TY - JOUR AU - Tresóné Takács, Virág AU - Bardóczi, Zsuzsanna AU - Orosz, Áron AU - Major, Ábel AU - Tar, Luca AU - Berki, Péter AU - Papp, Péter AU - Mayer, Márton István AU - Sebők, Hunor AU - Zsolt, Luca AU - Sós, Katalin Eszter AU - Káli, Szabolcs AU - Freund, Tamás AU - Nyíri, Gábor TI - Synaptic and dendritic architecture of different types of hippocampal somatostatin interneurons JF - PLOS BIOLOGY J2 - PLOS BIOL VL - 22 PY - 2024 IS - 3 PG - 54 SN - 1544-9173 DO - 10.1371/journal.pbio.3002539 UR - https://m2.mtmt.hu/api/publication/34749015 ID - 34749015 AB - GABAergic inhibitory neurons fundamentally shape the activity and plasticity of cortical circuits. A major subset of these neurons contains somatostatin (SOM); these cells play crucial roles in neuroplasticity, learning, and memory in many brain areas including the hippocampus, and are implicated in several neuropsychiatric diseases and neurodegenerative disorders. Two main types of SOM-containing cells in area CA1 of the hippocampus are oriens-lacunosum-moleculare (OLM) cells and hippocampo-septal (HS) cells. These cell types show many similarities in their soma-dendritic architecture, but they have different axonal targets, display different activity patterns in vivo, and are thought to have distinct network functions. However, a complete understanding of the functional roles of these interneurons requires a precise description of their intrinsic computational properties and their synaptic interactions. In the current study we generated, analyzed, and make available several key data sets that enable a quantitative comparison of various anatomical and physiological properties of OLM and HS cells in mouse. The data set includes detailed scanning electron microscopy (SEM)-based 3D reconstructions of OLM and HS cells along with their excitatory and inhibitory synaptic inputs. Combining this core data set with other anatomical data, patch-clamp electrophysiology, and compartmental modeling, we examined the precise morphological structure, inputs, outputs, and basic physiological properties of these cells. Our results highlight key differences between OLM and HS cells, particularly regarding the density and distribution of their synaptic inputs and mitochondria. For example, we estimated that an OLM cell receives about 8,400, whereas an HS cell about 15,600 synaptic inputs, about 16% of which are GABAergic. Our data and models provide insight into the possible basis of the different functionality of OLM and HS cell types and supply essential information for more detailed functional models of these neurons and the hippocampal network. LA - English DB - MTMT ER - TY - JOUR AU - Király, Bálint AU - Domonkos, Andor AU - Jelitai, Márta AU - Lopes-dos-Santos, Vítor AU - Martínez-Bellver, Sergio AU - Kocsis, Barnabás AU - Schlingloff, Dániel AU - Joshi, Abhilasha AU - Salib, Minas AU - Fiáth, Richárd AU - Barthó, Péter AU - Ulbert, István AU - Freund, Tamás AU - Viney, Tim J. AU - Dupret, David AU - Varga, Viktor AU - Hangya, Balázs TI - Author Correction: The medial septum controls hippocampal supra-theta oscillations JF - NATURE COMMUNICATIONS J2 - NAT COMMUN VL - 14 PY - 2023 IS - 1 PG - 1 SN - 2041-1723 DO - 10.1038/s41467-023-43190-6 UR - https://m2.mtmt.hu/api/publication/34400320 ID - 34400320 LA - English DB - MTMT ER - TY - JOUR AU - Király, Bálint AU - Domonkos, Andor AU - Jelitai, Márta AU - Lopes-dos-Santos, Vítor AU - Martínez-Bellver, Sergio AU - Kocsis, Barnabás AU - Schlingloff, Dániel AU - Joshi, Abhilasha AU - Salib, Minas AU - Fiáth, Richárd AU - Barthó, Péter AU - Ulbert, István AU - Freund, Tamás AU - Viney, Tim J. AU - Dupret, David AU - Varga, Viktor AU - Hangya, Balázs TI - The medial septum controls hippocampal supra-theta oscillations JF - NATURE COMMUNICATIONS J2 - NAT COMMUN VL - 14 PY - 2023 IS - 1 PG - 25 SN - 2041-1723 DO - 10.1038/s41467-023-41746-0 UR - https://m2.mtmt.hu/api/publication/34188237 ID - 34188237 AB - Hippocampal theta oscillations orchestrate faster beta-to-gamma oscillations facilitating the segmentation of neural representations during navigation and episodic memory. Supra-theta rhythms of hippocampal CA1 are coordinated by local interactions as well as inputs from the entorhinal cortex (EC) and CA3 inputs. However, theta-nested gamma-band activity in the medial septum (MS) suggests that the MS may control supra-theta CA1 oscillations. To address this, we performed multi-electrode recordings of MS and CA1 activity in rodents and found that MS neuron firing showed strong phase-coupling to theta-nested supra-theta episodes and predicted changes in CA1 beta-to-gamma oscillations on a cycle-by-cycle basis. Unique coupling patterns of anatomically defined MS cell types suggested that indirect MS-to-CA1 pathways via the EC and CA3 mediate distinct CA1 gamma-band oscillations. Optogenetic activation of MS parvalbumin-expressing neurons elicited theta-nested beta-to-gamma oscillations in CA1. Thus, the MS orchestrates hippocampal network activity at multiple temporal scales to mediate memory encoding and retrieval. LA - English DB - MTMT ER - TY - JOUR AU - Kocsis, Barnabás AU - Martínez-Bellver, Sergio AU - Fiáth, Richárd AU - Domonkos, Andor AU - Tóthné Sviatkó, Katalin AU - Schlingloff, Dániel AU - Barthó, Péter AU - Freund, Tamás AU - Ulbert, István AU - Káli, Szabolcs AU - Varga, Viktor AU - Hangya, Balázs TI - Huygens synchronization of medial septal pacemaker neurons generates hippocampal theta oscillation JF - CELL REPORTS J2 - CELL REP VL - 40 PY - 2022 IS - 5 PG - 29 SN - 2211-1247 DO - 10.1016/j.celrep.2022.111149 UR - https://m2.mtmt.hu/api/publication/33041472 ID - 33041472 N1 - Lendület Laboratory of Systems Neuroscience, Institute of Experimental Medicine, Budapest, 1083, Hungary Institute of Cognitive Neuroscience and Psychology, Research Centre for Natural Sciences, Budapest, 1117, Hungary Roska Tamás Doctoral School of Sciences and Technology, Faculty of Information Technology and Bionics, Pázmány Péter Catholic University, Budapest, 1083, Hungary Department of Anatomy and Human Embryology, Faculty of Medicine and Odontology, University of Valencia, Valencia, 46010, Spain Faculty of Information Technology and Bionics, Pázmány Péter Catholic University, Budapest, 1083, Hungary Cerebral Cortex Research Group, Institute of Experimental Medicine, Budapest, 1083, Hungary János Szentágothai Doctoral School of Neurosciences, Semmelweis University, Budapest, 1085, Hungary Sleep Oscillations Research Group, Research Centre for Natural Sciences, Budapest, 1117, Hungary Subcortical Modulation Research Group, Institute of Experimental Medicine, Budapest, 1083, Hungary Cited By :5 Export Date: 1 February 2024 Correspondence Address: Hangya, B.; Lendület Laboratory of Systems Neuroscience, Hungary; email: hangya.balazs@koki.hu Chemicals/CAS: parvalbumin, 56094-12-3, 83667-75-8; Parvalbumins Tradenames: DM2500, Leica Microsystems Manufacturers: Leica Microsystems Funding details: ELKH KEP-4/5/2021, ELKH KÖ-39/2021, K119650, NKFIH PD124175, PD134196, RRF-2.3.1-21-2022-00004, TUDFO/51757-1/2019-ITM Funding details: APOSTD/2019/003 Funding details: European Research Council, ERC, 715043 Funding details: Magyar Tudományos Akadémia, MTA, K135561, KH125294, LP2015-2/2015 Funding details: Kyoto University Funding details: Innovációs és Technológiai Minisztérium Funding text 1: The authors thank Katalin Lengyel for technical assistance and Drs. Tim Viney and Peter Somogyi for helpful comments on the manuscript. This work was supported by the “Lendület” Program of the Hungarian Academy of Sciences (LP2015-2/2015), NKFIH KH125294, NKFIH K135561, the ERC Starting Grant no. 715043 and SPIRITS 2020 of Kyoto University to B.H.; the NRDI Office of Hungary within the framework of the Artificial Intelligence National Laboratory Program (RRF-2.3.1-21-2022-00004) to B.H. V.V. and S.K.; NKFIH K119650 to P.B.; National Brain Research Program 1.2.1-NKP-2017-00002 to P.B. R.F. and I.U.; NKFIH PD124175 and PD134196 to R.F.; NKFIH TUDFO/51757-1/2019-ITM, ELKH KEP-4/5/2021, and ELKH KÖ-39/2021 to I.U.; the ÚNKP-20-3 New National Excellence Program of the Ministry for Innovation and Technology to B.K.; and the Generalitat Valenciana Postdoctoral Fellowship Program (APOSTD/2019/003) to S.M.B. We acknowledge the help of the Nikon Center of Excellence at the Institute of Experimental Medicine (IEM), Nikon Europe, Nikon Austria, and Auro-Science Consulting for kindly providing microscopy support and the supportive help of the Central Virus Laboratory of IEM. We thank Luigi Petrucco for open access science art at SciDraw (https://doi.org/10.5281/zenodo.3925903). B.H. developed the idea and conceptualized the manuscript. S.M.B. R.F. A.D. B.H. and P.B. performed the experiments, supervised by T.F.F. I.U. V.V. and B.H. B.K. S.M.B. and P.B. performed the data analysis. B.K. K.S. and D.S. generated the figures. D.S. performed immunocytochemistry. B.K. performed the modeling, supervised by S.K. B.H. wrote the manuscript with input from all authors. The authors declare no competing financial interests. Funding text 2: The authors thank Katalin Lengyel for technical assistance and Drs. Tim Viney and Peter Somogyi for helpful comments on the manuscript. This work was supported by the “Lendület” Program of the Hungarian Academy of Sciences ( LP2015-2/2015 ), NKFIH KH125294 , NKFIH K135561 , the ERC Starting Grant no. 715043 and SPIRITS 2020 of Kyoto University to B.H.; the NRDI Office of Hungary within the framework of the Artificial Intelligence National Laboratory Program ( RRF-2.3.1-21-2022-00004 ) to B.H., V.V., and S.K.; NKFIH K119650 to P.B.; National Brain Research Program 1.2.1-NKP-2017-00002 to P.B., R.F., and I.U.; NKFIH PD124175 and PD134196 to R.F.; NKFIH TUDFO/51757-1/2019-ITM , ELKH KEP-4/5/2021 , and ELKH KÖ-39/2021 to I.U.; the ÚNKP-20-3 New National Excellence Program of the Ministry for Innovation and Technology to B.K.; and the Generalitat Valenciana Postdoctoral Fellowship Program ( APOSTD/2019/003 ) to S.M.B. We acknowledge the help of the Nikon Center of Excellence at the Institute of Experimental Medicine (IEM) , Nikon Europe , Nikon Austria , and Auro-Science Consulting for kindly providing microscopy support and the supportive help of the Central Virus Laboratory of IEM. We thank Luigi Petrucco for open access science art at SciDraw ( https://doi.org/10.5281/zenodo.3925903 ). LA - English DB - MTMT ER - TY - JOUR AU - Ecker, András AU - Bagi, Bence AU - Vértes, Eszter AU - Steinbach-Németh, Orsolya AU - Karlócai, Rita AU - Papp, Orsolya I AU - Miklós, István AU - Hájos, Norbert AU - Freund, Tamás AU - Gulyás, Attila AU - Káli, Szabolcs TI - Hippocampal sharp wave-ripples and the associated sequence replay emerge from structured synaptic interactions in a network model of area CA3 JF - ELIFE J2 - ELIFE VL - 11 PY - 2022 PG - 29 SN - 2050-084X DO - 10.7554/eLife.71850 UR - https://m2.mtmt.hu/api/publication/32660835 ID - 32660835 AB - Hippocampal place cells are activated sequentially as an animal explores its environment. These activity sequences are internally recreated ('replayed'), either in the same or reversed order, during bursts of activity (sharp wave-ripples [SWRs]) that occur in sleep and awake rest. SWR-associated replay is thought to be critical for the creation and maintenance of long-term memory. In order to identify the cellular and network mechanisms of SWRs and replay, we constructed and simulated a data-driven model of area CA3 of the hippocampus. Our results show that the chain-like structure of recurrent excitatory interactions established during learning not only determines the content of replay, but is essential for the generation of the SWRs as well. We find that bidirectional replay requires the interplay of the experimentally confirmed, temporally symmetric plasticity rule, and cellular adaptation. Our model provides a unifying framework for diverse phenomena involving hippocampal plasticity, representations, and dynamics, and suggests that the structured neural codes induced by learning may have greater influence over cortical network states than previously appreciated. LA - English DB - MTMT ER - TY - JOUR AU - Jelitai, Márta AU - Barth, Albert AU - Komlósi, Ferenc AU - Freund, Tamás AU - Varga, Viktor TI - Activity and Coupling to Hippocampal Oscillations of Median Raphe GABAergic Cells in Awake Mice. JF - FRONTIERS IN NEURAL CIRCUITS J2 - FRONT NEURAL CIRCUIT VL - 15 PY - 2021 IS - 17 PG - 12 SN - 1662-5110 DO - 10.3389/fncir.2021.784034 UR - https://m2.mtmt.hu/api/publication/32528863 ID - 32528863 N1 - Subcortical Modulation Research Group, Institute of Experimental Medicine, Budapest, Hungary Laboratory of Cerebral Cortex Research, Institute of Experimental Medicine, Budapest, Hungary Faculty of Medicine, Heart and Vascular Centre, Semmelweis University, Budapest, Hungary Export Date: 2 February 2022 Correspondence Address: Jelitai, M.; Subcortical Modulation Research Group, Hungary; email: jelitai.marta@koki.hu Correspondence Address: Varga, V.; Subcortical Modulation Research Group, Hungary; email: varga.viktor@koki.hu Funding details: Magyar Tudományos Akadémia, MTA Funding details: Innovációs és Technológiai Minisztérium, ÚNKP_19-4 Funding details: National Research, Development and Innovation Office, FK129019, K132735 Funding text 1: This work was funded by the National Research, Development and Innovation Office, Hungary FK129019 grant to AB and K132735 grant to VV. AB was supported by the New National Excellence Program of the Ministry for Innovation and Technology (ÚNKP_19-4) and the Bolyai János Research Fellowship of the Hungarian Academy of Sciences. LA - English DB - MTMT ER - TY - JOUR AU - Sáray, Sára AU - Rössert, Christian A. AU - Appukuttan, Shailesh AU - Migliore, Rosanna AU - Vitale, Paola AU - Lupascu, Carmen A. AU - Bologna, Luca L. AU - Van Geit, Werner AU - Romani, Armando AU - Davison, Andrew P. AU - Muller, Eilif AU - Freund, Tamás AU - Káli, Szabolcs TI - HippoUnit: A software tool for the automated testing and systematic comparison of detailed models of hippocampal neurons based on electrophysiological data JF - PLOS COMPUTATIONAL BIOLOGY J2 - PLOS COMPUT BIOL VL - 17 PY - 2021 IS - 1 SN - 1553-734X DO - 10.1371/journal.pcbi.1008114 UR - https://m2.mtmt.hu/api/publication/31938779 ID - 31938779 N1 - Faculty of Information Technology and Bionics, Pazmany Peter Catholic University, Budapest, Hungary Institute of Experimental Medicine, Budapest, Hungary Blue Brain Project, Ecole Polytechnique Federale de Lausanne, Geneva, Switzerland Paris-Saclay Institute of Neuroscience, Centre National de la Recherche Scientifique/Universite Paris-Saclay, Gif-sur-Yvette, France Institute of Biophysics, National Research Council, Palermo, Italy Department of Neurosciences, Faculty of Medicine, University of Montreal, Montreal, Canada CHU Sainte-Justine Research Center, Montreal, Canada Quebec Artificial Intelligence Institute (Mila), Montreal, Canada Cited By :1 Export Date: 1 February 2022 Funding details: 720270, 785907, SGA1 Funding details: European Commission, EC Funding details: European Social Fund, ESF, EFOP-3.6.3-VEKOP- 16-2017-00002 Funding text 1: This project received funding from the European Union's Horizon 2020 Framework Programme for Research and Innovation under Specific Grant Agreements No. 720270 and No. 785907 (Human Brain Project SGA1 and SGA2). SS has been supported by the UNKP-19-3-III New National Excellence Program of the Ministry For Innovation and Technology (Hungary), and the European Union, co-financed by the European Social Fund (EFOP-3.6.3-VEKOP- 16-2017-00002). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. LA - English DB - MTMT ER - TY - JOUR AU - Laszlovszky, Tamás Kristóf AU - Schlingloff, Dániel AU - Hegedüs, Panna AU - Freund, Tamás AU - Gulyás, Attila AU - Kepecs, Adam AU - Hangya, Balázs TI - Distinct synchronization, cortical coupling and behavioral function of two basal forebrain cholinergic neuron types (vol 93, pg 513, 2020) JF - NATURE NEUROSCIENCE J2 - NAT NEUROSCI VL - 23 PY - 2020 IS - 10 SP - 1310 EP - 1310 PG - 1 SN - 1097-6256 DO - 10.1038/s41593-020-0702-y UR - https://m2.mtmt.hu/api/publication/31627527 ID - 31627527 LA - English DB - MTMT ER - TY - JOUR AU - Laszlovszky, Tamás Kristóf AU - Schlingloff, Dániel AU - Hegedüs, Panna AU - Freund, Tamás AU - Gulyás, Attila AU - Kepecs, Adam AU - Hangya, Balázs TI - Distinct synchronization, cortical coupling and behavioral function of two basal forebrain cholinergic neuron types JF - NATURE NEUROSCIENCE J2 - NAT NEUROSCI VL - 23 PY - 2020 IS - 8 SP - 992 EP - 1003 PG - 12 SN - 1097-6256 DO - 10.1038/s41593-020-0648-0 UR - https://m2.mtmt.hu/api/publication/31357306 ID - 31357306 N1 - Lendület Laboratory of Systems Neuroscience, Institute of Experimental Medicine, Budapest, Hungary János Szentágothai Doctoral School of Neurosciences, Semmelweis University, Budapest, Hungary Laboratory of Cerebral Cortex Research, Institute of Experimental Medicine, Budapest, Hungary Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, United States Departments of Neuroscience and Psychiatry, Washington University in St Louis, St Louis, MO, United States Cited By :30 Export Date: 20 April 2023 CODEN: NANEF Correspondence Address: Hangya, B.; Lendület Laboratory of Systems Neuroscience, Hungary; email: hangya.balazs@koki.mta.hu Funding details: National Institute of Neurological Disorders and Stroke, NINDS, R01NS075531, R01NS088661 Funding details: European Commission, EC;EU Funding details: European Research Council, ERC, 715043, K115441, KH124345 Funding details: Magyar Tudományos Akadémia, MTA, LP2015-2/2015 Funding details: Nemzeti Kutatási és Technológiai Hivatal, NKTH Funding details: Hungarian Science Foundation Funding details: Nemzeti Kutatási Fejlesztési és Innovációs Hivatal, NKFIH, KH125294 Funding details: Ministry for Innovation and Technology, EFOP-3.6.3-VEKOP-16-2017-00009 Funding text 1: We thank J. Szabadics, V. Varga, L. Acsády, N. Hádinger and G. Buzsáki for insightful discussions and comments on the manuscript and K. Sviatkó for help with graphics in Fig. 8. This work was supported by the ‘Lendület’ Program of the Hungarian Academy of Sciences (LP2015-2/2015), NKFIH KH125294 and the European Research Council Starting (grant no. 715043) to B.H., NKFIH K115441 and KH124345 to A.G., NINDS R01NS088661, R01NS075531 and McKnight Cognitive Disorders Award to A.K., ÚNKP-19-3 New National Excellence Program of the Ministry for Innovation and Technology to P.H., and EFOP-3.6.3-VEKOP-16-2017-00009 to D.S. and T.L. B.H. is a member of the FENS-Kavli Network of Excellence. AB - Basal forebrain cholinergic neurons (BFCNs) modulate synaptic plasticity, cortical processing, brain states and oscillations. However, whether distinct types of BFCNs support different functions remains unclear. Therefore, we recorded BFCNs in vivo, to examine their behavioral functions, and in vitro, to study their intrinsic properties. We identified two distinct types of BFCNs that differ in their firing modes, synchronization properties and behavioral correlates. Bursting cholinergic neurons (Burst-BFCNs) fired synchronously, phase-locked to cortical theta activity and fired precisely timed bursts after reward and punishment. Regular-firing cholinergic neurons (Reg-BFCNs) were found predominantly in the posterior basal forebrain, displayed strong theta rhythmicity and responded with precise single spikes after behavioral outcomes. In an auditory detection task, synchronization of Burst-BFCNs to the auditory cortex predicted the timing of behavioral responses, whereas tone-evoked cortical coupling of Reg-BFCNs predicted correct detections. We propose that differential recruitment of two basal forebrain cholinergic neuron types generates behavior-specific cortical activation. LA - English DB - MTMT ER - TY - JOUR AU - Sós, Katalin Eszter AU - Mayer, Márton István AU - Tresóné Takács, Virág AU - Major, Ábel AU - Bardóczi, Zsuzsanna AU - Beres, Barnabas M. AU - Szeles, Tamás AU - Saito, Takashi AU - Saido, Takaomi C. AU - Mody, István AU - Freund, Tamás AU - Nyíri, Gábor TI - Amyloid β induces interneuron-specific changes in the hippocampus of APPNL-F mice JF - PLOS ONE J2 - PLOS ONE VL - 15 PY - 2020 IS - 5 PG - 28 SN - 1932-6203 DO - 10.1371/journal.pone.0233700 UR - https://m2.mtmt.hu/api/publication/31337319 ID - 31337319 N1 - Department of Cellular and Network Neurobiology, Institute of Experimental Medicine, HAS, Budapest, Hungary János Szentágothai Doctoral School of Neurosciences, Semmelweis University, Budapest, Hungary Laboratory for Proteolytic Neuroscience, RIKEN, Center for Brain Science, Saitama, Japan Department of Neurocognitive Science, Nagoya City University Graduate School of Medical Science, Aichi, Japan Department of Neurology, University of California, Los Angeles, CA, United States Cited By :1 Export Date: 14 September 2021 CODEN: POLNC Correspondence Address: Nyiri, G.; Department of Cellular and Network Neurobiology, Hungary; email: nyiri.gabor@koki.mta.hu Chemicals/CAS: amyloid beta protein, 109770-29-8; parvalbumin, 56094-12-3, 83667-75-8; Amyloid beta-Peptides; amyloid beta-protein (1-40); amyloid beta-protein (1-42); Peptide Fragments; Receptors, GABA-A Funding details: 2017-1.2.1-NKP-2017-00002 Funding details: National Institutes of Health, NIH, NS030549 Funding details: Hungarian Scientific Research Fund, OTKA, K119521, NN125643, VKSZ_14-1-2O15-0155 Funding details: Emberi Eroforrások Minisztériuma, EMMI, EFOP-3.6.3-VEKOP-16-2017-00009, UNKP-16-2-I-ELTE-8315/22/2016, UNKP-18-02-I-SE-20 Funding details: National Research, Development and Innovation Office Funding text 1: This work was supported by the U.S. National Institutes of Health (www.nih.gov, NS030549), the National Research, Development and Innovation Office, Hungary (nkfih.gov.hu/forthe-applicants, OTKA K119521, OTKA NN125643, and VKSZ_14-1-2O15-0155) and the Hungarian Brain Research Program (agykutatas.hu, 2017-1.2.1-NKP-2017-00002). The New Nationa Excellence Program of the Ministry of Human Capacities (www.kormany.hu/en/ministry-ofhuman-resources), Hungary supported M.I.M (UNKP-16-2-I-ELTE-8315/22/2016) and A.M. (UNKP-18-02-I-SE-20). K.E.S. was supported by EFOP-3.6.3-VEKOP-16-2017-00009, Development of education of medicine, health and pharmaceutical sciences. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.*%blankline%* LA - English DB - MTMT ER -