https://m2.mtmt.hu/api/publication/3317103 ID - 3317103 AB - Corticotropin-releasing factor (CRF) and the urocortins (UCN 1, UCN 2 and UCN 3) belong to the same CRF peptide family, having similar amino acidic structure, but different pharmacological properties. Besides their principle role in the regulation of the stress response, CRF and CRF-like peptides have been implicated in the social behavior of many species. The aim of the present study was to determine the role of CRF and the urocortins in the social interaction of mice. Male CFLP mice were administered intracerebroventricularly (ICV) CRF, UCN 1, UCN 2 or UCN 3 and then investigated in a Crawley social interaction test arena, which consists of three different chambers. Two types of tests were performed. In both types, first the tested male was habituated with the middle chamber of the arena for 5 minutes and then it was allowed to explore the remaining chambers for another 5 minutes, during which the number of entries and the time of interaction were measured. In the first test examining the sociability of mice, an unknown male was put in the first chamber, while the third chamber was left empty. In the second test examining the preference for social novelty of mice, a known female, with which the male was familiarized previously for 24 hours, and an unknown female were set in the opposite chambers. ICV injection of CRF reduced significantly the number of entries and the time of interaction with the unknown male. In addition, it also reduced significantly the number of entries and the time of interaction with the unknown female, but not the known female. ICV injection of UCN 1 increased significantly the number of entries into the chamber of the unknown male, without changing the time of interaction. In contrast, it decreased considerably the number of entries into the chamber of both females, without changing the time of interaction. Central administration of UCN 2 and UCN 3 did not influence remarkably any of the parameters measured, except reducing the time of interaction between males. Our results demonstrate that CRF and UCN 1 play important, but different roles in the social interaction of mammals, which must be mediated by distinct receptors. Our results also suggest that UCN 2 and UCN 3 may be less relevant, but still involved in social behavior. The present study was sponsored by the Hungarian Brain Research Program and the Neuroscience Research Group of the Hungarian Academy. LA - English DB - MTMT ER - TY - JOUR AU - Balázs, Thurzó AU - Jászberényi, Miklós AU - Bagosi, Zsolt AU - Pataki, Imre AU - Eszter, Kádár AU - Szabó, Gyula AU - Telegdy, Gyula TI - Evidence of the dopamine-2 receptor mediated inhibition of the hypothalamic-pituitary-adrenal system; a rodent model of hypercortisolism in chronic neuropsychiatric disorders JF - TRANSLATIONAL BRAIN RHYTHMICITY J2 - TRANSL BRAIN RHYTHM VL - 1 PY - 2016 IS - 2 PG - 6 SN - 2397-8686 DO - 10.15761/TBR.1000110 UR - https://m2.mtmt.hu/api/publication/3277228 ID - 3277228 LA - English DB - MTMT ER -