TY - JOUR AU - Oraveczné Gyöngyösi, Eszter AU - László, Brigitta AU - Szalmás, Anita AU - Kónya, József AU - Veress, György TI - Transcriptional activity of the long control region in human papillomavirus type 33 intratype variants JF - VIROLOGY JOURNAL J2 - VIROL J VL - 20 PY - 2023 IS - 1 SN - 1743-422X DO - 10.1186/s12985-023-02114-y UR - https://m2.mtmt.hu/api/publication/34066112 ID - 34066112 LA - English DB - MTMT ER - TY - CHAP AU - Kónya, József ED - Takács, Mária TI - A húgy- és nemi szervekvírusfertőzései T2 - Orvosi virológia PB - Medicina Könyvkiadó Zrt. CY - Budapest SN - 9789632268484 PY - 2022 SP - 435 EP - 441 PG - 7 UR - https://m2.mtmt.hu/api/publication/33695039 ID - 33695039 LA - Hungarian DB - MTMT ER - TY - JOUR AU - László, Brigitta AU - Antal, László AU - Oraveczné Gyöngyösi, Eszter AU - Szalmás, Anita AU - Póliska, Szilárd AU - Veress, György AU - Kónya, József TI - Coordinated action of human papillomavirus type 16 E6 and E7 oncoproteins on competitive endogenous RNA (ceRNA) network members in primary human keratinocytes JF - BMC CANCER J2 - BMC CANCER VL - 21 PY - 2021 IS - 1 SN - 1471-2407 DO - 10.1186/s12885-021-08361-y UR - https://m2.mtmt.hu/api/publication/32061682 ID - 32061682 LA - English DB - MTMT ER - TY - JOUR AU - Szilágyi-Tolnai, Emese AU - Fauszt, Peter AU - Fidler, Gábor AU - Pesti-Asbóth, Georgina AU - Szilágyi, Endre AU - Stagel, Aniko AU - Kónya, József AU - Szabó, Judit AU - Stündl, László AU - Babinszky, László AU - Gálné Remenyik, Judit AU - Biró, Sándor AU - Paholcsek, Melinda TI - Nutraceuticals Induced Changes in the Broiler Gastrointestinal Tract Microbiota. JF - MSYSTEMS J2 - MSYSTEMS VL - 6 PY - 2021 IS - 2 SN - 2379-5077 DO - 10.1128/mSystems.01124-20 UR - https://m2.mtmt.hu/api/publication/31899640 ID - 31899640 AB - Effects of nutraceuticals on the intestinal microbiota are receiving increased attention; however, there are few studies investigating their effects on broiler meat production. The aim of this study was to implement feeding strategies and carry out a comprehensive trial examining the interplay between natural biologically active compounds such as carotenoids, anthocyanins, fermentable oligosaccharides, and synbiotics and the gastrointestinal tract microbiota. Our feeding program was applied to an intensive production system with a flock of 1,080 Ross 308 broilers. Aging induced significant changes through the feeding experiment. Nutraceuticals were shown to modulate broiler intestinal diversity and differentially enriched Lactobacillus, Enterococcus, Campylobacter, and Streptococcus in the core microbiome during the different stages of broiler rearing. Additionally, they did not remarkably affect animal growth performance; nevertheless, a positive correlation was found between body weight and Corynebacteriales and Pseudomonadales Furthermore, a diet high in carotenoid, fermentable oligosaccharide, and anthocyanin contents affected the number of beneficial genera such as Faecalibacterium, Lactobacillus, Blautia, and Ruminococcus With this comprehensive trial, we revealed that nutraceuticals induced modulations in broiler gastrointestinal tract microbiota. We believe that plant-derived immunostimulants, recycled from plant food waste products, can supplement antibiotic-free broiler meat production.IMPORTANCE In this trial, nutraceuticals were manufactured from waste products of food industry processing of Hungarian red sweet pepper and sour cherry and incorporated into the diet of poultry to investigate their effects on broilers' growth and the broiler gastrointestinal tract microbiota. To avoid the generation of food waste products, we believe that this approach can be developed into a sustainable, green approach that can be implemented in commercial antibiotic-free poultry to provide safe and high-quality meat. LA - English DB - MTMT ER - TY - JOUR AU - Oraveczné Gyöngyösi, Eszter AU - Szalmás, Anita AU - Kónya, József AU - Veress, György TI - Orientation-dependent toxic effect of human papillomavirus type 33 long control region DNA in Escherichia coli cells JF - VIRUS GENES J2 - VIRUS GENES VL - 56 PY - 2020 IS - 3 SP - 298 EP - 305 PG - 8 SN - 0920-8569 DO - 10.1007/s11262-020-01754-4 UR - https://m2.mtmt.hu/api/publication/31306115 ID - 31306115 LA - English DB - MTMT ER - TY - CONF AU - Veress, György AU - Kónya, József AU - Oraveczné Gyöngyösi, Eszter TI - Orientation-dependent toxic effect of human papillomavirus type 33 long control region DNA in Escherichia coli cells T2 - Acta Microbiologica et Immunologica Hungarica Volume 66 Supplement 1 PB - Akadémiai Kiadó C1 - Budapest T3 - Acta Microbiologia et Immunologica Hungarica Supplement, ISSN 1217-8950 ; 66/1. PY - 2019 SP - 109 EP - 110 PG - 2 UR - https://m2.mtmt.hu/api/publication/33542809 ID - 33542809 LA - English DB - MTMT ER - TY - CONF AU - Leila, Rahmani AU - Zsolt, Barnabás Éles AU - Kónya, József AU - Szalmás, Anita TI - Analysis of high-risk HPV E7 oncoprotein interaction with cytoplasmic protein tyrosine phosphatases T2 - Acta Microbiologica et Immunologica Hungarica Volume 66 Supplement 1 PB - Akadémiai Kiadó C1 - Budapest T3 - Acta Microbiologia et Immunologica Hungarica Supplement, ISSN 1217-8950 ; 66/1. PY - 2019 SP - 182 EP - 183 PG - 2 UR - https://m2.mtmt.hu/api/publication/30816488 ID - 30816488 LA - English DB - MTMT ER - TY - CONF AU - Zsolt, Barnabás Éles AU - Leila, Rahmani AU - Kónya, József AU - Szalmás, Anita TI - Comparison of low-risk and high-risk HPV E7 oncoproteins for association with PTPN14 T2 - Acta Microbiologica et Immunologica Hungarica Volume 66 Supplement 1 PB - Akadémiai Kiadó C1 - Budapest T3 - Acta Microbiologia et Immunologica Hungarica Supplement, ISSN 1217-8950 ; 66/1. PY - 2019 SP - 127 EP - 128 PG - 2 UR - https://m2.mtmt.hu/api/publication/30816468 ID - 30816468 LA - English DB - MTMT ER - TY - CONF AU - Bukta, Evelin AU - Molnár, Csaba AU - Kónya, József AU - Szalmás, Anita TI - Expression of cytoplasmic protein tyrosine phosphatases in cervical cancer T2 - Acta Microbiologica et Immunologica Hungarica Volume 66 Supplement 1 PB - Akadémiai Kiadó C1 - Budapest T3 - Acta Microbiologia et Immunologica Hungarica Supplement, ISSN 1217-8950 ; 66/1. PY - 2019 SP - 123 EP - 123 PG - 1 UR - https://m2.mtmt.hu/api/publication/30816441 ID - 30816441 LA - English DB - MTMT ER - TY - JOUR AU - Kolozsvári, László Róbert AU - Kónya, József AU - Paget, John AU - Schellevis, Francois G AU - Sándor, János AU - Szőllősi, Gergő József AU - Kolozsváriné Harsányi, Szilvia AU - Jancsó, Zoltán AU - Rurik, Imre TI - Patient-related factors, antibiotic prescribing and antimicrobial resistance of the commensal Staphylococcus aureus and Streptococcus pneumoniae in a healthy population - Hungarian results of the APRES study JF - BMC INFECTIOUS DISEASES J2 - BMC INFECT DIS VL - 19 PY - 2019 IS - 1 SN - 1471-2334 DO - 10.1186/s12879-019-3889-3 UR - https://m2.mtmt.hu/api/publication/30609141 ID - 30609141 N1 - Funding Agency and Grant Number: European Commission within the 7th Framework Program [223083] Funding text: The APRES project was funded by the European Commission within the 7th Framework Program (Grant Agreement number 223083). The funding body had no role in the study design and collection, analysis, and interpretation of data or in writing the manuscript. Department of Family and Occupational Medicine, Faculty of Public Health, University of Debrecen, Debrecen, Hungary Department of Medical Microbiology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary NIVEL, Netherlands Institute for Health Services Research, Utrecht, Netherlands Department of Preventive Medicine, Faculty of Public Health, University of Debrecen, Debrecen, Hungary Department of Health Systems Management, Faculty of Public Health, University of Debrecen, Debrecen, Hungary Department of General Practice and Elderly Care Medicine, Amsterdam Public Health Research Institute, VU University Medical Center, Amsterdam, Netherlands Cited By :1 Export Date: 5 May 2020 CODEN: BIDMB Correspondence Address: Kolozsvári, L.R.; Department of Family and Occupational Medicine, Faculty of Public Health, University of DebrecenHungary; email: kolozsvari.laszlo@sph.unideb.hu AB - Antimicrobial resistance (AMR) is an increasing public health problem worldwide. We studied some patient-related factors that might influence the antimicrobial resistance. and whether the volume of antibiotic prescribing of the primary care physicians correlate with the antibiotic resistance rates of commensal nasal Staphylococcus aureus and Streptococcus pneumoniae.The socio-demographic questionnaires, the antibiotic prescription and resistance data of commensal nasal S. aureus and S. pneumoniae were collected in the 20 participating Hungarian practices of the APRES study. Multivariate logistic regression analyses were performed on the patient-related data and the antimicrobial resistance of the S. aureus and S. pneumoniae on individual, patient level. Ecological analyses were performed with Spearman's rank correlations at practice level, the analyses were performed in the whole sample (all practices) and in the cohorts of primary care practices taking care of adults (adult practices) or children (paediatric practices).According to the multivariate model, age of the patients significantly influenced the antimicrobial resistance of the S. aureus (OR = 0.42, p = 0.004) and S. pneumoniae (OR = 0.89, p < 0.001). Living with children significantly increased the AMR of the S. pneumoniae (OR = 1.23, p = 0.019). In the cohorts of adult or paediatric practices, neither the age nor other variables influenced the AMR of the S. aureus and S. pneumoniae. At practice level, the prescribed volume of penicillins significantly correlated with the resistance rates of the S. aureus isolates to penicillin (rho = 0.57, p = 0.008). The volume of prescribed macrolides, lincosamides showed positive significant correlations with the S. pneumoniae resistance rates to clarithromycin and/or clindamycin in all practices (rho = 0.76, p = 0.001) and in the adult practices (rho = 0.63, p = 0.021).The age is an important influencing factor of antimicrobial resistance. The results also suggest that there may be an association between the antibiotic prescribing of the primary care providers and the antibiotic resistance of the commensal S. aureus and S. pneumoniae. The role of the primary care physicians in the appropriate antibiotic prescribing is very important to avoid the antibiotic resistance. LA - English DB - MTMT ER -