TY  - JOUR
AU  - Sudy, Roberta
AU  - Dereu, Domitille
AU  - Lin, Na
AU  - Pichon, Isabelle
AU  - Peták, Ferenc
AU  - Habre, Walid
AU  - Albu, Gergely
TI  - Respiratory effects of pressure support ventilation in spontaneously breathing patients under anaesthesia: Randomised controlled trial
JF  - ACTA ANAESTHESIOLOGICA SCANDINAVICA
J2  - ACTA ANAESTH SCAND
VL  - 68
PY  - 2024
IS  - 3
SP  - 311
EP  - 320
PG  - 10
SN  - 0001-5172
DO  - 10.1111/aas.14350
UR  - https://m2.mtmt.hu/api/publication/34554409
ID  - 34554409
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Tolnai, József
AU  - Ballók, Bence
AU  - Südy, Roberta
AU  - Schranc, Álmos István
AU  - Varga, Gabriella
AU  - Babik, Barna
AU  - Fodor, Gergely
AU  - Peták, Ferenc
TI  - Changes in lung mechanics and ventilation-perfusion match: comparison of pulmonary air- and thromboembolism in rats
JF  - BMC PULMONARY MEDICINE
J2  - BMC PULM MED
VL  - 24
PY  - 2024
IS  - 1
PG  - 10
SN  - 1471-2466
DO  - 10.1186/s12890-024-02842-z
UR  - https://m2.mtmt.hu/api/publication/34504307
ID  - 34504307
LA  - English
DB  - MTMT
ER  - 

TY  - BOOK
ED  - Tolnai, József
ED  - Peták, Ferenc
ED  - Fodor, Gergely
ED  - Rakonczay, Zoltán
TI  - 2023. évi Orvos- és Egészségtudományi TDK Konferencia
PB  - Szegedi Tudományegyetem
CY  - Szeged
PY  - 2023
SP  - 301
SN  - 9789633069592
UR  - https://m2.mtmt.hu/api/publication/34446677
ID  - 34446677
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Pálfi, Alexandra
AU  - Balogh, Ádám László
AU  - Polónyi, Gabriella
AU  - Schulcz, Domonkos
AU  - Zöllei, Éva
AU  - Bari, Gábor
AU  - Fodor, Gergely
AU  - Barath, Kristóf
AU  - Somfay, Attila
AU  - Peták, Ferenc
AU  - Babik, Barna
TI  - Post-COVID changes in lung function 6 months after veno-venous extracorporeal membrane oxygenation: a prospective observational clinical trial
JF  - FRONTIERS IN MEDICINE
J2  - FRONT MED
VL  - 10
PY  - 2023
PG  - 10
SN  - 2296-858X
DO  - 10.3389/fmed.2023.1288679
UR  - https://m2.mtmt.hu/api/publication/34444978
ID  - 34444978
AB  - <sec>BackgroundSevere coronavirus disease 2019 (COVID-19) may require veno-venous extracorporeal membrane oxygenation (V-V ECMO). While V-V ECMO is offered in severe lung injury to COVID-19, long-term respiratory follow-up in these patients is missing. Therefore, we aimed at providing comprehensive data on the long-term respiratory effects of COVID-19 requiring V-V ECMO support during the acute phase of infection.</sec><sec>MethodsIn prospective observational cohort study design, patients with severe COVID-19 receiving invasive mechanical ventilation and V-V ECMO (COVID group, n = 9) and healthy matched controls (n = 9) were evaluated 6 months after hospital discharge. Respiratory system resistance at 5 and 19 Hz (R5, R19), and the area under the reactance curve (AX5) was evaluated using oscillometry characterizing total and central airway resistances, and tissue elasticity, respectively. R5 and R19 difference (R5–R19) reflecting small airway function was also calculated. Forced expired volume in seconds (FEV1), forced expiratory vital capacity (FVC), functional residual capacity (FRC), carbon monoxide diffusion capacity (DLCO) and transfer coefficient (KCO) were measured.</sec><sec>ResultsThe COVID group had a higher AX5 and R5–R19 than the healthy matched control group. However, there was no significant difference in terms of R5 or R19. The COVID group had a lower FEV1 and FVC on spirometry than the healthy matched control group. Further, the COVID group had a lower FRC on plethysmography than the healthy matched control group. Meanwhile, the COVID group had a lower DLCO than healthy matched control group. Nevertheless, its KCO was within the normal range.</sec><sec>ConclusionSevere acute COVID-19 requiring V-V ECMO persistently impairs small airway function and reduces respiratory tissue elasticity, primarily attributed to lung restriction. These findings also suggest that even severe pulmonary pathologies of acute COVID-19 can manifest in a moderate but still persistent lung function impairment 6 months after hospital discharge.</sec><sec>Trial registrationNCT05812196.</sec>
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Ballók, Bence
AU  - Schranc, Álmos István
AU  - Tóth, Ibolya
AU  - Somogyi, Petra
AU  - Tolnai, József
AU  - Peták, Ferenc
AU  - Fodor, Gergely
TI  - Comparison of the respiratory effects of commonly utilized general anaesthesia regimes in male Sprague-Dawley rats
JF  - FRONTIERS IN PHYSIOLOGY
J2  - FRONT PHYSIOL
VL  - 14
PY  - 2023
PG  - 13
SN  - 1664-042X
DO  - 10.3389/fphys.2023.1249127
UR  - https://m2.mtmt.hu/api/publication/34145868
ID  - 34145868
N1  - Department of Medical Physics and Informatics, Albert Szent-Györgyi Medical School, University of Szeged, Szeged, Hungary            
            Unit for Anaesthesiological Investigations, Department of Anaesthesiology, Pharmacology, Intensive Care, and Emergency Medicine, University of Geneva, Geneva, Switzerland            
            Department of Cell Biology and Molecular Medicine, Albert Szent-Györgyi Medical School, University of Szeged, Szeged, Hungary            
            Export Date: 2 May 2024            
            Correspondence Address: Fodor, G.H.; Department of Medical Physics and Informatics, Hungary; email: fodor.gergely@med.u-szeged.hu            
            Chemicals/CAS: fentanyl, 437-38-7, 1443-54-5; glucose, 50-99-7, 84778-64-3, 8027-56-3; ketamine, 1867-66-9, 6740-88-1, 81771-21-3; lidocaine, 137-58-6, 24847-67-4, 56934-02-2, 73-78-9; methacholine, 55-92-5; pentobarbital, 57-33-0, 76-74-4; pipecuronium, 68399-58-6; propofol, 2078-54-8; sevoflurane, 28523-86-6; urethan, 51-79-6; xylazine, 23076-35-9, 7361-61-7            
            Tradenames: epoc, Epocal, Canada            
            Manufacturers: Epocal, Canada; AdInstruments, New Zealand; Harvard Apparatus, United States            
            Funding details: K138032, OTKA-NKFIH FK134274, UNKP-22-3-SZTE-236            
            Funding text 1: This work was supported by the Hungarian Basic Research Council Grant (OTKA-NKFIH FK134274 and K138032) and the UNKP-22-3-SZTE-236 New National Excellence Program of the Ministry for Innovation and Technology of the Hungarian Government.
AB  - Background: Respiratory parameters in experimental animals are often characterised under general anaesthesia. However, anaesthesia regimes may alter the functional and mechanical properties of the respiratory system. While most anaesthesia regimes have been shown to affect the respiratory system, the effects of general anaesthesia protocols commonly used in animal models on lung function have not been systematically compared.
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Schranc, Álmos István
AU  - Diaper, John
AU  - Südy, Roberta
AU  - Peták, Ferenc
AU  - Habre, Walid
AU  - Albu, Gergely
TI  - Lung recruitment by continuous negative extra-thoracic pressure support following one-lung ventilation: an experimental study
JF  - FRONTIERS IN PHYSIOLOGY
J2  - FRONT PHYSIOL
VL  - 14
PY  - 2023
PG  - 10
SN  - 1664-042X
DO  - 10.3389/fphys.2023.1160731
UR  - https://m2.mtmt.hu/api/publication/34107238
ID  - 34107238
AB  - Lung recruitment maneuvers following one-lung ventilation (OLV) increase the risk for the development of acute lung injury. The application of continuous negative extrathoracic pressure (CNEP) is gaining interest both in intubated and non-intubated patients. However, there is still a lack of knowledge on the ability of CNEP support to recruit whole lung atelectasis following OLV. We investigated the effects of CNEP following OLV on lung expansion, gas exchange, and hemodynamics. Ten pigs were anesthetized and mechanically ventilated with pressure-regulated volume control mode (PRVC; FiO 2 : 0.5, Fr: 30–35/min, VT: 7 mL/kg, PEEP: 5 cmH 2 O) for 1 hour, then baseline (BL) data for gas exchange (arterial partial pressure of oxygen, PaO 2 ; and carbon dioxide, PaCO 2 ), ventilation and hemodynamical parameters and lung aeration by electrical impedance tomography were recorded. Subsequently, an endobronchial blocker was inserted, and OLV was applied with a reduced VT of 5 mL/kg. Following a new set of measurements after 1 h of OLV, two-lung ventilation was re-established, combining PRVC (VT: 7 mL/kg) and CNEP (−15 cmH 2 O) without any hyperinflation maneuver and data collection was then repeated at 5 min and 1 h. Compared to OLV, significant increases in PaO 2 (154.1 ± 13.3 vs. 173.8 ± 22.1) and decreases in PaCO 2 (52.6 ± 11.7 vs. 40.3 ± 4.5 mmHg, p < 0.05 for both) were observed 5 minutes following initiation of CNEP, and these benefits in gas exchange remained after an hour of CNEP. Gradual improvements in lung aeration in the non-collapsed lung were also detected by electrical impedance tomography ( p < 0.05) after 5 and 60 min of CNEP. Hemodynamics and ventilation parameters remained stable under CNEP. Application of CNEP in the presence of whole lung atelectasis proved to be efficient in improving gas exchange via recruiting the lung without excessive airway pressures. These benefits of combined CNEP and positive pressure ventilation may have particular value in relieving atelectasis in the postoperative period of surgical procedures requiring OLV.
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Bayat, Sam
AU  - Degrugilliers, Loic
AU  - Porra, Liisa
AU  - Strengell, Satu
AU  - Peták, Ferenc
AU  - Habre, Walid
TI  - Fractal dimension of pulmonary gas and blood distribution assessed by synchrotron K-edge subtraction imaging: effect of bronchoconstriction
JF  - JOURNAL OF APPLIED PHYSIOLOGY
J2  - J APPL PHYSIOL
VL  - 134
PY  - 2023
IS  - 4
SP  - 995
EP  - 1003
PG  - 9
SN  - 8750-7587
DO  - 10.1152/japplphysiol.00051.2023
UR  - https://m2.mtmt.hu/api/publication/33841748
ID  - 33841748
AB  - We analyzed the fractal dimension (Df) of lung gas and blood distribution imaged with synchrotron radiation K-edge subtraction (KES), in six anesthetized adult New Zealand White rabbits. KES imaging was performed in upright position during stable Xe gas (64% in O2) inhalation and iodine infusion (Iomeron, 350 mg/mL), respectively, at baseline and after induced bronchoconstriction by aerosolized methacholine (125 mg/mL, 90 s) and bronchodilator (salbutamol, 10 mg/mL, 90 s) inhalation, at two axial image levels. Lung Xe and iodine images were segmented, and maps of regional lung gas and blood fractions were computed. The Df of lung gas (DfXe) and blood (DfIodine) distribution was computed based on a log-log plot of variation coefficient as a function of region volume. DfXe decreased significantly during bronchoconstriction (P < 0.0001), and remained low after salbutamol. DfIodine depended on the axial image level (P < 0.0001), but did not change with bronchoconstriction. DfXe was significantly associated with arterial PaO2 (R = 0.67, P = 0.002), and negatively associated with PaCO2 (R = -0.62, P = 0.006), respiratory resistance (R = -0.58, P = 0.011), and elastance (R = -0.55, P = 0.023). These data demonstrate the reduced Df of gas distribution during acute bronchoconstriction, and the association of this parameter with physiologically meaningful variables. This finding suggests a decreased complexity and space -filling properties of lung ventilation during bronchoconstriction, and could serve as a functional imaging biomarker in obstructive airway diseases.NEW & NOTEWORTHY Here, we used an energy-subtractive imaging technique to assess the fractal dimension (Df) of lung gas and blood distribution and the effect of acute bronchoconstriction. We found that Df of gas significantly decreases in broncho-constriction. Conversely, Df of blood exhibits gravity-dependent changes only, and is not affected by acute bronchoconstriction. Our data show that the fractal dimension of lung gas detects the emergence of clustered rather than scattered loss of ventilatory units during bronchoconstriction.
LA  - English
DB  - MTMT
ER  - 

TY  - BOOK
ED  - Tolnai, József
ED  - Peták, Ferenc
ED  - Rakonczay, Zoltán
TI  - Szegedi Tudományegyetem - Szent-Györgyi Albert Orvostudományi Kar, Fogorvostudományi Kar, Gyógyszerésztudományi Kar és Egészségtudományi és Szociális Képzési Kar 2022. évi Tudományos Diákköri Konferenciája
PB  - Szegedi Tudományegyetem (SZTE)
CY  - Szeged
PY  - 2022
SP  - 255
SN  - 9789633068908
UR  - https://m2.mtmt.hu/api/publication/33399502
ID  - 33399502
LA  - Hungarian
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Balogh, Ádám László
AU  - Südy, Roberta
AU  - Peták, Ferenc
AU  - Habre, Walid
AU  - Dos Santos Rocha, Andre
TI  - Sevoflurane and Hypercapnia Blunt the Physiological Variability of Spontaneous Breathing: A Comparative Interventional Study
JF  - FRONTIERS IN PHYSIOLOGY
J2  - FRONT PHYSIOL
VL  - 13
PY  - 2022
PG  - 10
SN  - 1664-042X
DO  - 10.3389/fphys.2022.871070
UR  - https://m2.mtmt.hu/api/publication/33285576
ID  - 33285576
AB  - Background: Although spontaneous breathing is known to exhibit substantial physiological fluctuation that contributes to alveolar recruitment, changes in the variability of the respiratory pattern following inhalation of carbon dioxide (CO 2 ) and volatile anesthetics have not been characterized. Therefore, we aimed at comparing the indices of breathing variability under wakefulness, sleep, hypercapnia and sedative and anesthetic concentrations of sevoflurane.
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Dos Santos Rocha, André
AU  - Diaper, John
AU  - Balogh, Ádám László
AU  - Marti, Christophe
AU  - Grosgurin, Olivier
AU  - Habre, Walid
AU  - Peták, Ferenc
AU  - Südy, Roberta
TI  - Effect of body position on the redistribution of regional lung aeration during invasive and non-invasive ventilation of COVID-19 patients
JF  - SCIENTIFIC REPORTS
J2  - SCI REP
VL  - 12
PY  - 2022
IS  - 1
PG  - 12
SN  - 2045-2322
DO  - 10.1038/s41598-022-15122-9
UR  - https://m2.mtmt.hu/api/publication/33285573
ID  - 33285573
N1  - Unit for Anaesthesiological Investigations, Division of Anaesthesiology, Department of Anaesthesiology, Pharmacology, Intensive Care and Emergency Medicine, University Hospitals of Geneva and University of Geneva, Rue Willy Donzé 6, Geneva, 1205, Switzerland            
            Department of Internal Medicine, University Hospitals of Geneva, Geneva, Switzerland            
            Department of Medical Physics and Informatics, University of Szeged, Szeged, Hungary            
            Cited By :2            
            Export Date: 3 April 2023            
            Correspondence Address: Dos Santos Rocha, A.; Unit for Anaesthesiological Investigations, Rue Willy Donzé 6, Switzerland; email: andre.dossantosrocha@unige.ch            
            Funding details: Hôpitaux Universitaires de Genève, HUG            
            Funding text 1: This research work was funded internally by the Unit for Anaesthesiological Investigations, University Hospitals of Geneva.
AB  - Severe COVID-19-related acute respiratory distress syndrome (C-ARDS) requires mechanical ventilation. While this intervention is often performed in the prone position to improve oxygenation, the underlying mechanisms responsible for the improvement in respiratory function during invasive ventilation and awake prone positioning in C-ARDS have not yet been elucidated. In this prospective observational trial, we evaluated the respiratory function of C-ARDS patients while in the supine and prone positions during invasive (n = 13) or non-invasive ventilation (n = 15). The primary endpoint was the positional change in lung regional aeration, assessed with electrical impedance tomography. Secondary endpoints included parameters of ventilation and oxygenation, volumetric capnography, respiratory system mechanics and intrapulmonary shunt fraction. In comparison to the supine position, the prone position significantly increased ventilation distribution in dorsal lung zones for patients under invasive ventilation (53.3 ± 18.3% vs. 43.8 ± 12.3%, percentage of dorsal lung aeration ± standard deviation in prone and supine positions, respectively; p  = 0.014); whereas, regional aeration in both positions did not change during non-invasive ventilation (36.4 ± 11.4% vs. 33.7 ± 10.1%; p  = 0.43). Prone positioning significantly improved the oxygenation both during invasive and non-invasive ventilation. For invasively ventilated patients reduced intrapulmonary shunt fraction, ventilation dead space and respiratory resistance were observed in the prone position. Oxygenation is improved during non-invasive and invasive ventilation with prone positioning in patients with C-ARDS. Different mechanisms may underly this benefit during these two ventilation modalities, driven by improved distribution of lung regional aeration, intrapulmonary shunt fraction and ventilation-perfusion matching. However, the differences in the severity of C-ARDS may have biased the sensitivity of electrical impedance tomography when comparing positional changes between the protocol groups.
LA  - English
DB  - MTMT
ER  -