@article{MTMT:32778125,
	title = {Memory Enhancement with Kynurenic Acid and Its Mechanisms in Neurotransmission},
	url = {https://m2.mtmt.hu/api/publication/32778125},
	author = {Martos, Diána and Tuka, Bernadett and Tanaka, Masaru and Vécsei, László and Telegdy, Gyula},
	doi = {10.3390/biomedicines10040849},
	journal-iso = {BIOMEDICINES},
	journal = {BIOMEDICINES},
	volume = {10},
	unique-id = {32778125},
	year = {2022},
	eissn = {2227-9059},
	orcid-numbers = {Tuka, Bernadett/0000-0002-1410-4666; Vécsei, László/0000-0001-8037-3672; Telegdy, Gyula/0000-0003-1734-4128}
}

@article{MTMT:31252899,
	title = {Antidepressant-like effects of kynurenic acid in a modified forced swim test.},
	url = {https://m2.mtmt.hu/api/publication/31252899},
	author = {Tanaka, Masaru and Bohár, Zsuzsanna and Martos, Diána and Telegdy, Gyula and Vécsei, László},
	doi = {10.1007/s43440-020-00067-5},
	journal-iso = {PHARMACOL REP},
	journal = {PHARMACOLOGICAL REPORTS},
	volume = {72},
	unique-id = {31252899},
	issn = {1734-1140},
	abstract = {Kynurenic acid (KYNA) is an L-tryptophan metabolite with neuromodulatory activities, regulating the release of neurotransmitters such as glutamate, dopamine (DA), and acetylcholine (Ach). Dysregulation of the kynurenine pathway has been associated with neurodegenerative, neurological, and psychological disorders such as Alzheimer's disease, Parkinson's disease, Huntington's disease, major depressive disorder, and schizophrenia.The antidepressant-like effects of KYNA were studied with a modified mouse forced swimming test (FST), and the potential involvement of the serotonin (SER), norepinephrine, DA, Ach, N-methyl-D-aspartate, or gamma-aminobutyric acid subunit A (GABAA) receptors in its antidepressant-like effect was assayed by modified combination mouse FST. In combination studies, the mice were pretreated with the respective receptor antagonist, cyproheptadine (CPH), phenoxybenzamine, yohimbine, propranolol, haloperidol (HPD), atropine, MK-801, or bicuculline (BCL).The FST revealed that KYNA reversed immobility, climbing, and swimming times, suggesting the antidepressant-like effects of KYNA. Furthermore, the combination studies showed that CPH prevented the antidepressant-like effects of KYNA on immobility, climbing, and swimming times, whereas HPD reduced climbing time and BCL influenced immobility and climbing times and prevented the effects of KYNA on swimming time.The results demonstrated, for the first time, the presence of antidepressant-like effects of KYNA in a modified mouse FST. Furthermore, modified combination FST showed that the antidepressant-like actions of KYNA strongly interacted with 5-hydroxytryptamine type 2 SER-ergic receptors, weakly interacted with D2, D3, D4 DA-ergic receptors, and interacted moderately with GABAA receptors.},
	keywords = {DEPRESSION; Antidepressants; NEUROTRANSMITTER RECEPTORS; Tryptophan Kynurenine Kynurenic acid},
	year = {2020},
	eissn = {2299-5684},
	pages = {449-455},
	orcid-numbers = {Telegdy, Gyula/0000-0003-1734-4128; Vécsei, László/0000-0001-8037-3672}
}

@article{MTMT:30330450,
	title = {Changes in striatal dopamine release and locomotor activity following acute withdrawal from chronic nicotine are mediated by CRF1, but not CRF2, receptors},
	url = {https://m2.mtmt.hu/api/publication/30330450},
	author = {Buzás, András and Bokor, Péter and Balangó, Beáta and Pintér, Dávid and Palotai, Miklós and Simon, Balázs and Csabafi, Krisztina and Telegdy, Gyula and Szabó, Gyula and Bagosi, Zsolt},
	doi = {10.1016/j.brainres.2018.10.028},
	journal-iso = {BRAIN RES},
	journal = {BRAIN RESEARCH},
	volume = {1706},
	unique-id = {30330450},
	issn = {0006-8993},
	year = {2019},
	eissn = {1872-6240},
	pages = {41-47},
	orcid-numbers = {Buzás, András/0000-0001-7318-4232; Csabafi, Krisztina/0000-0002-2008-7604; Telegdy, Gyula/0000-0003-1734-4128; Szabó, Gyula/0000-0002-3409-5357}
}

@article{MTMT:30330445,
	title = {The effects of the urocortins on the hypothalamic-pituitary-adrenal axis - similarities and discordancies between rats and mice},
	url = {https://m2.mtmt.hu/api/publication/30330445},
	author = {Bagosi, Zsolt and Csabafi, Krisztina and Karasz, Gergely and Jászberényi, Miklós and Földesi, Imre and Siska, Andrea and Szabó, Gyula and Telegdy, Gyula},
	doi = {10.1016/j.peptides.2018.10.014},
	journal-iso = {PEPTIDES},
	journal = {PEPTIDES},
	volume = {112},
	unique-id = {30330445},
	issn = {0196-9781},
	year = {2019},
	eissn = {1873-5169},
	pages = {1-13},
	orcid-numbers = {Csabafi, Krisztina/0000-0002-2008-7604; Jászberényi, Miklós/0000-0002-7287-7771; Földesi, Imre/0000-0002-3329-8136; Szabó, Gyula/0000-0002-3409-5357; Telegdy, Gyula/0000-0003-1734-4128}
}

@article{MTMT:27524046,
	title = {Kisspeptin modulates pain sensitivity of CFLP mice},
	url = {https://m2.mtmt.hu/api/publication/27524046},
	author = {Csabafi, Krisztina and Bagosi, Zsolt and Bodnár, Éva and Szakács, Júlia and Telegdy, Gyula and Szabó, Gyula},
	doi = {10.1016/j.peptides.2018.04.018},
	journal-iso = {PEPTIDES},
	journal = {PEPTIDES},
	volume = {105},
	unique-id = {27524046},
	issn = {0196-9781},
	year = {2018},
	eissn = {1873-5169},
	pages = {21-27},
	orcid-numbers = {Csabafi, Krisztina/0000-0002-2008-7604; Telegdy, Gyula/0000-0003-1734-4128; Szabó, Gyula/0000-0002-3409-5357}
}

@article{MTMT:3310034,
	title = {Anxiolytic- and antidepressant-like actions of Urocortin 2 and its fragments in mice},
	url = {https://m2.mtmt.hu/api/publication/3310034},
	author = {Bagosi, Zsolt and Csabafi, Krisztina and Balangó, B and Pintér, D and Szolomájer-Csikos, Orsolya and Bozsó, Zsolt and Tóth, Gábor and Telegdy, Gyula and Szabó, Gyula},
	doi = {10.1016/j.brainres.2017.12.011},
	journal-iso = {BRAIN RES},
	journal = {BRAIN RESEARCH},
	volume = {1680},
	unique-id = {3310034},
	issn = {0006-8993},
	year = {2018},
	eissn = {1872-6240},
	pages = {62-68},
	orcid-numbers = {Csabafi, Krisztina/0000-0002-2008-7604; Bozsó, Zsolt/0000-0002-5713-3096; Tóth, Gábor/0000-0002-3604-4385; Telegdy, Gyula/0000-0003-1734-4128; Szabó, Gyula/0000-0002-3409-5357}
}

@article{MTMT:3280538,
	title = {The effects of CRF and urocortins on the preference for social novelty of mice},
	url = {https://m2.mtmt.hu/api/publication/3280538},
	author = {Bagosi, Zsolt and Czebely-Lenart, A and Karasz, G and Csabafi, Krisztina and Jászberényi, Miklós and Telegdy, Gyula},
	doi = {10.1016/j.bbr.2017.02.009},
	journal-iso = {BEHAV BRAIN RES},
	journal = {BEHAVIOURAL BRAIN RESEARCH},
	volume = {324},
	unique-id = {3280538},
	issn = {0166-4328},
	abstract = {The aim of the present study was to determine the role of corticotropin-releasing factor (CRF), the urocortins (UCN 1, UCN 2 and UCN 3) and their receptors (CRF1 and CRF2) in the preference for social novelty of mice. Male CFLP mice were administered intracerebroventricularly (ICV) with CRF, UCN 1, UCN 2 or UCN 3 and/or antalarmin or astressin 2B, selective antagonists of CRF1 receptor and CRF2 receptor, respectively. The mice were investigated in a Crawley social interaction test arena consisting of three chambers: an unknown female was set in the first chamber and a known female, with which the male was familiarized previously for 24 h, was set in the third chamber. First the tested male was habituated with the middle chamber for 5 min and then allowed to explore the remaining chambers for 5 min, during which the number of entries and the time of interaction were measured. CRF decreased significantly the number of entries and the time of interaction with the unknown female, but not the known female. UCN 1 decreased significantly the number of entries into the chamber of the unknown female, but not the known female, without changing the time of interaction. All decreasing effects were reversed by antalarmin, but not astressin 2B. UCN 2 and UCN 3 didn't influence significantly any of the parameters. The present study suggests that CRF and UCN 1 decrease the preference for social novelty by activating CRF1 receptor, while UCN 2 and UCN 3, activating selectively CRF2 receptor, do not participate to male-female interaction. (C) 2017 Elsevier B.V. All rights reserved.},
	keywords = {Brain; PEPTIDES; MICE; FAMILY; CRF; PITUITARY-ADRENAL AXIS; CORTICOTROPIN-RELEASING-FACTOR; RECEPTORS; STRESS; Urocortins; ANXIETY-LIKE BEHAVIOR; BASOLATERAL AMYGDALA; FISH UROTENSIN-I; Social novelty},
	year = {2017},
	eissn = {1872-7549},
	pages = {146-154},
	orcid-numbers = {Csabafi, Krisztina/0000-0002-2008-7604; Jászberényi, Miklós/0000-0002-7287-7771; Telegdy, Gyula/0000-0003-1734-4128}
}

@article{MTMT:3280537,
	title = {The effects of CRF and urocortins on the sociability of mice},
	url = {https://m2.mtmt.hu/api/publication/3280537},
	author = {Bagosi, Zsolt and Karasz, G and Czebely-Lenart, A and Csabafi, Krisztina and Jászberényi, Miklós and Telegdy, Gyula},
	doi = {10.1016/j.brainres.2017.03.003},
	journal-iso = {BRAIN RES},
	journal = {BRAIN RESEARCH},
	volume = {1663},
	unique-id = {3280537},
	issn = {0006-8993},
	abstract = {The aim of our study was to determine the role of corticotropin-releasing factor (CRF), the urocortins (Ucn1, Ucn2 and Ucn3) and their receptors (CRF1 and CRF2) in the sociability of mice. Male CFLP mice were administered intracerebroventricularly (icv) with CRF and urocortins alone or in combination with antalarmin (specific CRF1 antagonist) and astressin(2B) (specific CRF2 antagonist) and then investigated in a Crawley social interaction test arena, that consists of three chambers. An unknown male in a cage was put in the first chamber and an empty cage was put in the opposite chamber. The tested male was habituated with the middle chamber for 5 min and then allowed to explore the remaining chambers for 5 min, during which the number of entries and the time of interaction were measured. Intracerebroventricular administration of CRF decreased significantly the number of entries and the time of interaction with the unknown male and these effects were blocked by antalarmin, but not astressin2B. In contrast, central administration of Ucn1 increased significantly the number of entries into the chamber of the unknown male, without changing the time of interaction and this effect was blocked by astressin2B, but not antalarmin. Central administration of Ucn2 and Ucn3 didn't influence remarkably the number of entries, but it reduced the time of interaction between the male mice. Our study suggests that CRF and Ucn1 may play important, but different roles in sociability, and that Ucn2 and Ucn3, playing similar roles, must be also involved in social interactions. (C) 2017 Elsevier B.V. All rights reserved.},
	keywords = {BEHAVIOR; MICE; CRF; BED NUCLEUS; CORTICOTROPIN-RELEASING-FACTOR; RECEPTORS; STRESS; anxiety; Urocortins; SOCIAL-INTERACTION TEST; SYRIAN-HAMSTERS; BASOLATERAL AMYGDALA; FISH UROTENSIN-I; Sociability},
	year = {2017},
	eissn = {1872-6240},
	pages = {114-122},
	orcid-numbers = {Csabafi, Krisztina/0000-0002-2008-7604; Jászberényi, Miklós/0000-0002-7287-7771; Telegdy, Gyula/0000-0003-1734-4128}
}

@CONFERENCE{MTMT:3317103,
	title = {The role of CRF and the urocortins in social interaction},
	url = {https://m2.mtmt.hu/api/publication/3317103},
	author = {Bagosi, Zsolt and Csabafi, Krisztina and Jászberényi, Miklós and Telegdy, Gyula},
	booktitle = {Abstracts of the 25th Annual Meeting of the International Behavioral Neuroscience Society},
	unique-id = {3317103},
	abstract = {Corticotropin-releasing factor (CRF) and the urocortins (UCN 1, UCN 2 and UCN 3) belong to the same CRF peptide family, having similar amino acidic structure, but different pharmacological properties. Besides their principle role in the regulation of the stress response, CRF and CRF-like peptides have been implicated in the social behavior of many species. The aim of the present study was to determine the role of CRF and the urocortins in the social interaction of mice. Male CFLP mice were administered intracerebroventricularly (ICV) CRF, UCN 1, UCN 2 or UCN 3 and then investigated in a Crawley social interaction test arena, which consists of three different chambers. Two types of tests were performed. In both types, first the tested male was habituated with the middle chamber of the arena for 5 minutes and then it was allowed to explore the remaining chambers for another 5 minutes, during which the number of entries and the time of interaction were measured. In the first test examining the sociability of mice, an unknown male was put in the first chamber, while the third chamber was left empty. In the second test examining the preference for social novelty of mice, a known female, with which the male was familiarized previously for 24 hours, and an unknown female were set in the opposite chambers. ICV injection of CRF reduced significantly the number of entries and the time of interaction with the unknown male. In addition, it also reduced significantly the number of entries and the time of interaction with the unknown female, but not the known female. ICV injection of UCN 1 increased significantly the number of entries into the chamber of the unknown male, without changing the time of interaction. In contrast, it decreased considerably the number of entries into the chamber of both females, without changing the time of interaction. Central administration of UCN 2 and UCN 3 did not influence remarkably any of the parameters measured, except reducing the time of interaction between males. Our results demonstrate that CRF and UCN 1 play important, but different roles in the social interaction of mammals, which must be mediated by distinct receptors. Our results also suggest that UCN 2 and UCN 3 may be less relevant, but still involved in social behavior.
		
		The present study was sponsored by the Hungarian Brain Research Program and the Neuroscience Research Group of the Hungarian Academy.},
	year = {2016},
	pages = {100-101},
	orcid-numbers = {Csabafi, Krisztina/0000-0002-2008-7604; Jászberényi, Miklós/0000-0002-7287-7771; Telegdy, Gyula/0000-0003-1734-4128}
}

@article{MTMT:3277228,
	title = {Evidence of the dopamine-2 receptor mediated inhibition of the hypothalamic-pituitary-adrenal system; a rodent model of hypercortisolism in chronic neuropsychiatric disorders},
	url = {https://m2.mtmt.hu/api/publication/3277228},
	author = {Balázs, Thurzó and Jászberényi, Miklós and Bagosi, Zsolt and Pataki, Imre and Eszter, Kádár and Szabó, Gyula and Telegdy, Gyula},
	doi = {10.15761/TBR.1000110},
	journal-iso = {TRANSL BRAIN RHYTHM},
	journal = {TRANSLATIONAL BRAIN RHYTHMICITY},
	volume = {1},
	unique-id = {3277228},
	year = {2016},
	eissn = {2397-8686},
	orcid-numbers = {Jászberényi, Miklós/0000-0002-7287-7771; Szabó, Gyula/0000-0002-3409-5357; Telegdy, Gyula/0000-0003-1734-4128}
}