@article{MTMT:34795630,
	title = {From psychophysiology to brain imaging: forty-five years MMN history of investigating acoustic change sensitivity},
	url = {https://m2.mtmt.hu/api/publication/34795630},
	author = {Csépe, Valéria and Honbolygó, Ferenc},
	doi = {10.1007/s42977-024-00216-4},
	journal-iso = {BIOL FUTURA},
	journal = {BIOLOGIA FUTURA},
	volume = {2024},
	unique-id = {34795630},
	issn = {2676-8615},
	abstract = {Forty-five years have passed since the first publication of the mismatch negativity (MMN) event-related brain potential (ERP) component. The first 10 years of research hardly gained any particular attention of the scientific community interested in acoustic perception. Debates on the nature of sensation versus perception were going on, and the technical possibilities to record ERPs, called in general evoked potentials, were very limited. Subtle changes in pure tone frequency or intensity giving rise to the MMN component were first investigated in humans. The background of the theoretical model developed by Risto Näätänen was the orientation reaction model of E.N. Sokolov published in 1963 so that the MMN was seen first as an electrophysiological correlate of auditory change detection. This fundamental ability of the auditory system seen as crucial for survival led to the development of the first animal model of the MMN (Csépe et al. in Clin Neurophysiol 66: 571–578, 1987). Indeed, it was confirmed that the MMN was the brain correlate of subtle changes detected that might alert to potential threats in the environment and direct the behavioral orientation. The investigations performed after 2000 introduced complex models and more sophisticated methods, both in animal and human studies, so that the MMN method was on the way to become a tool on the first place and not the main goal of research. This approach was further strengthened by the increasing number of studies on different clinical populations aiming at future applications. The aim of our review is to describe and redefine what the MMN may reflect in auditory perception and to show why and how this brain correlate of changes in the auditory scene can be used as a valuable tool in cognitive neuroscience research. We refer to publications selected to underly the argument the MMN cannot be classified anymore as a sign of simple change detection and not all the indicators used to confirm how genuine the MMN elicited by variations of tones are valid for those to  speech contrasts. We provide a fresh view on the broadly used MMN models, provided by some influential publications as well as on the unwritten history of MMN research aiming to give revised picture on what the MMN may truly reflect. We show how the focus and terminology of the MMN research have changed and what kind of misunderstandings and seemingly contradictive results prevent the MMN community to accept a generally usable cognitive model.},
	year = {2024},
	eissn = {2676-8607},
	orcid-numbers = {Csépe, Valéria/0000-0002-5021-6024; Honbolygó, Ferenc/0000-0002-5266-0188}
}

@article{MTMT:34743153,
	title = {The role of cognitive control and naming in aphasia},
	url = {https://m2.mtmt.hu/api/publication/34743153},
	author = {Kiss, Annamária and Csépe, Valéria},
	doi = {10.1007/s42977-024-00212-8},
	journal-iso = {BIOL FUTURA},
	journal = {BIOLOGIA FUTURA},
	volume = {2024},
	unique-id = {34743153},
	issn = {2676-8615},
	abstract = {The classical aphasia literature has placed considerable emphasis on the language-centered understanding of aphasia and failed to consider the role of executive functions (EFs) regarding different aspects of patients’ performance. Many current studies suggest deficits in EFs in individuals with aphasia, however, the available data is still limited. Here, our aim was to investigate the impairment of EFs and its potential negative effects on naming (slower performance, increased reaction time and/or decreased accuracy). We sought to determine whether the poor performance observed in word fluency task correlated with similar outcomes in naming. Our study involved five Hungarian post stroke aphasic patients (2 males and 3 females) between the ages of 60 and 70, as well as a control group matched for age and gender. The participants were diagnosed with different types of aphasia (global, Wernicke’s, anomic and conduction). This study employed various neuropsychological and linguistic batteries. By comparing the patients’ performance to that of the control group, we aimed to investigate the impacts of stroke. Within the aphasia group, we observed difficulties in following complex commands and a connection between general slowness and reduced accuracy in naming. We concluded that impairment of executive functions may have a negative impact on naming, comprehension, and fluency. Therefore, it is important to consider functional variations in neural networks, and to base our interpretations on the available psychophysiological data in literature. Our findings provide an alternative perspective to the traditional assessment of aphasia and highlight the importance of considering the role of executive functions.},
	year = {2024},
	eissn = {2676-8607},
	orcid-numbers = {Csépe, Valéria/0000-0002-5021-6024}
}

@article{MTMT:34479905,
	title = {Predictions about prosody facilitate lexical access: Evidence from P50/N100 and MMN components},
	url = {https://m2.mtmt.hu/api/publication/34479905},
	author = {Zora, Hatice and Wester, Janniek and Csépe, Valéria},
	doi = {10.1016/j.ijpsycho.2023.112262},
	journal-iso = {INT J PSYCHOPHYSIOL},
	journal = {INTERNATIONAL JOURNAL OF PSYCHOPHYSIOLOGY},
	volume = {194},
	unique-id = {34479905},
	issn = {0167-8760},
	year = {2023},
	eissn = {1872-7697},
	orcid-numbers = {Csépe, Valéria/0000-0002-5021-6024}
}

@article{MTMT:33587111,
	title = {Deterministic and probabilistic regularities underlying risky choices are acquired in a changing decision context},
	url = {https://m2.mtmt.hu/api/publication/33587111},
	author = {Kóbor, Andrea and Tóth-Fáber, Eszter and Balogh-Kardos, Zsófia Klára and Takács, Ádám and Éltető, Noémi and Janacsek, Karolina and Csépe, Valéria and Németh, Dezső},
	doi = {10.1038/s41598-023-27642-z},
	journal-iso = {SCI REP},
	journal = {SCIENTIFIC REPORTS},
	volume = {13},
	unique-id = {33587111},
	issn = {2045-2322},
	abstract = {Predictions supporting risky decisions could become unreliable when outcome probabilities temporarily change, making adaptation more challenging. Therefore, this study investigated whether sensitivity to the temporal structure in outcome probabilities can develop and remain persistent in a changing decision environment. In a variant of the Balloon Analogue Risk Task with 90 balloons, outcomes (rewards or balloon bursts) were predictable in the task’s first and final 30 balloons and unpredictable in the middle 30 balloons. The temporal regularity underlying the predictable outcomes differed across three experimental conditions. In the deterministic condition, a repeating three-element sequence dictated the maximum number of pumps before a balloon burst. In the probabilistic condition, a single probabilistic regularity ensured that burst probability increased as a function of pumps. In the hybrid condition, a repeating sequence of three different probabilistic regularities increased burst probabilities. In every condition, the regularity was absent in the middle 30 balloons. Participants were not informed about the presence or absence of the regularity. Sensitivity to both the deterministic and hybrid regularities emerged and influenced risk taking. Unpredictable outcomes of the middle phase did not deteriorate this sensitivity. In conclusion, humans can adapt their risky choices in a changing decision environment by exploiting the statistical structure that controls how the environment changes.},
	keywords = {feedback; EXPERIENCE; Adolescents; history; anxiety; STRATEGIES; IMPLICIT; Rewards; LEARN},
	year = {2023},
	eissn = {2045-2322},
	orcid-numbers = {Kóbor, Andrea/0000-0002-8416-3178; Janacsek, Karolina/0000-0001-7829-8220; Csépe, Valéria/0000-0002-5021-6024; Németh, Dezső/0000-0002-9629-5856}
}

@inbook{MTMT:33721720,
	title = {TANULÁS, TANÍTÁS ÉS A VÉGREHAJTÓ FUNKCIÓK},
	url = {https://m2.mtmt.hu/api/publication/33721720},
	author = {Csépe, Valéria},
	booktitle = {Hatékony tanulás},
	unique-id = {33721720},
	abstract = {A tanulmány a végrehajtó funkcióknak a tanulásban, társas és érzelmi fejlődésben és alkalmazkodásban betöltött szerepéből kiindulva mutatja be a tipikus fejlődés pszichológiai, pedagógiai és idegtudományi aspektusait. Bemutatja, hogy a fejlődést mely funkciók szerint követhetjük, s ezek atipikus fejlődése miként jelenik meg az egyén teljesítményében, s milyen kihívásokat jelent a pedagógiai munkában. A végrehajtó funkciók pszichológiai modelljeinek segítségével bemutatásra kerülnek azok a legfőbb összefüggések, amelyek az érzelemszabályozástól a társas interakciókon át a problémamegoldásig befolyásolhatják az iskolai sikert és az alacsony teljesítményt.},
	keywords = {tanulás; Végrehajtó Funkciók Rendszere (VFR); fejlődési szakaszok; gátlás; frissítés; munkaemlékezet; rugalmas gondolkodás; társas-érzelmi fejlődés; agyi hálózat},
	year = {2022},
	pages = {10-24},
	orcid-numbers = {Csépe, Valéria/0000-0002-5021-6024}
}

@misc{MTMT:33371960,
	title = {Inferential process of lexical access as evidenced by a mismatch negativity study},
	url = {https://m2.mtmt.hu/api/publication/33371960},
	author = {Zora, H. and Csépe, Valéria},
	unique-id = {33371960},
	year = {2022},
	orcid-numbers = {Csépe, Valéria/0000-0002-5021-6024}
}

@article{MTMT:33365063,
	title = {Hypothesis-driven genome-wide association studies provide novel insights into genetics of reading disabilities},
	url = {https://m2.mtmt.hu/api/publication/33365063},
	author = {Price, Kaitlyn M. and Wigg, Karen G. and Eising, Else and Feng, Yu and Blokland, Kirsten and Wilkinson, Margaret and Kerr, Elizabeth N. and Guger, Sharon L. and Abbondanza, Filippo and Allegrini, Andrea G. and Andlauer, Till F. M. and Bates, Timothy C. and Bernard, Manon and Bonte, Milene and Boomsma, Dorret I. and Bourgeron, Thomas and Brandeis, Daniel and Carreiras, Manuel and Ceroni, Fabiola and Csépe, Valéria and Dale, Philip S. and DeFries, John C. and de Jong, Peter F. and Démonet, Jean Francois and de Zeeuw, Eveline L. and Franken, Marie-Christine J. and Francks, Clyde and Gerritse, Margot and Gialluisi, Alessandro and Gordon, Scott D. and Gruen, Jeffrey R. and Hayiou-Thomas, Marianna E. and Hernández-Cabrera, Juan and Hottenga, Jouke-Jan and Hulme, Charles and Jansen, Philip R. and Kere, Juha and Koomar, Tanner and Landerl, Karin and Leonard, Gabriel T. and Liao, Zhijie and Luciano, Michelle and Lyytinen, Heikki and Martin, Nicholas G. and Martinelli, Angela and Maurer, Urs and Michaelson, Jacob J. and Mirza-Schreiber, Nazanin and Moll, Kristina and Monaco, Anthony P. and Morgan, Angela T. and Müller-Myhsok, Bertram and Newbury, Dianne F. and Nöthen, Markus M. and Olson, Richard K. and Paracchini, Silvia and Paus, Tomas and Pausova, Zdenka and Pennell, Craig E. and Pennington, Bruce F. and Plomin, Robert J. and Ramus, Franck and Reilly, Sheena and Richer, Louis and Rimfeld, Kaili and Schulte-Körne, Gerd and Shapland, Chin Yang and Simpson, Nuala H. and Smith, Shelley D. and Snowling, Margaret J. and St Pourcain, Beate and Stein, John F. and Talcott, Joel B. and Tiemeier, Henning and Tomblin, J. Bruce and Truong, Dongnhu T. and van Bergen, Elsje and van der Schroeff, Marc P. and Van Donkelaar, Marjolein and Verhoef, Ellen and Wang, Carol A. and Watkins, Kate E. and Whitehouse, Andrew J. O. and Willcutt, Erik G. and Wright, Margaret J. and Zhu, Gu and Fisher, Simon E. and Lovett, Maureen W. and Strug, Lisa J. and Barr, Cathy L.},
	doi = {10.1038/s41398-022-02250-z},
	journal-iso = {TRANSL PSYCHIAT},
	journal = {TRANSLATIONAL PSYCHIATRY},
	volume = {12},
	unique-id = {33365063},
	issn = {2158-3188},
	abstract = {Reading Disability (RD) is often characterized by difficulties in the phonology of the language. While the molecular mechanisms underlying it are largely undetermined, loci are being revealed by genome-wide association studies (GWAS). In a previous GWAS for word reading (Price, 2020), we observed that top single-nucleotide polymorphisms (SNPs) were located near to or in genes involved in neuronal migration/axon guidance (NM/AG) or loci implicated in autism spectrum disorder (ASD). A prominent theory of RD etiology posits that it involves disturbed neuronal migration, while potential links between RD-ASD have not been extensively investigated. To improve power to identify associated loci, we up-weighted variants involved in NM/AG or ASD, separately, and performed a new Hypothesis-Driven (HD)–GWAS. The approach was applied to a Toronto RD sample and a meta-analysis of the GenLang Consortium. For the Toronto sample ( n  = 624), no SNPs reached significance; however, by gene-set analysis, the joint contribution of ASD-related genes passed the threshold ( p ~1.45 × 10 –2 , threshold = 2.5 × 10 –2 ). For the GenLang Cohort ( n  = 26,558), SNPs in DOCK7 and CDH4 showed significant association for the NM/AG hypothesis (sFDR q = 1.02 × 10 –2 ). To make the GenLang dataset more similar to Toronto, we repeated the analysis restricting to samples selected for reading/language deficits ( n  = 4152). In this GenLang selected subset, we found significant association for a locus intergenic between BTG3 - C21orf91 for both hypotheses (sFDR q < 9.00 × 10 –4 ). This study contributes candidate loci to the genetics of word reading. Data also suggest that, although different variants may be involved, alleles implicated in ASD risk may be found in the same genes as those implicated in word reading. This finding is limited to the Toronto sample suggesting that ascertainment influences genetic associations.},
	year = {2022},
	eissn = {2158-3188},
	orcid-numbers = {Eising, Else/0000-0001-9819-1260; Csépe, Valéria/0000-0002-5021-6024; Fisher, Simon E./0000-0002-3132-1996; Barr, Cathy L./0000-0003-0361-0106}
}

@misc{MTMT:33188791,
	title = {Predictability-dependent encoding of statistical regularities in the early visual cortex},
	url = {https://m2.mtmt.hu/api/publication/33188791},
	author = {Kóbor, Andrea and Janacsek, Karolina and Hermann, Petra and Zavecz, Zsófia and Varga, Vera and Csépe, Valéria and Vidnyánszky, Zoltán and Kovács, Gyula and Németh, Dezső},
	doi = {10.31234/osf.io/axq49},
	unique-id = {33188791},
	year = {2022},
	orcid-numbers = {Kóbor, Andrea/0000-0002-8416-3178; Janacsek, Karolina/0000-0001-7829-8220; Zavecz, Zsófia/0000-0003-2532-7491; Csépe, Valéria/0000-0002-5021-6024; Németh, Dezső/0000-0002-9629-5856}
}

@article{MTMT:33188249,
	title = {Discovery of 42 genome-wide significant loci associated with dyslexia},
	url = {https://m2.mtmt.hu/api/publication/33188249},
	author = {Doust, Catherine and Fontanillas, Pierre and Eising, Else and Gordon, Scott D. and Wang, Zhengjun and Alagöz, Gökberk and Molz, Barbara and Aslibekyan, Stella and Auton, Adam and Babalola, Elizabeth and Bell, Robert K. and Bielenberg, Jessica and Bryc, Katarzyna and Bullis, Emily and Coker, Daniella and Partida, Gabriel Cuellar and Dhamija, Devika and Das, Sayantan and Elson, Sarah L. and Filshtein, Teresa and Fletez-Brant, Kipper and Freyman, Will and Gandhi, Pooja M. and Heilbron, Karl and Hicks, Barry and Hinds, David A. and Jewett, Ethan M. and Jiang, Yunxuan and Kukar, Katelyn and Lin, Keng-Han and Lowe, Maya and McCreight, Jey and McIntyre, Matthew H. and Micheletti, Steven J. and Moreno, Meghan E. and Mountain, Joanna L. and Nandakumar, Priyanka and Noblin, Elizabeth S. and O’Connell, Jared and Petrakovitz, Aaron A. and Poznik, G. David and Schumacher, Morgan and Shastri, Anjali J. and Shelton, Janie F. and Shi, Jingchunzi and Shringarpure, Suyash and Tran, Vinh and Tung, Joyce Y. and Wang, Xin and Wang, Wei and Weldon, Catherine H. and Wilton, Peter and Hernandez, Alejandro and Wong, Corinna and Tchakouté, Christophe Toukam and Abbondanza, Filippo and Allegrini, Andrea G. and Andlauer, Till F. M. and Barr, Cathy L. and Bernard, Manon and Blokland, Kirsten and Bonte, Milene and Boomsma, Dorret I. and Bourgeron, Thomas and Brandeis, Daniel and Carreiras, Manuel and Ceroni, Fabiola and Csépe, Valéria and Dale, Philip S. and de Jong, Peter F. and Démonet, Jean Francois and de Zeeuw, Eveline L. and Feng, Yu and Franken, Marie-Christine J. and Gerritse, Margot and Gialluisi, Alessandro and Guger, Sharon L. and Hayiou-Thomas, Marianna E. and Hernández-Cabrera, Juan and Hottenga, Jouke-Jan and Hulme, Charles and Jansen, Philip R. and Kere, Juha and Kerr, Elizabeth N. and Koomar, Tanner and Landerl, Karin and Leonard, Gabriel T. and Liao, Zhijie and Lovett, Maureen W. and Lyytinen, Heikki and Martinelli, Angela and Maurer, Urs and Michaelson, Jacob J. and Mirza-Schreiber, Nazanin and Moll, Kristina and Morgan, Angela T. and Müller-Myhsok, Bertram and Newbury, Dianne F. and Nöthen, Markus M. and Paus, Tomas and Pausova, Zdenka and Pennell, Craig E. and Plomin, Robert J. and Price, Kaitlyn M. and Ramus, Franck and Reilly, Sheena and Richer, Louis and Rimfeld, Kaili and Schulte-Körne, Gerd and Shapland, Chin Yang and Simpson, Nuala H. and Snowling, Margaret J. and Stein, John F. and Strug, Lisa J. and Tiemeier, Henning and Tomblin, J. Bruce and Truong, Dongnhu T. and van Bergen, Elsje and van der Schroeff, Marc P. and Van Donkelaar, Marjolein and Verhoef, Ellen and Wang, Carol A. and Watkins, Kate E. and Whitehouse, Andrew J. O. and Wigg, Karen G. and Wilkinson, Margaret and Zhu, Gu and Pourcain, Beate St and Francks, Clyde and Marioni, Riccardo E. and Zhao, Jingjing and Paracchini, Silvia and Talcott, Joel B. and Monaco, Anthony P. and Stein, John F. and Gruen, Jeffrey R. and Olson, Richard K. and Willcutt, Erik G. and DeFries, John C. and Pennington, Bruce F. and Smith, Shelley D. and Wright, Margaret J. and Martin, Nicholas G. and Auton, Adam and Bates, Timothy C. and Fisher, Simon E. and Luciano, Michelle},
	doi = {10.1038/s41588-022-01192-y},
	journal-iso = {NAT GENET},
	journal = {NATURE GENETICS},
	volume = {54},
	unique-id = {33188249},
	issn = {1061-4036},
	abstract = {Reading and writing are crucial life skills but roughly one in ten children are affected by dyslexia, which can persist into adulthood. Family studies of dyslexia suggest heritability up to 70%, yet few convincing genetic markers have been found. Here we performed a genome-wide association study of 51,800 adults self-reporting a dyslexia diagnosis and 1,087,070 controls and identified 42 independent genome-wide significant loci: 15 in genes linked to cognitive ability/educational attainment, and 27 new and potentially more specific to dyslexia. We validated 23 loci (13 new) in independent cohorts of Chinese and European ancestry. Genetic etiology of dyslexia was similar between sexes, and genetic covariance with many traits was found, including ambidexterity, but not neuroanatomical measures of language-related circuitry. Dyslexia polygenic scores explained up to 6% of variance in reading traits, and might in future contribute to earlier identification and remediation of dyslexia.},
	year = {2022},
	eissn = {1546-1718},
	orcid-numbers = {Fontanillas, Pierre/0000-0002-8944-4454; Eising, Else/0000-0001-9819-1260; Gordon, Scott D./0000-0001-7623-328X; Wang, Zhengjun/0000-0003-2326-4167; Molz, Barbara/0000-0002-9300-761X; Csépe, Valéria/0000-0002-5021-6024; Pourcain, Beate St/0000-0002-4680-3517; Francks, Clyde/0000-0002-9098-890X; Marioni, Riccardo E./0000-0003-4430-4260; Talcott, Joel B./0000-0001-7958-8369; Monaco, Anthony P./0000-0001-7480-3197; Gruen, Jeffrey R./0000-0001-7640-2071; Olson, Richard K./0000-0001-6399-571X; Wright, Margaret J./0000-0001-7133-4970; Martin, Nicholas G./0000-0003-4069-8020; Bates, Timothy C./0000-0002-1153-9007; Fisher, Simon E./0000-0002-3132-1996; Luciano, Michelle/0000-0002-7306-3008}
}

@article{MTMT:33084651,
	title = {Genome-wide analyses of individual differences in quantitatively assessed reading- and language-related skills in up to 34,000 people},
	url = {https://m2.mtmt.hu/api/publication/33084651},
	author = {Eising, Else and Mirza-Schreiber, Nazanin and de Zeeuw, Eveline L. and Wang, Carol A. and Truong, Dongnhu T. and Allegrini, Andrea G. and Shapland, Chin Yang and Zhu, Gu and Wigg, Karen G. and Gerritse, Margot L. and Molz, Barbara and Alagöz, Gökberk and Gialluisi, Alessandro and Abbondanza, Filippo and Rimfeld, Kaili and van Donkelaar, Marjolein and Liao, Zhijie and Jansen, Philip R. and Andlauer, Till F. M. and Bates, Timothy C. and Bernard, Manon and Blokland, Kirsten and Bonte, Milene and Børglum, Anders D. and Bourgeron, Thomas and Brandeis, Daniel and Ceroni, Fabiola and Csépe, Valéria and Dale, Philip S. and de Jong, Peter F. and DeFries, John C. and Démonet, Jean-François and Demontis, Ditte and Feng, Yu and Gordon, Scott D. and Guger, Sharon L. and Hayiou-Thomas, Marianna E. and Hernández-Cabrera, Juan A. and Hottenga, Jouke-Jan and Hulme, Charles and Kere, Juha and Kerr, Elizabeth N. and Koomar, Tanner and Landerl, Karin and Leonard, Gabriel T. and Lovett, Maureen W. and Lyytinen, Heikki and Martin, Nicholas G. and Martinelli, Angela and Maurer, Urs and Michaelson, Jacob J. and Moll, Kristina and Monaco, Anthony P. and Morgan, Angela T. and Nöthen, Markus M. and Pausova, Zdenka and Pennell, Craig E. and Pennington, Bruce F. and Price, Kaitlyn M. and Rajagopal, Veera M. and Ramus, Franck and Richer, Louis and Simpson, Nuala H. and Smith, Shelley D. and Snowling, Margaret J. and Stein, John and Strug, Lisa J. and Talcott, Joel B. and Tiemeier, Henning and van der Schroeff, Marc P. and Verhoef, Ellen and Watkins, Kate E. and Wilkinson, Margaret and Wright, Margaret J. and Barr, Cathy L. and Boomsma, Dorret I. and Carreiras, Manuel and Franken, Marie-Christine J. and Gruen, Jeffrey R. and Luciano, Michelle and Müller-Myhsok, Bertram and Newbury, Dianne F. and Olson, Richard K. and Paracchini, Silvia and Paus, Tomáš and Plomin, Robert and Reilly, Sheena and Schulte-Körne, Gerd and Tomblin, J. Bruce and van Bergen, Elsje and Whitehouse, Andrew J. O. and Willcutt, Erik G. and St Pourcain, Beate and Francks, Clyde and Fisher, Simon E.},
	doi = {10.1073/pnas.2202764119},
	journal-iso = {P NATL ACAD SCI USA},
	journal = {PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA},
	volume = {119},
	unique-id = {33084651},
	issn = {0027-8424},
	abstract = {The use of spoken and written language is a fundamental human capacity. Individual differences in reading- and language-related skills are influenced by genetic variation, with twin-based heritability estimates of 30 to 80% depending on the trait. The genetic architecture is complex, heterogeneous, and multifactorial, but investigations of contributions of single-nucleotide polymorphisms (SNPs) were thus far underpowered. We present a multicohort genome-wide association study (GWAS) of five traits assessed individually using psychometric measures (word reading, nonword reading, spelling, phoneme awareness, and nonword repetition) in samples of 13,633 to 33,959 participants aged 5 to 26 y. We identified genome-wide significant association with word reading (rs11208009, P = 1.098 × 10 −8 ) at a locus that has not been associated with intelligence or educational attainment. All five reading-/language-related traits showed robust SNP heritability, accounting for 13 to 26% of trait variability. Genomic structural equation modeling revealed a shared genetic factor explaining most of the variation in word/nonword reading, spelling, and phoneme awareness, which only partially overlapped with genetic variation contributing to nonword repetition, intelligence, and educational attainment. A multivariate GWAS of word/nonword reading, spelling, and phoneme awareness maximized power for follow-up investigation. Genetic correlation analysis with neuroimaging traits identified an association with the surface area of the banks of the left superior temporal sulcus, a brain region linked to the processing of spoken and written language. Heritability was enriched for genomic elements regulating gene expression in the fetal brain and in chromosomal regions that are depleted of Neanderthal variants. Together, these results provide avenues for deciphering the biological underpinnings of uniquely human traits.},
	year = {2022},
	eissn = {1091-6490},
	orcid-numbers = {Eising, Else/0000-0001-9819-1260; Shapland, Chin Yang/0000-0002-5797-1241; Molz, Barbara/0000-0002-9300-761X; Alagöz, Gökberk/0000-0003-0530-2780; Gialluisi, Alessandro/0000-0002-7388-4463; Rimfeld, Kaili/0000-0001-5139-065X; Liao, Zhijie/0000-0003-2351-0022; Andlauer, Till F. M./0000-0002-2917-5889; Bates, Timothy C./0000-0002-1153-9007; Blokland, Kirsten/0000-0002-0080-8320; Ceroni, Fabiola/0000-0002-7474-6361; Csépe, Valéria/0000-0002-5021-6024; Dale, Philip S./0000-0002-7697-8510; de Jong, Peter F./0000-0002-8806-0563; Demontis, Ditte/0000-0001-9124-2766; Hayiou-Thomas, Marianna E./0000-0003-1163-2671; Hulme, Charles/0000-0001-9499-5958; Kerr, Elizabeth N./0000-0002-9589-6502; Monaco, Anthony P./0000-0001-7480-3197; Morgan, Angela T./0000-0003-1147-7405; Nöthen, Markus M./0000-0002-8770-2464; Pennington, Bruce F./0000-0001-9541-8204; Rajagopal, Veera M./0000-0002-5236-168X; Richer, Louis/0000-0002-6590-3046; Snowling, Margaret J./0000-0003-0836-3861; Stein, John/0000-0001-5843-8986; Strug, Lisa J./0000-0003-0503-9740; van der Schroeff, Marc P./0000-0002-1360-8782; Verhoef, Ellen/0000-0002-8315-1095; Watkins, Kate E./0000-0002-2621-482X; Wilkinson, Margaret/0000-0001-5735-4051; Barr, Cathy L./0000-0003-0361-0106; Boomsma, Dorret I./0000-0002-7099-7972; Carreiras, Manuel/0000-0001-6726-7613; Gruen, Jeffrey R./0000-0001-7640-2071; Luciano, Michelle/0000-0002-7306-3008; Müller-Myhsok, Bertram/0000-0002-0719-101X; Reilly, Sheena/0000-0001-6506-4767; Francks, Clyde/0000-0002-9098-890X; Fisher, Simon E./0000-0002-3132-1996}
}