@article{MTMT:34802566,
	title = {Salicylic acid- and ethylene-dependent effects of the ER stress-inducer tunicamycin on the photosynthetic light reactions in tomato plants},
	url = {https://m2.mtmt.hu/api/publication/34802566},
	author = {Iqbal, Nadeem and Ördög, Attila and Koprivanacz, Péter and Kukri, András and Czékus, Zalán and Poór, Péter},
	doi = {10.1016/j.jplph.2024.154222},
	journal-iso = {J PLANT PHYSIOL},
	journal = {JOURNAL OF PLANT PHYSIOLOGY},
	volume = {295},
	unique-id = {34802566},
	issn = {0176-1617},
	year = {2024},
	eissn = {1618-1328},
	orcid-numbers = {Ördög, Attila/0000-0002-1867-8237; Poór, Péter/0000-0002-4539-6358}
}

@{MTMT:34756662,
	title = {Intelligens peptidek: mesterséges intelligencia felhasználása a peptaibolok kutatásában},
	url = {https://m2.mtmt.hu/api/publication/34756662},
	author = {Rozsnyói, Ákos and Balázs, Dóra Krisztina and Tyagi, Chetna and Terna, Gergő and Szekeres, András and Vágvölgyi, Csaba and Marik, Tamás and Kredics, László},
	booktitle = {III. Természettudományok helyzete hazánkban Egyetemtől a munkaerőpiacig Workshop: Absztraktfüzet},
	unique-id = {34756662},
	year = {2024},
	pages = {32-33},
	orcid-numbers = {Tyagi, Chetna/0000-0001-7067-4770; Szekeres, András/0000-0003-1651-4623; Vágvölgyi, Csaba/0000-0003-0009-7773; Marik, Tamás/0000-0002-0434-5685; Kredics, László/0000-0002-8837-3973}
}

@{MTMT:34756649,
	title = {Water solubility of fungal peptaibols and its effect on their bioactivity},
	url = {https://m2.mtmt.hu/api/publication/34756649},
	author = {Terna, Gergő and Tyagi, Chetna and Balázs, Dóra Krisztina and Rozsnyói, Ákos and Szekeres, András and Varga, Mónika and Vágvölgyi, Csaba and Kredics, László and Marik, Tamás},
	booktitle = {III. Természettudományok helyzete hazánkban Egyetemtől a munkaerőpiacig Workshop: Absztraktfüzet},
	unique-id = {34756649},
	year = {2024},
	pages = {29-31},
	orcid-numbers = {Tyagi, Chetna/0000-0001-7067-4770; Szekeres, András/0000-0003-1651-4623; Vágvölgyi, Csaba/0000-0003-0009-7773; Kredics, László/0000-0002-8837-3973; Marik, Tamás/0000-0002-0434-5685}
}

@article{MTMT:34749009,
	title = {Isolation and identification of fungal biodeteriogens from the wall of a cultural heritage church and potential applicability of antifungal proteins in protection},
	url = {https://m2.mtmt.hu/api/publication/34749009},
	author = {Dán, Kinga and Kocsubé, Sándor and Tóth, Liliána and Farkas, Attila and Rákhely, Gábor and Galgóczi, László Norbert},
	doi = {10.1016/j.culher.2024.03.002},
	journal-iso = {J CULT HERIT},
	journal = {JOURNAL OF CULTURAL HERITAGE},
	volume = {67},
	unique-id = {34749009},
	issn = {1296-2074},
	year = {2024},
	eissn = {1778-3674},
	pages = {194-202},
	orcid-numbers = {Tóth, Liliána/0000-0003-1400-6174; Galgóczi, László Norbert/0000-0002-6976-8910}
}

@{MTMT:34723493,
	title = {Mikovírusok azonosítása Rhizopus fajokban},
	url = {https://m2.mtmt.hu/api/publication/34723493},
	author = {Sávai, Gergő and Kartali, Tünde and Benci, Dániel Attila and Patai, Roland and Lipinszki, Zoltán and Vágvölgyi, Csaba and Papp, Tamás},
	booktitle = {Biotechnológiai Szakmai Nap Absztraktfüzet},
	unique-id = {34723493},
	year = {2024},
	orcid-numbers = {Lipinszki, Zoltán/0000-0002-2067-0832; Vágvölgyi, Csaba/0000-0003-0009-7773; Papp, Tamás/0000-0001-8211-5431}
}

@misc{MTMT:34718081,
	title = {mulea - an R package for enrichment analysis using multiple ontologies and empirical FDR correction},
	url = {https://m2.mtmt.hu/api/publication/34718081},
	author = {Turek, Cezary and Olbei, Marton and Stirling, Tamás and Fekete, Gergely and Tasnádi, Ervin Áron and Gul, Leila and Bohár, Balázs and Papp, Balázs and Jurkowski, Wiktor and Ari, Eszter},
	unique-id = {34718081},
	abstract = {Traditional gene set enrichment analyses are typically limited to a few ontologies and do not account for the interdependence of gene sets or terms, resulting in overcorrected p-values. To address these challenges, we introduce mulea, an R package offering comprehensive overrepresentation and functional enrichment analysis. mulea employs an innovative empirical false discovery rate (eFDR) correction method, specifically designed for interconnected biological data, to accurately identify significant terms within diverse ontologies. mulea expands beyond traditional tools by incorporating a wide range of ontologies, encompassing Gene Ontology, pathways, regulatory elements, genomic locations, and protein domains. This flexibility enables researchers to tailor enrichment analysis to their specific questions, such as identifying enriched transcriptional regulators in gene expression data or overrepresented protein domains in protein sets. To facilitate seamless analysis, mulea provides gene sets (in standardised GMT format) for 27 model organisms, covering 16 databases and various identifiers resulting in almost 900 files. Additionally, the muleaData ExperimentData Bioconductor package simplifies access to these pre-defined ontologies. Finally, mulea's architecture allows for easy integration of user-defined ontologies, expanding its applicability across diverse research areas. Availability and Implementation: Software for the tools demonstrated in this article is available as an R package on GitHub: https://github.com/ELTEbioinformatics/mulea.},
	year = {2024},
	orcid-numbers = {Stirling, Tamás/0000-0002-8964-6443; Ari, Eszter/0000-0001-7774-1067}
}

@article{MTMT:34691003,
	title = {17-Oxime ethers of oxidized ecdysteroid derivatives modulate oxidative stress in human brain endothelial cells and dose-dependently might protect or damage the blood-brain barrier},
	url = {https://m2.mtmt.hu/api/publication/34691003},
	author = {Vágvölgyi, Máté and Laczkó, Dávid and Santa Maria, Anaraquel and Vigh, Judit Piroska and Walter, Fruzsina and Berkecz, Róbert and Deli, Mária Anna and Tóth, Gábor and Hunyadi, Attila},
	doi = {10.1371/journal.pone.0290526},
	journal-iso = {PLOS ONE},
	journal = {PLOS ONE},
	volume = {19},
	unique-id = {34691003},
	issn = {1932-6203},
	abstract = {20-Hydroxyecdysone and several of its oxidized derivatives exert cytoprotective effect in mammals including humans. Inspired by this bioactivity of ecdysteroids, in the current study it was our aim to prepare a set of sidechain-modified derivatives and to evaluate their potential to protect the blood-brain barrier (BBB) from oxidative stress. Six novel ecdysteroids, including an oxime and five oxime ethers, were obtained through regioselective synthesis from a sidechain-cleaved calonysterone derivative 2 and fully characterized by comprehensive NMR techniques revealing their complete 1 H and 13 C signal assignments. Surprisingly, several compounds sensitized hCMEC/D3 brain microvascular endothelial cells to tert -butyl hydroperoxide (tBHP)-induced oxidative damage as recorded by impedance measurements. Compound 8 , containing a benzyloxime ether moiety in its sidechain, was the only one that exerted a protective effect at a higher, 10 μM concentration, while at lower (10 nM– 1 μM) concentrations it promoted tBHP-induced cellular damage. Brain endothelial cells were protected from tBHP-induced barrier integrity decrease by treatment with 10 μM of compound 8 , which also mitigated the intracellular reactive oxygen species production elevated by tBHP. Based on our results, 17-oxime ethers of oxidized ecdysteroids modulate oxidative stress of the BBB in a way that may point towards unexpected toxicity. Further studies are needed to evaluate any possible risk connected to dietary ecdysteroid consumption and CNS pathologies in which BBB damage plays an important role.},
	year = {2024},
	eissn = {1932-6203},
	orcid-numbers = {Vágvölgyi, Máté/0000-0002-2233-9422; Santa Maria, Anaraquel/0000-0003-3505-5477; Walter, Fruzsina/0000-0001-8145-2823; Berkecz, Róbert/0000-0002-9076-2177; Deli, Mária Anna/0000-0001-6084-6524; Hunyadi, Attila/0000-0003-0074-3472}
}

@article{MTMT:34627084,
	title = {Rational Design of Antifungal Peptides Based on the γ-Core Motif of a Neosartorya (Aspergillus) fischeri Antifungal Protein to Improve Structural Integrity, Efficacy, and Spectrum},
	url = {https://m2.mtmt.hu/api/publication/34627084},
	author = {Váradi, Györgyi and Bende, Gábor and Borics, Attila and Dán, Kinga and Rákhely, Gábor and Tóth, Gábor and Galgóczi, László Norbert},
	doi = {10.1021/acsomega.3c09377},
	journal-iso = {ACS OMEGA},
	journal = {ACS OMEGA},
	volume = {9},
	unique-id = {34627084},
	issn = {2470-1343},
	year = {2024},
	eissn = {2470-1343},
	pages = {7206-7214},
	orcid-numbers = {Váradi, Györgyi/0000-0001-7907-8908; Rákhely, Gábor/0000-0003-2557-3641; Tóth, Gábor/0000-0002-3604-4385; Galgóczi, László Norbert/0000-0002-6976-8910}
}

@article{MTMT:34542705,
	title = {Many roads to success: Alternative routes to building an economic shell in land snails},
	url = {https://m2.mtmt.hu/api/publication/34542705},
	author = {Páll-Gergely, Barna and Sipos, András Árpád and Harzhauser, Mathias and Örstan, Aydın and Winkler, Viola and Neubauer, Thomas A},
	doi = {10.1093/evolut/qpae018},
	journal-iso = {EVOLUTION},
	journal = {EVOLUTION},
	volume = {78},
	unique-id = {34542705},
	issn = {0014-3820},
	abstract = {Land snails exhibit an extraordinary variety of shell shapes. The way shells are constructed underlie biological and mechanical constraints that vary across gastropod clades. Here, we quantify shell geometry of the two largest groups, Stylommatophora and Cyclophoroidea, to assess the potential causes for variation in shell shape and its relative frequency. Based on µCT scans, we estimate material efficiency through 2D- and 3D-generalisations of the isoperimetric ratio, quantifying the ratios between area and perimeter of whorl cross-sections (2D) and shell volume and surface (3D), respectively. We find that stylommatophorans optimise material usage through whorl overlap, which may have promoted the diversification of flat-shelled species. Cyclophoroids are bound to a circular cross-section because of their operculum; flat shells are comparatively rare. Both groups show similar solutions for tall shells, where local geometry has a smaller effect because of the double overlap between previous and current whorls. Our results suggest that material efficiency is a driving factor in the selection of shell geometry. Essentially, the evolutionary success of Stylommatophora likely roots in their higher flexibility to produce an economic shell.},
	year = {2024},
	eissn = {1558-5646},
	pages = {778-786},
	orcid-numbers = {Páll-Gergely, Barna/0000-0002-6167-7221; Sipos, András Árpád/0000-0003-0440-2165; Neubauer, Thomas A/0000-0002-1398-9941}
}

@article{MTMT:34540973,
	title = {1,6-Hexanediol Is Inducing Homologous Recombination by Releasing BLM from Assemblysomes in Drosophila melanogaster},
	url = {https://m2.mtmt.hu/api/publication/34540973},
	author = {Gombás, Bence György and Villanyi, Zoltan},
	doi = {10.3390/ijms25031611},
	journal-iso = {INT J MOL SCI},
	journal = {INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES},
	volume = {25},
	unique-id = {34540973},
	issn = {1661-6596},
	abstract = {We recently demonstrated that 1,6-hexanediol inhibits the formation of assemblysomes. These membraneless cell organelles have important roles in co-translational protein complex assembly and also store halfway translated DNA damage response proteins for a timely stress response. Recognizing the therapeutic potential of 1,6-hexanediol in dismantling assemblysomes likely to be involved in chemo- or radiotherapy resistance of tumor cells, we initiated an investigation into the properties of 1,6-hexanediol. Our particular interest was to determine if this compound induces DNA double-strand breaks by releasing the BLM helicase. Its yeast ortholog Sgs1 was confirmed to be a component of assemblysomes. The BLM helicase induces DNA damage when overexpressed due to the DNA double-strand breaks it generates during its normal function to repair DNA damage sites. It is evident that storing Sgs1 helicase in assemblysomes is crucial to express the full-length functional protein only in the event of DNA damage. Alternatively, if we dissolve assemblysomes using 1,6-hexanediol, ribosome-nascent chain complexes might become targets of ribosome quality control. We explored these possibilities and found, through the Drosophila wing-spot test assay, that 1,6-hexanediol induces DNA double-strand breaks. Lethality connected to recombination events following 1,6-hexanediol treatment can be mitigated by inducing DNA double-strand breaks with X-ray. Additionally, we confirmed that SMC5 recruits DmBLM to DNA damage sites, as knocking it down abolishes the rescue effect of DNA double-strand breaks on 1,6-hexanediol-induced lethality in Drosophila melanogaster.},
	year = {2024},
	eissn = {1422-0067}
}