@article{MTMT:34554409,
	title = {Respiratory effects of pressure support ventilation in spontaneously breathing patients under anaesthesia: Randomised controlled trial},
	url = {https://m2.mtmt.hu/api/publication/34554409},
	author = {Sudy, Roberta and Dereu, Domitille and Lin, Na and Pichon, Isabelle and Peták, Ferenc and Habre, Walid and Albu, Gergely},
	doi = {10.1111/aas.14350},
	journal-iso = {ACTA ANAESTH SCAND},
	journal = {ACTA ANAESTHESIOLOGICA SCANDINAVICA},
	volume = {68},
	unique-id = {34554409},
	issn = {0001-5172},
	year = {2024},
	eissn = {1399-6576},
	pages = {311-320},
	orcid-numbers = {Sudy, Roberta/0000-0003-0080-7616; Peták, Ferenc/0000-0001-6249-9327; Albu, Gergely/0000-0002-7508-8567}
}

@article{MTMT:34504307,
	title = {Changes in lung mechanics and ventilation-perfusion match: comparison of pulmonary air- and thromboembolism in rats},
	url = {https://m2.mtmt.hu/api/publication/34504307},
	author = {Tolnai, József and Ballók, Bence and Südy, Roberta and Schranc, Álmos István and Varga, Gabriella and Babik, Barna and Fodor, Gergely and Peták, Ferenc},
	doi = {10.1186/s12890-024-02842-z},
	journal-iso = {BMC PULM MED},
	journal = {BMC PULMONARY MEDICINE},
	volume = {24},
	unique-id = {34504307},
	issn = {1471-2466},
	year = {2024},
	eissn = {1471-2466},
	orcid-numbers = {Tolnai, József/0000-0002-7648-764X; Ballók, Bence/0000-0002-6423-9796; Varga, Gabriella/0000-0003-1888-8629; Babik, Barna/0000-0003-3739-8879; Fodor, Gergely/0000-0002-4736-4966; Peták, Ferenc/0000-0001-6249-9327}
}

@book{MTMT:34446677,
	title = {2023. évi Orvos- és Egészségtudományi TDK Konferencia},
	url = {https://m2.mtmt.hu/api/publication/34446677},
	isbn = {9789633069592},
	editor = {Tolnai, József and Peták, Ferenc and Fodor, Gergely and Rakonczay, Zoltán},
	publisher = {Universití of Szeged},
	unique-id = {34446677},
	year = {2023},
	orcid-numbers = {Tolnai, József/0000-0002-7648-764X; Peták, Ferenc/0000-0001-6249-9327; Fodor, Gergely/0000-0002-4736-4966; Rakonczay, Zoltán/0000-0002-1499-3416}
}

@article{MTMT:34444978,
	title = {Post-COVID changes in lung function 6 months after veno-venous extracorporeal membrane oxygenation: a prospective observational clinical trial},
	url = {https://m2.mtmt.hu/api/publication/34444978},
	author = {Pálfi, Alexandra and Balogh, Ádám László and Polónyi, Gabriella and Schulcz, Domonkos and Zöllei, Éva and Bari, Gábor and Fodor, Gergely and Barath, Kristóf and Somfay, Attila and Peták, Ferenc and Babik, Barna},
	doi = {10.3389/fmed.2023.1288679},
	journal-iso = {FRONT MED},
	journal = {FRONTIERS IN MEDICINE},
	volume = {10},
	unique-id = {34444978},
	abstract = {<sec>BackgroundSevere coronavirus disease 2019 (COVID-19) may require veno-venous extracorporeal membrane oxygenation (V-V ECMO). While V-V ECMO is offered in severe lung injury to COVID-19, long-term respiratory follow-up in these patients is missing. Therefore, we aimed at providing comprehensive data on the long-term respiratory effects of COVID-19 requiring V-V ECMO support during the acute phase of infection.</sec><sec>MethodsIn prospective observational cohort study design, patients with severe COVID-19 receiving invasive mechanical ventilation and V-V ECMO (COVID group, n = 9) and healthy matched controls (n = 9) were evaluated 6 months after hospital discharge. Respiratory system resistance at 5 and 19 Hz (R5, R19), and the area under the reactance curve (AX5) was evaluated using oscillometry characterizing total and central airway resistances, and tissue elasticity, respectively. R5 and R19 difference (R5–R19) reflecting small airway function was also calculated. Forced expired volume in seconds (FEV1), forced expiratory vital capacity (FVC), functional residual capacity (FRC), carbon monoxide diffusion capacity (DLCO) and transfer coefficient (KCO) were measured.</sec><sec>ResultsThe COVID group had a higher AX5 and R5–R19 than the healthy matched control group. However, there was no significant difference in terms of R5 or R19. The COVID group had a lower FEV1 and FVC on spirometry than the healthy matched control group. Further, the COVID group had a lower FRC on plethysmography than the healthy matched control group. Meanwhile, the COVID group had a lower DLCO than healthy matched control group. Nevertheless, its KCO was within the normal range.</sec><sec>ConclusionSevere acute COVID-19 requiring V-V ECMO persistently impairs small airway function and reduces respiratory tissue elasticity, primarily attributed to lung restriction. These findings also suggest that even severe pulmonary pathologies of acute COVID-19 can manifest in a moderate but still persistent lung function impairment 6 months after hospital discharge.</sec><sec>Trial registrationNCT05812196.</sec>},
	year = {2023},
	eissn = {2296-858X},
	orcid-numbers = {Balogh, Ádám László/0000-0002-4386-9924; Fodor, Gergely/0000-0002-4736-4966; Somfay, Attila/0000-0001-5062-8152; Peták, Ferenc/0000-0001-6249-9327; Babik, Barna/0000-0003-3739-8879}
}

@article{MTMT:34145868,
	title = {Comparison of the respiratory effects of commonly utilized general anaesthesia regimes in male Sprague-Dawley rats},
	url = {https://m2.mtmt.hu/api/publication/34145868},
	author = {Ballók, Bence and Schranc, Álmos István and Tóth, Ibolya and Somogyi, Petra and Tolnai, József and Peták, Ferenc and Fodor, Gergely},
	doi = {10.3389/fphys.2023.1249127},
	journal-iso = {FRONT PHYSIOL},
	journal = {FRONTIERS IN PHYSIOLOGY},
	volume = {14},
	unique-id = {34145868},
	abstract = {Background: Respiratory parameters in experimental animals are often characterised under general anaesthesia. However, anaesthesia regimes may alter the functional and mechanical properties of the respiratory system. While most anaesthesia regimes have been shown to affect the respiratory system, the effects of general anaesthesia protocols commonly used in animal models on lung function have not been systematically compared.},
	year = {2023},
	eissn = {1664-042X},
	orcid-numbers = {Ballók, Bence/0000-0002-6423-9796; Tolnai, József/0000-0002-7648-764X; Peták, Ferenc/0000-0001-6249-9327; Fodor, Gergely/0000-0002-4736-4966}
}

@article{MTMT:34107238,
	title = {Lung recruitment by continuous negative extra-thoracic pressure support following one-lung ventilation: an experimental study},
	url = {https://m2.mtmt.hu/api/publication/34107238},
	author = {Schranc, Álmos István and Diaper, John and Südy, Roberta and Peták, Ferenc and Habre, Walid and Albu, Gergely},
	doi = {10.3389/fphys.2023.1160731},
	journal-iso = {FRONT PHYSIOL},
	journal = {FRONTIERS IN PHYSIOLOGY},
	volume = {14},
	unique-id = {34107238},
	abstract = {Lung recruitment maneuvers following one-lung ventilation (OLV) increase the risk for the development of acute lung injury. The application of continuous negative extrathoracic pressure (CNEP) is gaining interest both in intubated and non-intubated patients. However, there is still a lack of knowledge on the ability of CNEP support to recruit whole lung atelectasis following OLV. We investigated the effects of CNEP following OLV on lung expansion, gas exchange, and hemodynamics. Ten pigs were anesthetized and mechanically ventilated with pressure-regulated volume control mode (PRVC; FiO 2 : 0.5, Fr: 30–35/min, VT: 7 mL/kg, PEEP: 5 cmH 2 O) for 1 hour, then baseline (BL) data for gas exchange (arterial partial pressure of oxygen, PaO 2 ; and carbon dioxide, PaCO 2 ), ventilation and hemodynamical parameters and lung aeration by electrical impedance tomography were recorded. Subsequently, an endobronchial blocker was inserted, and OLV was applied with a reduced VT of 5 mL/kg. Following a new set of measurements after 1 h of OLV, two-lung ventilation was re-established, combining PRVC (VT: 7 mL/kg) and CNEP (−15 cmH 2 O) without any hyperinflation maneuver and data collection was then repeated at 5 min and 1 h. Compared to OLV, significant increases in PaO 2 (154.1 ± 13.3 vs. 173.8 ± 22.1) and decreases in PaCO 2 (52.6 ± 11.7 vs. 40.3 ± 4.5 mmHg, p < 0.05 for both) were observed 5 minutes following initiation of CNEP, and these benefits in gas exchange remained after an hour of CNEP. Gradual improvements in lung aeration in the non-collapsed lung were also detected by electrical impedance tomography ( p < 0.05) after 5 and 60 min of CNEP. Hemodynamics and ventilation parameters remained stable under CNEP. Application of CNEP in the presence of whole lung atelectasis proved to be efficient in improving gas exchange via recruiting the lung without excessive airway pressures. These benefits of combined CNEP and positive pressure ventilation may have particular value in relieving atelectasis in the postoperative period of surgical procedures requiring OLV.},
	year = {2023},
	eissn = {1664-042X},
	orcid-numbers = {Peták, Ferenc/0000-0001-6249-9327}
}

@article{MTMT:33841748,
	title = {Fractal dimension of pulmonary gas and blood distribution assessed by synchrotron K-edge subtraction imaging: effect of bronchoconstriction},
	url = {https://m2.mtmt.hu/api/publication/33841748},
	author = {Bayat, Sam and Degrugilliers, Loic and Porra, Liisa and Strengell, Satu and Peták, Ferenc and Habre, Walid},
	doi = {10.1152/japplphysiol.00051.2023},
	journal-iso = {J APPL PHYSIOL},
	journal = {JOURNAL OF APPLIED PHYSIOLOGY},
	volume = {134},
	unique-id = {33841748},
	issn = {8750-7587},
	abstract = {We analyzed the fractal dimension (Df) of lung gas and blood distribution imaged with synchrotron radiation K-edge subtraction (KES), in six anesthetized adult New Zealand White rabbits. KES imaging was performed in upright position during stable Xe gas (64% in O2) inhalation and iodine infusion (Iomeron, 350 mg/mL), respectively, at baseline and after induced bronchoconstriction by aerosolized methacholine (125 mg/mL, 90 s) and bronchodilator (salbutamol, 10 mg/mL, 90 s) inhalation, at two axial image levels. Lung Xe and iodine images were segmented, and maps of regional lung gas and blood fractions were computed. The Df of lung gas (DfXe) and blood (DfIodine) distribution was computed based on a log-log plot of variation coefficient as a function of region volume. DfXe decreased significantly during bronchoconstriction (P < 0.0001), and remained low after salbutamol. DfIodine depended on the axial image level (P < 0.0001), but did not change with bronchoconstriction. DfXe was significantly associated with arterial PaO2 (R = 0.67, P = 0.002), and negatively associated with PaCO2 (R = -0.62, P = 0.006), respiratory resistance (R = -0.58, P = 0.011), and elastance (R = -0.55, P = 0.023). These data demonstrate the reduced Df of gas distribution during acute bronchoconstriction, and the association of this parameter with physiologically meaningful variables. This finding suggests a decreased complexity and space -filling properties of lung ventilation during bronchoconstriction, and could serve as a functional imaging biomarker in obstructive airway diseases.NEW & NOTEWORTHY Here, we used an energy-subtractive imaging technique to assess the fractal dimension (Df) of lung gas and blood distribution and the effect of acute bronchoconstriction. We found that Df of gas significantly decreases in broncho-constriction. Conversely, Df of blood exhibits gravity-dependent changes only, and is not affected by acute bronchoconstriction. Our data show that the fractal dimension of lung gas detects the emergence of clustered rather than scattered loss of ventilatory units during bronchoconstriction.},
	keywords = {Asthma; computed tomography; Fractal dimension; lung ventilation; lung perfusion},
	year = {2023},
	eissn = {1522-1601},
	pages = {995-1003},
	orcid-numbers = {Peták, Ferenc/0000-0001-6249-9327}
}

@book{MTMT:33399502,
	title = {Szegedi Tudományegyetem - Szent-Györgyi Albert Orvostudományi Kar, Fogorvostudományi Kar, Gyógyszerésztudományi Kar és Egészségtudományi és Szociális Képzési Kar 2022. évi Tudományos Diákköri Konferenciája},
	url = {https://m2.mtmt.hu/api/publication/33399502},
	isbn = {9789633068908},
	editor = {Tolnai, József and Peták, Ferenc and Rakonczay, Zoltán},
	publisher = {SZTE},
	unique-id = {33399502},
	year = {2022},
	orcid-numbers = {Tolnai, József/0000-0002-7648-764X; Peták, Ferenc/0000-0001-6249-9327; Rakonczay, Zoltán/0000-0002-1499-3416}
}

@article{MTMT:33285576,
	title = {Sevoflurane and Hypercapnia Blunt the Physiological Variability of Spontaneous Breathing: A Comparative Interventional Study},
	url = {https://m2.mtmt.hu/api/publication/33285576},
	author = {Balogh, Ádám László and Südy, Roberta and Peták, Ferenc and Habre, Walid and Dos Santos Rocha, Andre},
	doi = {10.3389/fphys.2022.871070},
	journal-iso = {FRONT PHYSIOL},
	journal = {FRONTIERS IN PHYSIOLOGY},
	volume = {13},
	unique-id = {33285576},
	abstract = {Background: Although spontaneous breathing is known to exhibit substantial physiological fluctuation that contributes to alveolar recruitment, changes in the variability of the respiratory pattern following inhalation of carbon dioxide (CO 2 ) and volatile anesthetics have not been characterized. Therefore, we aimed at comparing the indices of breathing variability under wakefulness, sleep, hypercapnia and sedative and anesthetic concentrations of sevoflurane.},
	year = {2022},
	eissn = {1664-042X},
	orcid-numbers = {Balogh, Ádám László/0000-0002-4386-9924; Peták, Ferenc/0000-0001-6249-9327}
}

@article{MTMT:33285573,
	title = {Effect of body position on the redistribution of regional lung aeration during invasive and non-invasive ventilation of COVID-19 patients},
	url = {https://m2.mtmt.hu/api/publication/33285573},
	author = {Dos Santos Rocha, André and Diaper, John and Balogh, Ádám László and Marti, Christophe and Grosgurin, Olivier and Habre, Walid and Peták, Ferenc and Südy, Roberta},
	doi = {10.1038/s41598-022-15122-9},
	journal-iso = {SCI REP},
	journal = {SCIENTIFIC REPORTS},
	volume = {12},
	unique-id = {33285573},
	issn = {2045-2322},
	abstract = {Severe COVID-19-related acute respiratory distress syndrome (C-ARDS) requires mechanical ventilation. While this intervention is often performed in the prone position to improve oxygenation, the underlying mechanisms responsible for the improvement in respiratory function during invasive ventilation and awake prone positioning in C-ARDS have not yet been elucidated. In this prospective observational trial, we evaluated the respiratory function of C-ARDS patients while in the supine and prone positions during invasive (n = 13) or non-invasive ventilation (n = 15). The primary endpoint was the positional change in lung regional aeration, assessed with electrical impedance tomography. Secondary endpoints included parameters of ventilation and oxygenation, volumetric capnography, respiratory system mechanics and intrapulmonary shunt fraction. In comparison to the supine position, the prone position significantly increased ventilation distribution in dorsal lung zones for patients under invasive ventilation (53.3 ± 18.3% vs. 43.8 ± 12.3%, percentage of dorsal lung aeration ± standard deviation in prone and supine positions, respectively; p  = 0.014); whereas, regional aeration in both positions did not change during non-invasive ventilation (36.4 ± 11.4% vs. 33.7 ± 10.1%; p  = 0.43). Prone positioning significantly improved the oxygenation both during invasive and non-invasive ventilation. For invasively ventilated patients reduced intrapulmonary shunt fraction, ventilation dead space and respiratory resistance were observed in the prone position. Oxygenation is improved during non-invasive and invasive ventilation with prone positioning in patients with C-ARDS. Different mechanisms may underly this benefit during these two ventilation modalities, driven by improved distribution of lung regional aeration, intrapulmonary shunt fraction and ventilation-perfusion matching. However, the differences in the severity of C-ARDS may have biased the sensitivity of electrical impedance tomography when comparing positional changes between the protocol groups.},
	year = {2022},
	eissn = {2045-2322},
	orcid-numbers = {Balogh, Ádám László/0000-0002-4386-9924; Peták, Ferenc/0000-0001-6249-9327}
}