@article{MTMT:36112779, title = {Evolution into chaos – Implications of the trade-off between transmissibility and immune evasion}, url = {https://m2.mtmt.hu/api/publication/36112779}, author = {Golsa, Sayyar and Garab, Ábel and Röst, Gergely}, doi = {10.1016/j.idm.2025.04.003}, journal-iso = {INFECT DIS MODEL}, journal = {INFECTIOUS DISEASE MODELLING}, volume = {10}, unique-id = {36112779}, issn = {2468-2152}, year = {2025}, eissn = {2468-0427}, pages = {909-923}, orcid-numbers = {Golsa, Sayyar/0000-0002-8143-3187; Garab, Ábel/0000-0001-9693-1923; Röst, Gergely/0000-0001-9476-3284} } @article{MTMT:35669919, title = {Dynamics by control strategies targeting the effective reproduction number}, url = {https://m2.mtmt.hu/api/publication/35669919}, author = {Bartha, Ferenc Ágoston and Röst, Gergely}, doi = {10.1016/j.chaos.2024.115906}, journal-iso = {CHAOS SOLITON FRACT}, journal = {CHAOS SOLITONS & FRACTALS}, volume = {191}, unique-id = {35669919}, issn = {0960-0779}, year = {2025}, eissn = {1873-2887}, orcid-numbers = {Bartha, Ferenc Ágoston/0000-0002-7545-9145; Röst, Gergely/0000-0001-9476-3284} } @CONFERENCE{MTMT:35707536, title = {Fertőzésmodellezés egy hibrid matematikai rendszerben}, url = {https://m2.mtmt.hu/api/publication/35707536}, author = {Juhász, Nóra and Marzban, Sadegh and Han, Renji and Bartha, Ferenc Ágoston and Röst, Gergely and Farkas, Boróka}, booktitle = {AMK – 2024}, unique-id = {35707536}, year = {2024}, pages = {11-11}, orcid-numbers = {Juhász, Nóra/0000-0001-6560-7581; Bartha, Ferenc Ágoston/0000-0002-7545-9145; Röst, Gergely/0000-0001-9476-3284} } @CONFERENCE{MTMT:35707449, title = {Malaria dynamics with bimodality of incubation period in hosts in a seasonal environment}, url = {https://m2.mtmt.hu/api/publication/35707449}, author = {Ibrahim, Mahmoud Abdalla Ali and Dénes, Attila and Röst, Gergely}, booktitle = {AMK – 2024}, unique-id = {35707449}, year = {2024}, pages = {46-46}, orcid-numbers = {Ibrahim, Mahmoud Abdalla Ali/0000-0003-0258-2019; Dénes, Attila/0000-0003-1827-7932; Röst, Gergely/0000-0001-9476-3284} } @CONFERENCE{MTMT:35704621, title = {A mathematical model for cancer dynamics with treatment and saboteur bacteria}, url = {https://m2.mtmt.hu/api/publication/35704621}, author = {Geretovszky, Anna and Röst, Gergely}, booktitle = {AMK – 2024}, unique-id = {35704621}, year = {2024}, pages = {44-44}, orcid-numbers = {Röst, Gergely/0000-0001-9476-3284} } @CONFERENCE{MTMT:35697757, title = {Optimal control for maturity-structured systems}, url = {https://m2.mtmt.hu/api/publication/35697757}, author = {Das, Bornali and Balázs, István and Röst, Gergely}, booktitle = {AMK – 2024}, unique-id = {35697757}, year = {2024}, pages = {39-39}, orcid-numbers = {Balázs, István/0000-0003-2217-4960; Röst, Gergely/0000-0001-9476-3284} } @CONFERENCE{MTMT:35691243, title = {Real-time estimation of the effective reproduction number of COVID-19 from behavioral data}, url = {https://m2.mtmt.hu/api/publication/35691243}, author = {Bokányi, Eszter and Vizi, Zsolt and Koltai, Júlia and Röst, Gergely and Karsai, Márton}, booktitle = {AMK – 2024}, unique-id = {35691243}, year = {2024}, pages = {37-37}, orcid-numbers = {Vizi, Zsolt/0000-0003-2568-8633; Röst, Gergely/0000-0001-9476-3284} } @article{MTMT:35433805, title = {Probability of early infection extinction depends linearly on the virus clearance rate}, url = {https://m2.mtmt.hu/api/publication/35433805}, author = {Juhász, Nóra and Bartha, Ferenc Ágoston and Marzban, Sadegh and Han, R. and Röst, Gergely}, doi = {10.1098/rsos.240903}, journal-iso = {R SOC OPEN SCI}, journal = {ROYAL SOCIETY OPEN SCIENCE}, volume = {11}, unique-id = {35433805}, issn = {2054-5703}, abstract = {We provide an in silico study of stochastic viral infection extinction from a pharmacokinetical viewpoint. Our work considers a non-specific antiviral drug that increases the virus clearance rate, and we investigate the effect of this drug on early infection extinction. Infection extinction data are generated by a hybrid multiscale framework that applies both continuous and discrete mathematical approaches. The central result of our paper is the observation, analysis and explanation of a linear relationship between the virus clearance rate and the probability of early infection extinction. The derivation behind this simple relationship is given by merging different mathematical toolboxes.}, year = {2024}, eissn = {2054-5703}, orcid-numbers = {Juhász, Nóra/0000-0001-6560-7581; Bartha, Ferenc Ágoston/0000-0002-7545-9145; Röst, Gergely/0000-0001-9476-3284} } @article{MTMT:35250009, title = {Deviation from the recommended schedule: optimal dosing interval for a two-dose vaccination programme}, url = {https://m2.mtmt.hu/api/publication/35250009}, author = {Wang, Zhen and Röst, Gergely and Moghadasi, Mohammad}, doi = {10.1098/rsos.231971}, journal-iso = {R SOC OPEN SCI}, journal = {ROYAL SOCIETY OPEN SCIENCE}, volume = {11}, unique-id = {35250009}, issn = {2054-5703}, abstract = {Optimizing vaccination impact during an emerging disease becomes crucial when vaccine supply is limited, and robust protection requires multiple doses. Facing this challenge during the early stages of the COVID-19 vaccine deployment, a pivotal policy question arose: whether to administer a single dose to a larger proportion of the population by deferring the second dose, or to prioritize stronger protection for a smaller subset of the population with the established dosing interval from clinical trials. Using a delay-differential model and considering waning immunity and distribution capacity, we compared these strategies. We found that the efficacy of the first dose significantly influences the impact of delaying the second dose. Even for a relatively low efficacy of the first dose, a delayed strategy may outperform vaccination with the recommended dosing interval in reducing short-term hospitalizations and deaths despite increase in infections. The optimal delay, however, depends on the specific outcome measured and timelines within which the vaccination strategy is evaluated. We found transition lines for the relative reduction of infection, hospitalization and death below which vaccination with the recommended schedule is the preferred strategy. In a realistic parameter space, our results highlight scenarios in which the conclusions of previous studies are invalid.}, year = {2024}, eissn = {2054-5703}, orcid-numbers = {Röst, Gergely/0000-0001-9476-3284} } @inbook{MTMT:35244976, title = {Waiting for the Perfect Vaccine}, url = {https://m2.mtmt.hu/api/publication/35244976}, author = {Röst, Gergely and Zhen, Wang and Seyed, M. Moghadas}, booktitle = {Trends in Biomathematics: Exploring Epidemics, Eco-Epidemiological Systems, and Optimal Control Strategies}, doi = {10.1007/978-3-031-59072-6_10}, unique-id = {35244976}, abstract = {Vaccination has proven to be the most effective public health measure in the fight against various infectious diseases. For emerging or re-emerging diseases, a highly efficacious vaccine may not be available at the start of an outbreak. Timelines for availability of a safe and effective vaccine may significantly affect disease dynamics, its burden, and the healthcare resource utilization. Mitigating this impact may then rely on low-efficacy vaccines that may be rapidly produced and distributed to at-risk populations at the early stages of an outbreak. With the expectation for arrival of a more effective vaccine at a later stage of the outbreak, the optimal vaccination coverage with the existing, low-efficacy vaccines is elusive. While flattening the outbreak if a significant proportion of the susceptible population is vaccinated with a low-efficacy vaccine, the overall infections may not be minimized if a small proportion of the population left unvaccinated when a highly efficacious vaccine becomes available. The optimal coverage for early vaccination could thus depend on several parameters including the efficacy of the currently available vaccines, arrival timing of a more effective vaccine and its efficacy, and the transmissibility of the disease. Here, we develop a deterministic system of differential equations to investigate the optimal vaccination coverage with a low-efficacy vaccine within the aforementioned parameter space. Despite simplifying assumptions, we illustrate that minimizing the overall infections does not necessarily correspond to the highest coverage of early vaccination. However, a high vaccination coverage, even with a low-efficacy vaccine, may still contribute to alleviating severe disease outcomes and reducing healthcare resource utilization.}, year = {2024}, pages = {217-232}, orcid-numbers = {Röst, Gergely/0000-0001-9476-3284} }