TY - JOUR AU - Pham, Anh AU - Garai, Ildikó AU - Kovács, Árpád AU - Dér, Ádám AU - Szántó, Erika AU - Hascsi, Zsolt AU - Bátyi, Ferenc AU - Berényi, Ervin László AU - Pham, Thong Minh TI - Impact of Fluorodeoxyglucose-Positron Emission Tomography/Computed Tomography on Therapeutic Decisions and Radiotherapy Planning in Head and Neck Squamous Carcinoma: A Retrospective Study of 46 Patients JF - MEDICAL SCIENCE MONITOR J2 - MED SCI MONIT VL - 30 PY - 2023 SP - 1 EP - 7 PG - 7 SN - 1234-1010 DO - 10.12659/MSM.942122 UR - https://m2.mtmt.hu/api/publication/34506935 ID - 34506935 LA - English DB - MTMT ER - TY - JOUR AU - Rácz, Szilvia AU - Emri, Miklós AU - Opposits, Gábor AU - Berényi, Ervin László AU - Benczik, Lajos AU - Ludman, István Attila AU - Kappelmayer, János AU - Bhattoa Harjit, Pál TI - Laboratóriumi paraméterek kódolása a LOINC-rendszer szerint a Debreceni Egyetem Klinikai Központjában JF - ORVOSI HETILAP J2 - ORV HETIL VL - 164 PY - 2023 IS - 27 SP - 1043 EP - 1051 PG - 9 SN - 0030-6002 DO - 10.1556/650.2023.32814 UR - https://m2.mtmt.hu/api/publication/34089339 ID - 34089339 AB - Bevezetés: A Debreceni Egyetem adatvagyonának jelentős részét alkotja a Klinikai Központban zajló betegellátás során keletkezett orvosi, biokémiai és képi adat, rendszerezetlen változatban. Ezek kutatási célú alkalmazhatósága jelentősen korlátozott. Az egyetemi „Tématerületi Kiválósági Programon” belül, a „Big Data tématerület” keretében elindított K+F projekt legfontosabb célja az anonimizált adatvagyon elérhetővé tétele a felhasználók számára megfelelő transzformációs eljárások kidolgozásával. Az elemzésre kiválóan használható adatokat az in vitro rutindiagnosztikai laboratórium által szolgáltatott adatok jelentik. A rutindiagnosztikai gyakorlatban használatos adatmezőket rövidített, magyar nyelvű, nem standardizált kulcsszavak jelölik, és e kulcsszavak kódolására a nemzetközi Logikai Megfigyelési Azonosítók, Nevek és Kódok (Logical Observation Identifiers Names and Codes – LOINC) szabvány alkalmazását határoztuk el. Referencialaboratóriumok, egészségügyi szolgáltatók, kormányhivatalok, egészségügyi biztosítók, orvosi szoftverek és műszerek gyártói, kutatók, valamint az egészségügyi rendszert igénybe vevők világszerte használják a LOINC-rendszert az adatok azonosítására, valamint azok rendszerek közötti zökkenőmentes átadására. Célkitűzés: Célunk a Debreceni Egyetem Klinikai Központjának Laboratóriumi Medicina Intézete által meghatározott rutindiagnosztikai paraméterek (n = 448) megfeleltetése a LOINC kódolási rendszernek, figyelembe véve az azonos adatok hátterében az időbeli és módszertani eltéréseket. Módszerek: A laboratóriumi adatokhoz rendelt kulcsszavakat a kórházi informatikai rendszer üzemeltetőjétől kapott adatbázis alapján elemeztük. A rutindiagnosztikában használatos kulcsszavakat, megnevezéseket használtuk a LOINC-szabvány szerinti kódolásra azután, hogy a kódolás módszertanát áttanulmányoztuk, és megfelelő jártasságra tettünk szert az alkalmazásában. Eredmények: Magyarországon egyedülálló módon megfeleltettük az elvégzett rutindiagnosztikai laboratóriumi adatok és vizsgálatok elnevezéseit a LOINC-rendszer követelményeinek, és nyilvánosan hozzáférhetővé tettük őket a Debreceni Egyetem https://labmed.unideb.hu/hu/loinc-tablazatok világhálójának elérhetőségén. Következtetés: Az egységes nemzetközi LOINC-rendszer szerint kódolt adatok hatékonyabban elősegítik a Debreceni Egyetem nemzetközi integrációs törekvéseit, többek között a laboratóriumok közötti kommunikációt, valamint a nemzetközi, határokon átívelő információáramlást és a valamennyi érdekelttel való kapcsolattartást. Orv Hetil. 2023; 164(27): 1043–1051. LA - Hungarian DB - MTMT ER - TY - JOUR AU - Laczovics, Attila AU - Csige, István AU - Szabó, Sándor AU - Tóth, Albert AU - Kálmán, Ferenc Krisztián AU - Tóth, Imre AU - Fülöp, Zoltán AU - Berényi, Ervin László AU - Braun, Mihály TI - Relationship between gadolinium-based MRI contrast agent consumption and anthropogenic gadolinium in the influent of a wastewater treatment plant. JF - SCIENCE OF THE TOTAL ENVIRONMENT J2 - SCI TOTAL ENVIRON VL - 877 PY - 2023 PG - 8 SN - 0048-9697 DO - 10.1016/j.scitotenv.2023.162844 UR - https://m2.mtmt.hu/api/publication/33705033 ID - 33705033 N1 - Department of Medical Imaging, Division of Radiology and Imaging Science, Faculty of Medicine, University of Debrecen, Nagyerdei krt 98, Debrecen, H-4032, Hungary Doctoral School of Neuroscience, Faculty of Medicine, University of Debrecen, Nagyerdei krt 98, Debrecen, H-4032, Hungary Isotope Climatology and Environmental Research Centre, Institute for Nuclear Research, Hungarian Academy of Sciences, Bem tér 18/C, Debrecen, H-4026, Hungary Department of Biology, University of Nyíregyháza, PO Box 166, Nyíregyháza, H-4401, Hungary Department of Physical Chemistry, University of Debrecen, Egyetem tér 1, Debrecen, H-4032, Hungary Department of Inorganic and Analytical Chemistry, University of Debrecen, Egyetem tér 1, Debrecen, H-4032, Hungary Debrecen Waterworks Ltd., Hatvan u. 12-14, Debrecen, H-4025, Hungary Export Date: 27 March 2023 CODEN: STEVA Correspondence Address: Braun, M.; Isotope Climatology and Environmental Research Centre, Bem tér 18/C, Hungary; email: braun.mihaly@atomki.hu AB - Gadolinium-based contrast agents (GBCAs) used in magnetic resonance imaging (MRI) are highly resistant in the environment. They pass through wastewater treatment plants (WWTPs) unhindered escaping degradation. Although GBCAs are subjects of intensive research, we recognized that a quantitative approach to the mass balance of gadolinium, based on known input and output data, is missing. The administered amount of Gd as GBCAs, the number of out- and inpatients and the concentration of rare earth elements (REEs) in wastewater were monitored for 45 days in a medium sized city (ca. 203,000 inhabitants) with two MRI centres. An advection-dispersion type model was established to describe the transport of Gd in the wastewater system. The model calculates with patient locality, excretion kinetics of Gd and the yield of wastewater. The estimated and measured daily amount of anthropogenic gadolinium released to the WWTP were compared. GBCAs (Omniscan and Dotarem) were administered to 1008 patients representing a total of 700 ± 1 g Gd. The amount of total Gd entering the WWTP was 531 ± 2 g, of which the anthropogenic contribution (i.e. GBCAs) was 261 ± 6 g (49 ± 1 % of the total Gd) during the sampling campaign. Local residents and inpatients should fully release Gd in the city, but outpatients only partially. Overall, 37 ± 1 % of the total administered Gd was recovered in the wastewater, so the remaining 63 ± 1 % of administered Gd is expected to be dispensed outside of the sewer system. Our approach enables to better understand the dispersion of GBCAs originated Gd in an urban environment. LA - English DB - MTMT ER - TY - JOUR AU - Módis, László AU - Aradi, Zsófia AU - Horváth, Ildikó Fanny AU - Bencze, János AU - Papp, Tamás AU - Emri, Miklós AU - Berényi, Ervin László AU - Bugán, Antal AU - Szántó, Antónia TI - Central Nervous System Involvement in Primary Sjögren’s Syndrome: Narrative Review of MRI Findings JF - DIAGNOSTICS J2 - DIAGNOSTICS VL - 13 PY - 2023 IS - 1 SP - 14 SN - 2075-4418 DO - 10.3390/diagnostics13010014 UR - https://m2.mtmt.hu/api/publication/33542619 ID - 33542619 AB - Central nervous system (CNS) involvement is one of the numerous extraglandular manifestations of primary Sjögren’s syndrome (pSS). Moreover, neurological complaints precede the sicca symptoms in 25–60% of the cases. We review the magnetic resonance imaging (MRI) lesions typical for pSS, involving the conventional examination, volumetric and morphometric studies, diffusion tensor imaging (DTI) and resting-state fMRI. The most common radiological lesions in pSS are white matter hyperintensities (WMH), scattered alterations hyperlucent on T2 and FLAIR sequences, typically located periventricularly and subcortically. Cortical atrophy and ventricular dilatation can also occur in pSS. Whilst these conditions are thought to be more common in pSS than healthy controls, DTI and resting-state fMRI alterations demonstrate evident microstructural changes in pSS. As pSS is often accompanied by cognitive symptoms, these MRI alterations are expectedly related to them. This relationship is not clearly delineated in conventional MRI studies, but DTI and resting-state fMRI examinations show more convincing correlations. In conclusion, the CNS manifestations of pSS do not follow a certain pattern. As the link between the MRI lesions and clinical manifestations is not well established, more studies involving larger populations should be performed to elucidate the correlations. LA - English DB - MTMT ER - TY - JOUR AU - Borbély, Klaudia AU - Balogh, Hanna AU - Kardos, Ilona Blanka AU - Fontanini, Daniele Mariastefano AU - Oláh, László AU - Berényi, Ervin László AU - Maurovich-Horvat, Pál TI - CADASIL syndrome: Long-term follow-up on MRI JF - IMAGING J2 - IMAGING VL - 14 PY - 2022 IS - 2 SP - 109 EP - 112 PG - 4 SN - 2732-0960 DO - 10.1556/1647.2022.00059 UR - https://m2.mtmt.hu/api/publication/33631161 ID - 33631161 N1 - Department of Radiology, Medical Imaging Centre, Semmelweis University, Budapest, Hungary Department of Diagnostic Radiology, Heart and Vascular Centre, Semmelweis University, Budapest, Hungary Department of Medical Imaging, University of Debrecen, Debrecen, Hungary Department of Neurology, University of Debrecen, Debrecen, Hungary Export Date: 21 March 2023 Correspondence Address: Borbély, K.; Department of Radiology, Hungary; email: borbely.klaudia1995@gmail.com AB - Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL) is a hereditary vascular disorder inherited in an autosomal dominant manner. MRI plays a crucial role in the diagnosis and follow-up of patients. Characteristic MRI lesions include symmetric and bilateral white matter periventricular hyperintensities, lacunar infarcts and cerebral microbleeds. In our case report, we demonstrate a male patient with genetically confirmed CADASIL syndrome and the progression of symptoms with corresponding imaging findings throughout the years. LA - English DB - MTMT ER - TY - JOUR AU - Veres, Gergő AU - Kiss, János AU - Vas, Norman Félix AU - Kallos-Balogh, Piroska AU - Máthé, Nóra Beatrix AU - Lassen, Martin Lyngby AU - Berényi, Ervin László AU - Balkay, László TI - Phantom Study on the Robustness of MR Radiomics Features: comparing the Applicability of 3D Printed and Biological Phantoms JF - DIAGNOSTICS J2 - DIAGNOSTICS VL - 12 PY - 2022 IS - 9 SP - 1 EP - 24 PG - 24 SN - 2075-4418 DO - 10.3390/diagnostics12092196 UR - https://m2.mtmt.hu/api/publication/33117918 ID - 33117918 AB - The objectives of our study were to (a) evaluate the feasibility of using 3D printed phantoms in magnetic resonance imaging (MR) in assessing the robustness and repeatability of radiomic parameters and (b) to compare the results obtained from the 3D printed phantoms to metrics obtained in biological phantoms. To this end, three different 3D phantoms were printed: a Hilbert cube (5 × 5 × 5 cm3) and two cubic quick response (QR) code phantoms (a large phantom (large QR) (5 × 5 × 4 cm3) and a small phantom (small QR) (4 × 4 × 3 cm3)). All 3D printed and biological phantoms (kiwis, tomatoes, and onions) were scanned thrice on clinical 1.5 T and 3 T MR with 1 mm and 2 mm isotropic resolution. Subsequent analyses included analyses of several radiomics indices (RI), their repeatability and reliability were calculated using the coefficient of variation (CV), the relative percentage difference (RPD), and the interclass coefficient (ICC) parameters. Additionally, the readability of QR codes obtained from the MR images was examined with several mobile phones and algorithms. The best repeatability (CV ≤ 10%) is reported for the acquisition protocols with the highest spatial resolution. In general, the repeatability and reliability of RI were better in data obtained at 1.5 T (CV = 1.9) than at 3 T (CV = 2.11). Furthermore, we report good agreements between results obtained for the 3D phantoms and biological phantoms. Finally, analyses of the read-out rate of the QR code revealed better texture analyses for images with a spatial resolution of 1 mm than 2 mm. In conclusion, 3D printing techniques offer a unique solution to create textures for analyzing the reliability of radiomic data from MR scans. LA - English DB - MTMT ER - TY - GEN AU - Opposits, Gábor AU - Berényi, Ervin László AU - Emri, Miklós TI - Differential Privacy in Clinical Environment PY - 2022 UR - https://m2.mtmt.hu/api/publication/33099082 ID - 33099082 LA - English DB - MTMT ER - TY - JOUR AU - Erdei, Annamária AU - Gazdag, Annamária AU - Ujhelyi, Bernadett AU - Nagy, Edit B AU - Berényi, Ervin László AU - Berta, Eszter AU - Steiber, Zita AU - Barna, Sándor Kristóf AU - Mezősi, Emese AU - Bodor, Miklós AU - Nagy, Endre TI - Non-surgical orbital decompression using diuresis in dysthyroid optic neuropathy: a case report JF - EUROPEAN THYROID JOURNAL J2 - EUR THYROID J VL - 11 PY - 2022 IS - 5 PG - 5 SN - 2235-0640 DO - 10.1530/ETJ-22-0078 UR - https://m2.mtmt.hu/api/publication/33032320 ID - 33032320 AB - Dysthyroid optic neuropathy (DON) is a rare, severe form of thyroid eye disease, in which decreased visual acuity is accompanied by characteristic MRI findings. The treatment of DON has always been a challenge.In a patient in whom visual acuity deteriorated on the left eye, mannitol 20% 200 ml followed by furosemide 40 mg 6 hours later, administered daily, were initiated on the day of admission. Visual function by ophthalmology methods, and orbital compartment volumes and water content by MRI were followed. Intravenous diuretics resulted in immediate therapeutic response. Visual acuity improved from 20/50 to 20/25 after two days of treatment. MRI revealed decreasing water content of both the muscle and connective tissue compartments without any volume changes. Subsequently, corticosteroids and orbital irradiation were started. Orbital decompression surgery was not required.Edematous swelling of orbital tissues is an established contributor of local pressure increase in thyroid eye disease. Diuretics reduce orbital pressure and, if confirmed by others, may be useful additions to the standard of care in sight threatening DON. LA - English DB - MTMT ER - TY - JOUR AU - Papp, Tamás AU - Ferenczi, Zsuzsanna AU - Szilagyi, Bernadette AU - Petro, Matyas AU - Varga, Angelika AU - Kókai, Éva AU - Berényi, Ervin László AU - Oláh, Gábor AU - Halmos, Gábor AU - Szűcs, Péter AU - Mészár, Zoltán TI - Ultrasound Used for Diagnostic Imaging Facilitates Dendritic Branching of Developing Neurons in the Mouse Cortex JF - FRONTIERS IN NEUROSCIENCE J2 - FRONT NEUROSCI-SWITZ VL - 16 PY - 2022 SN - 1662-4548 DO - 10.3389/fnins.2022.803356 UR - https://m2.mtmt.hu/api/publication/32769720 ID - 32769720 N1 - Department of Medical Imaging, University of Debrecen, Debrecen, Hungary Department of Anatomy, Histology and Embryology, University of Debrecen, Debrecen, Hungary Department of Biopharmacy, University of Debrecen, Debrecen, Hungary MTA-Debreceni Egyetem, Neuroscience Research Group, Debrecen, Hungary Export Date: 18 January 2023 Correspondence Address: Papp, T.; Department of Medical Imaging, Hungary; email: papp.tamas@med.unideb.hu Funding details: 2017-1.2.1-NKP-00002, TKP2021-EGA-20 Funding text 1: This work was supported by the National Brain Project of Hungary (NAP2, 2017-1.2.1-NKP-00002) to ZM and PS and by the Thematic Excellence Programme TKP2021-EGA-20 (Biotechnology) of the Ministry for Innovation and Technology in Hungary to GH as well as by the UD Faculty of Medicine Research Fund (Bridging Fund) to AV. LA - English DB - MTMT ER - TY - JOUR AU - Veres, Gergő AU - Vas, Norman Félix AU - Lassen, Martin Lyngby AU - Béresová, Monika AU - Krizsán, Áron Krisztián AU - Forgács, Attila AU - Berényi, Ervin László AU - Balkay, László TI - Effect of grey-level discretization on texture feature on different weighted MRI images of diverse disease groups JF - PLOS ONE J2 - PLOS ONE VL - 16 PY - 2021 IS - 6 PG - 18 SN - 1932-6203 DO - 10.1371/journal.pone.0253419 UR - https://m2.mtmt.hu/api/publication/32333348 ID - 32333348 N1 - 312564 AB - PurposeMany studies of MRI radiomics do not include the discretization method used for the analyses, which might indicate that the discretization methods used are considered irrelevant. Our goals were to compare three frequently used discretization methods (lesion relative resampling (LRR), lesion absolute resampling (LAR) and absolute resampling (AR)) applied to the same data set, along with two different lesion segmentation approaches.MethodsWe analyzed the effects of altering bin widths or bin numbers for the three different sampling methods using 40 texture indices (TIs). The impact was evaluated on brain MRI studies obtained for 71 patients divided into three different disease groups: multiple sclerosis (MS, N = 22), ischemic stroke (IS, N = 22), cancer patients (N = 27). Two different MRI acquisition protocols were considered for all patients, a T2- and a post-contrast 3D T1-weighted MRI sequence. Elliptical and manually drawn VOIs were employed for both imaging series. Three different types of gray-level discretization methods were used: LRR, LAR and AR. Hypothesis tests were done among all diseased and control areas to compare the TI values in these areas. We also did correlation analyses between TI values and lesion volumes.ResultsIn general, no significant differences were reported in the results when employing the AR and LAR discretization methods. It was found that employing 38 TIs introduced variation in the results when the number of bin parameters was altered, suggesting that both the degree and direction of monotonicity between each TI value and binning parameters were characteristic for each TI. Furthermore, while TIs were changing with altering binning values, no changes correlated to neither disease nor the MRI sequence. We found that most indices correlated weakly with the volume, while the correlation coefficients were independent of both diseases analyzed and MR contrast. Several cooccurrence-matrix based texture parameters show a definite higher correlation when employing the LRR discretization method However, with the best correlations obtained for the manually drawn VOI. Hypothesis tests among all disease and control areas (co-lateral hemisphere) revealed that the AR or LAR discretization techniques provide more suitable texture features than LRR. In addition, the manually drawn segmentation gave fewer significantly different TIs than the ellipsoid segmentations. In addition, the amount of TIs with significant differences was increasing with increasing the number of bins, or decreasing bin widths.ConclusionOur findings indicate that the AR discretization method may offer the best texture analysis in MR image assessments. Employing too many bins or too large bin widths might reduce the selection of TIs that can be used for differential diagnosis. In general, more statistically different TIs were observed for elliptical segmentations when compared to the manually drawn VOIs. In the texture analysis of MR studies, studies and publications should report on all important parameters and methods related to data collection, corrections, normalization, discretization, and segmentation. LA - English DB - MTMT ER -