@article{MTMT:34813506,
	title = {Antitrombin-III-deficites gravidák - kezelési lehetőségek},
	url = {https://m2.mtmt.hu/api/publication/34813506},
	author = {Bíró, Krisztina and Ujhelyi, Zoltán and Schlammadinger, Ágota and Rázsó, Katalin and Buchholcz, Gyula and Boda, Zoltán},
	journal-iso = {GYÓGYSZERÉSZET},
	journal = {GYÓGYSZERÉSZET},
	volume = {68},
	unique-id = {34813506},
	issn = {0017-6036},
	year = {2024},
	pages = {62-66},
	orcid-numbers = {Bíró, Krisztina/0000-0002-2070-0608}
}

@CONFERENCE{MTMT:34756237,
	title = {4CPS-036 Evaluation of the diagnosis and antibiotic prescription pattern in patients hospitalised with urinary tract infections (UTIs)},
	url = {https://m2.mtmt.hu/api/publication/34756237},
	author = {Fésüs, Adina and Matuz, M and Hambalek, H and Ruzsa, R and Tánczos, B and Bácskay, I and Illés, Á and Benkő, R},
	booktitle = {Section 4: Clinical pharmacy services},
	doi = {10.1136/ejhpharm-2024-eahp.140},
	unique-id = {34756237},
	year = {2024},
	pages = {A68.2-A68},
	orcid-numbers = {Fésüs, Adina/0000-0002-6351-7715}
}

@CONFERENCE{MTMT:34756232,
	title = {4CPS-035 Impact of antibiotic stewardship programme (ASP) on antibiotic use and clinical outcomes in patients hospitalised with community-acquired pneumonia (CAP): retrospective observational before-after study},
	url = {https://m2.mtmt.hu/api/publication/34756232},
	author = {Fésüs, Adina and Baluku, P and Sipos, É and Somodi, S and Vaskó, A and Lekli, I and Berczi-Kun, E and Bácskay, I},
	booktitle = {Section 4: Clinical pharmacy services},
	doi = {10.1136/ejhpharm-2024-eahp.139},
	unique-id = {34756232},
	year = {2024},
	pages = {A68.1-A68},
	orcid-numbers = {Fésüs, Adina/0000-0002-6351-7715}
}

@article{MTMT:34618976,
	title = {High glucose promotes osteogenic differentiation of human lens epithelial cells through hypoxia-inducible factor (HIF) activation},
	url = {https://m2.mtmt.hu/api/publication/34618976},
	author = {Ababneh, Haneen and Balogh, Enikő and Csiki, Dávid Máté and Lente, Gréta and Fenyvesi, Ferenc and Tóth, Andrea and Jeney, Viktória},
	doi = {10.1002/jcp.31211},
	journal-iso = {J CELL PHYSIOL},
	journal = {JOURNAL OF CELLULAR PHYSIOLOGY},
	unique-id = {34618976},
	issn = {0021-9541},
	abstract = {Cataract, a leading cause of blindness, is characterised by lens opacification. Type 2 diabetes is associated with a two- to fivefold higher prevalence of cataracts. The risk of cataract formation increases with the duration of diabetes and the severity of hyperglycaemia. Hydroxyapatite deposition is present in cataractous lenses that could be the consequence of osteogenic differentiation and calcification of lens epithelial cells (LECs). We hypothesised that hyperglycaemia might promote the osteogenic differentiation of human LECs (HuLECs). Osteogenic medium (OM) containing excess phosphate and calcium with normal (1 g/L) or high (4.5 g/L) glucose was used to induce HuLEC calcification. High glucose accelerated and intensified OM-induced calcification of HuLECs, which was accompanied by hyperglycaemia-induced upregulation of the osteogenic markers Runx2, Sox9, alkaline phosphatase and osteocalcin, as well as nuclear translocation of Runx2. High glucose-induced calcification was abolished in Runx2-deficient HuLECs. Additionally, high glucose stabilised the regulatory alpha subunits of hypoxia-inducible factor 1 (HIF-1), triggered nuclear translocation of HIF-1 alpha and increased the expression of HIF-1 target genes. Gene silencing of HIF-1 alpha or HIF-2 alpha attenuated hyperglycaemia-induced calcification of HuLECs, while hypoxia mimetics (desferrioxamine, CoCl2) enhanced calcification of HuLECs under normal glucose conditions. Overall, this study suggests that high glucose promotes HuLEC calcification via Runx2 and the activation of the HIF-1 signalling pathway. These findings may provide new insights into the pathogenesis of diabetic cataracts, shedding light on potential factors for intervention to treat this sight-threatening condition.},
	keywords = {cataract; hyperglycaemia; Osteogenic differentiation; hypoxia-inducible factor (HIF); Lens epithelial cell; lens calcification},
	year = {2024},
	eissn = {1097-4652}
}

@article{MTMT:34546012,
	title = {Changes in the Composition of Unstimulated and Stimulated Saliva Due to Chewing Sour Cherry Gum and a Toothbrush Change},
	url = {https://m2.mtmt.hu/api/publication/34546012},
	author = {Skopkó, Boglárka Emese and Homoki, Judit Rita and Fazekas, Mónika Éva and Paholcsek, Melinda and Fauszt, Péter and Dávid, Péter and Stündl, László and Molnár, Piroska Bíróné and Forgács, Ildikó Noémi and Váradi, Judit and Bágyi, Kinga, Ágnes and Gálné Remenyik, Judit},
	doi = {10.3390/cells13030251},
	journal-iso = {CELLS-BASEL},
	journal = {CELLS},
	volume = {13},
	unique-id = {34546012},
	abstract = {Background: Our previous studies demonstrated that sour cherry anthocyanins (AC) reduce the salivary count of Streptococcus mutans and inhibit salivary amylase activity within 30 minutes after chewing AC gum. AC gum and changing toothbrushes after scaling reduced the Gram-negative species in the unstimulated salivary microbiota. The present study examined the effect of AC gums on salivary factors, including changes in microbiome. Methods: The study was conducted over three weeks with two groups; young adults (18–30) and adults (30–45). Ten participants changed their toothbrushes, while the other 10 participants did not change after the control period. After scaling, all participants received three doses of AC gum daily. The salivary mRNA and protein levels of cytokines, mucins, melatonin, and the microbiota of unstimulated and stimulated saliva were determined by polymerase chain reaction, enzyme-linked immunosorbent assay, and 16S rRNA gene sequencing. Results: Significantly higher levels of tumor necrosis factor α (TNFα), interleukin-1β (IL-1β), mucin5B (MUC5B), mucin7 (MUC7), and melatonin were detected in stimulated saliva. Correlation analysis of these factors with the microbiota showed positive correlations with the genera Lachnospiraceae, Eikenella, Saccharibacteria_(TM7), Streptococcus, Prevotella, and Haemophilus. Conclusions: AC chewing gum has a beneficial effect on the composition of the oral microbiome, and toothbrush replacement leads to changes in the levels of salivary pro-inflammatory cytokines.},
	year = {2024},
	eissn = {2073-4409},
	orcid-numbers = {Dávid, Péter/0000-0002-6451-1200}
}

@article{MTMT:34534306,
	title = {DNA methylome, R-loop and clinical exome profiling of patients with sporadic amyotrophic lateral sclerosis},
	url = {https://m2.mtmt.hu/api/publication/34534306},
	author = {Feró, Orsolya and Varga, Dóra and Nagy, Éva and Karányi, Zsolt and Sipos, Éva and Engelhardt, József and Török, Nóra and Balogh, István and Vető, Borbála and Likó, István and Fóthi, Ábel and Szabó, Zoltán and Halmos, Gábor and Vécsei, László and Arányi, Tamás and Székvölgyi, Lóránt},
	doi = {10.1038/s41597-024-02985-y},
	journal-iso = {SCI DATA},
	journal = {SCIENTIFIC DATA},
	volume = {11},
	unique-id = {34534306},
	abstract = {Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder characterized by the death of motor neurons, the aetiology of which is essentially unknown. Here, we present an integrative epigenomic study in blood samples from seven clinically characterised sporadic ALS patients to elucidate molecular factors associated with the disease. We used clinical exome sequencing (CES) to study DNA variants, DNA-RNA hybrid immunoprecipitation sequencing (DRIP-seq) to assess R-loop distribution, and reduced representation bisulfite sequencing (RRBS) to examine DNA methylation changes. The above datasets were combined to create a comprehensive repository of genetic and epigenetic changes associated with the ALS cases studied. This repository is well-suited to unveil new correlations within individual patients and across the entire patient cohort. The molecular attributes described here are expected to guide further mechanistic studies on ALS, shedding light on the underlying genetic causes and facilitating the development of new epigenetic therapies to combat this life-threatening disease.},
	year = {2024},
	eissn = {2052-4463},
	orcid-numbers = {Fóthi, Ábel/0000-0001-7398-9700; Vécsei, László/0000-0001-8037-3672}
}

@article{MTMT:34500966,
	title = {Chrysin Directing an Enhanced Solubility through the Formation of a Supramolecular Cyclodextrin–Calixarene Drug Delivery System: A Potential Strategy in Antifibrotic Diabetes Therapeutics},
	url = {https://m2.mtmt.hu/api/publication/34500966},
	author = {Hermenean, Anca and Dossi, Eleftheria and Hamilton, Alex and Trotta, Maria Consiglia and Russo, Marina and Lepre, Caterina Claudia and Sajtos, Csilla and Rusznyák, Ágnes and Váradi, Judit and Bácskay, Ildikó and Budai, István and D’Amico, Michele and Fenyvesi, Ferenc},
	doi = {10.3390/ph17010107},
	journal-iso = {PHARMACEUTICALS-BASE},
	journal = {PHARMACEUTICALS},
	volume = {17},
	unique-id = {34500966},
	abstract = {Calixarene 0118 (OTX008) and chrysin (CHR) are promising molecules for the treatment of fibrosis and diabetes complications but require an effective delivery system to overcome their low solubility and bioavailability. Sulfobutylated β-cyclodextrin (SBECD) was evaluated for its ability to increase the solubility of CHR by forming a ternary complex with OTX008. The resulting increase in solubility and the mechanisms of complex formation were identified through phase-solubility studies, while dynamic light-scattering assessed the molecular associations within the CHR-OTX008-SBECD system. Nuclear magnetic resonance, differential scanning calorimetry, and computational studies elucidated the interactions at the molecular level, and cellular assays confirmed the system’s biocompatibility. Combining SBECD with OTX008 enhances CHR solubility more than using SBECD alone by forming water-soluble molecular associates in a ternary complex. This aids in the solubilization and delivery of CHR and OTX008. Structural investigations revealed non-covalent interactions essential to complex formation, which showed no cytotoxicity in hyperglycemic in vitro conditions. A new ternary complex has been formulated to deliver promising antifibrotic agents for diabetic complications, featuring OTX008 as a key structural and pharmacological component.},
	year = {2024},
	eissn = {1424-8247},
	pages = {1-20},
	orcid-numbers = {Hermenean, Anca/0000-0001-8510-6653; Trotta, Maria Consiglia/0000-0001-9813-5955; Bácskay, Ildikó/0000-0001-8663-2890; Budai, István/0000-0002-8966-3817; D’Amico, Michele/0000-0002-6899-0595}
}

@article{MTMT:34452575,
	title = {Formulation and Evaluation of Transdermal Patches Containing BGP-15},
	url = {https://m2.mtmt.hu/api/publication/34452575},
	author = {Bácskay, Ildikó and Hosszú, Zsolt and Budai, István and Ujhelyi, Zoltán and Siposné Fehér, Pálma and Kósa, Dóra and Haimhoffer, Ádám and Pető, Ágota},
	doi = {10.3390/pharmaceutics16010036},
	journal-iso = {PHARMACEUTICS},
	journal = {PHARMACEUTICS},
	volume = {16},
	unique-id = {34452575},
	issn = {1999-4923},
	abstract = {BGP-15 is an active ingredient with many advantages, e.g., beneficial cardiovascular and anti-inflammatory effects. The transdermal administration of BGP-15 has great potential, which has not been investigated yet, despite the fact that it is a non-invasive and safe form of treatment. The aim of our study was to formulate transdermal patches containing BGP-15 and optimize the production with the Box–Behnken design of experiment. The most optimal formulation was further combined with penetration enhancers to improve bioavailability of the active ingredient, and the in vitro drug release and in vitro permeation of BGP-15 from the patches were investigated. FTIR spectra of BGP-15, the formulations and the components were also studied. The most optimal formulation based on the tested parameters was dried for 24 h, with 67% polyvinyl alcohol (PVA) content and low ethanol content. The selected penetration enhancer excipients were not cytotoxic on HaCaT cells. The FTIR measurements and SEM photography proved the compatibility of the active substance and the vehicle; BGP-15 was present in the polymer matrix in dissolved form. The bioavailability of BGP-15 was most significantly enhanced by the combination of Transcutol and Labrasol. The in vitro permeation study confirmed that the formulated patches successfully enabled the transdermal administration of BGP-15.},
	year = {2024},
	eissn = {1999-4923},
	orcid-numbers = {Budai, István/0000-0002-8966-3817}
}

@CONFERENCE{MTMT:34425898,
	title = {Evaluation of the antioxidant effect of kd15 and kd36 newly synthetized molecules},
	url = {https://m2.mtmt.hu/api/publication/34425898},
	author = {Fésüs, Adina and Anita, Kónya-Ábrahám and Éva, Sipos and Kitti, Szőke and István, Bak and Attila, Kiss-Szikszai and István, Lekli},
	booktitle = {FAMÉ 2023},
	unique-id = {34425898},
	year = {2023},
	pages = {223},
	orcid-numbers = {Fésüs, Adina/0000-0002-6351-7715}
}

@article{MTMT:34413320,
	title = {Evaluation of the Diagnosis and Antibiotic Prescription Pattern in Patients Hospitalized with Urinary Tract Infections: Single-Center Study from a University-Affiliated Hospital},
	url = {https://m2.mtmt.hu/api/publication/34413320},
	author = {Fésüs, Adina and Matuz, Mária and Papfalvi, Erika Piroska and Hambalek, Helga and Ruzsa, Roxána and Tánczos, Bence and Bácskay, Ildikó and Lekli, István and Illés, Árpád and Benkő, Ria},
	doi = {10.3390/antibiotics12121689},
	journal-iso = {ANTIBIOTICS-BASEL},
	journal = {ANTIBIOTICS},
	volume = {12},
	unique-id = {34413320},
	abstract = {UTIs (urinary tract infections) are common bacterial infections with a non-negligible hospitalization rate. The diagnosis of UTIs remains a challenge for prescribers and a common source of misdiagnosis. This retrospective observational study aimed to evaluate whether recorded diagnosis by clinicians and empirical antibiotic therapy met the EAU (European Association of Urology) guideline in patients hospitalized with UTI. The study was conducted at an internal medicine unit of a tertiary care medical center in Hungary. The diagnosis was assessed based on clinical presentation, physical examination, and laboratory (including microbiological) results, considering all the potential risk factors. Diagnosis was considered misdiagnosis when not confirmed by clinical presentation or clinical signs and symptoms. Evaluation of empirical antibiotic therapy was performed only for confirmed UTIs. Empirical treatment was considered guideline-adherent when complying with the relevant recommendations. Out of 185 patients, 41.6% failed to meet EAU-based UTI diagnosis criteria, of which 27.6% were misdiagnosed and 14.1% were ABU (asymptomatic bacteriuria). The diagnosis of urosepsis recorded at admission (9.7%, 18/185) was not confirmed either by clinical or microbiological tests in five (5/18) cases. The initial empirical therapies for UTI showed a relatively low rate (45.4%) of guideline adherence regarding agent selection. The most common guideline-non-adherent therapies were combinations with metronidazole (16.7%). Dosage appropriateness assessments showed a guideline adherence rate of 36.1%, and underdosing due to high body weight was common (9.3%). Overall (agent, route of administration, dose, duration) guideline adherence was found to be substantially low (10.2%). We found a relatively high rate of misdiagnosed UTIs. Written protocols on the ward may be crucial in reducing misdiagnosis and in optimizing antibiotic use.},
	year = {2023},
	eissn = {2079-6382},
	orcid-numbers = {Fésüs, Adina/0000-0002-6351-7715; Matuz, Mária/0000-0002-7877-2399; Lekli, István/0000-0002-0992-4176; Benkő, Ria/0000-0002-8009-8962}
}