@article{MTMT:34878193,
	title = {Annual epidemiological and health insurance disease burden of hip osteoarthritis in Hungary based on nationwide data},
	url = {https://m2.mtmt.hu/api/publication/34878193},
	author = {Kajos, Luca Fanni and Molics, Bálint and Elmer, Diána and Pónusz-Kovács, Dalma and Kovács, Bettina and Horváth, Lilla Anita and Csákvári, Tímea and Bódis, József and Boncz, Imre},
	doi = {10.1186/s12891-024-07513-y},
	journal-iso = {BMC MUSCULOSKEL DIS},
	journal = {BMC MUSCULOSKELETAL DISORDERS},
	volume = {25},
	unique-id = {34878193},
	issn = {1471-2474},
	abstract = {Health services utilization related to hip osteoarthritis imposes a significant burden on society and health care systems. Our aim was to analyse the epidemiological and health insurance disease burden of hip osteoarthritis in Hungary based on nationwide data.Data were extracted from the nationwide financial database of the National Health Insurance Fund Administration (NHIFA) of Hungary for the year 2018. The analysed data included annual patient numbers, prevalence, and age-standardized prevalence per 100,000 population in outpatient care, health insurance costs calculated for age groups and sexes for all types of care. Patients with hip osteoarthritis were identified using code M16 of the International Classification of Diseases (ICD), 10th revision. Age-standardised prevalence rates were calculated using the European Standard Population 2013 (ESP2013).Based on patient numbers of outpatient care, the prevalence per 100,000 among males was 1,483.7 patients (1.5%), among females 2,905.5 (2.9%), in total 2,226.2 patients (2.2%). The age-standardised prevalence was 1,734.8 (1.7%) for males and 2,594.8 (2.6%) for females per 100,000 population, for a total of 2,237.6 (2.2%). The prevalence per 100,000 population was higher for women in all age groups. In age group 30-39, 40-49, 50-59, 60-69 and 70 + the overall prevalence was 0.2%, 0.8%, 2.7%, 5.0% and 7.7%, respectively, describing a continuously increasing trend. In 2018, the NHIFA spent 42.31 million EUR on the treatment of hip osteoarthritis. Hip osteoarthritis accounts for 1% of total nationwide health insurance expenditures. 36.8% of costs were attributed to the treatment of male patients, and 63.2% to female patients. Acute inpatient care, outpatient care and chronic and rehabilitation inpatient care were the main cost drivers, accounting for 62.7%, 14.6% and 8.2% of the total health care expenditure for men, and 51.0%, 20.0% and 11.2% for women, respectively. The average annual treatment cost per patient was 3,627 EUR for men and 4,194 EUR for women.The prevalence of hip osteoarthritis was 1.96 times higher (the age-standardised prevalence was 1.5 times higher) in women compared to men. Acute inpatient care was the major cost driver in the treatment of hip osteoarthritis. The average annual treatment cost per patient was 15.6% higher for women compared to men.},
	keywords = {health insurance; outpatient care; hip osteoarthritis; DISEASE BURDEN; Financing; Acute inpatient care},
	year = {2024},
	eissn = {1471-2474},
	orcid-numbers = {Kajos, Luca Fanni/0000-0002-0574-5787; Csákvári, Tímea/0000-0002-3339-4953; Boncz, Imre/0000-0003-3699-6236}
}

@mastersthesis{MTMT:34840372,
	title = {A diabetes mellitus és a táplálkozási szokások egészségbiztosítási és egészség-gazdaságtani összefüggései},
	url = {https://m2.mtmt.hu/api/publication/34840372},
	author = {Csákvári, Tímea},
	unique-id = {34840372},
	year = {2024},
	orcid-numbers = {Csákvári, Tímea/0000-0002-3339-4953}
}

@article{MTMT:34836452,
	title = {Comparative analysis of the quality of life regarding patients who underwent hip replacement in public versus private hospitals in Hungary},
	url = {https://m2.mtmt.hu/api/publication/34836452},
	author = {Kajos, Luca Fanni and Molics, Bálint and Than, Péter and Gőbel, Gyula and Elmer, Diána and Pónusz-Kovács, Dalma and Csákvári, Tímea and Kovács, Bettina and Horváth, Lilla Anita and Bódis, József and Boncz, Imre},
	doi = {10.1038/s41598-024-60720-4},
	journal-iso = {SCI REP},
	journal = {SCIENTIFIC REPORTS},
	volume = {14},
	unique-id = {34836452},
	issn = {2045-2322},
	abstract = {The study aimed to investigate the impact of hip replacement surgery on the quality of life and to compare the outcomes by sociodemographic and surgical data in Hungarian public and private hospitals. Patients were selected at the Department of Orthopaedics (Clinical Centre, University of Pécs) and at the Da Vinci Private Clinic in Pécs. Patients completed the SF-36 and Oxford Hip Score (OHS) questionnaires before the surgery, 6 weeks and 3 months later. We also evaluated socio-demographic data, disease and surgical conditions. The research involved 128 patients, 60 patients in public, 68 patients in private hospital. Despite the different sociodemographic characteristics and surgical outcomes of public and private healthcare patients, both groups had significantly improved the quality of life 3 months after hip replacement surgery measured by OHS and SF-36 physical health scores (p < 0.001). In the mental health score, only the patients of the private health sector showed a significant improvement (p < 0.001). The extent of improvement did not differ between the two healthcare sectors according to the OHS questionnaire (p = 0.985). While the SF-36 physical health score showed a higher improvement for public patients (p = 0.027), the mental health score showed a higher improvement for private patients (p = 0.015).},
	keywords = {Hungary; Quality of Life; Hip replacement; SF-36; OHS; Public and private hospital},
	year = {2024},
	eissn = {2045-2322},
	orcid-numbers = {Kajos, Luca Fanni/0000-0002-0574-5787; Csákvári, Tímea/0000-0002-3339-4953; Boncz, Imre/0000-0003-3699-6236}
}

@article{MTMT:34796888,
	title = {Decidual γδT cells of early human pregnancy produce angiogenic and immunomodulatory proteins while also possessing cytotoxic potential},
	url = {https://m2.mtmt.hu/api/publication/34796888},
	author = {Nörenberg, Jasper Maximilian and Vida, P. and Bösmeier, I. and Forró, B. and Nörenberg, A. and Buda, Á. and Simon, Diána and Erdő-Bonyár, Szabina and Jáksó, Pál and Kovács, Kálmán András and Mikó, Éva and Berki, Tímea and Mezősi, Emese and Barakonyi, Alíz},
	doi = {10.3389/fimmu.2024.1382424},
	journal-iso = {FRONT IMMUNOL},
	journal = {FRONTIERS IN IMMUNOLOGY},
	volume = {15},
	unique-id = {34796888},
	issn = {1664-3224},
	year = {2024},
	eissn = {1664-3224},
	orcid-numbers = {Berki, Tímea/0000-0002-0134-8127; Mezősi, Emese/0000-0001-9367-3877}
}

@article{MTMT:34763514,
	title = {Clinical Benefits of Decreased Photo-Oxidative Stress on Human Embryo Development},
	url = {https://m2.mtmt.hu/api/publication/34763514},
	author = {Gödöny, Krisztina and Herczeg, Róbert and Gyenesei, Attila and Várnagy, Ákos and Bognár, Zoltán and Kovács, L. Gábor and Szekeres, Júlia and Mauchart, Péter and Nagy, Bernadett and Erostyák, János and Kovács, Kálmán András and Bódis, József},
	doi = {10.1159/000536358},
	journal-iso = {MED PRIN PRACT},
	journal = {MEDICAL PRINCIPLES AND PRACTICE},
	volume = {33},
	unique-id = {34763514},
	issn = {1011-7571},
	abstract = {<b><i>Objective:</i></b> Early embryonic development is characterized by rapid cell division and gene activation, making the embryo extremely sensitive to environmental influences. Light exposure can affect embryonic development through a direct toxic effect on the embryo via the generation of reactive oxygen species. In a previous study, we demonstrated the positive effect of improved light-protected embryo culture conditions implemented in our laboratory. This study aimed to investigate the changes in human embryo development under light protection during the conventional in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI). <b><i>Materials and Methods:</i></b> We tested the potential beneficial effect of light filters to reduce the risk of toxic effects of light. IVF outcomes were compared between two experimental conditions, light protection with red light filters versus no light protection as a control. <b><i>Results:</i></b> Blastocyst development rate in IVF was significantly higher in the light-protected group than in the group treated under conventional conditions (46.6 vs. 26.7%). In the case of ICSI, we obtained a similar result (44.5 vs. 31.6%). The rate of cryopreservation with at least one embryo was higher in the light-protected phase (32.8%) than in the conventionally manipulated phase (26.8%). The abortion rate was also significantly lower during the light-protected period in IVF, resulting in a higher live birth rate. <b><i>Conclusions:</i></b> The implementation of light protection to reduce the embryotoxic wavelengths of light in IVF centers may improve the blastocyst development rate and embryo quality while maintaining embryo safety.},
	keywords = {blastocyst; abortion; intracytoplasmic sperm injection; In vitro fertilization; Live birth rate; light protection},
	year = {2024},
	eissn = {1423-0151},
	pages = {112-121},
	orcid-numbers = {Herczeg, Róbert/0000-0002-5903-0082; Kovács, L. Gábor/0000-0001-5298-5401}
}

@article{MTMT:34753763,
	title = {An Alternative Application of Magnetic-Activated Cell Sorting: CD45 and CD235a Based Purification of Semen and Testicular Tissue Samples},
	url = {https://m2.mtmt.hu/api/publication/34753763},
	author = {Czétány, Péter and Balló, András and Márk, László and Török, Attila and Szántó, Árpád László and Máté, Gábor},
	doi = {10.3390/ijms25073627},
	journal-iso = {INT J MOL SCI},
	journal = {INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES},
	volume = {25},
	unique-id = {34753763},
	issn = {1661-6596},
	abstract = {Magnetic activated cell sorting (MACS) is a well-known sperm selection technique, which is able to remove apoptotic spermatozoa from semen samples using the classic annexinV based method. Leukocytes and erythrocytes in semen samples or in testicular tissue processed for in vitro fertilization (IVF) could exert detrimental effects on sperm. In the current study, we rethought the aforementioned technique and used magnetic microbeads conjugated with anti-CD45/CD235a antibodies to eliminate contaminating leukocytes and erythrocytes from leukocytospermic semen samples and testicular tissue samples gained via testicular sperm extraction (TESE). With this technique, a 15.7- and a 30.8-fold reduction could be achieved in the ratio of leukocytes in semen and in the number of erythrocytes in TESE samples, respectively. Our results show that MACS is a method worth to reconsider, with more potential alternative applications. Investigations to find molecules labeling high-quality sperm population and the development of positive selection procedures based on these might be a direction of future research.},
	year = {2024},
	eissn = {1422-0067},
	orcid-numbers = {Márk, László/0000-0002-9301-8159}
}

@article{MTMT:34729560,
	title = {Dietary nutrients during gestation cause obesity and related metabolic changes by altering DNA methylation in the offspring},
	url = {https://m2.mtmt.hu/api/publication/34729560},
	author = {Bokor, Szilvia and Csölle, Ildikó and Heidinger-Felső, Regina and Vass, Réka Anna and Funke Kiss, Simone and Ertl, Tibor and Molnár, Dénes},
	doi = {10.3389/fendo.2024.1287255},
	journal-iso = {FRONT ENDOCRINOL},
	journal = {FRONTIERS IN ENDOCRINOLOGY},
	volume = {15},
	unique-id = {34729560},
	issn = {1664-2392},
	abstract = {Growing evidence shows that maternal nutrition from preconception until lactation has an important effect on the development of non-communicable diseases in the offspring. Biological responses to environmental stress during pregnancy, including undernutrition or overnutrition of various nutrients, are transmitted in part by DNA methylation. The aim of the present narrative review is to summarize literature data on altered DNA methylation patterns caused by maternal macronutrient or vitamin intake and its association with offspring's phenotype (obesity and related metabolic changes). With our literature search, we found evidence for the association between alterations in DNA methylation pattern of different genes caused by maternal under- or overnutrition of several nutrients (protein, fructose, fat, vitamin D, methyl-group donor nutrients) during 3 critical periods of programming (preconception, pregnancy, lactation) and the development of obesity or related metabolic changes (glucose, insulin, lipid, leptin, adiponectin levels, blood pressure, non-alcoholic fatty liver disease) in offspring. The review highlights that maternal consumption of several nutrients could individually affect the development of offspring's obesity and related metabolic changes via alterations in DNA methylation.},
	keywords = {OBESITY; NUTRITION; metabolic syndrome; DNA methylation; epigenetic; Maternal},
	year = {2024},
	eissn = {1664-2392},
	orcid-numbers = {Vass, Réka Anna/0000-0002-0436-4261; Molnár, Dénes/0000-0002-3675-7019}
}

@inbook{MTMT:34724072,
	title = {A fizikai aktivitás összefüggése a mentális egészséggel a BMI tükrében az asszisztált reprodukciós kezelések során},
	url = {https://m2.mtmt.hu/api/publication/34724072},
	author = {Kovács, R and Skriba, Eszter and Szmatona, Gábor and Tándor, Zoltán and Prémusz, Viktória},
	booktitle = {Jubileumi tanulmánykötet: A Pécsi Tudományegyetem Egészségtudományi Kar Egészségtudományi Szakkollégium alapításának 10. évfordulójára},
	unique-id = {34724072},
	year = {2024},
	pages = {227-241},
	orcid-numbers = {Skriba, Eszter/0009-0004-9415-8606; Prémusz, Viktória/0000-0002-4059-104X}
}

@article{MTMT:34691008,
	title = {Regulation of iron metabolism in HEC‐1A endometrium cells by macrophage‐derived factors and fractalkine},
	url = {https://m2.mtmt.hu/api/publication/34691008},
	author = {Pandur, Edina and Pap, Ramóna and Jánosa, Gergely and Tamási, Kitti and Sipos, Katalin},
	doi = {10.1002/cbin.12144},
	journal-iso = {CELL BIOL INT},
	journal = {CELL BIOLOGY INTERNATIONAL},
	volume = {48},
	unique-id = {34691008},
	issn = {1065-6995},
	abstract = {Macrophages in the endometrium promote receptivity and implantation by secreting proinflammatory cytokines and other factors like fractalkine (FKN). Macrophages are closely linked to regulating iron homeostasis and can modulate iron availability in the tissue microenvironment. It has been revealed that the iron metabolism of the mother is crucial in fertility. Iron metabolism is strictly controlled by hepcidin, the principal iron regulatory protein. The inflammatory cytokines can modulate hepcidin synthesis and, therefore, the iron metabolism of the endometrium. It was proven recently that FKN, a unique chemokine, is implicated in maternal–fetal communication and may contribute to endometrial receptivity and implantation. In the present study, we investigated the effect of activated THP‐1 macrophages and FKN on the iron metabolism of the HEC‐1A endometrial cells. We established a noncontact coculture with or without recombinant human FKN supplementation to study the impact of the macrophage‐derived factors and FKN on the regulation of hepcidin synthesis and iron release and storage of endometrial cells. Based on our findings, the conditioned medium of the activated macrophages could modify hepcidin synthesis via the nuclear factor kappa‐light‐chain‐enhancer of activated B cells, the signal transducer and activator of transcription 3, and the transferrin receptor 2/bone morphogenetic protein 6/suppressor of mothers against decapentaplegic 1/5/8 signaling pathways, and FKN could alter this effect on the endometrial cells. It was also revealed that the conditioned macrophage medium and FKN modulated the iron release and storage of HEC‐1A cells. FKN signaling may be involved in the management of iron trafficking of the endometrium by the regulation of hepcidin. It can contribute to the iron supply for fetal development at the early stage of the pregnancy.},
	year = {2024},
	eissn = {1095-8355},
	pages = {737-754},
	orcid-numbers = {Pandur, Edina/0000-0001-5012-3242; Pap, Ramóna/0000-0002-3340-0102; Jánosa, Gergely/0000-0001-5374-6680; Sipos, Katalin/0000-0002-6706-2682}
}

@CONFERENCE{MTMT:34685271,
	title = {Magyarországi egészségbiztosítási kiadások elemzése a leggyakrabban előforduló infertilitás kórképhez kapcsolódóan},
	url = {https://m2.mtmt.hu/api/publication/34685271},
	author = {Pónusz-Kovács, Dalma and Kajos, Luca Fanni and Pónusz, Róbert and Elmer, Diána and Csákvári, Tímea and Boncz, Imre},
	booktitle = {VII. Zalaegerszegi nemzetközi egészségturizmus konferencia. Absztrakt kötet},
	unique-id = {34685271},
	year = {2024},
	pages = {50.},
	orcid-numbers = {Kajos, Luca Fanni/0000-0002-0574-5787; Csákvári, Tímea/0000-0002-3339-4953; Boncz, Imre/0000-0003-3699-6236}
}