@article{MTMT:33689834, title = {Removal and identification of external protein corona members from RBC-derived extracellular vesicles by surface manipulating antimicrobial peptides}, url = {https://m2.mtmt.hu/api/publication/33689834}, author = {Singh, Priyanka and Szigyártó, Imola Csilla and Ricci, Maria and Gaál, Anikó and Quemé Peña, Mayra and Kitka, Diána and Fülöp, Lívia and Turiák, Lilla and Drahos, László and Varga, Zoltán and Beke-Somfai, Tamás}, doi = {10.1002/jex2.78}, journal-iso = {J EXTRACELLULAR BIOL}, journal = {JOURNAL OF EXTRACELLULAR BIOLOGY}, volume = {2}, unique-id = {33689834}, issn = {2768-2811}, year = {2023}, eissn = {2768-2811}, orcid-numbers = {Ricci, Maria/0000-0002-8548-5427; Gaál, Anikó/0000-0003-4064-1825; Fülöp, Lívia/0000-0002-8010-0129; Turiák, Lilla/0000-0002-2139-8156; Drahos, László/0000-0001-9589-6652; Varga, Zoltán/0000-0002-5741-2669} } @article{MTMT:33330925, title = {Peptide-based chemical models for lytic polysaccharide monooxygenases}, url = {https://m2.mtmt.hu/api/publication/33330925}, author = {Hassoon, Azza Ahmed Mousad Megahed and Szorcsik, Attila and Fülöp, Lívia and Papp, Ibolya Zita and May, Nóra Veronika and Gajda, Tamás}, doi = {10.1039/D2DT02836K}, journal-iso = {J CHEM SOC DALTON TRANS}, journal = {JOURNAL OF THE CHEMICAL SOCIETY-DALTON TRANSACTIONS}, volume = {51}, unique-id = {33330925}, issn = {1472-7773}, abstract = {The Cu( ii )–HPH-NH 2 and Cu( ii )–HPHPY-NH 2 systems were proved to be relevant functional models of LPMOs, even at neutral pH.}, year = {2022}, pages = {17241-17254}, orcid-numbers = {Hassoon, Azza Ahmed Mousad Megahed/0000-0003-2384-7493; Fülöp, Lívia/0000-0002-8010-0129; Papp, Ibolya Zita/0000-0001-9202-9035; May, Nóra Veronika/0000-0003-4770-4681; Gajda, Tamás/0000-0001-5777-315X} } @article{MTMT:33265905, title = {Effects of sub-chronic, in vivo administration of sigma-1 receptor ligands on platelet and aortic arachidonate cascade in streptozotocin-induced diabetic rats}, url = {https://m2.mtmt.hu/api/publication/33265905}, author = {Váczi, Sándor and Barna, Lilla and Laczi, Krisztián and Tömösi, Ferenc and Rákhely, Gábor and Penke, Botond and Fülöp, Lívia and Bogár, Ferenc and Janáky, Tamás and Deli, Mária Anna and Mezei, Zsófia}, doi = {10.1371/journal.pone.0265854}, journal-iso = {PLOS ONE}, journal = {PLOS ONE}, volume = {17}, unique-id = {33265905}, issn = {1932-6203}, year = {2022}, eissn = {1932-6203}, orcid-numbers = {Váczi, Sándor/0000-0002-9642-7126; Laczi, Krisztián/0000-0002-9399-7406; Tömösi, Ferenc/0000-0002-6657-5777; Rákhely, Gábor/0000-0003-2557-3641; Penke, Botond/0000-0003-0938-0567; Fülöp, Lívia/0000-0002-8010-0129; Bogár, Ferenc/0000-0002-0611-1452; Janáky, Tamás/0000-0002-6466-8283; Deli, Mária Anna/0000-0001-6084-6524} } @article{MTMT:33111245, title = {Examination of Longitudinal Alterations in Alzheimer’s Disease-Related Neurogenesis in an APP/PS1 Transgenic Mouse Model, and the Effects of P33, a Putative Neuroprotective Agent Thereon}, url = {https://m2.mtmt.hu/api/publication/33111245}, author = {Szögi, Titanilla and Borbély, Emőke and Schuster, Ildikó and Bozsó, Zsolt and Sántha, Miklós and Tóth, Erzsébet Melinda and Penke, Botond and Fülöp, Lívia}, doi = {10.3390/ijms231810364}, journal-iso = {INT J MOL SCI}, journal = {INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES}, volume = {23}, unique-id = {33111245}, issn = {1661-6596}, abstract = {Neurogenesis plays a crucial role in cognitive processes. During aging and in Alzheimer’s disease (AD), altered neurogenesis and neuroinflammation are evident both in C57BL/6J, APPSwe/PS1dE9 (Tg) mice and humans. AD pathology may slow down upon drug treatment, for example, in a previous study of our group P33, a putative neuroprotective agent was found to exert advantageous effects on the elevated levels of APP, Aβ, and neuroinflammation. In the present study, we aimed to examine longitudinal alterations in neurogenesis, neuroinflammation and AD pathology in a transgenic (Tg) mouse model, and assessed the putative beneficial effects of long-term P33 treatment on AD-specific neurological alterations. Hippocampal cell proliferation and differentiation were significantly reduced between 8 and 12 months of age. Regarding neuroinflammation, significantly elevated astrogliosis and microglial activation were observed in 6- to 7-month-old Tg animals. The amounts of the molecules involved in the amyloidogenic pathway were altered from 4 months of age in Tg animals. P33-treatment led to significantly increased neurogenesis in 9-month-old animals. Our data support the hypothesis that altered neurogenesis may be a consequence of AD pathology. Based on our findings in the transgenic animal model, early pharmacological treatment before the manifestation of AD symptoms might ameliorate neurological decline.}, year = {2022}, eissn = {1422-0067}, orcid-numbers = {Szögi, Titanilla/0000-0002-9854-7340; Schuster, Ildikó/0000-0001-9997-5729; Bozsó, Zsolt/0000-0002-5713-3096; Penke, Botond/0000-0003-0938-0567; Fülöp, Lívia/0000-0002-8010-0129} } @CONFERENCE{MTMT:32908630, title = {A rendszeres testmozgás izom- és agyszövetre kifejtett nem-függő hatásainak vizsgálata a hiperlipidémia egérmodelljében}, url = {https://m2.mtmt.hu/api/publication/32908630}, author = {Dukay, Brigitta and Bódai, Zsófia and Csefová, Alexandra and Hajdu, Petra and Ruppert, Zsófia and Penke, Botond and Fülöp, Lívia and Szabó, Kitti and Keller-Pintér, Anikó and Dux, László and Gombos, Imre and Török, Zsolt and Sántha, Miklós and Tóth, E. Melinda}, booktitle = {51. Membrán-Transzport Konferencia}, unique-id = {32908630}, year = {2022}, orcid-numbers = {Penke, Botond/0000-0003-0938-0567; Fülöp, Lívia/0000-0002-8010-0129; Szabó, Kitti/0000-0002-1177-2036; Keller-Pintér, Anikó/0000-0002-4105-8458; Dux, László/0000-0002-1270-1678} } @article{MTMT:32801748, title = {Effects of sub-chronic, in vivo administration of sigma non-opioid intracellular receptor 1 ligands on platelet and aortic arachidonate cascade in rats}, url = {https://m2.mtmt.hu/api/publication/32801748}, author = {Váczi, Sándor and Barna, Lilla and Laczi, Krisztián and Tömösi, Ferenc and Rákhely, Gábor and Penke, Botond and Fülöp, Lívia and Bogár, Ferenc and Janáky, Tamás and Deli, Mária Anna and Mezei, Zsófia}, doi = {10.1016/j.ejphar.2022.174983}, journal-iso = {EUR J PHARMACOL}, journal = {EUROPEAN JOURNAL OF PHARMACOLOGY}, volume = {925}, unique-id = {32801748}, issn = {0014-2999}, year = {2022}, eissn = {1879-0712}, orcid-numbers = {Váczi, Sándor/0000-0002-9642-7126; Laczi, Krisztián/0000-0002-9399-7406; Tömösi, Ferenc/0000-0002-6657-5777; Rákhely, Gábor/0000-0003-2557-3641; Penke, Botond/0000-0003-0938-0567; Fülöp, Lívia/0000-0002-8010-0129; Bogár, Ferenc/0000-0002-0611-1452; Janáky, Tamás/0000-0002-6466-8283; Deli, Mária Anna/0000-0001-6084-6524} } @article{MTMT:32753552, title = {Novel Therapeutic Target for Prevention of Neurodegenerative Diseases: Modulation of Neuroinflammation with Sig-1R Ligands}, url = {https://m2.mtmt.hu/api/publication/32753552}, author = {Bogár, Ferenc and Fülöp, Lívia and Penke, Botond}, doi = {10.3390/biom12030363}, journal-iso = {BIOMOLECULES}, journal = {BIOMOLECULES}, volume = {12}, unique-id = {32753552}, issn = {2218-273X}, year = {2022}, eissn = {2218-273X}, orcid-numbers = {Bogár, Ferenc/0000-0002-0611-1452; Fülöp, Lívia/0000-0002-8010-0129; Penke, Botond/0000-0003-0938-0567} } @article{MTMT:32753550, title = {Impact of Two Neuronal Sigma-1 Receptor Modulators, PRE084 and DMT, on Neurogenesis and Neuroinflammation in an Aβ1–42-Injected, Wild-Type Mouse Model of AD}, url = {https://m2.mtmt.hu/api/publication/32753550}, author = {Borbély, Emőke and Varga, Viktória and Szögi, Titanilla and Schuster, Ildikó and Bozsó, Zsolt and Penke, Botond and Fülöp, Lívia}, doi = {10.3390/ijms23052514}, journal-iso = {INT J MOL SCI}, journal = {INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES}, volume = {23}, unique-id = {32753550}, issn = {1661-6596}, year = {2022}, eissn = {1422-0067}, orcid-numbers = {Szögi, Titanilla/0000-0002-9854-7340; Schuster, Ildikó/0000-0001-9997-5729; Bozsó, Zsolt/0000-0002-5713-3096; Penke, Botond/0000-0003-0938-0567; Fülöp, Lívia/0000-0002-8010-0129} } @article{MTMT:32491017, title = {S1R agonist modulates rat platelet eicosanoid synthesis and aggregation}, url = {https://m2.mtmt.hu/api/publication/32491017}, author = {Váczi, Sándor and Barna, Lilla and Harazin, András and Mészáros, Mária and Porkoláb, Gergő and Zvara, Ágnes and Ónody, Rita and Földesi, Imre and Veszelka, Szilvia and Penke, Botond and Fülöp, Lívia and Deli, Mária Anna and Mezei, Zsófia}, doi = {10.1080/09537104.2021.1981843}, journal-iso = {PLATELETS}, journal = {PLATELETS}, volume = {33}, unique-id = {32491017}, issn = {0953-7104}, abstract = {Sigma-1 receptor (S1R) is detected in different cell types and can regulate intracellular signaling pathways. S1R plays a role in the pathomechanism of diseases and the regulation of neurotransmitters. Fluvoxamine can bind to S1R and reduce the serotonin uptake of neurons and platelets. We therefore hypothesized that platelets express S1R, which can modify platelet function. The expression of the SIGMAR1 gene in rat platelets was examined with a reverse transcription polymerase chain reaction and a quantitative polymerase chain reaction. The receptor was also visualized by immunostaining and confocal laser scanning microscopy. The effect of S1R agonist PRE-084 on the eicosanoid synthesis of isolated rat platelets and ADP- and AA-induced platelet aggregation was examined. S1R was detected in rat platelets both at gene and protein levels. Pretreatment with PRE-084 of resting platelets induced elevation of eicosanoid synthesis. The rate of elevation in thromboxane B2 and prostaglandin D2 synthesis was similar, but the production of prostaglandin E2 was higher. The concentration-response curve showed a sigmoidal form. The most effective concentration of the agonist was 2 µM. PRE-084 increased the quantity of cyclooxygenase-1 as detected by ELISA. PRE-084 also elevated the ADP- and AA-induced platelet aggregation. S1R of platelets might regulate physiological or pathological functions. © 2021 Taylor & Francis Group, LLC.}, keywords = {AGGREGATION; PLATELETS; Sigma-1 receptor; Eicosanoid; PRE-084}, year = {2022}, eissn = {1369-1635}, pages = {709-718}, orcid-numbers = {Váczi, Sándor/0000-0002-9642-7126; Harazin, András/0000-0002-0904-5606; Földesi, Imre/0000-0002-3329-8136; Penke, Botond/0000-0003-0938-0567; Fülöp, Lívia/0000-0002-8010-0129; Deli, Mária Anna/0000-0001-6084-6524} } @article{MTMT:32132865, title = {Membrane Association Modes of Natural Anticancer Peptides: Mechanistic Details on Helicity, Orientation, and Surface Coverage}, url = {https://m2.mtmt.hu/api/publication/32132865}, author = {Quemé Peña, Mayra and Juhász, Tünde and Kohut, Gergely and Ricci, M. and Singh, Priyanka and Szigyártó, Imola Csilla and Papp, Ibolya Zita and Fülöp, Lívia and Beke-Somfai, Tamás}, doi = {10.3390/ijms22168613}, journal-iso = {INT J MOL SCI}, journal = {INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES}, volume = {22}, unique-id = {32132865}, issn = {1661-6596}, abstract = {Anticancer peptides (ACPs) could potentially offer many advantages over other cancer therapies. ACPs often target cell membranes, where their surface mechanism is coupled to a conformational change into helical structures. However, details on their binding are still unclear, which would be crucial to reach progress in connecting structural aspects to ACP action and to therapeutic developments. Here we investigated natural helical ACPs, Lasioglossin LL‐III, Macropin 1, Temporin‐La, FK‐16, and LL‐37, on model liposomes, and also on extracellular vesicles (EVs), with an outer leaflet composition similar to cancer cells. The combined simulations and experiments identified three distinct binding modes to the membranes. Firstly, a highly helical structure, lying mainly on the membrane surface; secondly, a similar, yet only partially helical structure with disordered regions; and thirdly, a helical monomeric form with a non‐inserted perpendicular orientation relative to the membrane surface. The latter allows large swings of the helix while the N‐terminal is anchored to the headgroup region. These results indicate that subtle differences in sequence and charge can result in altered binding modes. The first two modes could be part of the well‐known carpet model mechanism, whereas the newly identified third mode could be an intermediate state, existing prior to membrane insertion. © 2021 by the authors. Licensee MDPI, Basel, Switzerland.}, keywords = {SPECTROSCOPY; molecular dynamics; peptide conformation; Anticancer peptides; Flow‐linear dichroism}, year = {2021}, eissn = {1422-0067}, orcid-numbers = {Kohut, Gergely/0000-0002-6139-5136; Papp, Ibolya Zita/0000-0001-9202-9035; Fülöp, Lívia/0000-0002-8010-0129} }