@article{MTMT:34821651,
	title = {A Mass Spectrometry Strategy for Protein Quantification Based on the Differential Alkylation of Cysteines Using Iodoacetamide and Acrylamide},
	url = {https://m2.mtmt.hu/api/publication/34821651},
	author = {Virág, Dávid and Schlosser, Gitta and Borbély, Adina and Gellén, Gabriella and Papp, Dávid and Kaleta, Zoltán and Dalmadiné Kiss, Borbála and Antal, István and Ludányi, Krisztina},
	doi = {10.3390/ijms25094656},
	journal-iso = {INT J MOL SCI},
	journal = {INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES},
	volume = {25},
	unique-id = {34821651},
	issn = {1661-6596},
	abstract = {Mass spectrometry has become the most prominent yet evolving technology in quantitative proteomics. Today, a number of label-free and label-based approaches are available for the relative and absolute quantification of proteins and peptides. However, the label-based methods rely solely on the employment of stable isotopes, which are expensive and often limited in availability. Here we propose a label-based quantification strategy, where the mass difference is identified by the differential alkylation of cysteines using iodoacetamide and acrylamide. The alkylation reactions were performed under identical experimental conditions; therefore, the method can be easily integrated into standard proteomic workflows. Using high-resolution mass spectrometry, the feasibility of this approach was assessed with a set of tryptic peptides of human serum albumin. Several critical questions, such as the efficiency of labeling and the effect of the differential alkylation on the peptide retention and fragmentation, were addressed. The concentration of the quality control samples calculated against the calibration curves were within the ±20% acceptance range. It was also demonstrated that heavy labeled peptides exhibit a similar extraction recovery and matrix effect to light ones. Consequently, the approach presented here may be a viable and cost-effective alternative of stable isotope labeling strategies for the quantification of cysteine-containing proteins.},
	year = {2024},
	eissn = {1422-0067},
	pages = {4656-4668},
	orcid-numbers = {Virág, Dávid/0000-0001-8411-0773; Schlosser, Gitta/0000-0002-7637-7133; Gellén, Gabriella/0000-0002-9048-2722; Papp, Dávid/0000-0002-2006-7777; Kaleta, Zoltán/0000-0003-2350-5100; Dalmadiné Kiss, Borbála/0000-0002-5774-7880; Antal, István/0000-0002-5434-201X; Ludányi, Krisztina/0000-0002-2380-9529}
}

@article{MTMT:34813473,
	title = {Mathematical modeling of transdermal delivery of topical drug formulations in a dynamic microfluidic diffusion chamber in health and disease},
	url = {https://m2.mtmt.hu/api/publication/34813473},
	author = {Szederkényi, G. and Kocsis, Dorottya and Vághy, M.A. and Czárán, Domonkos Tamás and Sasvári, Péter and Lengyel, Miléna and Naszlady, M.B. and Kreis, F. and Antal, István and Csépányi-Kömi, Roland and Erdő, F.},
	doi = {10.1371/journal.pone.0299501},
	journal-iso = {PLOS ONE},
	journal = {PLOS ONE},
	volume = {19},
	unique-id = {34813473},
	issn = {1932-6203},
	abstract = {Mathematical models of epidermal and dermal transport are essential for optimization and development of products for percutaneous delivery both for local and systemic indication and for evaluation of dermal exposure to chemicals for assessing their toxicity. These models often help directly by providing information on the rate of drug penetration through the skin and thus on the dermal or systemic concentration of drugs which is the base of their pharmacological effect. The simulations are also helpful in analyzing experimental data, reducing the number of experiments and translating the in vitro investigations to an in-vivo setting. In this study skin penetration of topically administered caffeine cream was investigated in a skin-on-a-chip microfluidic diffusion chamber at room temperature and at 32̊C. Also the transdermal penetration of caffeine in healthy and diseased conditions was compared in mouse skins from intact, psoriatic and allergic animals. In the last experimental setup dexamethasone, indomethacin, piroxicam and diclofenac were examined as a cream formulation for absorption across the dermal barrier. All the measured data were used for making mathematical simulation in a three-compartmental model. The calculated and measured results showed a good match, which findings indicate that our mathematical model might be applied for prediction of drug delivery through the skin under different circumstances and for various drugs in the novel, miniaturized diffusion chamber. © 2024 Szederkényi et al. This is an open access article distributed under the terms of the Creative Commons Attribution License,},
	keywords = {ABSORPTION; DEXAMETHASONE; ARTICLE; MOUSE; PREDICTION; nonhuman; in vitro study; simulation; drug formulation; drug delivery system; indometacin; room temperature; CAFFEINE; diclofenac; mathematical model; piroxicam; drug penetration; cream; Product development; diffusion chamber; psoriasis; Epidermis; compartment model; skin penetration; dermis; skin on a chip},
	year = {2024},
	eissn = {1932-6203},
	orcid-numbers = {Lengyel, Miléna/0000-0001-8865-054X; Antal, István/0000-0002-5434-201X; Csépányi-Kömi, Roland/0000-0001-6825-7142}
}

@article{MTMT:34796435,
	title = {External quality assurance program for diagnostic complement laboratories: evaluation of the results of the past seven years},
	url = {https://m2.mtmt.hu/api/publication/34796435},
	author = {Kirschfink, M. and Frazer-Abel, A. and Bertalanné Balogh, Emese and Goseberg, S. and Weiss, N. and Prohászka, Zoltán},
	doi = {10.3389/fimmu.2024.1368399},
	journal-iso = {FRONT IMMUNOL},
	journal = {FRONTIERS IN IMMUNOLOGY},
	volume = {15},
	unique-id = {34796435},
	issn = {1664-3224},
	year = {2024},
	eissn = {1664-3224},
	orcid-numbers = {Bertalanné Balogh, Emese/0000-0002-1127-3923; Prohászka, Zoltán/0000-0003-1761-7982}
}

@article{MTMT:34631071,
	title = {Microparticles and multi-unit systems for advanced drug delivery},
	url = {https://m2.mtmt.hu/api/publication/34631071},
	author = {Kállai-Szabó, Nikolett and Farkas, Dóra and Lengyel, Miléna and Basa, Bálint and Fleck, C. and Antal, István},
	doi = {10.1016/j.ejps.2024.106704},
	journal-iso = {EUR J PHARM SCI},
	journal = {EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES},
	volume = {194},
	unique-id = {34631071},
	issn = {0928-0987},
	year = {2024},
	eissn = {1879-0720},
	orcid-numbers = {Kállai-Szabó, Nikolett/0000-0002-8164-3993; Farkas, Dóra/0000-0003-4737-2108; Lengyel, Miléna/0000-0001-8865-054X; Basa, Bálint/0000-0003-4546-1727; Antal, István/0000-0002-5434-201X}
}

@article{MTMT:34506340,
	title = {Long-term shelf-life liposomes for delivery of prednisolone and budesonide},
	url = {https://m2.mtmt.hu/api/publication/34506340},
	author = {Budavári, Bálint Péter and Karancsi, Áron and Pinke, Balázs Gábor and Pállinger, Éva and Juriga-Tóth, Krisztina and Király, Márton and Szász, Adrienn Zsófia and Voszka, István and Molnár, Kolos and Kőhidai, László and Jedlovszky-Hajdú, Angéla and S. Nagy, Krisztina},
	doi = {10.1016/j.molliq.2023.123756},
	journal-iso = {J MOL LIQ},
	journal = {JOURNAL OF MOLECULAR LIQUIDS},
	volume = {394},
	unique-id = {34506340},
	issn = {0167-7322},
	year = {2024},
	eissn = {1873-3166},
	orcid-numbers = {Budavári, Bálint Péter/0000-0002-9846-4609; Pállinger, Éva/0000-0002-5789-0951; Juriga-Tóth, Krisztina/0000-0002-7939-5492; Király, Márton/0000-0002-9792-663X; Voszka, István/0000-0002-4555-853X; Molnár, Kolos/0000-0002-9331-4652; Kőhidai, László/0000-0002-9002-0296; Jedlovszky-Hajdú, Angéla/0000-0003-2720-783X; S. Nagy, Krisztina/0000-0002-4942-2947}
}

@article{MTMT:34457260,
	title = {Very Low-Pressure CID Experiments: High Energy Transfer and Fragmentation Pattern at the Single Collision Regime},
	url = {https://m2.mtmt.hu/api/publication/34457260},
	author = {Szabó, Dániel and Gömöry, Ágnes and Ludányi, Krisztina and Vékey, Károly and Drahos, László},
	doi = {10.3390/molecules29010211},
	journal-iso = {MOLECULES},
	journal = {MOLECULES},
	volume = {29},
	unique-id = {34457260},
	issn = {1420-3049},
	year = {2024},
	eissn = {1420-3049},
	orcid-numbers = {Szabó, Dániel/0000-0003-3375-395X; Gömöry, Ágnes/0000-0001-5216-0135; Ludányi, Krisztina/0000-0002-2380-9529; Drahos, László/0000-0001-9589-6652}
}

@article{MTMT:34405975,
	title = {Inhalation Dosage Forms: A Focus on Dry Powder Inhalers and Their Advancements},
	url = {https://m2.mtmt.hu/api/publication/34405975},
	author = {MAGRAMANE, Sabrina and Vlahovic, Kristina and Gordon, Péter and Kállai-Szabó, Nikolett and Zelkó, Romána and Antal, István and Farkas, Dóra},
	doi = {10.3390/ph16121658},
	journal-iso = {PHARMACEUTICALS-BASE},
	journal = {PHARMACEUTICALS},
	volume = {16},
	unique-id = {34405975},
	abstract = {In this review, an extensive analysis of dry powder inhalers (DPIs) is offered, focusing on their characteristics, formulation, stability, and manufacturing. The advantages of pulmonary delivery were investigated, as well as the significance of the particle size in drug deposition. The preparation of DPI formulations was also comprehensively explored, including physico-chemical characterization of powders, powder processing techniques, and formulation considerations. In addition to manufacturing procedures, testing methods were also discussed, providing insights into the development and evaluation of DPI formulations. This review also explores the design basics and critical attributes specific to DPIs, highlighting the significance of their optimization to achieve an effective inhalation therapy. Additionally, the morphology and stability of 3 DPI capsules (Spiriva, Braltus, and Onbrez) were investigated, offering valuable insights into the properties of these formulations. Altogether, these findings contribute to a deeper understanding of DPIs and their development, performance, and optimization of inhalation dosage forms.},
	year = {2023},
	eissn = {1424-8247},
	orcid-numbers = {MAGRAMANE, Sabrina/0000-0001-6818-8300; Vlahovic, Kristina/0009-0002-0045-7425; Kállai-Szabó, Nikolett/0000-0002-8164-3993; Zelkó, Romána/0000-0002-5419-9137; Antal, István/0000-0002-5434-201X; Farkas, Dóra/0000-0003-4737-2108}
}

@misc{MTMT:34128875,
	title = {Drug delivery system for the improvement of patient centricity, compliance, and adherence},
	url = {https://m2.mtmt.hu/api/publication/34128875},
	author = {Antal, István},
	unique-id = {34128875},
	year = {2023},
	orcid-numbers = {Antal, István/0000-0002-5434-201X}
}

@article{MTMT:34096036,
	title = {Nanoformulation of lipase from Porcine pancreas by electrospinning as a novel alternative for enzyme-based per os therapies},
	url = {https://m2.mtmt.hu/api/publication/34096036},
	author = {Tóth, Gergő D. and Kállai-Szabó, Nikolett and Lengyel, Miléna and Süvegh, Károly and Ender, Ferenc and Katona, Gábor and Nochta-Kazsoki, Adrienn Katalin and Zelkó, Romána and Antal, István and Balogh, György Tibor and Balogh Weiser, Diána},
	doi = {10.1016/j.molliq.2023.122819},
	journal-iso = {J MOL LIQ},
	journal = {JOURNAL OF MOLECULAR LIQUIDS},
	volume = {389},
	unique-id = {34096036},
	issn = {0167-7322},
	year = {2023},
	eissn = {1873-3166},
	orcid-numbers = {Kállai-Szabó, Nikolett/0000-0002-8164-3993; Lengyel, Miléna/0000-0001-8865-054X; Süvegh, Károly/0000-0001-8147-0546; Katona, Gábor/0000-0003-1564-4813; Nochta-Kazsoki, Adrienn Katalin/0000-0002-0611-3124; Zelkó, Romána/0000-0002-5419-9137; Antal, István/0000-0002-5434-201X; Balogh, György Tibor/0000-0003-3347-1880; Balogh Weiser, Diána/0000-0002-9957-1203}
}

@article{MTMT:34096011,
	title = {Viscoelasticity of Liposomal Dispersions},
	url = {https://m2.mtmt.hu/api/publication/34096011},
	author = {Budai, Lívia and Budai, Marianna and Pápay, Zsófia Edit and Szalkai, Petra and Niczinger, Noémi and Kijima, S. and Sugibayashi, K. and Antal, István and Kállai-Szabó, Nikolett},
	doi = {10.3390/nano13162340},
	journal-iso = {NANOMATERIALS-BASEL},
	journal = {NANOMATERIALS},
	volume = {13},
	unique-id = {34096011},
	year = {2023},
	eissn = {2079-4991},
	orcid-numbers = {Budai, Lívia/0000-0002-6720-5989; Budai, Marianna/0000-0003-4947-9924; Pápay, Zsófia Edit/0000-0002-7653-1065; Niczinger, Noémi/0000-0002-2076-0643; Antal, István/0000-0002-5434-201X; Kállai-Szabó, Nikolett/0000-0002-8164-3993}
}