@article{MTMT:34760472,
	title = {Aromatase Inhibitors and Plasma Lipid Changes in Postmenopausal Women with Breast Cancer: A Systematic Review and Meta-Analysis},
	url = {https://m2.mtmt.hu/api/publication/34760472},
	author = {Bérczi, Bálint and Borbásné Farkas, Kornélia and Hegyi, Péter and Tóth, Barbara and Csupor, Dezső and Németh, Balázs and Lukács, Anita and Czumbel, László Márk and Kerémi, Beáta and Kiss, István and Szabó, Andrea and Varga, Gábor and Gerber, Gábor and Gyöngyi, Zoltán},
	doi = {10.3390/jcm13061818},
	journal-iso = {J CLIN MED},
	journal = {JOURNAL OF CLINICAL MEDICINE},
	volume = {13},
	unique-id = {34760472},
	abstract = {Background: Women are typically diagnosed with estrogen receptor-positive breast cancer around the postmenopausal period when declining estrogen levels initiate changes in lipid profiles. Aromatase inhibitors (AI) are used to prevent the progression of cancer; however, a further reduction in estrogen levels may have detrimental effects on lipid levels, which was our working hypothesis. Methods: Our meta-analysis was conducted on the lipid profiles of postmenopausal breast cancer patients at baseline and at different treatment time points. Results: We identified 15 studies, including 1708 patients. Studies using anastrozole (ANA), exemestane (EXE), letrozole (LET), and tamoxifen (TMX) were involved. Subgroup analyses revealed that 3- and 12-month administrations of LET and EXE lead to negative changes in lipid profiles that tend to alter the lipid profile undesirably, unlike ANA and TMX. Conclusions: Our results suggest that, despite statistically significant results, EXE and LET may not be sufficient to cause severe dyslipidemia in patients without cardiovascular comorbidities according to the AHA/ACC Guideline on the Management of Blood Cholesterol. However, the results may raise the question of monitoring the effects of AIs in patients, especially those with pre-existing cardiovascular risk factors such as dyslipidemia.},
	keywords = {[Meta-analysis]},
	year = {2024},
	eissn = {2077-0383},
	orcid-numbers = {Borbásné Farkas, Kornélia/0000-0002-5349-6527; Hegyi, Péter/0000-0003-0399-7259; Tóth, Barbara/0000-0002-6086-8819; Csupor, Dezső/0000-0002-4088-3333; Németh, Balázs/0000-0002-4914-9872; Lukács, Anita/0000-0002-0746-8920; Czumbel, László Márk/0000-0002-5915-0383; Kerémi, Beáta/0000-0003-4000-9440; Szabó, Andrea/0000-0003-4949-9431; Varga, Gábor/0000-0002-5506-8198; Gerber, Gábor/0000-0003-0256-2608; Gyöngyi, Zoltán/0000-0001-9330-9119}
}

@{MTMT:34723493,
	title = {Mikovírusok azonosítása Rhizopus fajokban},
	url = {https://m2.mtmt.hu/api/publication/34723493},
	author = {Sávai, Gergő and Kartali, Tünde and Benci, Dániel Attila and Patai, Roland and Lipinszki, Zoltán and Vágvölgyi, Csaba and Papp, Tamás},
	booktitle = {Biotechnológiai Szakmai Nap Absztraktfüzet},
	unique-id = {34723493},
	year = {2024},
	orcid-numbers = {Lipinszki, Zoltán/0000-0002-2067-0832; Vágvölgyi, Csaba/0000-0003-0009-7773; Papp, Tamás/0000-0001-8211-5431}
}

@article{MTMT:34691003,
	title = {17-Oxime ethers of oxidized ecdysteroid derivatives modulate oxidative stress in human brain endothelial cells and dose-dependently might protect or damage the blood-brain barrier},
	url = {https://m2.mtmt.hu/api/publication/34691003},
	author = {Vágvölgyi, Máté and Laczkó, Dávid and Santa Maria, Anaraquel and Vigh, Judit Piroska and Walter, Fruzsina and Berkecz, Róbert and Deli, Mária Anna and Tóth, Gábor and Hunyadi, Attila},
	doi = {10.1371/journal.pone.0290526},
	journal-iso = {PLOS ONE},
	journal = {PLOS ONE},
	volume = {19},
	unique-id = {34691003},
	issn = {1932-6203},
	abstract = {20-Hydroxyecdysone and several of its oxidized derivatives exert cytoprotective effect in mammals including humans. Inspired by this bioactivity of ecdysteroids, in the current study it was our aim to prepare a set of sidechain-modified derivatives and to evaluate their potential to protect the blood-brain barrier (BBB) from oxidative stress. Six novel ecdysteroids, including an oxime and five oxime ethers, were obtained through regioselective synthesis from a sidechain-cleaved calonysterone derivative 2 and fully characterized by comprehensive NMR techniques revealing their complete 1 H and 13 C signal assignments. Surprisingly, several compounds sensitized hCMEC/D3 brain microvascular endothelial cells to tert -butyl hydroperoxide (tBHP)-induced oxidative damage as recorded by impedance measurements. Compound 8 , containing a benzyloxime ether moiety in its sidechain, was the only one that exerted a protective effect at a higher, 10 μM concentration, while at lower (10 nM– 1 μM) concentrations it promoted tBHP-induced cellular damage. Brain endothelial cells were protected from tBHP-induced barrier integrity decrease by treatment with 10 μM of compound 8 , which also mitigated the intracellular reactive oxygen species production elevated by tBHP. Based on our results, 17-oxime ethers of oxidized ecdysteroids modulate oxidative stress of the BBB in a way that may point towards unexpected toxicity. Further studies are needed to evaluate any possible risk connected to dietary ecdysteroid consumption and CNS pathologies in which BBB damage plays an important role.},
	year = {2024},
	eissn = {1932-6203},
	orcid-numbers = {Vágvölgyi, Máté/0000-0002-2233-9422; Santa Maria, Anaraquel/0000-0003-3505-5477; Walter, Fruzsina/0000-0001-8145-2823; Berkecz, Róbert/0000-0002-9076-2177; Deli, Mária Anna/0000-0001-6084-6524; Hunyadi, Attila/0000-0003-0074-3472}
}

@article{MTMT:34666945,
	title = {Synthesis and Study of the Structure–Activity Relationship of Antiproliferative N-Substituted Isosteviol-Based 1,3-Aminoalcohols},
	url = {https://m2.mtmt.hu/api/publication/34666945},
	author = {Ozsvár, Dániel and Bózsity-Faragó, Noémi and Zupkó, István and Szakonyi, Zsolt},
	doi = {10.3390/ph17020262},
	journal-iso = {PHARMACEUTICALS-BASE},
	journal = {PHARMACEUTICALS},
	volume = {17},
	unique-id = {34666945},
	abstract = {Starting from isosteviol, a series of diterpenoid 1,3-aminoalcohol derivatives were prepared via stereoselective transformations. The acid-catalysed hydrolysis and rearrangement of natural stevioside produced isosteviol, which was transformed into the key intermediate methyl ester. In the next step, an 1,3-aminoalcohol library was prepared by the reductive amination of the intermediate 3-hydroxyaldehyde obtained from isosteviol in a two-step synthesis. To study the effect of the carboxylate ester function at position 4, the free carboxylic acid, benzyl ester and acryloyl ester analogues were prepared as elongated derivatives in comparison with our earlier results in this field. The antiproliferative activity of compounds against human tumour cell lines (A2780, HeLa, MCF-7 and MDA-MB-231) was investigated. In our preliminary study, the 1,3-aminoalcohol function with N-benzyl or (1H-imidazol-1-yl)-propyl substitution and benzyl ester moiety seemed essential for the reliable antiproliferative activity. The results obtained could be a good starting point to further functionalisation towards more efficient antiproliferative diterpenes.},
	year = {2024},
	eissn = {1424-8247},
	orcid-numbers = {Zupkó, István/0000-0003-3243-5300; Szakonyi, Zsolt/0000-0003-2432-8409}
}

@article{MTMT:34417276,
	title = {Stereoselective Synthesis and Antiproliferative Activity of Steviol-Based Diterpene 1,3-Aminoalcohol Regioisomers},
	url = {https://m2.mtmt.hu/api/publication/34417276},
	author = {Bai, Dorottya and Schelz, Zsuzsanna and Boncz, Mária Fanni and Zupkó, István and Szakonyi, Zsolt},
	doi = {10.3390/molecules28247962},
	journal-iso = {MOLECULES},
	journal = {MOLECULES},
	volume = {28},
	unique-id = {34417276},
	issn = {1420-3049},
	abstract = {A series of novel diterpene-type 1,3-aminoalcohols and their regioisomers have been synthesised from natural stevioside in a stereoselective manner. The key intermediate β-keto alcohol was prepared using Wagner–Meerwein rearrangement of the epoxide derived from steviol methyl ester. The primary aminoalcohol was formed via Raney-nickel-catalysed hydrogenation of an oxime, and a versatile library of aminoalcohols was synthesised using a Schiff base with the primary amines. The aminoalcohol regioisomers were prepared from the mesylate of the β-keto alcohols. The corresponding primary aminoalcohol was formed via the palladium-catalysed hydrogenation of hydroxyl-azide, and click reactions of the latter were also carried out. The new compounds were characterised using 1D- and 2D-NMR techniques and HRMS measurements. The in vitro investigations showed high inhibition of cell growth in human cancer cell lines (HeLa, SiHa, A2780, MCF-7 and MDA-MB-231) in the case of naphthalic N-substituted derivatives. The antiproliferative effects were assayed using the MTT method.},
	year = {2023},
	eissn = {1420-3049},
	orcid-numbers = {Schelz, Zsuzsanna/0000-0002-8519-4830; Boncz, Mária Fanni/0009-0008-7938-484X; Zupkó, István/0000-0003-3243-5300; Szakonyi, Zsolt/0000-0003-2432-8409}
}

@article{MTMT:34316518,
	title = {Mannich-type modifications of (−)-cannabidiol and (−)-cannabigerol leading to new, bioactive derivatives},
	url = {https://m2.mtmt.hu/api/publication/34316518},
	author = {Lőrincz, Eszter Boglárka and Tóth, Gergely and Spolárics, Júlia and Herczeg, Mihály and Hodek, Jan and Zupkó, István and Minorics, Renáta and Ádám, Dorottya and Oláh, Attila and Zouboulis, Christos C. and Weber, Jan and Nagy, Lajos and Ostorházi, Eszter and Bácskay, Ildikó and Borbás, Anikó and Herczegh, Pál and Bakai-Bereczki, Ilona},
	doi = {10.1038/s41598-023-45565-7},
	journal-iso = {SCI REP},
	journal = {SCIENTIFIC REPORTS},
	volume = {13},
	unique-id = {34316518},
	issn = {2045-2322},
	abstract = {(−)-Cannabidiol (CBD) and (−)-cannabigerol (CBG) are two major non-psychotropic phytocannabinoids that have many beneficial biological properties. However, due to their low water solubility and prominent first-pass metabolism, their oral bioavailability is moderate, which is unfavorable for medicinal use. Therefore, there is a great need for appropriate chemical modifications to improve their physicochemical and biological properties. In this study, Mannich-type reaction was used for the synthetic modification of CBD and CBG for the first time, and thus fifteen new cannabinoid derivatives containing one or two tertiary amino groups were prepared. Thereafter the antiviral, antiproliferative and antibacterial properties of the derivatives and their effects on certain skin cells were investigated. Some modified CBD derivatives showed remarkable antiviral activity against SARS-CoV-2 without cytotoxic effect, while synthetic modifications on CBG resulted in a significant increase in antiproliferative activity in some cases compared to the parent compound.},
	year = {2023},
	eissn = {2045-2322},
	orcid-numbers = {Herczeg, Mihály/0000-0002-7938-9789; Zupkó, István/0000-0003-3243-5300; Minorics, Renáta/0000-0001-9685-813X; Oláh, Attila/0000-0003-4122-5639; Ostorházi, Eszter/0000-0002-9459-7316; Borbás, Anikó/0000-0001-8462-4547; Bakai-Bereczki, Ilona/0000-0003-4601-7257}
}

@article{MTMT:34167387,
	title = {Experimental and DFT Atomistic Insights into the Mechanism of Corrosion Protection of Low-Carbon Steel in an Acidic Medium by Polymethoxyflavones from Citrus Peel Waste},
	url = {https://m2.mtmt.hu/api/publication/34167387},
	author = {Najem, Ayoub and Campos, Othon S. and Girst, Gábor and Mounir, Raji and Hunyadi, Attila and García-Antón, José and Bellaouchou, Abdelkbir and Amin, Hatem M. A. and Boudalia, Maria},
	doi = {10.1149/1945-7111/acfa69},
	journal-iso = {J ELECTROCHEM SOC},
	journal = {JOURNAL OF THE ELECTROCHEMICAL SOCIETY},
	volume = {170},
	unique-id = {34167387},
	issn = {0013-4651},
	abstract = {Developing green anticorrosive films is gaining great attention in science and engineering. Citrus fruit peels are mainly discarded as waste, although they can be an excellent repository of phytochemicals, that can be exploited as mitigating agents for corrosion. Herein, we report the high anticorrosion activity of a citrus extract for low-carbon steel in 1 M HCl solution at different temperatures. The main extract constituents were identified by MS and NMR. Two polymethoxyflavones (PMFs), namely nobiletin and heptamethoxyflavone, were identified as major constituents of the extract and the crude PMFs-based extract was investigated for corrosion protection. Using potentiodynamic polarization, weight loss and electrochemical impedance spectroscopy (EIS) methods, this extract revealed improved inhibition efficiency of 94%. The inhibition mechanism was elucidated by considering electrochemical kinetics and adsorption thermodynamics. SEM and UV–vis supported the electrochemical results. PMFs-based extract acted as a mixed-type inhibitor with a Langmuir model of adsorption. Importantly, DFT simulations provided atomic-level insights into the inhibition mechanism and unraveled donor-acceptor interactions between the methoxy groups of PMFs and iron atoms, facilitating the formation of a stable inhibition adsorption layer, and thus supporting the experimental findings. In addition to the physical barrier effect of PMF inhibitor, π -back bonding effect between PMF and steel was suggested.},
	year = {2023},
	eissn = {1945-7111},
	orcid-numbers = {Hunyadi, Attila/0000-0003-0074-3472; García-Antón, José/0000-0002-0289-1324; Amin, Hatem M. A./0000-0002-9250-8658}
}

@article{MTMT:34147029,
	title = {Furanonaphthoquinones, Diterpenes, and Flavonoids from Sweet Marjoram and Investigation of Antimicrobial, Bacterial Efflux, and Biofilm Formation Inhibitory Activities},
	url = {https://m2.mtmt.hu/api/publication/34147029},
	author = {Abu Ghazal, Tasneem and Veres, Katalin and Vidács, Lívia Melinda and Szemerédi, Nikoletta and Spengler, Gabriella and Berkecz, Róbert and Hohmann, Judit},
	doi = {10.1021/acsomega.3c03982},
	journal-iso = {ACS OMEGA},
	journal = {ACS OMEGA},
	volume = {8},
	unique-id = {34147029},
	issn = {2470-1343},
	year = {2023},
	eissn = {2470-1343},
	pages = {34816-34825},
	orcid-numbers = {Abu Ghazal, Tasneem/0000-0003-1574-5948; Veres, Katalin/0000-0001-7108-3622; Spengler, Gabriella/0000-0001-8085-0950; Berkecz, Róbert/0000-0002-9076-2177; Hohmann, Judit/0000-0002-2887-6392}
}

@article{MTMT:34131836,
	title = {Antiproliferative and Antimetastatic Properties of 16-Azidomethyl Substituted 3-O-Benzyl Estrone Analogs},
	url = {https://m2.mtmt.hu/api/publication/34131836},
	author = {Senobar Tahaei, Seyyed Ashkan and Kulmány, Ágnes Erika and Minorics, Renáta and Kiss, Anita and Szabó, Zoltán and Germán, Péter and Szebeni, Gábor and Gémes, Nikolett and Mernyák, Erzsébet and Zupkó, István},
	doi = {10.3390/ijms241813749},
	journal-iso = {INT J MOL SCI},
	journal = {INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES},
	volume = {24},
	unique-id = {34131836},
	issn = {1661-6596},
	abstract = {Four diastereomers of 16-azidomethyl substituted 3-O-benzyl estradiol (1–4) and their two estrone analogs (16AABE and 16BABE) were tested for their antiproliferative properties against human gynecological cancer cell lines. The estrones were selected for additional experiments based on their outstanding cell growth-inhibiting activities. Both compounds increased hypodiploid populations of breast cancer cells, and 16AABE elicited cell cycle disturbance as evidenced by flow cytometry. The two analogs substantially increased the rate of tubulin polymerization in vitro. 16AABE and 16BABE inhibited breast cancer cells’ migration and invasive ability, as evidenced by wound healing and Boyden chamber assays. Since both estrone analogs exerted remarkable estrogenic activities, as documented by a luciferase reporter gene assay, they can be considered as promising drug candidates for hormone-independent malignancies.},
	year = {2023},
	eissn = {1422-0067},
	orcid-numbers = {Minorics, Renáta/0000-0001-9685-813X; Kiss, Anita/0000-0003-3352-0996; Szabó, Zoltán/0000-0001-8278-8038; Szebeni, Gábor/0000-0002-6998-5632; Mernyák, Erzsébet/0000-0003-4494-1817; Zupkó, István/0000-0003-3243-5300}
}

@{MTMT:34066167,
	title = {Eye drop formulation. An ocular formulation comprising L-Ascorbic 6-palmitate (ASP) is provided. The formulation is useful in situation wherein the maintenance of corneal transparency is at risk e..g. during or after corneal surgeries},
	url = {https://m2.mtmt.hu/api/publication/34066167},
	author = {Balogh, György Tibor and Katona, Gábor and Csóka, Ildikó and Zupkó, István and Nagy, Zoltán Zsolt and Kiss, Huba and Takács, Ágnes and Csorba, Anita},
	unique-id = {34066167},
	year = {2023},
	orcid-numbers = {Balogh, György Tibor/0000-0003-3347-1880; Katona, Gábor/0000-0003-1564-4813; Zupkó, István/0000-0003-3243-5300}
}