TY  - JOUR
AU  - Mayeka, James G.
AU  - Atilaw, Yoseph
AU  - Shadrack, Daniel M.
AU  - Sarnyai, Farkas
AU  - Csala, Miklós
AU  - Németh, Krisztina
AU  - Nyandoro, Stephen S.
AU  - Tamási, Viola
AU  - Erdelyi, Mate
AU  - Munissi, Joan J.E.
TI  - Flavonoids from the leaves of Monanthotaxis filipes modulate PCSK9 and LDLR
JF  - SCIENTIFIC AFRICAN
J2  - SCI AFRICAN
VL  - 28
PY  - 2025
PG  - 11
SN  - 2468-2276
DO  - 10.1016/j.sciaf.2025.e02709
UR  - https://m2.mtmt.hu/api/publication/36102520
ID  - 36102520
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Gulyás, Kinga Virág
AU  - Zhou, Liping
AU  - Salamonsen, Daniel
AU  - Prester, Andreas
AU  - Bartels, Kim
AU  - Bosman, Robert
AU  - Haffke, Paul
AU  - Li, Jintian
AU  - Tamási, Viola
AU  - Deufel, Fritz
AU  - Thoma, Johannes
AU  - Andersson Rasmussen, Anna
AU  - Csala, Miklós
AU  - Schroder Leiros, Hanna-Kirsti
AU  - Xu, Zhijian
AU  - Widersten, Mikael
AU  - Rohde, Holger
AU  - Schulz, Eike C.
AU  - Zhu, Weiliang
AU  - Erdélyi, Máté
TI  - Dynamically chiral phosphonic acid-type metallo-β-lactamase inhibitors
JF  - COMMUNICATIONS CHEMISTRY
J2  - COMMUN CHEM
VL  - 8
PY  - 2025
IS  - 1
PG  - 13
SN  - 2399-3669
DO  - 10.1038/s42004-025-01510-5
UR  - https://m2.mtmt.hu/api/publication/36102781
ID  - 36102781
AB  - Antibiotic resistance is a growing global health threat that risks the lives of millions. Among the resistance mechanisms, that mediated by metallo-β-lactamases is of particular concern as these bacterial enzymes dismantle most β-lactam antibiotics, which are our widest applied and cheapest to produce antibiotic agents. So far, no clinically applicable metallo-β-lactamase inhibitors are available. Aiming to adapt to structural variations, we introduce the inhibitor concept: dynamically chiral phosphonic acids. We demonstrate that they are straightforward to synthesize, penetrate bacterial membranes, inhibit the metallo-β-lactamase enzymes NDM-1, VIM-2 and GIM-1, and are non-toxic to human cells. Mimicking the transition state of β-lactam hydrolysis, they target the Zn ions of the metallo-β-lactamase active site. As a unique feature, both of their stereoisomers bind metallo-β-lactamases, which provides them unparalleled adaptability to the structural diversity of these enzymes, and may allow them to hamper bacteria’s ability for resistance development.
LA  - English
DB  - MTMT
ER  - 

TY  - BOOK
ED  - Csala, Miklós
ED  - Sipeki, Szabolcs
TI  - Molecular Cell Biology
PB  - Semmelweis Kiadó
CY  - Budapest
PY  - 2025
SN  - 9789633316900
UR  - https://m2.mtmt.hu/api/publication/36437867
ID  - 36437867
LA  - English
DB  - MTMT
ER  - 

TY  - CHAP
AU  - Csala, Miklós
ED  - Csala, Miklós
ED  - Sipeki, Szabolcs
TI  - RNA synthesis and its regulation
T2  - Molecular Cell Biology
PB  - Semmelweis Kiadó
CY  - Budapest
SN  - 9789633316900
PY  - 2025
SP  - 68
EP  - 93
PG  - 26
UR  - https://m2.mtmt.hu/api/publication/36443126
ID  - 36443126
LA  - English
DB  - MTMT
ER  - 

TY  - CHAP
AU  - Csala, Miklós
ED  - Csala, Miklós
ED  - Sipeki, Szabolcs
TI  - Molecular biology of viruses
T2  - Molecular Cell Biology
PB  - Semmelweis Kiadó
CY  - Budapest
SN  - 9789633316900
PY  - 2025
SP  - 150
EP  - 185
PG  - 36
UR  - https://m2.mtmt.hu/api/publication/36443133
ID  - 36443133
LA  - English
DB  - MTMT
ER  - 

TY  - CHAP
AU  - Csala, Miklós
ED  - Csala, Miklós
ED  - Sipeki, Szabolcs
TI  - Control of the eukaryotic cell cycle
T2  - Molecular Cell Biology
PB  - Semmelweis Kiadó
CY  - Budapest
SN  - 9789633316900
PY  - 2025
SP  - 186
EP  - 198
PG  - 13
UR  - https://m2.mtmt.hu/api/publication/36443144
ID  - 36443144
LA  - English
DB  - MTMT
ER  - 

TY  - CHAP
AU  - Csala, Miklós
ED  - Csala, Miklós
ED  - Sipeki, Szabolcs
TI  - Apoptosis
T2  - Molecular Cell Biology
PB  - Semmelweis Kiadó
CY  - Budapest
SN  - 9789633316900
PY  - 2025
SP  - 199
EP  - 214
PG  - 16
UR  - https://m2.mtmt.hu/api/publication/36443150
ID  - 36443150
LA  - English
DB  - MTMT
ER  - 

TY  - CHAP
AU  - Csala, Miklós
ED  - Csala, Miklós
ED  - Sipeki, Szabolcs
TI  - Molecular basis of tumor formation
T2  - Molecular Cell Biology
PB  - Semmelweis Kiadó
CY  - Budapest
SN  - 9789633316900
PY  - 2025
SP  - 221
EP  - 231
PG  - 11
UR  - https://m2.mtmt.hu/api/publication/36443158
ID  - 36443158
LA  - English
DB  - MTMT
ER  - 

TY  - GEN
AU  - Palczert, Zoltán
AU  - Blanka, Tóth
AU  - Sarnyai, Farkas
AU  - Emese, Domokos
AU  - Anar, Batzorig
AU  - Zsófia, Gonda
AU  - Mária, Katalin Geringen
AU  - Csala, Miklós
AU  - Tamási, Viola
TI  - Identification of ceramide synthase (CERS) isoenzyme(s) involved in the incorporation of trans fatty acids
PY  - 2025
UR  - https://m2.mtmt.hu/api/publication/36945794
ID  - 36945794
N1  - Poszter
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Tibori, Kinga
AU  - Zámbó, Veronika
AU  - Orosz, Gabriella
AU  - Szelényi, Péter
AU  - Sarnyai, Farkas
AU  - Tamási, Viola
AU  - Rónai, Zsolt
AU  - Csala, Miklós
AU  - Kereszturi, Éva
TI  - Allele-specific effect of various dietary fatty acids and ETS1 transcription factor on SCD1 expression
JF  - SCIENTIFIC REPORTS
J2  - SCI REP
VL  - 14
PY  - 2024
IS  - 1
PG  - 14
SN  - 2045-2322
DO  - 10.1038/s41598-023-50700-5
UR  - https://m2.mtmt.hu/api/publication/34473748
ID  - 34473748
N1  - Funding Agency and Grant Number: Hungarian National Research, Development and Innovation Office (NKFIH) [FK138115, K131680, PD142709]; Ministry of Innovation and Technology of Hungary from the National Research, Development and Innovation Fund [TKP2021-EGA-24]
            Funding text: This work was supported by the Hungarian National Research, Development and Innovation Office (NKFIH grant numbers: FK138115, K131680 and PD142709). Project no. TKP2021-EGA-24 was implemented with the support provided by the Ministry of Innovation and Technology of Hungary from the National Research, Development and Innovation Fund, and financed under the TKP2021-EGA funding scheme.
AB  - Overnutrition and genetic predisposition are major risk factors for various metabolic disorders. Stearoyl-CoA desaturase-1 (SCD1) plays a key role in these conditions by synthesizing unsaturated fatty acids (FAs), thereby promoting fat storage and alleviating lipotoxicity. Expression of SCD1 is influenced by various saturated and cis-unsaturated FAs, but the possible role of dietary trans FAs (TFAs) and SCD1 promoter polymorphisms in its regulations has not been addressed. Therefore, we aimed to investigate the impact of the two main TFAs, vaccenate and elaidate, and four common promoter polymorphisms (rs1054411, rs670213, rs2275657, rs2275656) on SCD1 expression in HEK293T and HepG2 cell cultures using luciferase reporter assay, qPCR and immunoblotting. We found that SCD1 protein and mRNA levels as well as SCD1 promoter activity are markedly elevated by elaidate, but not altered by vaccenate. The promoter polymorphisms did not affect the basal transcriptional activity of SCD1 . However, the minor allele of rs1054411 increased SCD1 expression in the presence of various FAs. Moreover, this variant was predicted in silico and verified in vitro to reduce the binding of ETS1 transcription factor to SCD1 promoter. Although we could not confirm an association with type 2 diabetes mellitus, the FA-dependent and ETS1-mediated effect of rs1054411 polymorphism deserves further investigation as it may modulate the development of lipid metabolism-related conditions.
LA  - English
DB  - MTMT
ER  -