@article{MTMT:34452555, title = {Kutatómunka a Fizikai Kémia és Anyagtudományi Tanszéken}, url = {https://m2.mtmt.hu/api/publication/34452555}, author = {Kállay-Menyhárd, Alfréd and Renkeczné Tátraaljai, Dóra and Pukánszky, Béla Jr. and Nagyné László, Krisztina and Bulátkó, Anna and Nagyné Albert, Emőke and Tegze, Borbála Ágnes and Márton, Péter and Hórvölgyi, Zoltán and Gyarmati, Benjámin Sándor and Szilágyi, András Ferenc and Hessz, Dóra and Kubinyi, Miklós and Kállay, Mihály}, journal-iso = {MAGY KEM LAP}, journal = {MAGYAR KÉMIKUSOK LAPJA}, volume = {78}, unique-id = {34452555}, issn = {0025-0163}, year = {2023}, eissn = {1588-1199}, pages = {370-375}, orcid-numbers = {Nagyné László, Krisztina/0000-0003-4499-3983; Szilágyi, András Ferenc/0000-0001-6898-1755; Hessz, Dóra/0000-0003-3033-2762} } @article{MTMT:34140818, title = {The interaction between mucin and poly(amino acid)s with controlled cationic group content in bulk phase and in thin layers}, url = {https://m2.mtmt.hu/api/publication/34140818}, author = {Stankovits, József Gergely and Ábrahám, Ágnes and Kiss, Éva and Varga, Zoltán and Misra, Anil and Szilágyi, András Ferenc and Gyarmati, Benjámin Sándor}, doi = {10.1016/j.ijbiomac.2023.126826}, journal-iso = {INT J BIOL MACROMOL}, journal = {INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES}, volume = {253}, unique-id = {34140818}, issn = {0141-8130}, abstract = {The type and concentration of charged groups in polymers have a key role in mucoadhesive interactions. A series of cationic poly(amino acid)s with different charge densities was designed to unravel the correlation between chemical structure and mucin-polymer interactions. Colloidal interactions between the mucin protein and synthetic polyaspartamides were tested by dynamic light scattering, zeta potential measurements and turbidimetric titration as a function of polymer-to-mucin mass ratio. The mucoadhesive interactions displayed a strongly non -linear change with polymer composition. The attractive interactions between mucin and the polyaspartamides with at least 50 % cationic groups caused increased light scattering of dispersions due to the aggregation of mucin particles upon their charge reversal. Interactions were further analysed in a thin mucin layer to model life-like situations using a quartz crystal microbalance (QCM) in flow mode. Results pointed out that the fully cationic polyaspartamide is not necessarily superior to derivatives with lower cationic group content. The maximum of adsorbed mass of polymers on mucin was experienced at medium cationic group contents. This emphasizes the relevance of cationic polyaspartamides as mucoadhesive excipients due to their multiple functionalities and the possibility of fine-tuning their interactions with mucin via straightforward chemical steps.}, keywords = {POLYMERS; ADSORPTION; GEL; CHARGE; QUARTZ-CRYSTAL MICROBALANCE; mucoadhesion; QUARTZ CRYSTAL MICROBALANCE; polyelectrolyte; QCM; Poly(aspartic acid); GASTRIC MUCIN; MUCOADHESIVE INTERACTIONS}, year = {2023}, eissn = {1879-0003}, orcid-numbers = {Ábrahám, Ágnes/0000-0003-2586-8650; Kiss, Éva/0000-0002-4757-4437; Varga, Zoltán/0000-0002-5741-2669; Szilágyi, András Ferenc/0000-0001-6898-1755} } @article{MTMT:33734502, title = {In situ gelation of thiolated poly(aspartic acid) derivatives through oxidant-free disulfide formation for ophthalmic drug delivery}, url = {https://m2.mtmt.hu/api/publication/33734502}, author = {Szilágyi, Barnabás Áron and Gyarmati, Benjámin Sándor and L. Kiss, Eszter and Budai-Szűcs, Mária and Misra, Anil and Csányi, Erzsébet and Nagyné László, Krisztina and Szilágyi, András Ferenc}, doi = {10.1016/j.colsurfb.2023.113254}, journal-iso = {COLLOID SURFACE B}, journal = {COLLOIDS AND SURFACES B: BIOINTERFACES}, volume = {225}, unique-id = {33734502}, issn = {0927-7765}, year = {2023}, eissn = {1873-4367}, orcid-numbers = {Budai-Szűcs, Mária/0000-0001-5187-5702; Csányi, Erzsébet/0000-0002-3010-1959; Nagyné László, Krisztina/0000-0003-4499-3983; Szilágyi, András Ferenc/0000-0001-6898-1755} } @article{MTMT:32896153, title = {1,4-Pentanediol: Vapor Pressure, Density, Viscosity, Refractive Index, and Its Isobaric Vapor–Liquid Equilibrium with 2-Methyltetrahydrofurane}, url = {https://m2.mtmt.hu/api/publication/32896153}, author = {Al-Lami, Munaf and Szilágyi, András Ferenc and Havasi, Dávid and Mika, László Tamás}, doi = {10.1021/acs.jced.2c00049}, journal-iso = {J CHEM ENG DATA}, journal = {JOURNAL OF CHEMICAL AND ENGINEERING DATA}, volume = {67}, unique-id = {32896153}, issn = {0021-9568}, year = {2022}, eissn = {1520-5134}, pages = {1450-1459}, orcid-numbers = {Al-Lami, Munaf/0000-0002-2844-9454; Szilágyi, András Ferenc/0000-0001-6898-1755; Havasi, Dávid/0000-0003-3366-4009} } @article{MTMT:32895627, title = {Thiolated cationic poly(aspartamides) with side group dependent gelation properties for the delivery of anionic polyelectrolytes}, url = {https://m2.mtmt.hu/api/publication/32895627}, author = {Mammadova, Aysel and Gyarmati, Benjámin Sándor and Sárdi, Kitti and Paudics, Adrien and Varga, Zoltán and Szilágyi, András Ferenc}, doi = {10.1039/D2TB00674J}, journal-iso = {J MATER CHEM B}, journal = {JOURNAL OF MATERIALS CHEMISTRY B}, volume = {10}, unique-id = {32895627}, issn = {2050-750X}, abstract = {In situ gellable polymers have potential applications as injectable formulations in drug delivery and regenerative medicine. Herein, thiolated cationic polyaspartamides were synthesised via two different approaches to correlate the side group structure with gelation properties, gel strength and drug release kinetics. Cysteamine (CEA) was used as a thiolating agent to prepare thiolated cationic polyaspartamide groups with short thiolated side groups. As a new pathway, thiolactone chemistry was integrated with cationic modification of polyaspartamides to prepare thiolated derivatives with longer, flexible side groups using N-acetyl-DL-homocysteine (NAH) thiolactone. Both types of thiolated polyaspartamides could be converted into stiff hydrogels under mild reaction conditions through oxidation-induced intermolecular disulfide formation. We confirmed that the longer side groups largely accelerated gelation and the stiffness of the resultant hydrogels was higher than that of the CEA-modified counterparts. Both the gelation time and stiffness could be adjusted by the degree of thiolation. Poly(aspartic acid) (PASP) derivatives with a controlled concentration of anionic groups were entrapped in the hydrogels during the in situ gelation. Based on the possible electrostatic interaction between the linear anionic polyelectrolytes and the cationic polymer network, we hypothesized that the release of the encapsulated material is controlled by the charge density. In accordance, fully anionic PASP was entrapped completely in the hydrogels, whereas a reduction in the number of anionic groups caused the partial release of PASP derivatives. NAH- and CEA- modified cationic polyaspartamide hydrogels showed distinct release rates, indicating the interplay between cationic and thiol functionalities in release kinetics.}, year = {2022}, eissn = {2050-7518}, pages = {5946-5957}, orcid-numbers = {Gyarmati, Benjámin Sándor/0000-0002-8795-7264; Paudics, Adrien/0000-0001-7083-0753; Varga, Zoltán/0000-0002-5741-2669; Szilágyi, András Ferenc/0000-0001-6898-1755} } @article{MTMT:32765035, title = {A robust mucin-containing poly(vinyl alcohol) hydrogel model for the in vitro characterization of mucoadhesion of solid dosage forms}, url = {https://m2.mtmt.hu/api/publication/32765035}, author = {Gyarmati, Benjámin Sándor and Stankovits, József Gergely and Szilágyi, Barnabás Áron and Galata, Dorián László and Gordon, Péter and Szilágyi, András Ferenc}, doi = {10.1016/j.colsurfb.2022.112406}, journal-iso = {COLLOID SURFACE B}, journal = {COLLOIDS AND SURFACES B: BIOINTERFACES}, volume = {213}, unique-id = {32765035}, issn = {0927-7765}, keywords = {rheology; Poly(vinyl alcohol); Mucosa mimetic}, year = {2022}, eissn = {1873-4367}, orcid-numbers = {Szilágyi, András Ferenc/0000-0001-6898-1755} } @article{MTMT:32759014, title = {Synthesis, complex formation and corneal permeation of cyclodextrin-modified, thiolated poly(aspartic acid) as self-gelling formulation of dexamethasone}, url = {https://m2.mtmt.hu/api/publication/32759014}, author = {Gyarmati, Benjámin Sándor and Dargó, Gergő and Szilágyi, Barnabás Áron and Vincze, Anna and Facskó, Réka and Budai-Szűcs, Mária and L. Kiss, Eszter and Szente, Lajos and Szilágyi, András Ferenc and Balogh, György Tibor}, doi = {10.1016/j.ejpb.2022.03.008}, journal-iso = {EUR J PHARM BIOPHARM}, journal = {EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS}, volume = {174}, unique-id = {32759014}, issn = {0939-6411}, year = {2022}, eissn = {1873-3441}, pages = {1-9}, orcid-numbers = {Dargó, Gergő/0000-0002-1141-8379; Vincze, Anna/0000-0002-9756-574X; Facskó, Réka/0000-0002-5611-0597; Budai-Szűcs, Mária/0000-0001-5187-5702; Szilágyi, András Ferenc/0000-0001-6898-1755; Balogh, György Tibor/0000-0003-3347-1880} } @article{MTMT:32653430, title = {Viscous and filamentous bulking in activated sludge: Rheological and hydrodynamic modelling based on experimental data}, url = {https://m2.mtmt.hu/api/publication/32653430}, author = {Bakos, Vince and Gyarmati, Benjámin Sándor and Csizmadia, Péter and Till, Sára and Vachoud, L. and Göde, P. Nagy and Tardy, Gábor Márk and Szilágyi, András Ferenc and Jobbágy, A. and Wisniewski, C.}, doi = {10.1016/j.watres.2022.118155}, journal-iso = {WATER RES}, journal = {WATER RESEARCH}, volume = {214}, unique-id = {32653430}, issn = {0043-1354}, abstract = {Although achieving good activated sludge settleability is a key requirement for meeting effluent quality criteria, wastewater treatment plants often face undesired floc structure changes. Filamentous bulking has widely been studied, however, viscous sludge formation much less investigated so far. Our main goal was to find relationship between sludge floc structure and related rheological properties, moreover, to estimate pressure loss in pipe networks through hydrodynamic modelling of the non-Newtonian flows in case of well settling (ideal-like), viscous and filamentous sludge. Severe viscous and filamentous kinds of bulking were generated separately in continuous-flow lab-scale systems initially seeded with the same reference (ideal-like) biomass and the entire evolution of viscous and filamentous bulking was monitored. The results suggested correlation between the rheological properties and the floc structure transformations, and showed the most appropriate fit for the Herschel-Bulkley model (vs. Power-law and Bingham). Validated computational fluid dynamics studies estimated the pipe pressure loss in a wide Reynolds number range for the initial well settling (reference) and the final viscous and filamentous sludge as well. A practical standard modelling protocol was developed for improving energy efficiency of sludge pumping in different floc structure scenarios.}, year = {2022}, eissn = {1879-2448}, orcid-numbers = {Csizmadia, Péter/0000-0001-5490-6383; Till, Sára/0000-0002-3806-198X; Szilágyi, András Ferenc/0000-0001-6898-1755} } @article{MTMT:32515084, title = {Cross-Linked Enzyme-Adhered Nanoparticles (CLEANs) for Continuous-Flow Bioproduction}, url = {https://m2.mtmt.hu/api/publication/32515084}, author = {Nagy, Flóra and Bell, Evelin and Jipa, Monica and Hornyánszky, Gábor and Szilágyi, András Ferenc and Nagyné László, Krisztina and Katona, Gábor and Paizs, Csaba and Poppe, László and Balogh Weiser, Diána}, doi = {10.1002/cssc.202102284}, journal-iso = {CHEMSUSCHEM}, journal = {CHEMSUSCHEM}, volume = {15}, unique-id = {32515084}, issn = {1864-5631}, abstract = {Nanostructured but micro-sized biocatalysts were created by bottom-up technology using multi-functionalized silica nanoparticles (NPs) as nano-sized building blocks to form cross-linked enzyme-adhered nanoparticles (CLEANs) as robust micro-sized particles with beneficial internal structure and good mechanical properties. Systematic surface modification of NPs with a grafting mixture consisting of organosilanes with reactive (aminopropyl) and inert (e. g., vinyl, propyl, phenyl, or octyl) functions resulted in functional NPs enabling cross-linking agents, such as glutardialdehyde or bisepoxides (glycerol diglycidyl ether, neopentylglycol diglycidyl ether, and poly(propylene glycol) diglycidyl ether), to bind and cross-link enzymes covalently and to form macroporous microparticles. These CLEANs were able to diminish several weaknesses of traditional cross-linked enzyme aggregates as biocatalysts, such as poor mechanical resistance, difficult recovery, and storage, strengthening their use for packed-bed enzyme reactors. Lipase B from Candida antarctica (CaLB) was selected as model enzyme for development of robust CLEANs, which were successfully tested for various industrially relevant applications including a kinetic resolution of a racemic alcohol and the production of various natural fragrance compounds under continuous-flow conditions.}, year = {2022}, eissn = {1864-564X}, orcid-numbers = {Szilágyi, András Ferenc/0000-0001-6898-1755; Nagyné László, Krisztina/0000-0003-4499-3983; Paizs, Csaba/0000-0002-7403-7098; Poppe, László/0000-0002-8358-1378; Balogh Weiser, Diána/0000-0002-9957-1203} } @article{MTMT:32242806, title = {Entrapment of Phenylalanine Ammonia-Lyase in Nanofibrous Polylactic Acid Matrices by Emulsion Electrospinning}, url = {https://m2.mtmt.hu/api/publication/32242806}, author = {Koplányi, Gábor and Bell, Evelin and Molnár, Zsófia Klára and Tóth, Gergő Dániel and Józó, Muriel and Szilágyi, András Ferenc and Ender, Ferenc and Pukánszky, Béla and Vértessy, Beáta (Grolmuszné) and Poppe, László and Balogh Weiser, Diána}, doi = {10.3390/catal11101149}, journal-iso = {CATALYSTS}, journal = {CATALYSTS}, volume = {11}, unique-id = {32242806}, year = {2021}, eissn = {2073-4344}, orcid-numbers = {Koplányi, Gábor/0000-0002-3791-1057; Szilágyi, András Ferenc/0000-0001-6898-1755; Ender, Ferenc/0000-0003-3800-5707; Poppe, László/0000-0002-8358-1378; Balogh Weiser, Diána/0000-0002-9957-1203} }