@{MTMT:34827442, title = {Light-activated Molecular Switches, Machines and Motors}, url = {https://m2.mtmt.hu/api/publication/34827442}, author = {Kunfi, Attila and London, Gábor}, booktitle = {Reference Module in Chemistry, Molecular Sciences and Chemical Engineering}, doi = {10.1016/B978-0-443-15742-4.00031-4}, unique-id = {34827442}, year = {2024} } @article{MTMT:34821706, title = {Revisiting Hafner’s Azapentalenes: The Chemistry of 1,3-Bis(dimethylamino)-2-azapentalene}, url = {https://m2.mtmt.hu/api/publication/34821706}, author = {Meiszter, Enikő and Gazdag, Tamás and Mayer, Péter J. and Kunfi, Attila and Holczbauer, Tamás and Sulyok-Eiler, Máté and London, Gábor}, doi = {10.1021/acs.joc.3c02564}, journal-iso = {J ORG CHEM}, journal = {JOURNAL OF ORGANIC CHEMISTRY}, unique-id = {34821706}, issn = {0022-3263}, abstract = {Stable azaheterocyclic derivatives of pentalene have been reported by the group of Hafner in the 1970s. However, these structures remained of low interest until recently, when they started to be investigated in the context of organic light-emitting diodes’ (OLEDs’) development. Herein, we revisit the synthesis of stable azapentalene derivative 1,3-bis(dimethylamino)-2-azapentalene and further explore its properties both computationally and experimentally. Beyond the reproduction and optimization of some previously reported transformations, such as formylation and amine substitution, the available scope of reactions was expanded with azo-coupling, selective halogenations, and cross-coupling reactions. © 2024 The Authors. Published by American Chemical Society.}, year = {2024}, eissn = {1520-6904}, orcid-numbers = {Mayer, Péter J./0000-0003-4891-3119; Sulyok-Eiler, Máté/0000-0002-3968-8776} } @{MTMT:34773104, title = {VISIBLE LIGHT SENSITIVE PHOTOREMOVABLE PROTECTING GROUPS, PREPARATION PROCESS THEREOF, PHOTOACTIVATABLE CONJUGATES COMPRISING THEM AND USES THEREOF}, url = {https://m2.mtmt.hu/api/publication/34773104}, author = {BOJTÁR, MÁRTON and EGYED, ALEXANDRA and NÉMETH, KRISZTINA and Kele, Péter}, unique-id = {34773104}, year = {2024} } @article{MTMT:34744629, title = {Photoinduced Decarboxylative Borylation of N -Hydroxyphthalimide Esters with Hypoboric Acid}, url = {https://m2.mtmt.hu/api/publication/34744629}, author = {Nagy, Bálint and Gonda, Zsombor and Földesi, Tamás and Fehér, Péter Pál and Stirling, András and Tolnai, Gergely László and Novák, Zoltán}, doi = {10.1021/acs.orglett.4c00511}, journal-iso = {ORG LETT}, journal = {ORGANIC LETTERS}, unique-id = {34744629}, issn = {1523-7060}, year = {2024}, eissn = {1523-7052}, orcid-numbers = {Földesi, Tamás/0000-0002-8516-5992; Fehér, Péter Pál/0000-0002-6927-4523; Stirling, András/0000-0002-1696-7932; Tolnai, Gergely László/0000-0002-5253-5117; Novák, Zoltán/0000-0001-5525-3070} } @article{MTMT:34720633, title = {Novel-Type GABA B PAMs: Structure–Activity Relationship in Light of the Protein Structure}, url = {https://m2.mtmt.hu/api/publication/34720633}, author = {Krámos, Balázs and Hadady, Zsuzsa and Makó, Attila and Szántó, Gábor and Felföldi, Nóra and Magdó, Ildikó and Bobok, Amrita Ágnes and Bata, Imre and Román, Viktor and Visegrády, András and Keserű, György Miklós and Greiner, István and Éles, János}, doi = {10.1021/acsmedchemlett.3c00560}, journal-iso = {ACS MED CHEM LETT}, journal = {ACS MEDICINAL CHEMISTRY LETTERS}, unique-id = {34720633}, issn = {1948-5875}, year = {2024}, orcid-numbers = {Krámos, Balázs/0000-0002-6387-7382; Greiner, István/0000-0002-5336-2828; Éles, János/0000-0001-9185-1123} } @article{MTMT:34719334, title = {Selective Transformation of 1,3‐Cyclooctadiene into Novel Functionalized Azaheterocycles, β‐Amino Esters, and Lactams by Means of Ring‐Rearrangement Metathesis}, url = {https://m2.mtmt.hu/api/publication/34719334}, author = {Semghouli, Anas and Drahos, László and Volk, Balázs and Kiss, Loránd}, doi = {10.1002/ejoc.202400170}, journal-iso = {EUR J ORG CHEM}, journal = {EUROPEAN JOURNAL OF ORGANIC CHEMISTRY}, unique-id = {34719334}, issn = {1434-193X}, abstract = {Diversity‐oriented synthesis of some novel functionalized azaheterocyclic β‐amino esters with multiple chiral centers from 1,3‐cyclooctadiene‐based β‐amino acids through a stereocontrolled synthetic route has been accomplished. The strategy was based on the creation of some novel unsaturated N‐protected cyclic β‐amino esters from 1,3‐cyclooctadiene. Products were subjected to ring‐opening metathesis (ROM) followed by selective ring‐closing metathesis (RCM). A comparative investigation on the selectivity, regarding the catalysts, yields, conversions, and substrate directing effect on ring‐rearrangement metathesis (RRM) transformation has been accomplished. Importantly, the procedure used in this synthetic process does not affect the configuration of the chiral centers. The pathway takes place across conservation of the configurations of the stereocenters; therefore, the architectural skeleton of the starting cyclooctene‐based β‐amino acids predetermined the structure of the new azaheterocyclic systems.}, year = {2024}, eissn = {1099-0690}, pages = {e202400170}, orcid-numbers = {Volk, Balázs/0000-0002-2019-1874} } @article{MTMT:34718013, title = {Boronic acid inhibitors of penicillin-binding protein 1b: serine and lysine labelling agents}, url = {https://m2.mtmt.hu/api/publication/34718013}, author = {Kollár, Levente and Grabrijan, Katarina and Hrast Rambaher, Martina and Bozovičar, Krištof and Imre, Tímea and Ferenczy, György and Gobec, Stanislav and Keserű, György Miklós}, doi = {10.1080/14756366.2024.2305833}, journal-iso = {J ENZYM INHIB MED CH}, journal = {JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY}, volume = {39}, unique-id = {34718013}, issn = {1475-6366}, year = {2024}, eissn = {1475-6374}, orcid-numbers = {Ferenczy, György/0000-0002-5771-4616} } @article{MTMT:34684024, title = {Bioorthogonal Reactions in Bioimaging}, url = {https://m2.mtmt.hu/api/publication/34684024}, author = {Kozma, Eszter and Kele, Péter}, doi = {10.1007/s41061-024-00452-1}, journal-iso = {TOP CURR CHEM (2016-)}, journal = {TOPICS IN CURRENT CHEMISTRY}, volume = {382}, unique-id = {34684024}, issn = {2365-0869}, abstract = {Visualization of biomolecules in their native environment or imaging-aided understanding of more complex biomolecular processes are one of the focus areas of chemical biology research, which requires selective, often site-specific labeling of targets. This challenging task is effectively addressed by bioorthogonal chemistry tools in combination with advanced synthetic biology methods. Today, the smart combination of the elements of the bioorthogonal toolbox allows selective installation of multiple markers to selected targets, enabling multicolor or multimodal imaging of biomolecules. Furthermore, recent developments in bioorthogonally applicable probe design that meet the growing demands of superresolution microscopy enable more complex questions to be addressed. These novel, advanced probes enable highly sensitive, low-background, single- or multiphoton imaging of biological species and events in live organisms at resolutions comparable to the size of the biomolecule of interest. Herein, the latest developments in bioorthogonal fluorescent probe design and labeling schemes will be discussed in the context of in cellulo/in vivo (multicolor and/or superresolved) imaging schemes. The second part focuses on the importance of genetically engineered minimal bioorthogonal tags, with a particular interest in site-specific protein tagging applications to answer biological questions.}, year = {2024}, eissn = {2364-8961} } @article{MTMT:34651053, title = {Mechanochemical Scholl Reaction on Phenylated Cyclopentadiene Core: One-Step Synthesis of Fluoreno[5]helicenes}, url = {https://m2.mtmt.hu/api/publication/34651053}, author = {Bati, Gabor and Csókás, Dániel and Stuparu, Mihaiela C.}, doi = {10.1002/chem.202302971}, journal-iso = {CHEM-EUR J}, journal = {CHEMISTRY-A EUROPEAN JOURNAL}, volume = {30}, unique-id = {34651053}, issn = {0947-6539}, keywords = {mechanochemistry; Arenes; annulation; corannulene, fused-ring systems}, year = {2024}, eissn = {1521-3765}, pages = {e2023029}, orcid-numbers = {Bati, Gabor/0000-0002-4543-8124} } @article{MTMT:34646716, title = {Stereocontrol via Propeller Chirality in FLP‐Catalyzed Asymmetric Hydrogenation}, url = {https://m2.mtmt.hu/api/publication/34646716}, author = {Kótai, Bianka and Laczkó, Gergely and Hamza, Andrea and Pápai, Imre}, doi = {10.1002/chem.202400241}, journal-iso = {CHEM-EUR J}, journal = {CHEMISTRY-A EUROPEAN JOURNAL}, unique-id = {34646716}, issn = {0947-6539}, abstract = {Utilization of chiral frustrated Lewis pairs as catalysts in enantioselective hydrogenation of unsaturated molecules represents a promising approach in asymmetric synthesis. In our effort to improve our current understanding of the factors governing the stereoselectivity in these catalytic processes, herein we examined the mechanism of direct hydrogenation of aromatic enamines catalyzed by a binaphthyl–based chiral amino–borane. Our computational analysis reveals that only one particular conformer of the key borohydride reaction intermediate can be regarded as a reactive form of this species. This borohydride conformer has a well–defined chiral propeller shape, which induces facial selectivity in the hydride transfer to pro–chiral iminium intermediates. The propeller chirality of the reactive borohydride conformer is generated by the axially chiral binaphthyl scaffold of the amino–borane catalyst through stabilizing π‐π stacking interactions. This new computational insight can be readily used to interpret the high degree of stereoinduction observed for these reactions. We expect that the concept of chirality relay could be further exploited in catalyst design endeavors.}, year = {2024}, eissn = {1521-3765} }