@article{MTMT:34817464,
	title = {Specific and shared biological functions of PARP2 – is PARP2 really a lil’ brother of PARP1?},
	url = {https://m2.mtmt.hu/api/publication/34817464},
	author = {Szántó, Magdolna and Yélamos, J and Bay, Péter},
	journal-iso = {EXPERT REV MOL MED},
	journal = {EXPERT REVIEWS IN MOLECULAR MEDICINE},
	unique-id = {34817464},
	issn = {1462-3994},
	year = {2024},
	eissn = {1462-3994}
}

@article{MTMT:34483936,
	title = {Cell-free ascites from ovarian cancer patients induces Warburg metabolism and cell proliferation through TGFbeta-ERK signalling},
	url = {https://m2.mtmt.hu/api/publication/34483936},
	author = {Szeőcs, Dóra and Vida, Beáta and Petővári, Gábor and Póliska, Szilárd and Janka, Eszter Anna and Sipos, Adrienn and Uray (Davis), Karen L. and Sebestyén, Anna and Krasznai, Zoárd Tibor and Bay, Péter},
	doi = {10.1007/s11357-023-01056-1},
	journal-iso = {GEROSCIENCE},
	journal = {GEROSCIENCE: OFFICIAL JOURNAL OF THE AMERICAN AGING ASSOCIATION (AGE)},
	unique-id = {34483936},
	issn = {2509-2715},
	abstract = {Ascites plays a key role in supporting the metastatic potential of ovarian cancer cells. Shear stress and carry-over of cancer cells by ascites flow support carcinogenesis and metastasis formation. In addition, soluble factors may participate in the procarcinogenic effects of ascites in ovarian cancer. This study aimed to determine the biological effects of cell-free ascites on carcinogenesis in ovarian cancer cells. Cell-free ascites from ovarian cancer patients (ASC) non-selectively induced cell proliferation in multiple models of ovarian cancer and untransformed primary human dermal fibroblasts. Furthermore, ASC induced a Warburg-type rearrangement of cellular metabolism in A2780 ovarian cancer cells characterized by increases in cellular oxygen consumption and glycolytic flux; increases in glycolytic flux were dominant. ASC induced mitochondrial uncoupling and fundamentally reduced fatty acid oxidation. Ascites-elicited effects were uniform among ascites specimens. ASC-elicited transcriptomic changes in A2780 ovarian cancer cells included induction of the TGF beta-ERK/MEK pathway, which plays a key role in inducing cell proliferation and oncometabolism. ASC-induced gene expression changes, as well as the overexpression of members of the TGF beta signaling system, were associated with poor survival in ovarian cancer patients. We provided evidence that the activation of the autocrine/paracrine of TGF beta signaling system may be present in bladder urothelial carcinoma and stomach adenocarcinoma. Database analysis suggests that the TGF beta system may feed forward bladder urothelial carcinoma and stomach adenocarcinoma. Soluble components of ASC support the progression of ovarian cancer. These results suggest that reducing ascites production may play an essential role in the treatment of ovarian cancer by inhibiting the progression and reducing the severity of the disease.},
	year = {2024},
	eissn = {2509-2723},
	orcid-numbers = {Petővári, Gábor/0000-0002-1957-2864; Janka, Eszter Anna/0000-0003-0724-5281; Sebestyén, Anna/0000-0001-8814-4794}
}

@article{MTMT:34148390,
	title = {Distinct subsets of anti-pulmonary autoantibodies correlate with disease severity and survival in severe COVID-19 patients},
	url = {https://m2.mtmt.hu/api/publication/34148390},
	author = {Tóth, Emese and Fagyas, Miklós and Nagy, Béla and Siket, Ivetta Mányiné and Szőke, Blanka and Mártha, Lilla and Mahdi, Mohamed and Erdősi, Gábor and Pólik, Zsófia and Kappelmayer, János and Papp, Zoltán and Borbély, Attila and Szabó, Tamás and Balla, József and Balla, György and Bácsi, Attila and Szekanecz, Zoltán and Bay, Péter and Tóth, Attila},
	doi = {10.1007/s11357-023-00887-2},
	journal-iso = {GEROSCIENCE},
	journal = {GEROSCIENCE: OFFICIAL JOURNAL OF THE AMERICAN AGING ASSOCIATION (AGE)},
	volume = {46},
	unique-id = {34148390},
	issn = {2509-2715},
	abstract = {Autoantibodies targeting the lung tissue were identified in severe COVID-19 patients in this retrospective study. Fifty-three percent of 104 patients developed anti-pulmonary antibodies, the majority of which were IgM class, suggesting that they developed upon infection with SARS-CoV-2. Anti-pulmonary antibodies correlated with worse pulmonary function and a higher risk of multiorgan failure that was further aggravated if 3 or more autoantibody clones were simultaneously present (multi-producers). Multi-producer patients were older than the patients with less or no autoantibodies. One of the identified autoantibodies (targeting a pulmonary protein of ~ 50 kDa) associated with worse clinical outcomes, including mortality. In summary, severe COVID-19 is associated with the development of lung-specific autoantibodies, which may worsen the clinical outcome. Tissue proteome-wide tests, such as the ones applied here, can be used to detect autoimmunity in the post-COVID state to identify the cause of symptoms and to reveal a new target for treatment.},
	year = {2024},
	eissn = {2509-2723},
	pages = {1561-1574}
}

@{MTMT:34449504,
	title = {Half-sandwich transition metal complexes and uses thereof},
	url = {https://m2.mtmt.hu/api/publication/34449504},
	author = {Bay, Péter and Bokor, Éva and Somsák, László and Kacsir, István and Buglyó, Péter and Sipos, Adrienn and Kardos, Gábor and Toth, Zoltan and Kis, Gyorgy Attila},
	unique-id = {34449504},
	abstract = {The invention relates to half-sandwich transition metal complexes with general formula (I), (wherein in Me is a transition metal ion selected from the group consisting of Ru, Os, Rh, Ir, Pd and Pt, preferably selected from Ru, Os, Rh, Ir, X is a halogen selected from the group consisting of Cl, Br and I, preferably Cl,Ar is a capping mol. having a Cs or C6 aromatic ring substituted with one or more, preferably one to five or one to six straight or branched chain C1-C6 alkyl, preferably C1-C3 alkyl, resp.); and uses thereof, in particular in neo-plastic diseas or as antifungal agent.},
	keywords = {half sandwich transition metal},
	year = {2023},
	orcid-numbers = {Somsák, László/0000-0002-9103-9845; Buglyó, Péter/0000-0002-6714-7598}
}

@article{MTMT:34089348,
	title = {Identification of Bacterial Metabolites Modulating Breast Cancer Cell Proliferation and Epithelial-Mesenchymal Transition},
	url = {https://m2.mtmt.hu/api/publication/34089348},
	author = {Ujlaki, Gyula and Kovács, Tünde and Vida, András and Kókai, Endre and Rauch, Boglárka and Schwarcz, Szandra and Mikó, Edit and Janka, Eszter and Sipos, Adrienn and Hegedűs, Csaba and Uray (Davis), Karen L. and Nagy, Péter and Bay, Péter},
	doi = {10.3390/molecules28155898},
	journal-iso = {MOLECULES},
	journal = {MOLECULES},
	volume = {28},
	unique-id = {34089348},
	issn = {1420-3049},
	abstract = {Breast cancer patients are characterized by the oncobiotic transformation of multiple microbiome communities, including the gut microbiome. Oncobiotic transformation of the gut microbiome impairs the production of antineoplastic bacterial metabolites. The goal of this study was to identify bacterial metabolites with antineoplastic properties. We constructed a 30-member bacterial metabolite library and screened the library compounds for effects on cell proliferation and epithelial-mesenchymal transition. The metabolites were applied to 4T1 murine breast cancer cells in concentrations corresponding to the reference serum concentrations. However, yric acid, glycolic acid, d-mannitol, 2,3-butanediol, and trans-ferulic acid exerted cytostatic effects, and 3-hydroxyphenylacetic acid, 4-hydroxybenzoic acid, and vanillic acid exerted hyperproliferative effects. Furthermore, 3-hydroxyphenylacetic acid, 4-hydroxybenzoic acid, 2,3-butanediol, and hydrocinnamic acid inhibited epithelial-to-mesenchymal (EMT) transition. We identified redox sets among the metabolites (d-mannitol—d-mannose, 1-butanol—butyric acid, ethylene glycol—glycolic acid—oxalic acid), wherein only one partner within the set (d-mannitol, butyric acid, glycolic acid) possessed bioactivity in our system, suggesting that changes to the local redox potential may affect the bacterial secretome. Of the nine bioactive metabolites, 2,3-butanediol was the only compound with both cytostatic and anti-EMT properties.},
	year = {2023},
	eissn = {1420-3049},
	orcid-numbers = {Janka, Eszter/0000-0003-0724-5281; Nagy, Péter/0000-0002-7466-805X}
}

@article{MTMT:34034279,
	title = {PARP2 promotes inflammation in psoriasis by modulating estradiol biosynthesis in keratinocytes},
	url = {https://m2.mtmt.hu/api/publication/34034279},
	author = {Antal, Dóra and Pór, Ágnes and Kovács, Ilona and Dull, Katalin and Póliska, Szilárd and Ujlaki, Gyula and Demény, Máté Ágoston and Szöllősi, Attila and Kiss, Borbála and Szegedi, Andrea and Bay, Péter and Szántó, Magdolna},
	doi = {10.1007/s00109-023-02338-z},
	journal-iso = {J MOL MED-JMM},
	journal = {JOURNAL OF MOLECULAR MEDICINE-JMM},
	volume = {101},
	unique-id = {34034279},
	issn = {0946-2716},
	year = {2023},
	eissn = {1432-1440},
	pages = {987-999},
	orcid-numbers = {Pór, Ágnes/0000-0002-2945-0684; Kovács, Ilona/0000-0003-0629-5615; Dull, Katalin/0000-0001-5594-0364; Póliska, Szilárd/0000-0002-9722-251X; Szöllősi, Attila/0000-0001-6046-8236; Kiss, Borbála/0000-0002-6076-9984; Szegedi, Andrea/0000-0003-2109-9014}
}

@{MTMT:33998388,
	title = {PARP2 promotes inflammation in psoriasis by modulating estradiol biosynthesis in keratinocytes .},
	url = {https://m2.mtmt.hu/api/publication/33998388},
	author = {Antal, Dóra and Pór, Ágnes and Kovács, Ilona and Dull, Katalin and Póliska, Szilárd and Ujlaki, Gyula and Demény, Máté Ágoston and Szöllősi, A. G. and Kiss, B. and Szegedi, Andrea and Bay, Péter and Szántó, Magdolna},
	booktitle = {FEBS Advanced Lecture Course: PARP 2023: Research on the family of poly(ADP-ribose) polymerases; Book of Abstracts},
	unique-id = {33998388},
	year = {2023},
	pages = {60}
}

@article{MTMT:33870536,
	title = {PARP2 poly(ADP-ribosyl)ates nuclear factor erythroid 2-related factor 2 (NRF2) affecting NRF2 subcellular localization},
	url = {https://m2.mtmt.hu/api/publication/33870536},
	author = {Jankó, Laura and Tóth, Emese and Laczik, Miklós and Rauch, Boglárka and Janka, Eszter and Bálint, Bálint László and Bay, Péter},
	doi = {10.1038/s41598-023-35076-w},
	journal-iso = {SCI REP},
	journal = {SCIENTIFIC REPORTS},
	volume = {13},
	unique-id = {33870536},
	issn = {2045-2322},
	abstract = {PARP2 is a member of the PARP enzyme family. Although, PARP2 plays role in DNA repair, it has regulatory roles in mitochondrial and lipid metabolism, it has pivotal role in bringing about the adverse effects of pharmacological PARP inhibitors. Previously, we showed that the ablation of PARP2 induces oxidative stress and, consequently, mitochondrial fragmentation. In attempt to identify the source of the reactive species we assessed the possible role of a central regulator of cellular antioxidant defense, nuclear factor erythroid 2-related factor 2 (NRF2). The silencing of PARP2 did not alter either the mRNA or the protein expression of NRF2, but changed its subcellular localization, decreasing the proportion of nuclear, active fraction of NRF2. Pharmacological inhibition of PARP2 partially restored the normal localization pattern of NRF2 and in line with that, we showed that NRF2 is PARylated that is absent in the cells in which PARP2 was silenced. Apparently, the PARylation of NRF2 by PARP2 has pivotal role in regulating the subcellular (nuclear) localization of NRF2. The silencing of PARP2 rearranged the expression of genes encoding proteins with antioxidant function, among these a subset of NRF2-dependent genes.},
	year = {2023},
	eissn = {2045-2322},
	orcid-numbers = {Bálint, Bálint László/0000-0002-6163-7190}
}

@article{MTMT:33764771,
	title = {The pro- and antineoplastic effects of deoxycholic acid in pancreatic adenocarcinoma cell models},
	url = {https://m2.mtmt.hu/api/publication/33764771},
	author = {Schwarcz, Szandra and Kovács, Patrik Bence and Kovács, Tünde and Ujlaki, Gyula and Nyerges, P. and Uray (Davis), Karen L. and Bay, Péter and Mikó, Edit},
	doi = {10.1007/s11033-023-08453-x},
	journal-iso = {MOL BIOL REP},
	journal = {MOLECULAR BIOLOGY REPORTS},
	volume = {50},
	unique-id = {33764771},
	issn = {0301-4851},
	year = {2023},
	eissn = {1573-4978},
	pages = {5273-5282}
}

@article{MTMT:33734265,
	title = {Half-Sandwich Type Platinum-Group Metal Complexes of C-Glucosaminyl Azines: Synthesis and Antineoplastic and Antimicrobial Activities},
	url = {https://m2.mtmt.hu/api/publication/33734265},
	author = {Kacsir, István and Sipos, Adrienn and Major, Evelin and Bajusz, Nikolett and Bényei, Attila Csaba and Buglyó, Péter and Somsák, László and Kardos, Gábor and Bay, Péter and Bokor, Éva},
	doi = {10.3390/molecules28073058},
	journal-iso = {MOLECULES},
	journal = {MOLECULES},
	volume = {28},
	unique-id = {33734265},
	issn = {1420-3049},
	abstract = {While platinum-based compounds such as cisplatin form the backbone of chemotherapy, the use of these compounds is limited by resistance and toxicity, driving the development of novel complexes with cytostatic properties. In this study, we synthesized a set of half-sandwich complexes of platinum-group metal ions (Ru(II), Os(II), Ir(III) and Rh(III)) with an N,N-bidentate ligand comprising a C-glucosaminyl group and a heterocycle, such as pyridine, pyridazine, pyrimidine, pyrazine or quinoline. The sugar-containing ligands themselves are unknown compounds and were obtained by nucleophilic additions of lithiated heterocycles to O-perbenzylated 2-nitro-glucal. Reduction of the adducts and, where necessary, subsequent protecting group manipulations furnished the above C-glucosaminyl heterocycles in their O-perbenzylated, O-perbenzoylated and O-unprotected forms. The derived complexes were tested on A2780 ovarian cancer cells. Pyridine, pyrazine and pyridazine-containing complexes proved to be cytostatic and cytotoxic on A2780 cells, while pyrimidine and quinoline derivatives were inactive. The best complexes contained pyridine as the heterocycle. The metal ion with polyhapto arene/arenyl moiety also impacted on the biological activity of the complexes. Ruthenium complexes with p-cymene and iridium complexes with Cp* had the best performance in ovarian cancer cells, followed by osmium complexes with p-cymene and rhodium complexes with Cp*. Finally, the chemical nature of the protective groups on the hydroxyl groups of the carbohydrate moiety were also key determinants of bioactivity; in particular, O-benzyl groups were superior to O-benzoyl groups. The IC50 values of the complexes were in the low micromolar range, and, importantly, the complexes were less active against primary, untransformed human dermal fibroblasts; however, the anticipated therapeutic window is narrow. The bioactive complexes exerted cytostasis on a set of carcinomas such as cell models of glioblastoma, as well as breast and pancreatic cancers. Furthermore, the same complexes exhibited bacteriostatic properties against multiresistant Gram-positive Staphylococcus aureus and Enterococcus clinical isolates in the low micromolar range.},
	keywords = {RHODIUM; Osmium; Staphylococcus aureus; iridium; RUTHENIUM; Enterococcus; cytostasis; azines; Ovarian cancer; methicillin-resistant Staphylococcus aureus (MRSA); Half-sandwich complex; vancomycin-resistant Enterococcus (VRE); C-glucosaminyl heterocycles},
	year = {2023},
	eissn = {1420-3049},
	orcid-numbers = {Buglyó, Péter/0000-0002-6714-7598; Somsák, László/0000-0002-9103-9845}
}