TY - JOUR AU - Singh, Priyanka AU - Szigyártó, Imola Csilla AU - Ricci, Maria AU - Gaál, Anikó AU - Quemé Peña, Mayra AU - Kitka, Diána AU - Fülöp, Lívia AU - Turiák, Lilla AU - Drahos, László AU - Varga, Zoltán AU - Beke-Somfai, Tamás TI - Removal and identification of external protein corona members from RBC-derived extracellular vesicles by surface manipulating antimicrobial peptides JF - JOURNAL OF EXTRACELLULAR BIOLOGY J2 - J EXTRACELLULAR BIOL VL - 2 PY - 2023 IS - 3 PG - 15 SN - 2768-2811 DO - 10.1002/jex2.78 UR - https://m2.mtmt.hu/api/publication/33689834 ID - 33689834 LA - English DB - MTMT ER - TY - JOUR AU - Hassoon, Azza Ahmed Mousad Megahed AU - Szorcsik, Attila AU - Fülöp, Lívia AU - Papp, Ibolya Zita AU - May, Nóra Veronika AU - Gajda, Tamás TI - Peptide-based chemical models for lytic polysaccharide monooxygenases JF - JOURNAL OF THE CHEMICAL SOCIETY-DALTON TRANSACTIONS J2 - J CHEM SOC DALTON TRANS VL - 51 PY - 2022 IS - 45 SP - 17241 EP - 17254 PG - 14 SN - 1472-7773 DO - 10.1039/D2DT02836K UR - https://m2.mtmt.hu/api/publication/33330925 ID - 33330925 AB - The Cu( ii )–HPH-NH 2 and Cu( ii )–HPHPY-NH 2 systems were proved to be relevant functional models of LPMOs, even at neutral pH. LA - English DB - MTMT ER - TY - JOUR AU - Váczi, Sándor AU - Barna, Lilla AU - Laczi, Krisztián AU - Tömösi, Ferenc AU - Rákhely, Gábor AU - Penke, Botond AU - Fülöp, Lívia AU - Bogár, Ferenc AU - Janáky, Tamás AU - Deli, Mária Anna AU - Mezei, Zsófia TI - Effects of sub-chronic, in vivo administration of sigma-1 receptor ligands on platelet and aortic arachidonate cascade in streptozotocin-induced diabetic rats JF - PLOS ONE J2 - PLOS ONE VL - 17 PY - 2022 IS - 11 PG - 23 SN - 1932-6203 DO - 10.1371/journal.pone.0265854 UR - https://m2.mtmt.hu/api/publication/33265905 ID - 33265905 LA - English DB - MTMT ER - TY - JOUR AU - Szögi, Titanilla AU - Borbély, Emőke AU - Schuster, Ildikó AU - Bozsó, Zsolt AU - Sántha, Miklós AU - Tóth, Erzsébet Melinda AU - Penke, Botond AU - Fülöp, Lívia TI - Examination of Longitudinal Alterations in Alzheimer’s Disease-Related Neurogenesis in an APP/PS1 Transgenic Mouse Model, and the Effects of P33, a Putative Neuroprotective Agent Thereon JF - INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES J2 - INT J MOL SCI VL - 23 PY - 2022 IS - 18 PG - 17 SN - 1661-6596 DO - 10.3390/ijms231810364 UR - https://m2.mtmt.hu/api/publication/33111245 ID - 33111245 N1 - Funding Agency and Grant Number: National Research, Development and Innovation Office [GINOP-2.3.2-15-2016-00060]; Hungarian Brain Research Program I and II [KTIA_13_NAP-A-III/7, 2017-1.2.1-NKP-2017-00002]; Ministry of Human Capacities, Hungary [20391-3/2018/FEKUSTRAT]; Ministry of Innovation and Technology of Hungary from the National Research, Development and Innovation Fund [TKP2021-EGA-32] Funding text: This project was supported by the National Research, Development and Innovation Office (GINOP-2.3.2-15-2016-00060) and by the Hungarian Brain Research Program I and II (Grant No. KTIA_13_NAP-A-III/7, and 2017-1.2.1-NKP-2017-00002). Support by the Ministry of Human Capacities, Hungary (grant 20391-3/2018/FEKUSTRAT) and the Ministry of Innovation and Technology of Hungary from the National Research, Development and Innovation Fund (TKP2021-EGA-32) is acknowledged. AB - Neurogenesis plays a crucial role in cognitive processes. During aging and in Alzheimer’s disease (AD), altered neurogenesis and neuroinflammation are evident both in C57BL/6J, APPSwe/PS1dE9 (Tg) mice and humans. AD pathology may slow down upon drug treatment, for example, in a previous study of our group P33, a putative neuroprotective agent was found to exert advantageous effects on the elevated levels of APP, Aβ, and neuroinflammation. In the present study, we aimed to examine longitudinal alterations in neurogenesis, neuroinflammation and AD pathology in a transgenic (Tg) mouse model, and assessed the putative beneficial effects of long-term P33 treatment on AD-specific neurological alterations. Hippocampal cell proliferation and differentiation were significantly reduced between 8 and 12 months of age. Regarding neuroinflammation, significantly elevated astrogliosis and microglial activation were observed in 6- to 7-month-old Tg animals. The amounts of the molecules involved in the amyloidogenic pathway were altered from 4 months of age in Tg animals. P33-treatment led to significantly increased neurogenesis in 9-month-old animals. Our data support the hypothesis that altered neurogenesis may be a consequence of AD pathology. Based on our findings in the transgenic animal model, early pharmacological treatment before the manifestation of AD symptoms might ameliorate neurological decline. LA - English DB - MTMT ER - TY - CONF AU - Dukay, Brigitta AU - Bódai, Zsófia AU - Csefová, Alexandra AU - Hajdu, Petra AU - Ruppert, Zsófia AU - Penke, Botond AU - Fülöp, Lívia AU - Szabó, Kitti AU - Keller-Pintér, Anikó AU - Dux, László AU - Gombos, Imre AU - Török, Zsolt AU - Sántha, Miklós AU - Tóth, E. Melinda TI - A rendszeres testmozgás izom- és agyszövetre kifejtett nem-függő hatásainak vizsgálata a hiperlipidémia egérmodelljében T2 - 51. Membrán-Transzport Konferencia PY - 2022 PG - 1 UR - https://m2.mtmt.hu/api/publication/32908630 ID - 32908630 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Váczi, Sándor AU - Barna, Lilla AU - Laczi, Krisztián AU - Tömösi, Ferenc AU - Rákhely, Gábor AU - Penke, Botond AU - Fülöp, Lívia AU - Bogár, Ferenc AU - Janáky, Tamás AU - Deli, Mária Anna AU - Mezei, Zsófia TI - Effects of sub-chronic, in vivo administration of sigma non-opioid intracellular receptor 1 ligands on platelet and aortic arachidonate cascade in rats JF - EUROPEAN JOURNAL OF PHARMACOLOGY J2 - EUR J PHARMACOL VL - 925 PY - 2022 PG - 10 SN - 0014-2999 DO - 10.1016/j.ejphar.2022.174983 UR - https://m2.mtmt.hu/api/publication/32801748 ID - 32801748 N1 - További támogatások: ÚNKP-20-3-SZTE-503; Richter Gedeon Nyrt. Centenáriumi Alapítvány 2020/K/21/2503 LA - English DB - MTMT ER - TY - JOUR AU - Bogár, Ferenc AU - Fülöp, Lívia AU - Penke, Botond TI - Novel Therapeutic Target for Prevention of Neurodegenerative Diseases: Modulation of Neuroinflammation with Sig-1R Ligands JF - BIOMOLECULES J2 - BIOMOLECULES VL - 12 PY - 2022 IS - 3 PG - 16 SN - 2218-273X DO - 10.3390/biom12030363 UR - https://m2.mtmt.hu/api/publication/32753552 ID - 32753552 LA - English DB - MTMT ER - TY - JOUR AU - Borbély, Emőke AU - Varga, Viktória AU - Szögi, Titanilla AU - Schuster, Ildikó AU - Bozsó, Zsolt AU - Penke, Botond AU - Fülöp, Lívia TI - Impact of Two Neuronal Sigma-1 Receptor Modulators, PRE084 and DMT, on Neurogenesis and Neuroinflammation in an Aβ1–42-Injected, Wild-Type Mouse Model of AD JF - INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES J2 - INT J MOL SCI VL - 23 PY - 2022 IS - 5 PG - 20 SN - 1661-6596 DO - 10.3390/ijms23052514 UR - https://m2.mtmt.hu/api/publication/32753550 ID - 32753550 N1 - Funding Agency and Grant Number: National Research, Development, and Innovation Office [GINOP-2.3.2-15-2016-00060]; Hungarian Brain Research Program I [KTIA_13_NAP-A-III/7, 2017-1.2.1-NKP-2017-00002]; Ministry of Innovation and Technology of Hungary from the National Research, Development and Innovation Fund [TKP2021EGA-32]; Hungarian Brain Research Program II [KTIA_13_NAP-A-III/7, 2017-1.2.1-NKP-2017-00002] Funding text: This project was supported by the National Research, Development, and Innovation Office (GINOP-2.3.2-15-2016-00060) and by the Hungarian Brain Research Program I and II-Grant No. KTIA_13_NAP-A-III/7, and 2017-1.2.1-NKP-2017-00002. Support by the Ministry of Innovation and Technology of Hungary from the National Research, Development and Innovation Fund (TKP2021EGA-32) is acknowledged. LA - English DB - MTMT ER - TY - JOUR AU - Váczi, Sándor AU - Barna, Lilla AU - Harazin, András AU - Mészáros, Mária AU - Porkoláb, Gergő AU - Zvara, Ágnes AU - Ónody, Rita AU - Földesi, Imre AU - Veszelka, Szilvia AU - Penke, Botond AU - Fülöp, Lívia AU - Deli, Mária Anna AU - Mezei, Zsófia TI - S1R agonist modulates rat platelet eicosanoid synthesis and aggregation JF - PLATELETS J2 - PLATELETS VL - 33 PY - 2022 IS - 5 SP - 709 EP - 718 PG - 10 SN - 0953-7104 DO - 10.1080/09537104.2021.1981843 UR - https://m2.mtmt.hu/api/publication/32491017 ID - 32491017 AB - Sigma-1 receptor (S1R) is detected in different cell types and can regulate intracellular signaling pathways. S1R plays a role in the pathomechanism of diseases and the regulation of neurotransmitters. Fluvoxamine can bind to S1R and reduce the serotonin uptake of neurons and platelets. We therefore hypothesized that platelets express S1R, which can modify platelet function. The expression of the SIGMAR1 gene in rat platelets was examined with a reverse transcription polymerase chain reaction and a quantitative polymerase chain reaction. The receptor was also visualized by immunostaining and confocal laser scanning microscopy. The effect of S1R agonist PRE-084 on the eicosanoid synthesis of isolated rat platelets and ADP- and AA-induced platelet aggregation was examined. S1R was detected in rat platelets both at gene and protein levels. Pretreatment with PRE-084 of resting platelets induced elevation of eicosanoid synthesis. The rate of elevation in thromboxane B2 and prostaglandin D2 synthesis was similar, but the production of prostaglandin E2 was higher. The concentration-response curve showed a sigmoidal form. The most effective concentration of the agonist was 2 µM. PRE-084 increased the quantity of cyclooxygenase-1 as detected by ELISA. PRE-084 also elevated the ADP- and AA-induced platelet aggregation. S1R of platelets might regulate physiological or pathological functions. © 2021 Taylor & Francis Group, LLC. LA - English DB - MTMT ER - TY - JOUR AU - Quemé Peña, Mayra AU - Juhász, Tünde AU - Kohut, Gergely AU - Ricci, M. AU - Singh, Priyanka AU - Szigyártó, Imola Csilla AU - Papp, Ibolya Zita AU - Fülöp, Lívia AU - Beke-Somfai, Tamás TI - Membrane Association Modes of Natural Anticancer Peptides: Mechanistic Details on Helicity, Orientation, and Surface Coverage JF - INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES J2 - INT J MOL SCI VL - 22 PY - 2021 IS - 16 PG - 26 SN - 1661-6596 DO - 10.3390/ijms22168613 UR - https://m2.mtmt.hu/api/publication/32132865 ID - 32132865 AB - Anticancer peptides (ACPs) could potentially offer many advantages over other cancer therapies. ACPs often target cell membranes, where their surface mechanism is coupled to a conformational change into helical structures. However, details on their binding are still unclear, which would be crucial to reach progress in connecting structural aspects to ACP action and to therapeutic developments. Here we investigated natural helical ACPs, Lasioglossin LL‐III, Macropin 1, Temporin‐La, FK‐16, and LL‐37, on model liposomes, and also on extracellular vesicles (EVs), with an outer leaflet composition similar to cancer cells. The combined simulations and experiments identified three distinct binding modes to the membranes. Firstly, a highly helical structure, lying mainly on the membrane surface; secondly, a similar, yet only partially helical structure with disordered regions; and thirdly, a helical monomeric form with a non‐inserted perpendicular orientation relative to the membrane surface. The latter allows large swings of the helix while the N‐terminal is anchored to the headgroup region. These results indicate that subtle differences in sequence and charge can result in altered binding modes. The first two modes could be part of the well‐known carpet model mechanism, whereas the newly identified third mode could be an intermediate state, existing prior to membrane insertion. © 2021 by the authors. Licensee MDPI, Basel, Switzerland. LA - English DB - MTMT ER -