@article{MTMT:35483819, title = {Systematic analysis and network mapping of disease associations in autoimmune polyglandular syndrome.}, url = {https://m2.mtmt.hu/api/publication/35483819}, author = {Pham-Dobor, Gréta and Kaltenecker, Péter and Temesfői, Viktória and Bajnok, László Zoltán and Nemes, Orsolya and Bódis, Beáta and Mezősi, Emese}, doi = {10.1210/clinem/dgae701}, journal-iso = {J CLIN ENDOCR METAB}, journal = {JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM}, volume = {110}, unique-id = {35483819}, issn = {0021-972X}, abstract = {The purpose of our work was to provide a data-driven perspective to APS, a complex autoimmune disorder, supplementing traditional clinical observations.Medical records of 7559 patients were analyzed, autoimmune origin was proved in 3180 cases of which 380 (12%) had APS. Associations of component disorders were investigated by computational methods to reveal typical patterns of disease development.Twenty-eight distinct autoimmune disorders were diagnosed forming 113 combinations. The 10 most frequent combinations were responsible for 51,3% of cases. HT and GD were differentiated as main cornerstones of APS, sharing several comorbidities. HT was the most common manifestation (67.4%), followed by GD (26.8%) and T1D (20.8%). APS started significantly earlier in men than in women. Thyroid autoimmunity was frequently linked to gastrointestinal and systemic manifestations and these patterns of associations substantially differed from that of T1D, AD or CeD when present as first manifestations, suggesting the possibility of a common biological cause.APS is more frequent than reported. Classifying APS requires a shift of perspective towards disease associations rather than disorder prevalence.}, keywords = {Diabetes; network mapping; systemic analysis; autoimmune polyglandular syndrome; autoimmune thyroid disorders; Multiple autoimmune syndromes; autoimmunities}, year = {2025}, eissn = {1945-7197}, pages = {1716-1728}, orcid-numbers = {Temesfői, Viktória/0000-0002-2990-6258; Mezősi, Emese/0000-0001-9367-3877} } @article{MTMT:35650667, title = {Current legal standpoint on surrogacy in Hungary}, url = {https://m2.mtmt.hu/api/publication/35650667}, author = {Farkas, Bálint and Kolumbán, Szilárd-Szilamér and Papp, Kata Szilvia and Fazekas, Gábor and Kovács, Kálmán András and Bódis, József}, doi = {10.1007/s10815-024-03361-w}, journal-iso = {J ASSIST REPROD GEN}, journal = {JOURNAL OF ASSISTED REPRODUCTION AND GENETICS}, volume = {42}, unique-id = {35650667}, issn = {1058-0468}, year = {2025}, eissn = {1573-7330}, orcid-numbers = {Farkas, Bálint/0000-0003-0638-2057} } @article{MTMT:35737507, title = {Interaction between breastfeeding duration and an obesity genetic risk score to predict body fat composition in European adolescents: The HELENA study}, url = {https://m2.mtmt.hu/api/publication/35737507}, author = {Baxevanis, Georgios K. and Iglesia, Iris and Seral‐Cortes, Miguel and Sabroso‐Lasa, Sergio and Flores‐Barrantes, Paloma and Gottrand, Frédéric and Meirhaeghe, Aline and Kafatos, Anthony and Widhalm, Kurt and Hockamp, Nele and Molnár, Dénes and Marcos, Ascensión and Nova, Esther and González‐Gross, Marcela and Gesteiro, Eva and Gutiérrez, Ángel and Manios, Yannis and Anastasiou, Costas A. and Rodríguez, Gerardo and Moreno, Luis A.}, doi = {10.1111/ijpo.13205}, journal-iso = {PED OBES}, journal = {PEDIATRIC OBESITY}, volume = {20}, unique-id = {35737507}, issn = {2047-6302}, year = {2025}, eissn = {2047-6310}, orcid-numbers = {Baxevanis, Georgios K./0009-0004-7018-6805; Iglesia, Iris/0000-0002-2219-3646; Seral‐Cortes, Miguel/0000-0003-2198-2704; Molnár, Dénes/0000-0002-3675-7019; Anastasiou, Costas A./0000-0002-3536-3034; Moreno, Luis A./0000-0003-0454-653X} } @article{MTMT:35752662, title = {Follicular Fluid Vanin-1 Levels in Patients Undergoing Ivf: A Preliminary Study}, url = {https://m2.mtmt.hu/api/publication/35752662}, author = {Várnagy, Ákos and Mauchart, Péter and Nagy, Gábor and Bódis, József and Sulyok, Endre}, doi = {10.3390/antiox14020133}, journal-iso = {ANTIOXIDANTS-BASEL}, journal = {ANTIOXIDANTS}, volume = {14}, unique-id = {35752662}, abstract = {This preliminary study was designed to determine follicular fluid (FF) vanin-1 levels, to assess their relation to serum vanin-1 and to reveal their potential to predict the outcome of in vitro fertilization (IVF). Eighteen unselected, consecutive women undergoing IVF were included. Serum and pooled FF samples were obtained simultaneously during routine IVF procedures. Vanin-1 levels were measured by using commercially available ELISA kits. As most of the values were below 0.6 ng/mL, the data are given as optical density. It was found that vanin-1 can be detected in FF and that it is not significantly related to its maternal serum levels (p = 0.06). FF vanin-1 levels proved to be higher in non-pregnant as compared to pregnant women (p < 0.04). There are significant positive relationships between the FF to serum vanin-1 ratio and body mass index (BMI, p < 0.02), anti-Müllerian hormone (AMH, p < 0.02) and baseline serum estradiol (p < 0.01). Moreover, the FF/serum vanin-1 ratio tended to increase with cumulative FSH dose, but this increase did not reach statistical significance (p = 0.064). It may be concluded that FF vanin-1 may serve as a biomarker to predict IVF outcome. To confirm this contention, further studies are to be performed.}, year = {2025}, eissn = {2076-3921}, orcid-numbers = {Nagy, Gábor/0000-0002-2943-2750} } @article{MTMT:35778437, title = {A méhátültetés céljából történő szervkivétel sebészi lépései agyhalott donor esetében}, url = {https://m2.mtmt.hu/api/publication/35778437}, author = {Farkas, Bálint and Kovács, Kálmán András and Kolumbán, Szilárd-Szilamér and Papp, Kata Szilvia and Márton, Zsombor and Bódis, József and Fazekas, Gábor}, doi = {10.1556/650.2025.33247}, journal-iso = {ORV HETIL}, journal = {ORVOSI HETILAP}, volume = {166}, unique-id = {35778437}, issn = {0030-6002}, abstract = {Bevezetés: Az abszolút méheredetű infertilitás új sebészi kezelési módszere az uterustranszplantáció. A humán agyha- lott donoros méhátültetésre való felkészülés jegyében kadáverműtéteket végeztünk. Célkitűzés: A műtétek célja az anatómiai képletek azonosítása, a graftkivétel lépéseinek demonstrálása és a szakmai stáb csapatként való munkájának gyakorlása volt. Módszer: Etikai engedély birtokában, a kegyeleti és a személyes jogok tiszteletben tartásával, kadávereken az uretert a kismedencébe való belépésétől kipreparáltuk, az arteria és vena iliaca interna mellső (visceralis) és hátsó (fali) ágcso- portját felkerestük, lekötöttük és átvágtuk a parametrium vascularis kötegeinek épen tartásával, majd hosszú hüvely- mandzsettával együtt hysterectomiát végeztünk. Eredmények: A műtétet 3 esetből 3-ban sikeresnek minősítettük, mivel sikerült az uterust kétoldali intakt parametri- ummal és ép vasculaturával eltávolítani. Megbeszélés: Az uterustranszplantáció során a graft élő és agyhalott donorból származhat. Mindkét beavatkozásnak számos előnye és hátránya is van. Jelenleg tudományos vita tárgyát képezi, hogy melyik a preferált szervkivételi mód- szer, de mindenesetre a megfelelő felkészülés és gyakorlás kadáveren elengedhetetlen. Következtetés: A kadáverműtéteket alkalmasnak tartjuk és ajánljuk a humán agyhalott donoros méheltávolításra való felkészülés céljából. | Introduction: A new surgical treatment method for absolute uterine infertility is uterus transplantation. We per- formed cadaver surgeries in preparation for human deceased donor uterus transplantation. Objective: The objective of the surgeries was to identify anatomical structures, to demonstrate the steps of graft re- trieval, and to practice the collaboration of the medical staff as a team. Method: With the approval of the ethical committee, respecting the mercy and personal rights of the deceased, we dissected the ureter from its entry into the minor pelvis, also dissected the parietal and visceral branches of the inter- nal iliac artery and vein, then clamped and cut them, while keeping the vascular bundles of the parametrium intact. Finally, a hysterectomy was performed along with the long vaginal cuff. Results: The operation was successful in 3 out of 3 cases, as it was possible to remove the uterus with bilaterally intact parametrium and intact vasculature. Discussion: During uterus transplantation, the graft can originate from a living or deceased (brain-dead) donor. Both interventions have many advantages and disadvantages. Currently, it is a matter of scientific debate which is the pre- ferred method of organ removal, but in any case, proper preparation and practice are essential. Conclusion: We consider and recommend cadaver surgeries as it is suitable for preparation for human brain-dead donor uterus transplantation.}, year = {2025}, eissn = {1788-6120}, pages = {385-391}, orcid-numbers = {Farkas, Bálint/0000-0003-0638-2057} } @article{MTMT:35780627, title = {Effects of light exposure during IVF: transcriptomic analysis of murine embryos and embryo-derived EVs}, url = {https://m2.mtmt.hu/api/publication/35780627}, author = {Nagy, Bence Péter and Bognár, Zoltán and Csabai-Tanics, Tímea Judith and Fekete, Nóra and Buzás, Edit Irén and Kovács, Árpád Ferenc and Szekeres, Júlia and Pállinger, Éva}, doi = {10.3389/fimmu.2025.1429252}, journal-iso = {FRONT IMMUNOL}, journal = {FRONTIERS IN IMMUNOLOGY}, volume = {16}, unique-id = {35780627}, issn = {1664-3224}, year = {2025}, eissn = {1664-3224}, orcid-numbers = {Buzás, Edit Irén/0000-0002-3744-206X; Kovács, Árpád Ferenc/0000-0002-7742-160X; Pállinger, Éva/0000-0002-5789-0951} } @article{MTMT:35808205, title = {Endocrine and Metabolic Effects of Nutrition in Children and Adolescents.}, url = {https://m2.mtmt.hu/api/publication/35808205}, author = {Erhardt, Éva and Molnár, Dénes}, doi = {10.3390/nu17040707}, journal-iso = {NUTRIENTS}, journal = {NUTRIENTS}, volume = {17}, unique-id = {35808205}, abstract = {Child health is a cornerstone of social well-being, and nutrition plays a crucial role in shaping the growth and development of young individuals [...].}, year = {2025}, eissn = {2072-6643}, orcid-numbers = {Molnár, Dénes/0000-0002-3675-7019} } @article{MTMT:35844371, title = {The Efficacy of Soleus Push-Up in Individuals with Prediabetes: A Pilot Study}, url = {https://m2.mtmt.hu/api/publication/35844371}, author = {Elek, Dávid and Tóth, Miklós and Sonkodi, Balázs and Ács, Pongrác and Kovács, L. Gábor and Tardi, Péter and Melczer, Csaba}, doi = {10.3390/sports13030081}, journal-iso = {SPORTS}, journal = {SPORTS}, volume = {13}, unique-id = {35844371}, issn = {2075-4663}, year = {2025}, eissn = {2075-4663}, orcid-numbers = {Ács, Pongrác/0000-0002-4999-7345; Kovács, L. Gábor/0000-0001-5298-5401; Tardi, Péter/0000-0002-5091-7373; Melczer, Csaba/0000-0002-8197-0572} } @article{MTMT:35909651, title = {Epidemiological disease burden and annual, nationwide health insurance treatment cost of female infertility based on real-world health insurance claims data in Hungary.}, url = {https://m2.mtmt.hu/api/publication/35909651}, author = {Pónusz-Kovács, Dalma and Csákvári, Tímea and Sántics-Kajos, Luca Fanni and Elmer, Diána and Pónusz, Róbert and Kovács, Bettina and Várnagy, Ákos and Kovács, Kálmán András and Bódis, József and Boncz, Imre}, doi = {10.1186/s12913-025-12348-x}, journal-iso = {BMC HEALTH SERV RES}, journal = {BMC HEALTH SERVICES RESEARCH}, volume = {25}, unique-id = {35909651}, issn = {1472-6963}, abstract = {Infertility affects more than 50 million couples worldwide, resulting in a significant burden on individuals and society. Its prevalence ranges from 8-12% among developed countries. The growing number of patients poses an increasing challenge to the healthcare system and its funding. Our quantitative, descriptive, and cross-sectional study aimed to analyze the prevalence and annual nationwide health insurance treatment cost of female infertility in Hungary in 2019.We used claims data obtained from the Hungarian National Health Insurance Fund Administration (NHFIA). The number of patients, total and age-specific prevalence, annual health insurance expenditure, and the distribution of costs by age group were evaluated. Infertility was determined according to the World Health Organization International Classification of Diseases codes (N.97.0, N97.1, N97.2, N97.3, N97.4, N97.8, and N97.9) and the utilization of each healthcare service type. During the study descriptive statistics, correlation analysis and t-test were used.In 2019, the NHIFA spent a total of 7.2 billion HUF (22.2 million EUR) on female infertility treatment in Hungary (33,151 women in outpatient care). The most significant costs were related to inpatient care (4.1 billion HUF, 12.7 million EUR). The highest number of patients and prevalence (650.4 per 100,000 women) were found in outpatient care. In inpatient care, the prevalence is substantially lower (206.7 per 100,000 women). Regardless of its type, female infertility mainly affects patients in the 30-39 years age group (number of patients: 18,156 women). The average annual health insurance expenditure per capita was 1,083 EUR.Reproductive health education, prevention, and medical screening play inevitable roles in the early stages of reproductive life to reduce the risk of infertility and decrease treatment costs.}, keywords = {PREVALENCE; Hungary; EPIDEMIOLOGY; cost; female infertility}, year = {2025}, eissn = {1472-6963}, orcid-numbers = {Csákvári, Tímea/0000-0002-3339-4953; Sántics-Kajos, Luca Fanni/0000-0002-0574-5787; Kovács, Bettina/0009-0002-7548-1278; Boncz, Imre/0000-0003-3699-6236} } @article{MTMT:36011950, title = {Hungarian Translation and Validation of the Pelvic Organ Prolapse Symptom Score.}, url = {https://m2.mtmt.hu/api/publication/36011950}, author = {Kolumbán, Szilárd-Szilamér and Borbásné Farkas, Kornélia and Tiringer, István and Kovács, Kálmán András and Nemeth, Zoltan and Farkas, Bálint}, doi = {10.1007/s00192-025-06090-5}, journal-iso = {INT UROGYNECOL J}, journal = {INTERNATIONAL UROGYNECOLOGY JOURNAL}, unique-id = {36011950}, issn = {0937-3462}, abstract = {Pelvic organ prolapse (POP) significantly affects women's quality of life, making the availability of validated, culturally adapted tools for reliable symptom evaluation essential. In this study, the Pelvic Organ Prolapse Symptom Score (POP-SS) was translated into Hungarian and validated, with the assessment of its psychometric properties for clinical and research use.In total, 125 women diagnosed with symptomatic POP (Pelvic Organ Prolapse Quantification Score-POP-Q stage ≥ 2) completed the Hungarian POP-SS (POP-SS-H), the Hungarian version of the Australian Pelvic Floor Questionnaire (AFPQ-H), and the short version of the World Health Organization Quality of Life questionnaire (WHOQOL-BREF). Exploratory factor analysis was performed, McDonald's ω was used to assess internal consistency, and intraclass correlation coefficients (ICCs) were used to examine test-retest reliability over a 2-week interval.The POP-SS-H demonstrated strong psychometric properties (overall ICC = 0.96, p < 0.001). Item ICCs were 0.69-0.99, with "difficulty in emptying the bladder" being the most stable. The scale has a two-factor ("prolapse and urinary distress" and "abdominal strain and bowel discomfort") structure. McDonald's ω was 0.75, confirming its good internal consistency. The scale's convergent validity was demonstrated through correlations with AFPQ-H and WHOQOL-BREF subscale scores.The POP-SS-H is a reliable and valid instrument for the assessment of prolapse-related symptoms. Its high degrees of test-retest reliability and internal consistency make it suitable for clinical follow-up and research. The tool addresses a significant gap in pelvic-floor disorder management in Hungary, although further research is recommended to assess its sensitivity in the tracking of symptom changes after treatment.}, keywords = {ADAPTATION; Quality of Life; Hungarian; Screening questionnaire; urogynecology; Pelvic organ prolapse Symptoms}, year = {2025}, eissn = {1433-3023}, orcid-numbers = {Borbásné Farkas, Kornélia/0000-0002-5349-6527; Farkas, Bálint/0000-0003-0638-2057} }