@inproceedings{MTMT:34831171,
	title = {Ciklodextrin-segített kapilláris elektroforézis: benzil-izokinolin alkaloidok enantiomer-elválasztása},
	url = {https://m2.mtmt.hu/api/publication/34831171},
	author = {Várnagy, Erzsébet and Tóth, Gergő and Hosztafi, Sándor and Fejős, Ida and Malanga, Milo and Béni, Szabolcs},
	booktitle = {Biotechnológus Napok 2024},
	unique-id = {34831171},
	year = {2024},
	pages = {22},
	orcid-numbers = {Várnagy, Erzsébet/0009-0004-8348-4545; Tóth, Gergő/0000-0001-5341-319X; Hosztafi, Sándor/0000-0003-3793-4651; Fejős, Ida/0000-0002-3458-0854; Béni, Szabolcs/0000-0001-7056-6825}
}

@article{MTMT:34830527,
	title = {Cyclodextrin encapsulation enabling the anticancer repositioning of disulfiram: Preparation, analytical and in vitro biological characterization of the inclusion complexes},
	url = {https://m2.mtmt.hu/api/publication/34830527},
	author = {Benkő, Beáta Mária and Tóth, Gergő and Moldvai, Dorottya and Kádár, Szabina and Szabó, Edina and Szabó, Zoltán-István and Mazákné Kraszni, Márta and Szente, Lajos and Fiser, Béla and Sebestyén, Anna and Zelkó, Romána and Sebe, István},
	doi = {10.1016/j.ijpharm.2024.124187},
	journal-iso = {INT J PHARM},
	journal = {INTERNATIONAL JOURNAL OF PHARMACEUTICS},
	volume = {In press},
	unique-id = {34830527},
	issn = {0378-5173},
	year = {2024},
	eissn = {1873-3476},
	orcid-numbers = {Benkő, Beáta Mária/0000-0002-3608-6219; Tóth, Gergő/0000-0001-5341-319X; Szabó, Edina/0000-0001-9616-5122; Szabó, Zoltán-István/0000-0002-8740-0212; Mazákné Kraszni, Márta/0000-0003-4364-9486; Sebestyén, Anna/0000-0001-8814-4794; Zelkó, Romána/0000-0002-5419-9137; Sebe, István/0000-0003-0752-781X}
}

@article{MTMT:34821651,
	title = {A Mass Spectrometry Strategy for Protein Quantification Based on the Differential Alkylation of Cysteines Using Iodoacetamide and Acrylamide},
	url = {https://m2.mtmt.hu/api/publication/34821651},
	author = {Virág, Dávid and Schlosser, Gitta and Borbély, Adina and Gellén, Gabriella and Papp, Dávid and Kaleta, Zoltán and Dalmadiné Kiss, Borbála and Antal, István and Ludányi, Krisztina},
	doi = {10.3390/ijms25094656},
	journal-iso = {INT J MOL SCI},
	journal = {INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES},
	volume = {25},
	unique-id = {34821651},
	issn = {1661-6596},
	abstract = {Mass spectrometry has become the most prominent yet evolving technology in quantitative proteomics. Today, a number of label-free and label-based approaches are available for the relative and absolute quantification of proteins and peptides. However, the label-based methods rely solely on the employment of stable isotopes, which are expensive and often limited in availability. Here we propose a label-based quantification strategy, where the mass difference is identified by the differential alkylation of cysteines using iodoacetamide and acrylamide. The alkylation reactions were performed under identical experimental conditions; therefore, the method can be easily integrated into standard proteomic workflows. Using high-resolution mass spectrometry, the feasibility of this approach was assessed with a set of tryptic peptides of human serum albumin. Several critical questions, such as the efficiency of labeling and the effect of the differential alkylation on the peptide retention and fragmentation, were addressed. The concentration of the quality control samples calculated against the calibration curves were within the ±20% acceptance range. It was also demonstrated that heavy labeled peptides exhibit a similar extraction recovery and matrix effect to light ones. Consequently, the approach presented here may be a viable and cost-effective alternative of stable isotope labeling strategies for the quantification of cysteine-containing proteins.},
	year = {2024},
	eissn = {1422-0067},
	pages = {4656-4668},
	orcid-numbers = {Virág, Dávid/0000-0001-8411-0773; Schlosser, Gitta/0000-0002-7637-7133; Gellén, Gabriella/0000-0002-9048-2722; Papp, Dávid/0000-0002-2006-7777; Kaleta, Zoltán/0000-0003-2350-5100; Dalmadiné Kiss, Borbála/0000-0002-5774-7880; Antal, István/0000-0002-5434-201X; Ludányi, Krisztina/0000-0002-2380-9529}
}

@article{MTMT:34819821,
	title = {In situ captured antibacterial action of membrane-incising peptide lamellae},
	url = {https://m2.mtmt.hu/api/publication/34819821},
	author = {el Battioui, Kamal and Chakraborty, Sohini and Wacha, András and Molnár, Dániel and Quemé-Peña, Mayra and Szigyártó, Imola Cs. and Szabó, Csenge Lilla and Bodor, Andrea and Horváti, Kata and Gyulai, Gergő and Bősze, Szilvia and Mihály, Judith and Jezsó, Bálint and Románszki, Loránd and Tóth, Judit and Varga, Zoltán and Mándity, István and Juhász, Tünde and Beke-Somfai, Tamás},
	doi = {10.1038/s41467-024-47708-4},
	journal-iso = {NAT COMMUN},
	journal = {NATURE COMMUNICATIONS},
	volume = {15},
	unique-id = {34819821},
	issn = {2041-1723},
	abstract = {Developing unique mechanisms of action are essential to combat the growing issue of antimicrobial resistance. Supramolecular assemblies combining the improved biostability of non-natural compounds with the complex membrane-attacking mechanisms of natural peptides are promising alternatives to conventional antibiotics. However, for such compounds the direct visual insight on antibacterial action is still lacking. Here we employ a design strategy focusing on an inducible assembly mechanism and utilized electron microscopy (EM) to follow the formation of supramolecular structures of lysine-rich heterochiral β 3 -peptides, termed lamellin-2K and lamellin-3K, triggered by bacterial cell surface lipopolysaccharides. Combined molecular dynamics simulations, EM and bacterial assays confirmed that the phosphate-induced conformational change on these lamellins led to the formation of striped lamellae capable of incising the cell envelope of Gram-negative bacteria thereby exerting antibacterial activity. Our findings also provide a mechanistic link for membrane-targeting agents depicting the antibiotic mechanism derived from the in-situ formation of active supramolecules.},
	year = {2024},
	eissn = {2041-1723},
	orcid-numbers = {Wacha, András/0000-0002-9609-0893; Szabó, Csenge Lilla/0000-0002-6508-3439; Bodor, Andrea/0000-0002-7422-298X; Gyulai, Gergő/0000-0002-1352-2014; Jezsó, Bálint/0000-0002-1306-4797; Románszki, Loránd/0000-0002-6347-5228; Tóth, Judit/0000-0002-0965-046X; Varga, Zoltán/0000-0002-5741-2669; Mándity, István/0000-0003-2865-6143; Beke-Somfai, Tamás/0000-0002-4788-3758}
}

@article{MTMT:34813473,
	title = {Mathematical modeling of transdermal delivery of topical drug formulations in a dynamic microfluidic diffusion chamber in health and disease},
	url = {https://m2.mtmt.hu/api/publication/34813473},
	author = {Szederkényi, G. and Kocsis, Dorottya and Vághy, M.A. and Czárán, Domonkos Tamás and Sasvári, Péter and Lengyel, Miléna and Naszlady, M.B. and Kreis, F. and Antal, István and Csépányi-Kömi, Roland and Erdő, F.},
	doi = {10.1371/journal.pone.0299501},
	journal-iso = {PLOS ONE},
	journal = {PLOS ONE},
	volume = {19},
	unique-id = {34813473},
	issn = {1932-6203},
	abstract = {Mathematical models of epidermal and dermal transport are essential for optimization and development of products for percutaneous delivery both for local and systemic indication and for evaluation of dermal exposure to chemicals for assessing their toxicity. These models often help directly by providing information on the rate of drug penetration through the skin and thus on the dermal or systemic concentration of drugs which is the base of their pharmacological effect. The simulations are also helpful in analyzing experimental data, reducing the number of experiments and translating the in vitro investigations to an in-vivo setting. In this study skin penetration of topically administered caffeine cream was investigated in a skin-on-a-chip microfluidic diffusion chamber at room temperature and at 32̊C. Also the transdermal penetration of caffeine in healthy and diseased conditions was compared in mouse skins from intact, psoriatic and allergic animals. In the last experimental setup dexamethasone, indomethacin, piroxicam and diclofenac were examined as a cream formulation for absorption across the dermal barrier. All the measured data were used for making mathematical simulation in a three-compartmental model. The calculated and measured results showed a good match, which findings indicate that our mathematical model might be applied for prediction of drug delivery through the skin under different circumstances and for various drugs in the novel, miniaturized diffusion chamber. © 2024 Szederkényi et al. This is an open access article distributed under the terms of the Creative Commons Attribution License,},
	keywords = {ABSORPTION; DEXAMETHASONE; ARTICLE; MOUSE; PREDICTION; nonhuman; in vitro study; simulation; drug formulation; drug delivery system; indometacin; room temperature; CAFFEINE; diclofenac; mathematical model; piroxicam; drug penetration; cream; Product development; diffusion chamber; psoriasis; Epidermis; compartment model; skin penetration; dermis; skin on a chip},
	year = {2024},
	eissn = {1932-6203},
	orcid-numbers = {Lengyel, Miléna/0000-0001-8865-054X; Antal, István/0000-0002-5434-201X; Csépányi-Kömi, Roland/0000-0001-6825-7142}
}

@article{MTMT:34804378,
	title = {Solving the puzzle of 2-hydroxypropyl β-cyclodextrin: Detailed assignment of the substituent distribution by NMR spectroscopy},
	url = {https://m2.mtmt.hu/api/publication/34804378},
	author = {Kalydi, Eszter and Malanga, Milo and Nielsen, Thorbjørn Terndrup and Wimmer, Reinhard and Béni, Szabolcs},
	doi = {10.1016/j.carbpol.2024.122167},
	journal-iso = {CARBOHYD POLYM},
	journal = {CARBOHYDRATE POLYMERS},
	unique-id = {34804378},
	issn = {0144-8617},
	year = {2024},
	eissn = {1879-1344},
	orcid-numbers = {Béni, Szabolcs/0000-0001-7056-6825}
}

@article{MTMT:34796435,
	title = {External quality assurance program for diagnostic complement laboratories: evaluation of the results of the past seven years},
	url = {https://m2.mtmt.hu/api/publication/34796435},
	author = {Kirschfink, M. and Frazer-Abel, A. and Bertalanné Balogh, Emese and Goseberg, S. and Weiss, N. and Prohászka, Zoltán},
	doi = {10.3389/fimmu.2024.1368399},
	journal-iso = {FRONT IMMUNOL},
	journal = {FRONTIERS IN IMMUNOLOGY},
	volume = {15},
	unique-id = {34796435},
	issn = {1664-3224},
	year = {2024},
	eissn = {1664-3224},
	orcid-numbers = {Bertalanné Balogh, Emese/0000-0002-1127-3923; Prohászka, Zoltán/0000-0003-1761-7982}
}

@article{MTMT:34779723,
	title = {Olfactory genes affect major depression in highly educated, emotionally stable, lean women: a bridge between animal models and precision medicine},
	url = {https://m2.mtmt.hu/api/publication/34779723},
	author = {Eszlári, Nóra and Hullám, Gábor István and Gál, Zsófia and Török, Dóra and Nagy, Tamás and Millinghoffer, András Dániel and Baksa, Dániel and Gonda, Xénia and Antal, Péter and Bagdy, György and Juhász, Gabriella},
	doi = {10.1038/s41398-024-02867-2},
	journal-iso = {TRANSL PSYCHIAT},
	journal = {TRANSLATIONAL PSYCHIATRY},
	volume = {14},
	unique-id = {34779723},
	issn = {2158-3188},
	abstract = {Most current approaches to establish subgroups of depressed patients for precision medicine aim to rely on biomarkers that require highly specialized assessment. Our present aim was to stratify participants of the UK Biobank cohort based on three readily measurable common independent risk factors, and to investigate depression genomics in each group to discover common and separate biological etiology. Two-step cluster analysis was run separately in males ( n  = 149,879) and females ( n  = 174,572), with neuroticism (a tendency to experience negative emotions), body fat percentage, and years spent in education as input variables. Genome-wide association analyses were implemented within each of the resulting clusters, for the lifetime occurrence of either a depressive episode or recurrent depressive disorder as the outcome. Variant-based, gene-based, gene set-based, and tissue-specific gene expression test were applied. Phenotypically distinct clusters with high genetic intercorrelations in depression genomics were found. A two-cluster solution was the best model in each sex with some differences including the less important role of neuroticism in males. In females, in case of a protective pattern of low neuroticism, low body fat percentage, and high level of education, depression was associated with pathways related to olfactory function. While also in females but in a risk pattern of high neuroticism, high body fat percentage, and less years spent in education, depression showed association with complement system genes. Our results, on one hand, indicate that alteration of olfactory pathways, that can be paralleled to the well-known rodent depression models of olfactory bulbectomy, might be a novel target towards precision psychiatry in females with less other risk factors for depression. On the other hand, our results in multi-risk females may provide a special case of immunometabolic depression.},
	year = {2024},
	eissn = {2158-3188},
	orcid-numbers = {Eszlári, Nóra/0000-0003-4913-028X; Hullám, Gábor István/0000-0002-4765-2351; Gál, Zsófia/0000-0002-9441-1497; Török, Dóra/0000-0001-9213-4345; Nagy, Tamás/0000-0002-0137-4341; Baksa, Dániel/0000-0002-7826-9179; Gonda, Xénia/0000-0001-9015-4203; Bagdy, György/0000-0001-8141-3410; Juhász, Gabriella/0000-0002-5975-4267}
}

@article{MTMT:34779108,
	title = {Diterpenes Isolated from Three Different Plectranthus Sensu Lato Species and Their Antiproliferative Activities against Gynecological and Glioblastoma Cancer Cells},
	url = {https://m2.mtmt.hu/api/publication/34779108},
	author = {Gáborová, Mária and Vágvölgyi, Máté and Tayeb, Bizhar Ahmed and Minorics, Renáta and Zupkó, István and Jurček, Ondřej and Béni, Szabolcs and Kubínová, Renata and Balogh, György Tibor and Hunyadi, Attila},
	doi = {10.1021/acsomega.4c00800},
	journal-iso = {ACS OMEGA},
	journal = {ACS OMEGA},
	volume = {9},
	unique-id = {34779108},
	issn = {2470-1343},
	year = {2024},
	eissn = {2470-1343},
	pages = {18495-18504},
	orcid-numbers = {Vágvölgyi, Máté/0000-0002-2233-9422; Tayeb, Bizhar Ahmed/0000-0001-5197-564X; Minorics, Renáta/0000-0001-9685-813X; Zupkó, István/0000-0003-3243-5300; Béni, Szabolcs/0000-0001-7056-6825; Balogh, György Tibor/0000-0003-3347-1880; Hunyadi, Attila/0000-0003-0074-3472}
}

@article{MTMT:34776969,
	title = {Assessment of the practical impact of adjusting beta-lactam dosages based on therapeutic drug monitoring in critically ill adult patients: a systematic review and meta-analysis of randomized clinical trials and observational studies},
	url = {https://m2.mtmt.hu/api/publication/34776969},
	author = {Gulyás, Eszter and Horváth, István László and Engh, Marie Anne and Bunduc, Stefania and Dembrovszky, Fanni and Fehérvári, Péter and Bánvölgyi, András and Csupor, Dezső and Hegyi, Péter and Karvaly, Gellért Balázs},
	doi = {10.1038/s41598-024-58200-w},
	journal-iso = {SCI REP},
	journal = {SCIENTIFIC REPORTS},
	volume = {14},
	unique-id = {34776969},
	issn = {2045-2322},
	year = {2024},
	eissn = {2045-2322},
	orcid-numbers = {Engh, Marie Anne/0000-0003-4269-5130; Dembrovszky, Fanni/0000-0001-6953-3591; Bánvölgyi, András/0000-0002-7071-1364; Csupor, Dezső/0000-0002-4088-3333; Hegyi, Péter/0000-0003-0399-7259; Karvaly, Gellért Balázs/0000-0003-2468-5633}
}