@article{MTMT:34103124, title = {Adherence to inhaled corticosteroids and long-acting β2-agonists in asthma: A MASK-air study}, url = {https://m2.mtmt.hu/api/publication/34103124}, author = {Sousa-Pinto, B. and Louis, R. and Anto, J.M. and Amaral, R. and Sá-Sousa, A. and Czarlewski, W. and Brussino, L. and Canonica, G.W. and Chaves, Loureiro C. and Cruz, A.A. and Gemicioglu, B. and Haahtela, T. and Kupczyk, M. and Kvedariene, V. and Larenas-Linnemann, D.E. and Okamoto, Y. and Ollert, M. and Pfaar, O. and Pham-Thi, N. and Puggioni, F. and Regateiro, F.S. and Romantowski, J. and Sastre, J. and Scichilone, N. and Taborda-Barata, L. and Ventura, M.T. and Agache, I. and Bedbrook, A. and Becker, S. and Bergmann, K.C. and Bosnic-Anticevich, S. and Bonini, M. and Boulet, L.-P. and Brusselle, G. and Buhl, R. and Cecchi, L. and Charpin, D. and de, Blay F. and Del, Giacco S. and Ivancevich, J.C. and Jutel, M. and Klimek, L. and Kraxner, Helga and Kuna, P. and Laune, D. and Makela, M. and Morais-Almeida, M. and Nadif, R. and Niedoszytko, M. and Papadopoulos, N.G. and Papi, A. and Patella, V. and Pétré, B. and Rivero, Yeverino D. and Robalo, Cordeiro C. and Roche, N. and Rouadi, P.W. and Samolinski, B. and Savouré, M. and Shamji, M.H. and Sheikh, A. and Suppli, Ulrik C. and Usmani, O.S. and Valiulis, A. and Yorgancioglu, A. and Zuberbier, T. and Fonseca, J.A. and Costa, E.M. and Bousquet, J.}, doi = {10.1016/j.pulmoe.2023.07.004}, journal-iso = {PULMONOLOGY}, journal = {PULMONOLOGY}, volume = {31}, unique-id = {34103124}, issn = {2531-0429}, abstract = {Introduction: Adherence to controller medication is a major problem in asthma management, being difficult to assess and tackle. mHealth apps can be used to assess adherence. We aimed to assess the adherence to inhaled corticosteroids+long-acting β2-agonists (ICS+LABA) in users of the MASK-air® app, comparing the adherence to ICS+formoterol (ICS+F) with that to ICS+other LABA. Materials and methods: We analysed complete weeks of MASK-air® data (2015-2022; 27 countries) from patients with self-reported asthma and ICS+LABA use. We compared patients reporting ICS+F versus ICS+other LABA on adherence levels, symptoms and symptom-medication scores. We built regression models to assess whether adherence to ICS+LABA was associated with asthma control or short-acting beta-agonist (SABA) use. Sensitivity analyses were performed considering the weeks with no more than one missing day. Results: In 2598 ICS+LABA users, 621 (23.9%) reported 4824 complete weeks and 866 (33.3%) reported weeks with at most one missing day. Higher adherence (use of medication ≥80% of weekly days) was observed for ICS+other LABA (75.1%) when compared to ICS+F (59.3%), despite both groups displaying similar asthma control and work productivity. The ICS+other LABA group was associated with more days of SABA use than the ICS+F group (median=71.4% versus 57.1% days). Each additional weekly day of ICS+F use was associated with a 4.1% less risk in weekly SABA use (95%CI=-6.5;-1.6%;p=0.001). For ICS+other LABA, the percentage was 8.2 (95%CI=-11.6;-5.0%;p<0.001). Conclusions: In asthma patients adherent to the MASK-air app, adherence to ICS+LABA was high. ICS+F users reported lower adherence but also a lower SABA use and a similar level of control. © 2023 Sociedade Portuguesa de Pneumologia}, keywords = {Inhaled corticosteroids; Asthma; Adherence; Formoterol; Long-acting-β2 agonist}, year = {2025}, eissn = {2531-0437}, orcid-numbers = {Kraxner, Helga/0000-0002-0331-5345} } @article{MTMT:35765074, title = {Tinnitus and Its Comorbidities: A Comprehensive Analysis of Their Relationships}, url = {https://m2.mtmt.hu/api/publication/35765074}, author = {Maihoub, Stefani and Mavrogeni, Panayiota and Molnár, Viktória and Molnár, András}, doi = {10.3390/jcm14041285}, journal-iso = {J CLIN MED}, journal = {JOURNAL OF CLINICAL MEDICINE}, volume = {14}, unique-id = {35765074}, abstract = {Objectives: This study aimed to explore the demographic and clinical features of tinnitus individuals and analyse its correlation with associated comorbidities. Methods: The study population comprised 147 participants (66 men, 81 women; median age: 52 years) who experienced persistent tinnitus. Comprehensive assessments were carried out, including audiological examinations, scoring using the Tinnitus Handicap Inventory, and thorough medical evaluations. Statistical analyses were applied to explore the correspondences between tinnitus, hearing loss, and various comorbidities, including cardiovascular conditions, metabolic disorders, gastroesophageal reflux disease, autoimmune diseases, pulmonary diseases, and allergic rhinitis. Results: The analysis indicated a slight predominance of females, comprising 55.1% of the participants, with a median onset of tinnitus around the age of 50. Chronic tinnitus was noted, lasting approximately 46 months. Hearing loss was noted in 52.4% of patients, with bilateral tinnitus being the most prevalent type, affecting 44.2% of individuals. Dyslipidaemia was found to significantly predict bilateral tinnitus (p = 0.003*) and left-sided tinnitus (p = 0.023*). Additionally, atherosclerosis was associated with hearing impairment (p = 0.006*) and right-sided tinnitus (p = 0.044*). Dyslipidaemia was also significantly correlated with elevated intensity values (p = 0.04*). Furthermore, atherosclerosis was significantly associated with higher levels of hearing loss (p < 0.00001*). Conclusions: The study emphasises the complex nature of tinnitus and its links to cardiovascular, metabolic, and other comorbidities, highlighting the necessity for comprehensive, interdisciplinary management.}, keywords = {tinnitus; Hearing loss; Tinnitus Handicap Inventory; auditory impairment; comorbidities}, year = {2025}, eissn = {2077-0383}, orcid-numbers = {Molnár, Viktória/0000-0002-2508-4429; Molnár, András/0000-0002-4417-5166} } @article{MTMT:35767137, title = {Survival analysis of laryngeal squamous cell cancer, considering different treatment modalities and other factors influencing survival – a monocentric retrospective investigation}, url = {https://m2.mtmt.hu/api/publication/35767137}, author = {Répássy, Gábor Dénes (Ifj.) and Molnár, András and Maihoub, Stefani and Hargas, Dóra and Tamás, László}, doi = {10.1007/s00405-025-09229-8}, journal-iso = {EUR ARCH OTO-RHINO-L}, journal = {EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY}, volume = {282}, unique-id = {35767137}, issn = {0937-4477}, keywords = {larynx cancer; CHEMORADIATION; influencing factors; p16 expression; survival}, year = {2025}, eissn = {1434-4726}, pages = {1989-2000}, orcid-numbers = {Répássy, Gábor Dénes (Ifj.)/0000-0002-9381-2272; Molnár, András/0000-0002-4417-5166; Tamás, László/0000-0003-3723-9149} } @article{MTMT:35798754, title = {Prevention of noise-induced hearing loss in children – evidence-informed recommendations for safe listening at events}, url = {https://m2.mtmt.hu/api/publication/35798754}, author = {Gáborján, Anita and Koscsó, Gábor and Garai, Réka and Tamás, László and Vicsi, Klára and Hacki, Tamás}, doi = {10.1080/14992027.2025.2467789}, journal-iso = {INT J AUDIOL}, journal = {INTERNATIONAL JOURNAL OF AUDIOLOGY}, volume = {64}, unique-id = {35798754}, issn = {1499-2027}, year = {2025}, eissn = {1708-8186}, pages = {1017-1026}, orcid-numbers = {Garai, Réka/0000-0001-6201-764X; Tamás, László/0000-0003-3723-9149; Hacki, Tamás/0000-0001-9524-6748} } @article{MTMT:35956166, title = {Tapasztalataink egy, a szédüléses panaszok ellátására szakosodott hazai magánrendelésen}, url = {https://m2.mtmt.hu/api/publication/35956166}, author = {Molnár, András and Molnár, Viktória and Maihoub, Stefani}, doi = {10.1556/650.2025.33253}, journal-iso = {ORV HETIL}, journal = {ORVOSI HETILAP}, volume = {166}, unique-id = {35956166}, issn = {0030-6002}, abstract = {Bevezetés: A szédülés gyakori panasz a mindennapi klinikai gyakorlatban. Amennyiben a részletes és célzott kivizsgálás és ellátás nem történik meg, a panaszok fennmaradásával kell számolnunk, egyéb tünetek megjelenését okozva. Célkitűzés: A szédüléses panaszokra specializálódott rendelésen szerzett tapasztalataink ismertetése. Módszer: A jelen kutatás egy szédülésre specializálódott rendelés beteganyagát vette figyelembe. Ennek során a részletes anamnézisfelvétel mellett célzott egyensúlyrendszeri vizsgálatok, tisztahangküszöb-audiometria, agykoponya-CT és agykoponya-MRI, valamint carotis-vertebralis Doppler-ultrahangvizsgálat eredményeit értékeltük. A szédülés és a fülzúgás mindennapi életvitelre kifejtett hatásának vizsgálatához a DHI (Dizziness Handicap Inventory) és a THI (Tinnitus Handicap Inventory) kérdőíveket alkalmaztuk. Eredmények: A kutatásba összesen 121 beteget (átlagéletkor: 51,40 ± 13,38 év; 72 nőbeteg) vontunk be. A szédülés kezdetének időtartama 5 hónap mediánértékre volt tehető, 240 hónap maximális érték mellett. A szédülés több mint 60%-ban forgó jellegű volt, 1,5 óra medián-időtartammal. Halláscsökkenés közel 30%-ban, tinnitus több mint 50%-ban jelentkezett. A tinnitus vonatkozásában domináltak a kétoldali panaszok (38,7%). Fejfájás közel 30%-ban jelentkezett, amely igen nagy arányban (81,25%) mutatott összefüggést a szédüléssel. A diagnózisok megoszlása alapján a leggyakoribb kórképek a benignus paroxysmalis positionalis vertigo (24,8%), a vestibularis migrén (22,3%), az extravestibularis eltérések (19,8%) és a Ménière-betegség (18,2%) voltak. Egyensúlyrendszeri fizikális vizsgálatok alapján spontán vestibularis tünet ritkán volt azonosítható (5%). Fejimpulzusteszt alapján eltérés kissé nagyobb arányban (10%) igazolódott. Positionalis nystagmus csupán 13%-ban jelentkezett, amely rendkívül kis arány a benignus paroxysmalis positionalis vertigo gyakoriságához képest. Agykoponya-CT-vizsgálat 24%-ban készült, 65%-ban teljesen negatív eredménnyel. Az agykoponya-MRI esetében az arányok 74% és 35% voltak. A carotis-vertebralis Doppler-ultrahangvizsgálat 62%-ban zárult negatív eredménnyel. A DHI-kérdőívek alapján a súlyos (41%), míg a THI-kérdőívek alapján az enyhe (34%) és a közepesen súlyos (32%) életminőség-romlás volt a leggyakoribb. Következtetés: A szédülés hátterében számos ok állhat, vestibularis és extravestibularis okok egyaránt. A nem időben megkezdett és nem megfelelő kivizsgálás a diagnózis és a terápia megkezdésének késlekedéséhez vezet, életminőség-romlást és pszichés társtünetek megjelenését okozva. | Introduction: Vertigo is a frequent issue in everyday medical practice. Without specific examinations, it can persist, leading to co-occurring symptoms. Objective: To present our experiences gained at a clinic specialising in vertigo. Method: In this study, patients were enrolled at a clinic specialising in vertigo. Detailed case histories, physical assessments of the vestibular system, pure-tone audiometry, brain CT/MRI, and carotid vertebral Doppler ultrasonography results were examined. To assess the impact of symptoms, the Dizziness Handicap Inventory (DHI) and the Tinnitus Handicap Inventory (THI) were administered. Results: 121 patients (51.40 ± 13.38 years; 72 women) were enrolled. The median onset of vertigo was recorded at 5 months, with a maximum of 240 months. Spinning sensations were reported in more than 60% of the attacks, with a median duration of 1.5 hours. Hearing loss occurred in approximately 30%, while tinnitus was noted in 50%, with bilateral tinnitus being the most common (38.7%). Headaches occurred in approximately 30%, with a significant proportion related to vertigo (81.25%). The most frequent diagnoses were benign paroxysmal positional vertigo (24.8%), vestibular migraine (22.3%), non-vestibular causes (19.8%), and Ménière’s disease (18.2%). Spontaneous vestibular signs occurred at low rates (5%). The head-impulse test was positive slightly more often (10%). Positional nystagmus was detected in 13%, which is a low percentage, especially given the high prevalence of benign paroxysmal positional vertigo. Brain CT scan was conducted in 24%, with 65% having negative results. In comparison, brain MRI was performed in 74%, and 35% yielded negative results. Carotid Doppler ultrasonography showed normal results in 62%. Severe vertigo was reported in 41%, while mild (34%) and moderately severe (32%) tinnitus were the most commonly reported handicaps. Conclusion: There are various causes of vertigo, including vestibular and non-vestibular factors. Delays in diagnosis and a lack of specialised testing lead to a delay in treatment, worsening the quality of life and contributing to psychiatric comorbidities.}, keywords = {headache; Differential diagnosis; vertigo; tinnitus; Hearing loss; SZÉDÜLÉS; halláscsökkenés; differenciáldiagnosztika; fejfájás; fülzúgás; centrális vestibularis laesio; perifériás vestibularis laesio; central vestibular laesion; peripheral vestibular laesion}, year = {2025}, eissn = {1788-6120}, pages = {413-420}, orcid-numbers = {Molnár, András/0000-0002-4417-5166; Molnár, Viktória/0000-0002-2508-4429} } @article{MTMT:35965484, title = {The Influence of Carotid and Vertebral Doppler Ultrasonography and Brain MRI Abnormalities on Hearing Levels, Tinnitus Intensities and Frequencies}, url = {https://m2.mtmt.hu/api/publication/35965484}, author = {Molnár, András and Molnár, Viktória and Mavrogeni, Panayiota and Maihoub, Stefani}, doi = {10.3390/audiolres15020029}, journal-iso = {AUDIOL RES}, journal = {AUDIOLOGY RESEARCH}, volume = {15}, unique-id = {35965484}, issn = {2039-4330}, abstract = {Objectives: This study aimed to analyse the potential influence of abnormalities detected through carotid–vertebral ultrasonography and brain MRI on pure-tone averages (PTAs) and the frequency and intensity of tinnitus. Methods: 423 participants with subjective tinnitus were enrolled in this investigation. All patients underwent carotid– vertebral ultrasonography, brain MRI, and pure-tone audiometry, including tinnitus matching. Results: The median values for tinnitus onset indicated chronic tinnitus in most cases. Regarding tinnitus location, left-sided symptoms (32%) and bilateral symptoms (44%) were the most prevalent. In analysing the effects of abnormalities detected by carotid–vertebral ultrasonography on PTAs, a statistically significant difference was found between the groups (p = 0.0037). Specifically, individuals with intimal hyperplasia had significantly higher PTAs (p = 0.02), as did those with carotid artery plaques (p = 0.005). However, no significant differences in PTAs were noted in relation to carotid artery stenosis (p = 0.07). Similar trends emerged regarding tinnitus intensity (p = 0.013), with significantly higher values observed in the presence of any carotid–vertebral ultrasonography abnormalities. In contrast, tinnitus frequencies were not significantly affected (p = 0.401). Regarding brain MRI findings, Fazekas scores of 2 (p = 0.02) and 3 (p = 0.0052) significantly influenced PTAs. For tinnitus intensity, Fazekas scores of 2 (p = 0.0027) and 3 (p = 0.0005), and the presence of acoustic neuromas (p = 0.019), significantly impacted the intensity values. However, tinnitus frequencies were not significantly (p = 0.36) influenced by brain MRI abnormalities. Conclusions: The findings of this study show that carotid–vertebral ultrasonography and brain MRI abnormalities significantly influence PTAs and tinnitus intensities.}, keywords = {brain MRI; tinnitus; pure-tone averages; tinnitus intensity; tinnitus frequency; carotid–vertebral Doppler ultrasonography;}, year = {2025}, eissn = {2039-4349}, orcid-numbers = {Molnár, András/0000-0002-4417-5166; Molnár, Viktória/0000-0002-2508-4429} } @article{MTMT:36012692, title = {Adherence to Treatment in Allergic Rhinitis During the Pollen Season in Europe: A MASK-air Study}, url = {https://m2.mtmt.hu/api/publication/36012692}, author = {Sousa-Pinto, B. and Costa, E.M. and Vieira, R.J. and Klimek, L. and Czarlewski, W. and Pfaar, O. and Bedbrook, A. and Amaral, R. and Brussino, L. and Kvedariene, V. and Larenas-Linnemann, D.E. and Iinuma, T. and Pham-Thi, N. and Regateiro, F.S. and Taborda-Barata, L. and Ventura, M.T. and Ansotegui, I.J. and Bergmann, K.C. and Canonica, G.W. and Cardona, V. and Cecchi, L. and Cherrez-Ojeda, I. and Cingi, C. and Cruz, A.A. and Del, Giacco S. and Devillier, P. and Fokkens, W.J. and Gemicioglu, B. and Haahtela, T. and Ivancevich, J.C. and Kuna, P. and Kraxner, Helga and Laune, D. and Louis, R. and Makris, M. and Morais-Almeida, M. and Mösges, R. and Niedoszytko, M. and Papadopoulos, N.G. and Patella, V. and Pereira, A.M. and Reitsma, S. and Robles-Velasco, K. and Rouadi, P.W. and Samolinski, B. and Sova, M. and Toppila-Salmi, S.K. and Sastre, J. and Valiulis, A. and Yorgancioglu, A. and Zidarn, M. and Zuberbier, T. and Fonseca, J.A. and Bousquet, J.}, doi = {10.1111/cea.70004}, journal-iso = {CLIN EXP ALLERGY}, journal = {CLINICAL AND EXPERIMENTAL ALLERGY}, volume = {55}, unique-id = {36012692}, issn = {0954-7894}, year = {2025}, eissn = {1365-2222}, pages = {226-238}, orcid-numbers = {Kraxner, Helga/0000-0002-0331-5345} } @article{MTMT:36070495, title = {Fasting Glucose, Haemoglobin A1C (HbA1c), Blood Lipid, and Triglyceride–Glucose Index Parameters in Relation to Subjective Tinnitus}, url = {https://m2.mtmt.hu/api/publication/36070495}, author = {Molnár, András and Molnár, Viktória and Mavrogeni, Panayiota and Maihoub, Stefani}, doi = {10.3390/biomedicines13040824}, journal-iso = {BIOMEDICINES}, journal = {BIOMEDICINES}, volume = {13}, unique-id = {36070495}, abstract = {Objectives: This study aimed to analyse blood glucose and lipid levels in subjective tinnitus compared to healthy controls. Method: A total of 414 patients with subjective tinnitus and 274 healthy participants were enrolled. All participants underwent comprehensive laboratory testing, which included measurements of fasting blood glucose, HbA1c, and blood lipids. Results: The tinnitus group had significantly higher glucose levels than the control group (p = 0.024). Additionally, the HbA1c levels were higher in the tinnitus group (p = 0.006). Tinnitus patients exhibited elevated levels of total cholesterol (p < 0.001), triglycerides (p < 0.001), and LDL (p < 0.001). However, HDL levels showed no significant difference (p = 0.984). Although the triglyceride–glucose index tends to show higher values in the tinnitus group, this difference is statistically insignificant (p = 0.688). ROC indicated that LDL had the highest sensitivity for predicting tinnitus (AUC = 0.620; p < 0.001, 95% CI: 0.573–0.668). Other parameters showed significant results, excluding the triglyceride–glucose index (AUC = 0.514; p = 0.688, 95% CI: 0.443–0.585), which was not a significant predictor. Glucose levels significantly correlate with age (rho = 0.338, p < 0.001) and tinnitus onset (rho = 0.107, p = 0.034). Additionally, age showed a significant correlation with total cholesterol levels (rho = 0.156, p = 0.002) and triglycerides (rho = 0.121, p = 0.020) and tinnitus onset (rho = 0.344, p < 0.001). Logistic regression analysis revealed that the presence of tinnitus was significantly associated with elevated HbA1c levels (p = 0.007) and TG levels (p = 0.001). Furthermore, the occurrence of chronic tinnitus was significantly influenced by elevated glucose levels (p = 0.026). Conclusions: The results showed increased glucose and blood lipid levels in tinnitus. LDL levels exhibited the highest sensitivity in predicting tinnitus. However, the TyG index was not a significant predictor. Given the cross-sectional design of the study, which may limit the results, further longitudinal studies are necessary.}, keywords = {GLUCOSE; Triglycerides; LDL; HDL; HbA1c; total cholesterol; Subjective tinnitus; Triglyceride-glucose index; cardiovascular risk}, year = {2025}, eissn = {2227-9059}, orcid-numbers = {Molnár, András/0000-0002-4417-5166; Molnár, Viktória/0000-0002-2508-4429} } @article{MTMT:36089522, title = {Prehospital Emergency Finger Thoracostomy in Compensated Obstructive Shock: Benefits and Outcomes}, url = {https://m2.mtmt.hu/api/publication/36089522}, author = {Sutori, David and Erdélyi, László Sándor and Uri, Imre and Zavori, Laszlo and Ferkai, Luca Anna and Hetzman, László and Gebei, Robert and Kecskés, Gabriella and Molnár, F. Tamás}, doi = {10.1016/j.injury.2025.112331}, journal-iso = {INJURY}, journal = {INJURY: INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED}, volume = {56}, unique-id = {36089522}, issn = {0020-1383}, year = {2025}, eissn = {1879-0267}, orcid-numbers = {Ferkai, Luca Anna/0000-0003-4976-1516} } @article{MTMT:36096601, title = {Artificial intelligence in the diagnosis of obstructive sleep apnea: a scoping review}, url = {https://m2.mtmt.hu/api/publication/36096601}, author = {Kara, Miklós and Lakner, Zoltán and Tamás, László and Molnár, Viktória}, doi = {10.1007/s00405-025-09377-x}, journal-iso = {EUR ARCH OTO-RHINO-L}, journal = {EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY}, volume = {in press}, unique-id = {36096601}, issn = {0937-4477}, year = {2025}, eissn = {1434-4726}, orcid-numbers = {Kara, Miklós/0009-0005-7861-5288; Tamás, László/0000-0003-3723-9149; Molnár, Viktória/0000-0002-2508-4429} }