@{MTMT:34560879,
	title = {Etikai szempontok a klinikai kutatásokban. Az etikai engedélyeztetés gyakorlata},
	url = {https://m2.mtmt.hu/api/publication/34560879},
	author = {Szentmiklósi, József András},
	booktitle = {Klinikai kutatások - átfogó ismeretek a tervezéstől a közlésig},
	unique-id = {34560879},
	year = {2024},
	pages = {285-309}
}

@article{MTMT:31656028,
	title = {Egyes, antioxidáns mellékhatású „vérnyomás”gyógyszerek hatása magas vérnyomásban szenvedő és egészséges személyek vérsejtjeinek fagocitakemilumineszcenciájára in vitro},
	url = {https://m2.mtmt.hu/api/publication/31656028},
	author = {Sipka, Sándor and Nagy, Andrea and Szentmiklósi, József András and Kemény, Ágnes and Kovács, Judit},
	doi = {10.1556/650.2020.31856},
	journal-iso = {ORV HETIL},
	journal = {ORVOSI HETILAP},
	volume = {161},
	unique-id = {31656028},
	issn = {0030-6002},
	abstract = {Összefoglaló. Bevezetés: Az atorvasztatin (koleszterincsökkentő), nifedipin (Ca2+-antagonista), kaptopril (angiotenzinkonvertáz-gátló) vegyületek a magas vérnyomás komplex kezelésének "alap"gyógyszerei. Mindhárom antioxidáns is. Célkitűzés: A tanulmány célja annak megválaszolása volt, hogy e molekulák gátolhatják-e a vérsejtek fagocitaműködését. Betegek és módszer: Magas vérnyomásos betegek: 15 fő, 39-80 éves, nő: 6, férfi: 9. Egészséges kontroll: 7 fő, 30-75 éves, nő: 3, férfi: 4. A vizsgálat a téli hónapokban zajlott. A zimozán- (Saccharomyces cerevisiae) részecskék fagocitózisa során képződő kemilumineszcencia mérése perifériás vérben a gyógyszerek jelenlétében történt luminométerrel. A gátlást a stimulációs index értékének csökkenésével jellemeztük. Eredmények: Mindhárom vegyület gátolta a kemilumineszcenciát (oxigénszabadgyök-képzést) a 65 év feletti, magas vérnyomásos betegek többségében: 11/13 főnél. Főleg magasabb életkorban és cukorbetegségben, de más társbetegségekben nőtt a gátlás. Következtetés: Az idős, magas vérnyomásos betegek fokozott orvosi figyelmet igényelnek a téli időszakokban, mivel antioxidáns hatással is rendelkező "alap"gyógyszereiknek, egyéntől függően, lehetnek gátló hatásaik a fagociták mikrobaölő, oxigénszabadgyök-termelő képességére. Orv Hetil. 2020; 161(45): 1908-1913.Atorvastatin (cholesterol synthesis blocker), nifedipine (Ca2+ antagonist), captopril (angiotensin-convertase inhibitor) are basic drugs in the therapy of hypertension. They are also antioxidants.To investigate whether these molecules can inhibit the phagocytic activity of peripheral blood cells.Hypertension group: 15 patients with ages between 39-80 years (6 women and 9 men). Healthy control group: 7 individuals with ages between 30-75 years (3 women and 4 men). The study was carried out in wintertime. The measurement of phagocytic activity was carried out by luminometry in peripheral blood samples. Chemiluminescence intensities were determined by the engulfment of zymosan (Saccharomyces cerevisiae) particles in the presence of drugs. The inhibitory effects were characterized by the decreased values of the stimulation index.All three substances decreased the chemiluminescence (reactive oxygen species production) in the majority of samples from hypertensive patients over 65 years: in 11 of 13 patients. Stronger inhibition was detected in older, diabetic patients with other co-morbidities, too.Older patients with hypertension require a special attention in wintertime. Antihypertensive drugs with antioxidant capabilities may have individually different inhibitory effects on the production of reactive oxygen species by phagocytes, which decreases their antimicrobial potency. Orv Hetil. 2020; 161(45): 1908-1913.},
	keywords = {CAPTOPRIL; HYPERTENSION; ATORVASTATIN; nifedipine; chemiluminescence; magas vérnyomás; atorvasztatin; kaptopril; kemilumineszcencia; nifedipin},
	year = {2020},
	eissn = {1788-6120},
	pages = {1908-1913},
	orcid-numbers = {Kemény, Ágnes/0000-0002-4523-3938}
}

@article{MTMT:31102623,
	title = {Effect of antithyroid drugs on the occurrence of antibodies against type 2 deiodinase (DIO2), which are involved in hyperthyroid Graves' disease influencing the therapeutic efficacy},
	url = {https://m2.mtmt.hu/api/publication/31102623},
	author = {Molnár, Ildikó and Szentmiklósi, József András and Gesztelyi, Rudolf and Somogyine-Vari, Eva},
	doi = {10.1007/s10238-018-00542-7},
	journal-iso = {CLIN EXP MED},
	journal = {CLINICAL AND EXPERIMENTAL MEDICINE},
	volume = {19},
	unique-id = {31102623},
	issn = {1591-8890},
	abstract = {Graves' disease is an organ-specific autoimmune disease with hyperthyroidism, diffuse goiter and autoantibodies against TSH receptor, thyroid peroxidase (TPO) and/or thyroglobulin (Tg). Graves' hyperthyroidism is characterized by T-3 dominance due to the conversion of T-4 into T-3 through type 1 and 2 deiodinase enzymes (DIO1, DIO2). Methimazole (MMI) and propylthiouracil (PTU) therapies inhibit thyroid hormone synthesis blocking the activity of deiodinase and TPO enzymes. The study investigated the occurrence of autoantibodies against DIO2 peptides (cys- and hom-peptides) with the effect of antithyroid drugs on their frequencies in 78 patients with Graves' disease and 30 controls. In hyperthyroidism, the presence of DIO2 peptide antibodies was as follows: 20 and 11 cases out of 51 for cys- and hom-peptide antibodies, respectively, of whom 8 cases possessed antibodies against both peptides. Antithyroid drugs differently influenced their frequencies, which were greater in PTU than in MMI (3/6 vs 13/45 cases, P < 0.016 for cys- and 0/6 vs 2/45 cases for hom-peptide antibodies). Antibodies against both peptides demonstrated more reduced levels of anti-TPO (P < 0.003) and anti-Tg antibodies (P < 0.002) compared with those without peptide antibodies. PTU compared with MMI increased the levels of TSH receptor antibodies (32.5 UI/l vs 2.68IU/l, P < 0.009). MMI treatment led to more reduced FT3 levels and FT3/FT4 ratios in hyperthyroid Graves' ophthalmopathy (P < 0.028 for FT3, P < 0.007 for FT3/FT4 ratio). In conclusion, the presence of DIO2 peptide antibodies is connected to Graves' hyperthyroidism influencing the levels of antibodies against TPO, Tg and TSH receptor, as well as the therapeutic efficacy of antithyroid drugs.},
	keywords = {hyperthyroidism; Graves' disease; Type 2 deiodinase; antithyroid drugs; Antithyroid antibodies},
	year = {2019},
	eissn = {1591-9528},
	pages = {245-254},
	orcid-numbers = {Gesztelyi, Rudolf/0000-0001-7911-055X}
}

@article{MTMT:31012994,
	title = {Accuracy and Precision of the Receptorial Responsiveness Method (RRM) in the Quantification of A1 Adenosine Receptor Agonists},
	url = {https://m2.mtmt.hu/api/publication/31012994},
	author = {Vargáné Szabó, Adrienn Mónika and Viczján, Gábor and Erdei, Tamás Dániel and Simon, Ildiko and Kiss, Rita and Szentmiklósi, József András and Juhász, Béla and Papp, Csaba Sándor and Zsuga, Judit and Pinter, Akos and Szilvassy, Zoltan and Gesztelyi, Rudolf},
	doi = {10.3390/ijms20246264},
	journal-iso = {INT J MOL SCI},
	journal = {INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES},
	volume = {20},
	unique-id = {31012994},
	issn = {1661-6596},
	year = {2019},
	eissn = {1422-0067},
	orcid-numbers = {Kiss, Rita/0000-0003-1208-366X; Zsuga, Judit/0000-0002-5350-8188; Gesztelyi, Rudolf/0000-0001-7911-055X}
}

@article{MTMT:3407995,
	title = {FSCPX, a Chemical Widely Used as an Irreversible A1 Adenosine Receptor Antagonist, Modifies the Effect of NBTI, a Nucleoside Transport Inhibitor, by Reducing the Interstitial Adenosine Level in the Guinea Pig Atrium},
	url = {https://m2.mtmt.hu/api/publication/3407995},
	author = {Erdei, Tamás Dániel and Vargáné Szabó, Adrienn Mónika and Lampé, Nóra and Szabo, K and Kiss, Rita and Zsuga, Judit and Papp, Csaba Sándor and Pintér, Ákos and Szentmiklósi, József András and Szilvassy, Z and Juhász, Béla and Gesztelyi, Rudolf},
	doi = {10.3390/molecules23092186},
	journal-iso = {MOLECULES},
	journal = {MOLECULES},
	volume = {23},
	unique-id = {3407995},
	issn = {1420-3049},
	year = {2018},
	eissn = {1420-3049},
	orcid-numbers = {Kiss, Rita/0000-0003-1208-366X; Zsuga, Judit/0000-0002-5350-8188; Gesztelyi, Rudolf/0000-0001-7911-055X}
}

@article{MTMT:3282362,
	title = {Influencing effect of medications on the frequency of antibodies against protein sequences of type 2 deiodinase and their relationship with the thyroid hormone and antibody levels in hyperthyropid Graves' ophthalmopathy.},
	url = {https://m2.mtmt.hu/api/publication/3282362},
	author = {Molnár, Ildikó and Szentmiklósi, József András and Gesztelyi, Rudolf and Somogyiné-Vári, Éva},
	journal-iso = {IMMUNOLÓGIAI SZEMLE},
	journal = {IMMUNOLÓGIAI SZEMLE},
	volume = {9},
	unique-id = {3282362},
	issn = {2061-0203},
	year = {2017},
	pages = {17-18},
	orcid-numbers = {Gesztelyi, Rudolf/0000-0001-7911-055X}
}

@article{MTMT:3276201,
	title = {Hyperthyroidism in patients with Graves' ophthalmopathy, and thyroidal, skeletal and eye muscle specific type 2 deiodinase enzyme activities.},
	url = {https://m2.mtmt.hu/api/publication/3276201},
	author = {Molnár, Ildikó and Szentmiklósi, József András and Somogyiné-Vári, Éva},
	doi = {10.1055/s-0043-113831},
	journal-iso = {EXP CLIN ENDOCR DIAB},
	journal = {EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES},
	volume = {125},
	unique-id = {3276201},
	issn = {0947-7349},
	abstract = {Graves' ophthalmopathy is characterized by hyperthyroidism, which is associated with higher serum T 3 levels than T 4 due to deiodinase enzymes. The effect of Graves' patient's sera (n=52) with elevated thyroid hormone and TSH receptor or thyroid peroxidase antibody (anti-TPO) levels was investigated on thyroidal, skeletal and eye muscle type 2 deiodinase enzyme (DII) activities. DII activities were measured with 125 I-T 4 substrate, while thyroid hormone and antibody levels with immunoassays. In Graves' ophthalmopathy, sera with elevated FT 4 or FT 3 levels reduced DII activites remarkably in all tissue fractions. Thyroidal DII activities were lower than those using eye muscle fraction (0.6±0.22 vs 1.14±0.43 pmol/mg/min, P<0.006). Effect of sera with increased FT 3 levels demonstrated also reduced DII activities in patients with Graves' ophthalmopathy after methimazole therapy compared to those who had no ophthalmopathy (2.88±2 vs 20.42±11.82 pmol/mg/min, P<0.006 for thyroidal fraction, 4.07±2.72 vs 29.22±15.46 pmol/mg/min, P<0.004 for skeletal muscle, 5.3±3.47 vs 37.87±18.82 pmol/mg/min, P<0.003 for eye muscle). Hyperthyroid sera with TSH receptor antibodies resulted in increased DII activities, while sera with anti-TPO antibodies were connected to lower DII activities in Graves' ophthalmopathy. In summary, the actions of hyperthyroid sera derived from patients with Graves' disease were tested on tissue-specific DII activities. Elevated FT 4 level-induced DII inactivation is present in Graves' ophthalmopathy, which seems to be also present at the beginning of methimazole therapy. Stimulating TSH receptor antibiodies increased DII activities via their nongenomic effects using sera of hyperthyroid Graves' ophthalmopathy, but anti-TPO antibodies could influence DII activities via altering FT 4 levels.},
	year = {2017},
	eissn = {1439-3646},
	pages = {514-521}
}

@article{MTMT:3224927,
	title = {Methodical Challenges and a Possible Resolution in the Assessment of Receptor Reserve for Adenosine, an Agonist with Short Half-Life},
	url = {https://m2.mtmt.hu/api/publication/3224927},
	author = {Zsuga, Judit and Erdei, Tamás Dániel and Szabo, K and Lampé, Nóra and Papp, Csaba Sándor and Pintér, Ákos and Szentmiklósi, József András and Juhász, Béla and Szilvássy, Zoltán and Gesztelyi, Rudolf},
	doi = {10.3390/molecules22050839},
	journal-iso = {MOLECULES},
	journal = {MOLECULES},
	volume = {22},
	unique-id = {3224927},
	issn = {1420-3049},
	year = {2017},
	eissn = {1420-3049},
	orcid-numbers = {Zsuga, Judit/0000-0002-5350-8188; Gesztelyi, Rudolf/0000-0001-7911-055X}
}

@article{MTMT:3282366,
	title = {Antibodies against human eye muscle tissue fractions bind to type 2 5’deiodinase and inhibit the lymphocyte MAPK activation derived from hyperthyroid patients with Graves’ disease.},
	url = {https://m2.mtmt.hu/api/publication/3282366},
	author = {Molnár, Ildikó and Szentmiklósi, József András and Somogyiné-Vári, Éva},
	journal-iso = {ENDOCR ABSTR},
	journal = {ENDOCRINE ABSTRACTS},
	volume = {41},
	unique-id = {3282366},
	issn = {1470-3947},
	year = {2016},
	eissn = {1479-6848}
}

@article{MTMT:3282368,
	title = {Effect of patient sera on type 2 5’-deiodinase enzyme activity using human thyroid, skeletal and eye muscle tissue fractions in hyperthyroid Graves’ ophthalmopathy.},
	url = {https://m2.mtmt.hu/api/publication/3282368},
	author = {Molnár, Ildikó and Szentmiklósi, József András and Somogyiné-Vári, Éva},
	journal-iso = {THYROID},
	journal = {THYROID},
	volume = {25},
	unique-id = {3282368},
	issn = {1050-7256},
	year = {2015},
	eissn = {1557-9077}
}