@article{MTMT:34196545,
	title = {Morphoelectric and transcriptomic divergence of the layer 1 interneuron repertoire in human versus mouse neocortex},
	url = {https://m2.mtmt.hu/api/publication/34196545},
	author = {Chartrand, Thomas and Dalley, Rachel and Close, Jennie and Goriounova, Natalia A. and Lee, Brian R. and Mann, Rusty and Miller, Jeremy A. and Molnár, Gábor and Mukora, Alice and Alfiler, Lauren and Baker, Katherine and Bakken, Trygve E. and Berg, Jim and Bertagnolli, Darren and Braun, Thomas and Brouner, Krissy and Casper, Tamara and Csajbók, Éva and Dee, Nick and Egdorf, Tom and Enstrom, Rachel and Galakhova, Anna A. and Gary, Amanda and Gelfand, Emily and Goldy, Jeff and Hadley, Kristen and Heistek, Tim S. and Hill, DiJon and Jorstad, Nik and Kim, Lisa and Kocsis, Ágnes Katalin and Kruse, Lauren and Kunst, Michael and Leon, Gabriela and Long, Brian and Mallory, Matthew and McGraw, Medea and McMillen, Delissa and Melief, Erica J. and Mihut, Norbert and Ng, Lindsay and Nyhus, Julie and Oláh, Gáspár and Ozsvár, Attila and Omstead, Victoria and Péterfi, Zoltán Attila and Pom, Alice and Potekhina, Lydia and Rajanbabu, Ramkumar and Rózsa, Márton and Ruiz, Augustin and Sandle, Joanna Grace and Sunkin, Susan M. and Szöts, Ildikó and Tieu, Michael and Tóth, Martin and Trinh, Jessica and Vargas, Sara and Vumbaco, David and Williams, Grace and Wilson, Julia and Yao, Zizhen and Barzó, Pál and Cobbs, Charles and Ellenbogen, Richard G. and Esposito, Luke and Ferreira, Manuel and Gouwens, Nathan W. and Grannan, Benjamin and Gwinn, Ryder P. and Hauptman, Jason S. and Jarsky, Tim and Keene, C. Dirk and Ko, Andrew L. and Koch, Christof and Ojemann, Jeffrey G. and Patel, Anoop and Ruzevick, Jacob and Silbergeld, Daniel L. and Smith, Kimberly and Sorensen, Staci A. and Tasic, Bosiljka and Ting, Jonathan T. and Waters, Jack and de Kock, Christiaan P.J. and Mansvelder, Huib D. and Tamás, Gábor and Zeng, Hongkui and Kalmbach, Brian and Lein, Ed S.},
	doi = {10.1126/science.adf0805},
	journal-iso = {SCIENCE},
	journal = {SCIENCE},
	volume = {382},
	unique-id = {34196545},
	issn = {0036-8075},
	abstract = {Neocortical layer 1 (L1) is a site of convergence between pyramidal-neuron dendrites and feedback axons where local inhibitory signaling can profoundly shape cortical processing. Evolutionary expansion of human neocortex is marked by distinctive pyramidal neurons with extensive L1 branching, but whether L1 interneurons are similarly diverse is underexplored. Using Patch-seq recordings from human neurosurgical tissue, we identified four transcriptomic subclasses with mouse L1 homologs, along with distinct subtypes and types unmatched in mouse L1. Subclass and subtype comparisons showed stronger transcriptomic differences in human L1 and were correlated with strong morphoelectric variability along dimensions distinct from mouse L1 variability. Accompanied by greater layer thickness and other cytoarchitecture changes, these findings suggest that L1 has diverged in evolution, reflecting the demands of regulating the expanded human neocortical circuit.},
	year = {2023},
	eissn = {1095-9203},
	orcid-numbers = {Chartrand, Thomas/0000-0002-7093-8681; Dalley, Rachel/0000-0001-7461-7845; Close, Jennie/0000-0001-9234-5855; Goriounova, Natalia A./0000-0002-5917-983X; Lee, Brian R./0000-0002-3210-5638; Mann, Rusty/0000-0002-0226-2069; Miller, Jeremy A./0000-0003-4549-588X; Molnár, Gábor/0000-0001-7959-139X; Mukora, Alice/0000-0001-8431-985X; Alfiler, Lauren/0000-0003-4847-7900; Baker, Katherine/0000-0002-5454-8026; Bakken, Trygve E./0000-0003-3373-7386; Berg, Jim/0000-0002-3300-5399; Bertagnolli, Darren/0000-0002-6626-1567; Braun, Thomas/0000-0002-1416-2065; Brouner, Krissy/0000-0001-5790-7154; Casper, Tamara/0000-0003-1638-3651; Csajbók, Éva/0000-0002-7089-5431; Dee, Nick/0000-0002-2831-9254; Egdorf, Tom/0000-0001-9059-8904; Enstrom, Rachel/0000-0003-0100-927X; Galakhova, Anna A./0000-0002-5538-0624; Gary, Amanda/0000-0002-6397-1520; Gelfand, Emily/0000-0003-2175-5894; Goldy, Jeff/0000-0001-5140-6922; Hadley, Kristen/0000-0002-4504-8724; Hill, DiJon/0000-0001-8879-2476; Jorstad, Nik/0000-0001-7906-9470; Kim, Lisa/0000-0003-3811-8680; Kruse, Lauren/0000-0002-3428-2443; Kunst, Michael/0000-0003-4159-8056; Long, Brian/0000-0002-7793-5969; Mallory, Matthew/0000-0002-8744-3837; McGraw, Medea/0000-0001-5267-489X; McMillen, Delissa/0000-0002-3413-4424; Melief, Erica J./0000-0002-3570-3289; Ng, Lindsay/0000-0002-4134-1608; Nyhus, Julie/0000-0002-2006-8235; Oláh, Gáspár/0000-0003-4708-2368; Ozsvár, Attila/0000-0001-5803-1174; Omstead, Victoria/0000-0002-3796-970X; Pom, Alice/0000-0001-9057-040X; Potekhina, Lydia/0000-0001-8879-7920; Rajanbabu, Ramkumar/0000-0002-7891-7578; Rózsa, Márton/0000-0003-3547-0750; Ruiz, Augustin/0000-0002-8361-5152; Sunkin, Susan M./0000-0001-9893-3834; Szöts, Ildikó/0000-0002-8564-4379; Tieu, Michael/0000-0001-9286-5623; Tóth, Martin/0000-0001-5973-0401; Trinh, Jessica/0000-0002-5064-8898; Vumbaco, David/0000-0001-8115-3081; Williams, Grace/0000-0002-8463-2886; Yao, Zizhen/0000-0002-9361-5607; Barzó, Pál/0000-0001-8717-748X; Cobbs, Charles/0000-0001-7688-4293; Ellenbogen, Richard G./0000-0002-3463-1009; Esposito, Luke/0000-0002-3565-9126; Grannan, Benjamin/0000-0002-6029-2821; Gwinn, Ryder P./0000-0002-5849-7975; Jarsky, Tim/0000-0002-4399-539X; Keene, C. Dirk/0000-0002-5291-1469; Ko, Andrew L./0000-0002-6253-9891; Koch, Christof/0000-0001-6482-8067; Ojemann, Jeffrey G./0000-0001-7580-8934; Smith, Kimberly/0000-0002-3142-1970; Tasic, Bosiljka/0000-0002-6861-4506; Ting, Jonathan T./0000-0001-8266-0392; Waters, Jack/0000-0002-2312-4183; de Kock, Christiaan P.J./0000-0002-6697-0179; Mansvelder, Huib D./0000-0003-1365-5340; Tamás, Gábor/0000-0002-7905-6001; Zeng, Hongkui/0000-0002-0326-5878; Kalmbach, Brian/0000-0003-3136-8097; Lein, Ed S./0000-0001-9012-6552}
}

@article{MTMT:34196534,
	title = {Temporal disparity of action potentials triggered in axon initial segments and distal axons in the neocortex},
	url = {https://m2.mtmt.hu/api/publication/34196534},
	author = {Rózsa, Márton and Tóth, Martin and Oláh, Gáspár and Baka, Judith and Lákovics, Rajmund and Barzó, Pál and Tamás, Gábor},
	doi = {10.1126/sciadv.ade4511},
	journal-iso = {SCI ADV},
	journal = {SCIENCE ADVANCES},
	volume = {9},
	unique-id = {34196534},
	issn = {2375-2548},
	abstract = {Neural population activity determines the timing of synaptic inputs, which arrive to dendrites, cell bodies, and axon initial segments (AISs) of cortical neurons. Action potential initiation in the AIS (AIS-APs) is driven by input integration, and the phase preference of AIS-APs during network oscillations is characteristic to cell classes. Distal regions of cortical axons do not receive synaptic inputs, yet experimental induction protocols can trigger retroaxonal action potentials (RA-APs) in axons distal from the soma. We report spontaneously occurring RA-APs in human and rodent cortical interneurons that appear uncorrelated to inputs and population activity. Network-linked triggering of AIS-APs versus input-independent timing of RA-APs of the same interneurons results in disparate temporal contribution of a single cell to in vivo network operation through perisomatic and distal axonal firing.},
	keywords = {Humans; NEURONS; AXONS; human; Electrophysiology; physiology; ACTION-POTENTIALS; Action Potentials; action potential; DENDRITE; Dendrites; neocortex; Axon initial segment; NETWORK OSCILLATIONS; SYNAPTIC INPUT; axon; Cortical neurons; Protocol cans; Neural populations; Cell bodies; Population activities; Action potential initiations; Distal regions},
	year = {2023},
	eissn = {2375-2548},
	orcid-numbers = {Rózsa, Márton/0000-0003-3547-0750; Tóth, Martin/0000-0001-5973-0401; Oláh, Gáspár/0000-0003-4708-2368; Baka, Judith/0000-0002-8803-0217; Lákovics, Rajmund/0000-0001-7261-2522; Barzó, Pál/0000-0001-8717-748X; Tamás, Gábor/0000-0002-7905-6001}
}

@article{MTMT:33647921,
	title = {Glutathione Transferases are Involved in Salicylic Acid-Induced Transcriptional Reprogramming},
	url = {https://m2.mtmt.hu/api/publication/33647921},
	author = {Horváth, Edit and Bela, Krisztina and Kulman, Kitti and Faragó, Nóra and Riyazuddin, Riyazuddin and Gallé, Ágnes and Puskás, László and Csiszár, Jolán},
	doi = {10.1007/s00344-023-10915-2},
	journal-iso = {J PLANT GROWTH REGUL},
	journal = {JOURNAL OF PLANT GROWTH REGULATION},
	volume = {42},
	unique-id = {33647921},
	issn = {0721-7595},
	abstract = {Salicylic acid (SA) plays a crucial role not only in defence against pathogen attacks, but also in abiotic stress responses. Recently, some key steps of SA signalling outlined the importance of redox state-dependent processes. This study explores the role of glutathione transferases (GSTs) in the transcriptional reprogramming of redox status-related genes in seven-day-old wild type and Atgst mutant Arabidopsis thaliana plants. The timing of redox changes, detected by the redox-sensitive green fluorescent protein (roGFP2), differed in wild type roots treated with 10 μM or 100 μM SA. Our results verified how the applied SA concentrations had different effect on the expression of oxidative stress- and redox-related genes, among them on the expression of AtGSTF8 and AtGSTU19 genes. Lower vitality and less negative E GSH values were specific characteristics of the Atgst mutants compared to the wild type plants throughout the experiment. Changes in the redox potential were only modest in the mutants after SA treatments. A slightly modified gene expression pattern was observed in control conditions and after 1 h of SA treatments in Atgst mutants compared to Col-0 roots. These data originating from the whole roots provide indirect evidence for the role of the investigated AtGSTF8 and AtGSTU19 isoenzymes in the transduction of the redox signal. Our results demonstrate that the investigated Arabidopsis GSTs have a role in maintaining the levels of reactive oxygen species- and redox homeostasis and are involved in transcriptional reprogramming in the roots.},
	year = {2023},
	eissn = {1435-8107},
	pages = {4497-4510},
	orcid-numbers = {Horváth, Edit/0000-0002-7501-2060; Bela, Krisztina/0000-0003-0124-4552; Gallé, Ágnes/0000-0002-8347-8469; Csiszár, Jolán/0000-0001-7250-3000}
}

@article{MTMT:33644822,
	title = {HCN channels at the cell soma ensure the rapid electrical reactivity of fast-spiking interneurons in human neocortex},
	url = {https://m2.mtmt.hu/api/publication/33644822},
	author = {Szegedi, Viktor and Bakos , Emőke and Furdan, Szabina and H. Kovács, Bálint Barna and Varga, Dániel and Erdélyi, Miklós and Barzó, Pál and Szűcs, Attila and Tamás, Gábor and Lamsa, Karri},
	doi = {10.1371/journal.pbio.3002001},
	journal-iso = {PLOS BIOL},
	journal = {PLOS BIOLOGY},
	volume = {21},
	unique-id = {33644822},
	issn = {1544-9173},
	abstract = {Accumulating evidence indicates that there are substantial species differences in the properties of mammalian neurons, yet theories on circuit activity and information processing in the human brain are based heavily on results obtained from rodents and other experimental animals. This knowledge gap may be particularly important for understanding the neocortex, the brain area responsible for the most complex neuronal operations and showing the greatest evolutionary divergence. Here, we examined differences in the electrophysiological properties of human and mouse fast-spiking GABAergic basket cells, among the most abundant inhibitory interneurons in cortex. Analyses of membrane potential responses to current input, pharmacologically isolated somatic leak currents, isolated soma outside-out patch recordings, and immunohistochemical staining revealed that human neocortical basket cells abundantly express hyperpolarization-activated cyclic nucleotide-gated cation (HCN) channel isoforms HCN1 and HCN2 at the cell soma membrane, whereas these channels are sparse at the rodent basket cell soma membrane. Antagonist experiments showed that HCN channels in human neurons contribute to the resting membrane potential and cell excitability at the cell soma, accelerate somatic membrane potential kinetics, and shorten the lag between excitatory postsynaptic potentials and action potential generation. These effects are important because the soma of human fast-spiking neurons without HCN channels exhibit low persistent ion leak and slow membrane potential kinetics, compared with mouse fast-spiking neurons. HCN channels speed up human cell membrane potential kinetics and help attain an input–output rate close to that of rodent cells. Computational modeling demonstrated that HCN channel activity at the human fast-spiking cell soma membrane is sufficient to accelerate the input–output function as observed in cell recordings. Thus, human and mouse fast-spiking neurons exhibit functionally significant differences in ion channel composition at the cell soma membrane to set the speed and fidelity of their input–output function. These HCN channels ensure fast electrical reactivity of fast-spiking cells in human neocortex.},
	year = {2023},
	eissn = {1545-7885},
	orcid-numbers = {Szegedi, Viktor/0000-0003-4191-379X; Varga, Dániel/0000-0003-0391-5057; Erdélyi, Miklós/0000-0002-9501-5752; Barzó, Pál/0000-0001-8717-748X; Szűcs, Attila/0000-0001-9733-4135; Tamás, Gábor/0000-0002-7905-6001; Lamsa, Karri/0000-0002-4609-1337}
}

@article{MTMT:32467760,
	title = {Human neocortical expansion involves glutamatergic neuron diversification},
	url = {https://m2.mtmt.hu/api/publication/32467760},
	author = {Berg, J. and Sorensen, S.A. and Ting, J.T. and Miller, J.A. and Chartrand, T. and Buchin, A. and Bakken, T.E. and Budzillo, A. and Dee, N. and Ding, S.-L. and Gouwens, N.W. and Hodge, R.D. and Kalmbach, B. and Lee, C. and Lee, B.R. and Alfiler, L. and Baker, K. and Barkan, E. and Beller, A. and Berry, K. and Bertagnolli, D. and Bickley, K. and Bomben, J. and Braun, T. and Brouner, K. and Casper, T. and Chong, P. and Crichton, K. and Dalley, R. and de, Frates R. and Desta, T. and Lee, S.D. and D’Orazi, F. and Dotson, N. and Egdorf, T. and Enstrom, R. and Farrell, C. and Feng, D. and Fong, O. and Furdan, Szabina and Galakhova, A.A. and Gamlin, C. and Gary, A. and Glandon, A. and Goldy, J. and Gorham, M. and Goriounova, N.A. and Gratiy, S. and Graybuck, L. and Gu, H. and Hadley, K. and Hansen, N. and Heistek, T.S. and Henry, A.M. and Heyer, D.B. and Hill, D.J. and Hill, C. and Hupp, M. and Jarsky, T. and Kebede, S. and Keene, L. and Kim, L. and Kim, M.-H. and Kroll, M. and Latimer, C. and Levi, B.P. and Link, K.E. and Mallory, M. and Mann, R. and Marshall, D. and Maxwell, M. and McGraw, M. and McMillen, D. and Melief, E. and Mertens, E.J. and Mezei, L. and Mihut, Norbert and Mok, S. and Molnár, Gábor and Mukora, A. and Ng, L. and Ngo, K. and Nicovich, P.R. and Nyhus, J. and Oláh, Gáspár and Oldre, A. and Omstead, V. and Ozsvár, Attila and Park, D. and Peng, H. and Pham, T. and Pom, C.A. and Potekhina, L. and Rajanbabu, R. and Ransford, S. and Reid, D. and Rimorin, C. and Ruiz, A. and Sandman, D. and Sulc, J. and Sunkin, S.M. and Szafer, A. and Szemenyei, Viktor and Thomsen, E.R. and Tieu, M. and Torkelson, A. and Trinh, J. and Tung, H. and Wakeman, W. and Waleboer, F. and Ward, K. and Wilbers, R. and Williams, G. and Yao, Z. and Yoon, J.-G. and Anastassiou, C. and Arkhipov, A. and Barzó, Pál and Bernard, A. and Cobbs, C. and de, Witt Hamer P.C. and Ellenbogen, R.G. and Esposito, L. and Ferreira, M. and Gwinn, R.P. and Hawrylycz, M.J. and Hof, P.R. and Idema, S. and Jones, A.R. and Keene, C.D. and Ko, A.L. and Murphy, G.J. and Ng, L. and Ojemann, J.G. and Patel, A.P. and Phillips, J.W. and Silbergeld, D.L. and Smith, K. and Tasic, B. and Yuste, R. and Segev, I. and de, Kock C.P.J. and Mansvelder, H.D. and Tamás, Gábor and Zeng, H. and Koch, C. and Lein, E.S.},
	doi = {10.1038/s41586-021-03813-8},
	journal-iso = {NATURE},
	journal = {NATURE},
	volume = {598},
	unique-id = {32467760},
	issn = {0028-0836},
	year = {2021},
	eissn = {1476-4687},
	pages = {151-158},
	orcid-numbers = {Oláh, Gáspár/0000-0003-4708-2368; Ozsvár, Attila/0000-0001-5803-1174; Barzó, Pál/0000-0001-8717-748X; Tamás, Gábor/0000-0002-7905-6001}
}

@article{MTMT:32250210,
	title = {Elevation of hilar mossy cell activity suppresses hippocampal excitability and avoidance behavior},
	url = {https://m2.mtmt.hu/api/publication/32250210},
	author = {Wang, Kai-Yi and Wu, Jei-Wei and Cheng, Jen-Kun and Chen, Chun-Chung and Wong, Wai-Yi and Averkin, Róbert and Tamás, Gábor and Nakazawa, Kazu and Lien, Cheng-Chang},
	doi = {10.1016/j.celrep.2021.109702},
	journal-iso = {CELL REP},
	journal = {CELL REPORTS},
	volume = {36},
	unique-id = {32250210},
	issn = {2211-1247},
	abstract = {Modulation of hippocampal dentate gyrus (DG) excitability regulates anxiety. In the DG, glutamatergic mossy cells (MCs) receive the excitatory drive from principal granule cells (GCs) and mediate the feedback excitation and inhibition of GCs. However, the circuit mechanism by which MCs regulate anxiety-related information routing through hippocampal circuits remains unclear. Moreover, the correlation between MC activity and anxiety states is unclear. In this study, we first demonstrate, by means of calcium fiber photometry, that MC activity in the ventral hippocampus (vHPC) of mice increases while they explore anxiogenic environments. Next, juxtacellular recordings reveal that optogenetic activation of MCs preferentially recruits GABAergic neurons, thereby suppressing GCs and ventral CA1 neurons. Finally, chemogenetic excitation of MCs in the vHPC reduces avoidance behaviors in both healthy and anxious mice. These results not only indicate an anxiolytic role of MCs but also suggest that MCs may be a potential therapeutic target for anxiety disorders.},
	keywords = {IN-VIVO; NEURONS; anxiety; Medial prefrontal cortex; GRANULE CELLS; DORSAL; ventral hippocampus; COGNITIVE FLEXIBILITY; MOUSE DENTATE GYRUS},
	year = {2021},
	eissn = {2211-1247},
	orcid-numbers = {Tamás, Gábor/0000-0002-7905-6001}
}

@article{MTMT:32186919,
	title = {Predominantly linear summation of metabotropic postsynaptic potentials follows coactivation of neurogliaform interneurons},
	url = {https://m2.mtmt.hu/api/publication/32186919},
	author = {Ozsvár, Attila and Komlósi, Gergely and Oláh, Gáspár and Baka, Judith and Molnár, Gábor and Tamás, Gábor},
	doi = {10.7554/eLife.65634},
	journal-iso = {ELIFE},
	journal = {ELIFE},
	volume = {10},
	unique-id = {32186919},
	issn = {2050-084X},
	abstract = {Summation of ionotropic receptor-mediated responses is critical in neuronal computation by shaping input-output characteristics of neurons. However, arithmetics of summation for metabotropic signals are not known. We characterized the combined ionotropic and metabotropic output of neocortical neurogliaform cells (NGFCs) using electrophysiological and anatomical methods in the rat cerebral cortex. These experiments revealed that GABA receptors are activated outside release sites and confirmed coactivation of putative NGFCs in superficial cortical layers in vivo. Triple recordings from presynaptic NGFCs converging to a postsynaptic neuron revealed sublinear summation of ionotropic GABA(A) responses and linear summation of metabotropic GABA(B) responses. Based on a model combining properties of volume transmission and distributions of all NGFC axon terminals, we predict that in 83% of cases one or two NGFCs can provide input to a point in the neuropil. We suggest that interactions of metabotropic GABAergic responses remain linear even if most superficial layer interneurons specialized to recruit GABA(B) receptors are simultaneously active.},
	keywords = {INHIBITION; PYRAMIDAL CELLS; DIFFUSION; K+ channels; GABAERGIC INTERNEURONS; CA1 AREA; GABA-B RECEPTORS; G-protein activation; Spillover},
	year = {2021},
	eissn = {2050-084X},
	orcid-numbers = {Ozsvár, Attila/0000-0001-5803-1174; Oláh, Gáspár/0000-0003-4708-2368; Baka, Judith/0000-0002-8803-0217; Tamás, Gábor/0000-0002-7905-6001}
}

@article{MTMT:32037613,
	title = {Systemic administration of ivabradine, a hyperpolarization-activated cyclic nucleotide-gated channel inhibitor, blocks spontaneous absence seizures},
	url = {https://m2.mtmt.hu/api/publication/32037613},
	author = {Iacone, Yasmine and Morais, Tatiana P. and David, Francois and Delicata, Francis and Sandle, Joanna and Raffai, Tímea and Parri, Harri Rheinallt and Weisser, Johan Juhl and Bundgaard, Christoffer and Klewe, Ib Vestergaard and Tamás, Gábor and Thomsen, Morten Skott and Crunelli, Vincenzo and Lőrincz, László Magor},
	doi = {10.1111/epi.16926},
	journal-iso = {EPILEPSIA},
	journal = {EPILEPSIA},
	volume = {62},
	unique-id = {32037613},
	issn = {0013-9580},
	abstract = {Objective Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels are known to be involved in the generation of absence seizures (ASs), and there is evidence that cortical and thalamic HCN channel dysfunctions may have a proabsence role. Many HCN channel blockers are available, but their role in ASs has been investigated only by localized brain injection or in in vitro model systems due to their limited brain availability. Here, we investigated the effect on ASs of orally administered ivabradine (an HCN channel blocker approved for the treatment of heart failure in humans) following injection of the P-glycoprotein inhibitor elacridar, which is known to increase penetration into the brain of drug substrates for this efflux transporter. The action of ivabradine was also tested following in vivo microinjection into the cortical initiation network (CIN) of the somatosensory cortex and in the thalamic ventrobasal nucleus (VB) as well as on cortical and thalamocortical neurons in brain slices. Methods We used electroencephalographic recordings in freely moving Genetic Absence Epilepsy Rats From Strasbourg (GAERSs) to assess the action of oral administration of ivabradine, with and without elacridar, on ASs. Ivabradine was also microinjected into the CIN and VB of GAERSs in vivo and applied to Wistar CIN and GAERS VB slices while recording patch-clamped cortical Layer 5/6 and thalamocortical neurons, respectively. Results Oral administration of ivabradine markedly and dose-dependently reduced ASs. Ivabradine injection into CIN abolished ASs and elicited small-amplitude 4-7-Hz waves (without spikes), whereas in the VB it was less potent. Moreover, ivabradine applied to GAERS VB and Wistar CIN slices selectively decreased HCN channel-dependent properties of cortical Layer 5/6 pyramidal and thalamocortical neurons, respectively. Significance These results provide the first demonstration of the antiabsence action of a systemically administered HCN channel blocker, indicating the potential of this class of drugs as a novel therapeutic avenue for ASs.},
	keywords = {MODEL; CORTEX; EPILEPSY; valproic acid; childhood; Pacemaker; anticonvulsant; THALAMOCORTICAL NEURONS; CHILDHOOD ABSENCE EPILEPSY; NETWORK MECHANISMS; rat; I-h current; OPERATIONAL CLASSIFICATION},
	year = {2021},
	eissn = {1528-1167},
	pages = {1729-1743},
	orcid-numbers = {Delicata, Francis/0000-0002-5339-5275; Tamás, Gábor/0000-0002-7905-6001}
}

@article{MTMT:31953949,
	title = {Cell-Type Specific Arousal-Dependent Modulation of Thalamic Activity in the Lateral Geniculate Nucleus},
	url = {https://m2.mtmt.hu/api/publication/31953949},
	author = {Molnár, Benedek and Sere, Péter and Bordé, Sándor and Koós, Krisztián and Zsigri, Nikolett and Horváth, Péter and Lőrincz, László Magor},
	doi = {10.1093/texcom/tgab020},
	journal-iso = {CEREB CORTEX COMMUN},
	journal = {CEREBRAL CORTEX COMMUNICATIONS},
	volume = {2},
	unique-id = {31953949},
	year = {2021},
	eissn = {2632-7376},
	orcid-numbers = {Bordé, Sándor/0000-0002-2333-2628}
}

@article{MTMT:31889143,
	title = {A community-based transcriptomics classification and nomenclature of neocortical cell types (vol 23, pg 1456, 2020)},
	url = {https://m2.mtmt.hu/api/publication/31889143},
	author = {Yuste, Rafael and Hawrylycz, Michael and Aalling, Nadia and Aguilar-Valles, Argel and Arendt, Detlev and Arnedillo, Ruben Armananzas and Ascoli, Giorgio A. and Bielza, Concha and Bokharaie, Vahid and Bergmann, Tobias Borgtoft and Bystron, Irina and Capogna, Marco and Chang, Yoonjeung and Clemens, Ann and de, Kock Christiaan P. J. and DeFelipe, Javier and Dos, Santos Sandra Esmeralda and Dunville, Keagan and Feldmeyer, Dirk and Fiath, Richard and Fishell, Gordon James and Foggetti, Angelica and Gao, Xuefan and Ghaderi, Parviz and Goriounova, Natalia A. and Guentuerkuen, Onur and Hagihara, Kenta and Hall, Vanessa Jane and Helmstaedter, Moritz and Herculano, Suzana and Hilscher, Markus M. and Hirase, Hajime and Hjerling-Leffler, Jens and Hodge, Rebecca and Huang, Josh and Huda, Rafiq and Khodosevich, Konstantin and Kiehn, Ole and Koch, Henner and Kuebler, Eric S. and Kuhnemund, Malte and Larranaga, Pedro and Lelieveldt, Boudewijn and Louth, Emma Louise and Lui, Jan H. and Mansvelder, Huibert D. and Marin, Oscar and Martinez-Trujillo, Julio and Chameh, Homeira Moradi and Nath, Alok and Nedergaard, Maiken and Nemec, Pavel and Ofer, Netanel and Pfisterer, Ulrich Gottfried and Pontes, Samuel and Redmond, William and Rossier, Jean and Sanes, Joshua R. and Scheuermann, Richard and Serrano-Saiz, Esther and Steiger, Jochen F. and Somogyi, Peter and Tamás, Gábor and Tolias, Andreas Savas and Tosches, Maria Antonietta and Garcia, Miguel Turrero and Vieira, Hermany Munguba and Wozny, Christian and Wuttke, Thomas V. and Yong, Liu and Yuan, Juan and Zeng, Hongkui and Lein, Ed},
	doi = {10.1038/s41593-020-00768-3},
	journal-iso = {NAT NEUROSCI},
	journal = {NATURE NEUROSCIENCE},
	volume = {24},
	unique-id = {31889143},
	issn = {1097-6256},
	year = {2021},
	eissn = {1546-1726},
	pages = {613-613},
	orcid-numbers = {Fiath, Richard/0000-0001-8732-2691; Tamás, Gábor/0000-0002-7905-6001}
}